diff --git a/Marlin/Conditionals.h b/Marlin/Conditionals.h
index 41dcec76c39c..c70c84ca70bd 100644
--- a/Marlin/Conditionals.h
+++ b/Marlin/Conditionals.h
@@ -395,10 +395,10 @@
   #endif
 
   /**
-   * Avoid double-negatives for enabling features
+   * Host keep alive
    */
-  #if DISABLED(DISABLE_HOST_KEEPALIVE)
-    #define HOST_KEEPALIVE_FEATURE
+  #ifndef DEFAULT_KEEPALIVE_INTERVAL
+    #define DEFAULT_KEEPALIVE_INTERVAL 2
   #endif
 
   /**
diff --git a/Marlin/Configuration.h b/Marlin/Configuration.h
index 3b164a4f65c0..c45f6fcf3c73 100644
--- a/Marlin/Configuration.h
+++ b/Marlin/Configuration.h
@@ -733,13 +733,11 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 //
 // Host Keepalive
 //
-// By default Marlin will send a busy status message to the host
+// When enabled Marlin will send a busy status message to the host
 // every couple of seconds when it can't accept commands.
 //
-//#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
-#if DISABLED(DISABLE_HOST_KEEPALIVE)
-  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
-#endif
+#define HOST_KEEPALIVE_FEATURE        // Disable this if your host doesn't like keepalive messages
+#define DEFAULT_KEEPALIVE_INTERVAL 2  // Number of seconds between "busy" messages. Set with M113.
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/Felix/Configuration.h b/Marlin/example_configurations/Felix/Configuration.h
index 57292b218e3a..a705f6531539 100644
--- a/Marlin/example_configurations/Felix/Configuration.h
+++ b/Marlin/example_configurations/Felix/Configuration.h
@@ -716,13 +716,11 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 //
 // Host Keepalive
 //
-// By default Marlin will send a busy status message to the host
+// When enabled Marlin will send a busy status message to the host
 // every couple of seconds when it can't accept commands.
 //
-//#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
-#if DISABLED(DISABLE_HOST_KEEPALIVE)
-  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
-#endif
+#define HOST_KEEPALIVE_FEATURE       // Disable this if your host doesn't like keepalive messages
+#define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/Hephestos/Configuration.h b/Marlin/example_configurations/Hephestos/Configuration.h
index 4bf40859facc..de0375c3becb 100644
--- a/Marlin/example_configurations/Hephestos/Configuration.h
+++ b/Marlin/example_configurations/Hephestos/Configuration.h
@@ -725,13 +725,11 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = true; // set to true to invert the lo
 //
 // Host Keepalive
 //
-// By default Marlin will send a busy status message to the host
+// When enabled Marlin will send a busy status message to the host
 // every couple of seconds when it can't accept commands.
 //
-//#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
-#if DISABLED(DISABLE_HOST_KEEPALIVE)
-  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
-#endif
+#define HOST_KEEPALIVE_FEATURE       // Disable this if your host doesn't like keepalive messages
+#define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/Hephestos_2/Configuration.h b/Marlin/example_configurations/Hephestos_2/Configuration.h
index 285ffb536f22..24a61f962e91 100644
--- a/Marlin/example_configurations/Hephestos_2/Configuration.h
+++ b/Marlin/example_configurations/Hephestos_2/Configuration.h
@@ -727,13 +727,11 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 //
 // Host Keepalive
 //
-// By default Marlin will send a busy status message to the host
+// When enabled Marlin will send a busy status message to the host
 // every couple of seconds when it can't accept commands.
 //
-//#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
-#if DISABLED(DISABLE_HOST_KEEPALIVE)
-  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
-#endif
+#define HOST_KEEPALIVE_FEATURE       // Disable this if your host doesn't like keepalive messages
+#define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/K8200/Configuration.h b/Marlin/example_configurations/K8200/Configuration.h
index 17290bc875a2..81a01062d97f 100644
--- a/Marlin/example_configurations/K8200/Configuration.h
+++ b/Marlin/example_configurations/K8200/Configuration.h
@@ -750,13 +750,11 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 //
 // Host Keepalive
 //
-// By default Marlin will send a busy status message to the host
+// When enabled Marlin will send a busy status message to the host
 // every couple of seconds when it can't accept commands.
 //
-//#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
-#if DISABLED(DISABLE_HOST_KEEPALIVE)
-  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
-#endif
+#define HOST_KEEPALIVE_FEATURE       // Disable this if your host doesn't like keepalive messages
+#define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/RepRapWorld/Megatronics/Configuration.h b/Marlin/example_configurations/RepRapWorld/Megatronics/Configuration.h
index 22d776619139..95c14b1ce874 100644
--- a/Marlin/example_configurations/RepRapWorld/Megatronics/Configuration.h
+++ b/Marlin/example_configurations/RepRapWorld/Megatronics/Configuration.h
@@ -733,13 +733,11 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 //
 // Host Keepalive
 //
-// By default Marlin will send a busy status message to the host
+// When enabled Marlin will send a busy status message to the host
 // every couple of seconds when it can't accept commands.
 //
-//#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
-#if DISABLED(DISABLE_HOST_KEEPALIVE)
-  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
-#endif
+#define HOST_KEEPALIVE_FEATURE       // Disable this if your host doesn't like keepalive messages
+#define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/RigidBot/Configuration.h b/Marlin/example_configurations/RigidBot/Configuration.h
index 42a086495a21..60eb579e21ff 100644
--- a/Marlin/example_configurations/RigidBot/Configuration.h
+++ b/Marlin/example_configurations/RigidBot/Configuration.h
@@ -728,13 +728,11 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 //
 // Host Keepalive
 //
-// By default Marlin will send a busy status message to the host
+// When enabled Marlin will send a busy status message to the host
 // every couple of seconds when it can't accept commands.
 //
-//#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
-#if DISABLED(DISABLE_HOST_KEEPALIVE)
-  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
-#endif
+#define HOST_KEEPALIVE_FEATURE       // Disable this if your host doesn't like keepalive messages
+#define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/SCARA/Configuration.h b/Marlin/example_configurations/SCARA/Configuration.h
index 4bc60ac2aa1b..460479fcff11 100644
--- a/Marlin/example_configurations/SCARA/Configuration.h
+++ b/Marlin/example_configurations/SCARA/Configuration.h
@@ -741,13 +741,11 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 //
 // Host Keepalive
 //
-// By default Marlin will send a busy status message to the host
+// When enabled Marlin will send a busy status message to the host
 // every couple of seconds when it can't accept commands.
 //
-//#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
-#if DISABLED(DISABLE_HOST_KEEPALIVE)
-  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
-#endif
+#define HOST_KEEPALIVE_FEATURE       // Disable this if your host doesn't like keepalive messages
+#define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/TAZ4/Configuration.h b/Marlin/example_configurations/TAZ4/Configuration.h
index 7b52693b94a6..f8d760cc7514 100644
--- a/Marlin/example_configurations/TAZ4/Configuration.h
+++ b/Marlin/example_configurations/TAZ4/Configuration.h
@@ -754,13 +754,11 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 //
 // Host Keepalive
 //
-// By default Marlin will send a busy status message to the host
+// When enabled Marlin will send a busy status message to the host
 // every couple of seconds when it can't accept commands.
 //
-//#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
-#if DISABLED(DISABLE_HOST_KEEPALIVE)
-  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
-#endif
+#define HOST_KEEPALIVE_FEATURE       // Disable this if your host doesn't like keepalive messages
+#define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/WITBOX/Configuration.h b/Marlin/example_configurations/WITBOX/Configuration.h
index aecbdc75d15c..7b67831d5f3f 100644
--- a/Marlin/example_configurations/WITBOX/Configuration.h
+++ b/Marlin/example_configurations/WITBOX/Configuration.h
@@ -725,13 +725,11 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = true; // set to true to invert the lo
 //
 // Host Keepalive
 //
-// By default Marlin will send a busy status message to the host
+// When enabled Marlin will send a busy status message to the host
 // every couple of seconds when it can't accept commands.
 //
-//#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
-#if DISABLED(DISABLE_HOST_KEEPALIVE)
-  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
-#endif
+#define HOST_KEEPALIVE_FEATURE       // Disable this if your host doesn't like keepalive messages
+#define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/adafruit/ST7565/Configuration.h b/Marlin/example_configurations/adafruit/ST7565/Configuration.h
index 5eb8301be56b..0a0d9f21f0c6 100644
--- a/Marlin/example_configurations/adafruit/ST7565/Configuration.h
+++ b/Marlin/example_configurations/adafruit/ST7565/Configuration.h
@@ -733,13 +733,11 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 //
 // Host Keepalive
 //
-// By default Marlin will send a busy status message to the host
+// When enabled Marlin will send a busy status message to the host
 // every couple of seconds when it can't accept commands.
 //
-//#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
-#if DISABLED(DISABLE_HOST_KEEPALIVE)
-  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
-#endif
+#define HOST_KEEPALIVE_FEATURE       // Disable this if your host doesn't like keepalive messages
+#define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/delta/biv2.5/Configuration.h b/Marlin/example_configurations/delta/biv2.5/Configuration.h
index 6cbb21ae5116..c827fb0c1dc7 100644
--- a/Marlin/example_configurations/delta/biv2.5/Configuration.h
+++ b/Marlin/example_configurations/delta/biv2.5/Configuration.h
@@ -862,13 +862,11 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = true; // set to true to invert the lo
 //
 // Host Keepalive
 //
-// By default Marlin will send a busy status message to the host
+// When enabled Marlin will send a busy status message to the host
 // every couple of seconds when it can't accept commands.
 //
-//#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
-#if DISABLED(DISABLE_HOST_KEEPALIVE)
-  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
-#endif
+#define HOST_KEEPALIVE_FEATURE       // Disable this if your host doesn't like keepalive messages
+#define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/delta/generic/Configuration.h b/Marlin/example_configurations/delta/generic/Configuration.h
index e6f049528ad0..75e8d0434121 100644
--- a/Marlin/example_configurations/delta/generic/Configuration.h
+++ b/Marlin/example_configurations/delta/generic/Configuration.h
@@ -862,13 +862,11 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = true; // set to true to invert the lo
 //
 // Host Keepalive
 //
-// By default Marlin will send a busy status message to the host
+// When enabled Marlin will send a busy status message to the host
 // every couple of seconds when it can't accept commands.
 //
-//#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
-#if DISABLED(DISABLE_HOST_KEEPALIVE)
-  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
-#endif
+#define HOST_KEEPALIVE_FEATURE       // Disable this if your host doesn't like keepalive messages
+#define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/delta/kossel_mini/Configuration.h b/Marlin/example_configurations/delta/kossel_mini/Configuration.h
index e55d2941ee59..2d2585e953f3 100644
--- a/Marlin/example_configurations/delta/kossel_mini/Configuration.h
+++ b/Marlin/example_configurations/delta/kossel_mini/Configuration.h
@@ -866,13 +866,11 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 //
 // Host Keepalive
 //
-// By default Marlin will send a busy status message to the host
+// When enabled Marlin will send a busy status message to the host
 // every couple of seconds when it can't accept commands.
 //
-//#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
-#if DISABLED(DISABLE_HOST_KEEPALIVE)
-  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
-#endif
+#define HOST_KEEPALIVE_FEATURE       // Disable this if your host doesn't like keepalive messages
+#define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/delta/kossel_pro/Configuration.h b/Marlin/example_configurations/delta/kossel_pro/Configuration.h
index 61c6eee00837..6a548b65e259 100644
--- a/Marlin/example_configurations/delta/kossel_pro/Configuration.h
+++ b/Marlin/example_configurations/delta/kossel_pro/Configuration.h
@@ -859,13 +859,11 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 //
 // Host Keepalive
 //
-// By default Marlin will send a busy status message to the host
+// When enabled Marlin will send a busy status message to the host
 // every couple of seconds when it can't accept commands.
 //
-//#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
-#if DISABLED(DISABLE_HOST_KEEPALIVE)
-  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
-#endif
+#define HOST_KEEPALIVE_FEATURE       // Disable this if your host doesn't like keepalive messages
+#define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/delta/kossel_xl/Configuration.h b/Marlin/example_configurations/delta/kossel_xl/Configuration.h
index 37240d13680e..cf8aefe8ed92 100644
--- a/Marlin/example_configurations/delta/kossel_xl/Configuration.h
+++ b/Marlin/example_configurations/delta/kossel_xl/Configuration.h
@@ -867,13 +867,11 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 //
 // Host Keepalive
 //
-// By default Marlin will send a busy status message to the host
+// When enabled Marlin will send a busy status message to the host
 // every couple of seconds when it can't accept commands.
 //
-//#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
-#if DISABLED(DISABLE_HOST_KEEPALIVE)
-  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
-#endif
+#define HOST_KEEPALIVE_FEATURE       // Disable this if your host doesn't like keepalive messages
+#define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/makibox/Configuration.h b/Marlin/example_configurations/makibox/Configuration.h
index 3d21ed402aaa..4e1ea0e64672 100644
--- a/Marlin/example_configurations/makibox/Configuration.h
+++ b/Marlin/example_configurations/makibox/Configuration.h
@@ -736,13 +736,11 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 //
 // Host Keepalive
 //
-// By default Marlin will send a busy status message to the host
+// When enabled Marlin will send a busy status message to the host
 // every couple of seconds when it can't accept commands.
 //
-//#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
-#if DISABLED(DISABLE_HOST_KEEPALIVE)
-  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
-#endif
+#define HOST_KEEPALIVE_FEATURE       // Disable this if your host doesn't like keepalive messages
+#define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/tvrrug/Round2/Configuration.h b/Marlin/example_configurations/tvrrug/Round2/Configuration.h
index 32bfc9cd04d3..2e4969c6eb89 100644
--- a/Marlin/example_configurations/tvrrug/Round2/Configuration.h
+++ b/Marlin/example_configurations/tvrrug/Round2/Configuration.h
@@ -727,13 +727,11 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = true; // set to true to invert the lo
 //
 // Host Keepalive
 //
-// By default Marlin will send a busy status message to the host
+// When enabled Marlin will send a busy status message to the host
 // every couple of seconds when it can't accept commands.
 //
-//#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
-#if DISABLED(DISABLE_HOST_KEEPALIVE)
-  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
-#endif
+#define HOST_KEEPALIVE_FEATURE       // Disable this if your host doesn't like keepalive messages
+#define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
 
 //
 // M100 Free Memory Watcher