diff --git a/src/OrchardCore.Modules/OrchardCore.Localization/Startup.cs b/src/OrchardCore.Modules/OrchardCore.Localization/Startup.cs
index 8c825301c3d..73b06eab34c 100644
--- a/src/OrchardCore.Modules/OrchardCore.Localization/Startup.cs
+++ b/src/OrchardCore.Modules/OrchardCore.Localization/Startup.cs
@@ -1,4 +1,5 @@
 using System;
+using System.Threading.Tasks;
 using Microsoft.AspNetCore.Builder;
 using Microsoft.AspNetCore.Routing;
 using Microsoft.Extensions.DependencyInjection;
@@ -41,12 +42,12 @@ public override void ConfigureServices(IServiceCollection services)
         }
 
         /// <inheritdocs />
-        public override void Configure(IApplicationBuilder app, IEndpointRouteBuilder routes, IServiceProvider serviceProvider)
+        public override async ValueTask ConfigureAsync(IApplicationBuilder app, IEndpointRouteBuilder routes, IServiceProvider serviceProvider)
         {
             var localizationService = serviceProvider.GetService<ILocalizationService>();
 
-            var defaultCulture = localizationService.GetDefaultCultureAsync().GetAwaiter().GetResult();
-            var supportedCultures = localizationService.GetSupportedCulturesAsync().GetAwaiter().GetResult();
+            var defaultCulture = await localizationService.GetDefaultCultureAsync();
+            var supportedCultures = await localizationService.GetSupportedCulturesAsync();
 
             var localizationOptions = serviceProvider.GetService<IOptions<RequestLocalizationOptions>>().Value;
             var ignoreSystemSettings = serviceProvider.GetService<IOptions<CultureOptions>>().Value.IgnoreSystemSettings;
diff --git a/src/OrchardCore/OrchardCore.Abstractions/Modules/Builder/OrchardCoreBuilder.cs b/src/OrchardCore/OrchardCore.Abstractions/Modules/Builder/OrchardCoreBuilder.cs
index ba41209dfc6..b3c679717ea 100644
--- a/src/OrchardCore/OrchardCore.Abstractions/Modules/Builder/OrchardCoreBuilder.cs
+++ b/src/OrchardCore/OrchardCore.Abstractions/Modules/Builder/OrchardCoreBuilder.cs
@@ -1,5 +1,6 @@
 using System;
 using System.Collections.Generic;
+using System.Threading.Tasks;
 using Microsoft.AspNetCore.Builder;
 using Microsoft.AspNetCore.Routing;
 using OrchardCore.Environment.Shell.Builders;
@@ -97,6 +98,46 @@ public OrchardCoreBuilder Configure(Action<IApplicationBuilder> configure, int o
             return Configure((app, routes, sp) => configure(app), order);
         }
 
+        /// <summary>
+        /// This async action gets called for each tenant. Use this method to configure the tenant pipeline.
+        /// </summary>
+        /// <param name="configureAsync">The async action to execute when configuring the request's pipeline for a tenant.</param>
+        /// <param name="order">The order of the action to execute. Lower values will be executed first.</param>
+        public OrchardCoreBuilder Configure(Func<IApplicationBuilder, IEndpointRouteBuilder, IServiceProvider, ValueTask> configureAsync, int order = 0)
+        {
+            if (!_actions.TryGetValue(order, out var actions))
+            {
+                actions = _actions[order] = new StartupActions(order);
+
+                ApplicationServices.AddTransient<IStartup>(sp => new StartupActionsStartup(
+                    sp.GetRequiredService<IServiceProvider>(), actions, order));
+            }
+
+            actions.AsyncConfigureActions.Add(configureAsync);
+
+            return this;
+        }
+
+        /// <summary>
+        /// This async action gets called for each tenant. Use this method to configure the tenant pipeline.
+        /// </summary>
+        /// <param name="configureAsync">The async action to execute when configuring the request's pipeline for a tenant.</param>
+        /// <param name="order">The order of the action to execute. Lower values will be executed first.</param>
+        public OrchardCoreBuilder Configure(Func<IApplicationBuilder, IEndpointRouteBuilder, ValueTask> configureAsync, int order = 0)
+        {
+            return Configure((app, routes, sp) => configureAsync(app, routes), order);
+        }
+
+        /// <summary>
+        /// This async action gets called for each tenant. Use this method to configure the tenant pipeline.
+        /// </summary>
+        /// <param name="configureAsync">The async action to execute when configuring the request's pipeline for a tenant.</param>
+        /// <param name="order">The order of the action to execute. Lower values will be executed first.</param>
+        public OrchardCoreBuilder Configure(Func<IApplicationBuilder, ValueTask> configureAsync, int order = 0)
+        {
+            return Configure((app, routes, sp) => configureAsync(app), order);
+        }
+
         public OrchardCoreBuilder EnableFeature(string id)
         {
             return ConfigureServices(services =>
diff --git a/src/OrchardCore/OrchardCore.Abstractions/Modules/Builder/StartupActions.cs b/src/OrchardCore/OrchardCore.Abstractions/Modules/Builder/StartupActions.cs
index 7fd53da5a12..bb34dfafe2b 100644
--- a/src/OrchardCore/OrchardCore.Abstractions/Modules/Builder/StartupActions.cs
+++ b/src/OrchardCore/OrchardCore.Abstractions/Modules/Builder/StartupActions.cs
@@ -1,5 +1,6 @@
 using System;
 using System.Collections.Generic;
+using System.Threading.Tasks;
 using Microsoft.AspNetCore.Builder;
 using Microsoft.AspNetCore.Routing;
 
@@ -14,8 +15,13 @@ public StartupActions(int order)
 
         public int Order { get; }
 
-        public ICollection<Action<IServiceCollection, IServiceProvider>> ConfigureServicesActions { get; } = new List<Action<IServiceCollection, IServiceProvider>>();
+        public ICollection<Action<IServiceCollection, IServiceProvider>> ConfigureServicesActions { get; } =
+            new List<Action<IServiceCollection, IServiceProvider>>();
 
-        public ICollection<Action<IApplicationBuilder, IEndpointRouteBuilder, IServiceProvider>> ConfigureActions { get; } = new List<Action<IApplicationBuilder, IEndpointRouteBuilder, IServiceProvider>>();
+        public ICollection<Action<IApplicationBuilder, IEndpointRouteBuilder, IServiceProvider>> ConfigureActions { get; } =
+            new List<Action<IApplicationBuilder, IEndpointRouteBuilder, IServiceProvider>>();
+
+        public ICollection<Func<IApplicationBuilder, IEndpointRouteBuilder, IServiceProvider, ValueTask>> AsyncConfigureActions { get; } =
+            new List<Func<IApplicationBuilder, IEndpointRouteBuilder, IServiceProvider, ValueTask>>();
     }
 }
diff --git a/src/OrchardCore/OrchardCore.Abstractions/Modules/Builder/StartupActionsStartup.cs b/src/OrchardCore/OrchardCore.Abstractions/Modules/Builder/StartupActionsStartup.cs
index 603ecbe7e83..20273aaf0d9 100644
--- a/src/OrchardCore/OrchardCore.Abstractions/Modules/Builder/StartupActionsStartup.cs
+++ b/src/OrchardCore/OrchardCore.Abstractions/Modules/Builder/StartupActionsStartup.cs
@@ -1,4 +1,5 @@
 using System;
+using System.Threading.Tasks;
 using Microsoft.AspNetCore.Builder;
 using Microsoft.AspNetCore.Routing;
 using Microsoft.Extensions.DependencyInjection;
@@ -37,5 +38,18 @@ public override void Configure(IApplicationBuilder app, IEndpointRouteBuilder ro
                 configure?.Invoke(app, routes, serviceProvider);
             }
         }
+
+        public override async ValueTask ConfigureAsync(IApplicationBuilder app, IEndpointRouteBuilder routes, IServiceProvider serviceProvider)
+        {
+            foreach (var asyncConfigure in _actions.AsyncConfigureActions)
+            {
+                if (asyncConfigure is null)
+                {
+                    continue;
+                }
+
+                await asyncConfigure(app, routes, serviceProvider);
+            }
+        }
     }
 }
diff --git a/src/OrchardCore/OrchardCore.Abstractions/Modules/IAsyncStartup.cs b/src/OrchardCore/OrchardCore.Abstractions/Modules/IAsyncStartup.cs
new file mode 100644
index 00000000000..24519cea75e
--- /dev/null
+++ b/src/OrchardCore/OrchardCore.Abstractions/Modules/IAsyncStartup.cs
@@ -0,0 +1,21 @@
+using System;
+using System.Threading.Tasks;
+using Microsoft.AspNetCore.Builder;
+using Microsoft.AspNetCore.Routing;
+
+namespace OrchardCore.Modules
+{
+    /// <summary>
+    /// An implementation of this interface allows to configure asynchronously the tenant pipeline.
+    /// </summary>
+    public interface IAsyncStartup
+    {
+        /// <summary>
+        /// This method gets called by the runtime. Use this method to configure the tenant pipeline.
+        /// </summary>
+        /// <param name="builder"></param>
+        /// <param name="routes"></param>
+        /// <param name="serviceProvider"></param>
+        ValueTask ConfigureAsync(IApplicationBuilder builder, IEndpointRouteBuilder routes, IServiceProvider serviceProvider);
+    }
+}
diff --git a/src/OrchardCore/OrchardCore.Abstractions/Modules/StartupBase.cs b/src/OrchardCore/OrchardCore.Abstractions/Modules/StartupBase.cs
index e24c6972224..97087c5dbbd 100644
--- a/src/OrchardCore/OrchardCore.Abstractions/Modules/StartupBase.cs
+++ b/src/OrchardCore/OrchardCore.Abstractions/Modules/StartupBase.cs
@@ -1,11 +1,12 @@
 using System;
+using System.Threading.Tasks;
 using Microsoft.AspNetCore.Builder;
 using Microsoft.AspNetCore.Routing;
 using Microsoft.Extensions.DependencyInjection;
 
 namespace OrchardCore.Modules
 {
-    public abstract class StartupBase : IStartup
+    public abstract class StartupBase : IStartup, IAsyncStartup
     {
         /// <inheritdoc />
         public virtual int Order { get; } = 0;
@@ -22,5 +23,8 @@ public virtual void ConfigureServices(IServiceCollection services)
         public virtual void Configure(IApplicationBuilder app, IEndpointRouteBuilder routes, IServiceProvider serviceProvider)
         {
         }
+
+        /// <inheritdoc />
+        public virtual ValueTask ConfigureAsync(IApplicationBuilder app, IEndpointRouteBuilder routes, IServiceProvider serviceProvider) => default;
     }
 }
diff --git a/src/OrchardCore/OrchardCore/Modules/Extensions/ShellPipelineExtensions.cs b/src/OrchardCore/OrchardCore/Modules/Extensions/ShellPipelineExtensions.cs
index 26dc7b4b252..21a04fa9756 100644
--- a/src/OrchardCore/OrchardCore/Modules/Extensions/ShellPipelineExtensions.cs
+++ b/src/OrchardCore/OrchardCore/Modules/Extensions/ShellPipelineExtensions.cs
@@ -8,6 +8,7 @@
 using Microsoft.AspNetCore.Hosting;
 using Microsoft.AspNetCore.Hosting.Server;
 using Microsoft.AspNetCore.Http.Features;
+using Microsoft.AspNetCore.Routing;
 using Microsoft.Extensions.DependencyInjection;
 using OrchardCore.Environment.Shell;
 using OrchardCore.Environment.Shell.Builders;
@@ -17,6 +18,8 @@ namespace OrchardCore.Modules;
 
 public static class ShellPipelineExtensions
 {
+    private const string EndpointRouteBuilder = "__EndpointRouteBuilder";
+
     private static readonly ConcurrentDictionary<string, SemaphoreSlim> _semaphores = new();
 
     /// <summary>
@@ -31,7 +34,7 @@ public static async Task BuildPipelineAsync(this ShellContext context)
         {
             if (!context.HasPipeline())
             {
-                context.Pipeline = context.BuildPipeline();
+                context.Pipeline = await context.BuildPipelineInternalAsync();
             }
         }
         finally
@@ -43,22 +46,20 @@ public static async Task BuildPipelineAsync(this ShellContext context)
     /// <summary>
     /// Builds the tenant pipeline.
     /// </summary>
-    private static IShellPipeline BuildPipeline(this ShellContext context)
+    private static async ValueTask<IShellPipeline> BuildPipelineInternalAsync(this ShellContext context)
     {
         var features = context.ServiceProvider.GetService<IServer>()?.Features;
         var builder = new ApplicationBuilder(context.ServiceProvider, features ?? new FeatureCollection());
         var startupFilters = builder.ApplicationServices.GetService<IEnumerable<IStartupFilter>>();
 
-        Action<IApplicationBuilder> configure = builder =>
-        {
-            ConfigurePipeline(builder);
-        };
-
+        Action<IApplicationBuilder> configure = builder => { };
         foreach (var filter in startupFilters.Reverse())
         {
             configure = filter.Configure(configure);
         }
 
+        await ConfigurePipelineAsync(builder);
+
         configure(builder);
 
         var shellPipeline = new ShellRequestPipeline
@@ -72,19 +73,35 @@ private static IShellPipeline BuildPipeline(this ShellContext context)
     /// <summary>
     /// Configures the tenant pipeline.
     /// </summary>
-    private static void ConfigurePipeline(IApplicationBuilder builder)
+    private static async ValueTask ConfigurePipelineAsync(IApplicationBuilder builder)
     {
         // 'IStartup' instances are ordered by module dependencies with a 'ConfigureOrder' of 0 by default.
         // 'OrderBy' performs a stable sort, so the order is preserved among equal 'ConfigureOrder' values.
         var startups = builder.ApplicationServices.GetServices<IStartup>().OrderBy(s => s.ConfigureOrder);
 
+        // Should be done first.
+        builder.UseRouting();
+
+        // Try to retrieve the current 'IEndpointRouteBuilder'.
+        if (!builder.Properties.TryGetValue(EndpointRouteBuilder, out var obj) ||
+            obj is not IEndpointRouteBuilder routes)
+        {
+            throw new InvalidOperationException("Failed to retrieve the current endpoint route builder.");
+        }
+
+        // Routes can be then configured outside 'UseEndpoints()'.
         var services = ShellScope.Services;
-        builder.UseRouting().UseEndpoints(routes =>
+        foreach (var startup in startups)
         {
-            foreach (var startup in startups)
+            if (startup is IAsyncStartup asyncStartup)
             {
-                startup.Configure(builder, routes, services);
+                await asyncStartup.ConfigureAsync(builder, routes, services);
             }
-        });
+
+            startup.Configure(builder, routes, services);
+        }
+
+        // Knowing that routes are already configured.
+        builder.UseEndpoints(routes => { });
     }
 }