diff --git a/libsyclinterface/CMakeLists.txt b/libsyclinterface/CMakeLists.txt
index 4c6987901a..1ee4bafd31 100644
--- a/libsyclinterface/CMakeLists.txt
+++ b/libsyclinterface/CMakeLists.txt
@@ -114,10 +114,10 @@ if(WIN32)
     set(CMAKE_C_FLAGS "${CMAKE_C_FLAGS} ${WARNING_FLAGS}")
     set(CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS} ${WARNING_FLAGS}")
     set(CMAKE_C_FLAGS_DEBUG
-        "${CMAKE_C_FLAGS_DEBUG} ${WARNING_FLAGS} -ggdb3 -DDEBUG"
+        "${CMAKE_C_FLAGS_DEBUG} ${WARNING_FLAGS} -O0 -ggdb3 -DDEBUG"
     )
     set(CMAKE_CXX_FLAGS_DEBUG
-        "${CMAKE_CXX_FLAGS_DEBUG} ${WARNING_FLAGS} -ggdb3 -DDEBUG"
+        "${CMAKE_CXX_FLAGS_DEBUG} ${WARNING_FLAGS} -O0 -ggdb3 -DDEBUG"
     )
 elseif(UNIX)
     string(CONCAT WARNING_FLAGS
@@ -152,10 +152,10 @@ elseif(UNIX)
     set(CMAKE_C_FLAGS "${CMAKE_C_FLAGS} ${CFLAGS}")
     set(CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS} ${CXXFLAGS}")
     set(CMAKE_C_FLAGS_DEBUG
-        "${CMAKE_C_FLAGS_DEBUG} ${CFLAGS} -ggdb3 -DDEBUG"
+        "${CMAKE_C_FLAGS_DEBUG} ${CFLAGS} -O0 -ggdb3 -DDEBUG"
     )
     set(CMAKE_CXX_FLAGS_DEBUG
-        "${CMAKE_CXX_FLAGS_DEBUG} ${CXXFLAGS} -ggdb3 -DDEBUG"
+        "${CMAKE_CXX_FLAGS_DEBUG} ${CXXFLAGS} -O0 -ggdb3 -DDEBUG"
     )
 else()
     message(FATAL_ERROR "Unsupported system.")