diff --git a/WORKSPACE b/WORKSPACE
index b48e85017ff129..92ea222b2a8b51 100644
--- a/WORKSPACE
+++ b/WORKSPACE
@@ -2,12 +2,15 @@ workspace(name = "com_github_grpc_grpc")
 
 load("@bazel_tools//tools/build_defs/repo:http.bzl", "http_archive")
 load("//bazel:grpc_deps.bzl", "grpc_deps", "grpc_test_only_deps")
+load("//bazel:grpc_python_deps.bzl", "grpc_python_deps")
 load("@bazel_tools//tools/build_defs/repo:git.bzl", "git_repository")
 
 grpc_deps()
 
 grpc_test_only_deps()
 
+grpc_python_deps()
+
 register_execution_platforms(
     "//third_party/toolchains:local",
     "//third_party/toolchains:local_large",
diff --git a/bazel/cc_grpc_library.bzl b/bazel/cc_grpc_library.bzl
index dea493eaf20160..8ffe0795352319 100644
--- a/bazel/cc_grpc_library.bzl
+++ b/bazel/cc_grpc_library.bzl
@@ -1,5 +1,6 @@
 """Generates and compiles C++ grpc stubs from proto_library rules."""
 
+load("@rules_proto//proto:defs.bzl", "proto_library")
 load("//bazel:generate_cc.bzl", "generate_cc")
 load("//bazel:protobuf.bzl", "well_known_proto_libs")
 
@@ -64,7 +65,7 @@ def cc_grpc_library(
         if well_known_protos:
             proto_deps += well_known_proto_libs()
 
-        native.proto_library(
+        proto_library(
             name = proto_target,
             srcs = srcs,
             deps = proto_deps,
diff --git a/bazel/grpc_build_system.bzl b/bazel/grpc_build_system.bzl
index 95c639c9dbc55f..752831b533b3f7 100644
--- a/bazel/grpc_build_system.bzl
+++ b/bazel/grpc_build_system.bzl
@@ -106,7 +106,7 @@ def grpc_cc_library(
         testonly = testonly,
         linkopts = linkopts,
         includes = [
-            "include", 
+            "include",
             "src/core/ext/upb-generated", # Once upb code-gen issue is resolved, remove this.
         ],
         alwayslink = alwayslink,
@@ -181,7 +181,7 @@ def grpc_cc_test(name, srcs = [], deps = [], external_deps = [], args = [], data
         "exec_compatible_with": exec_compatible_with,
     }
     if uses_polling:
-        # the vanilla version of the test should run on platforms that only 
+        # the vanilla version of the test should run on platforms that only
         # support a single poller
         native.cc_test(
             name = name,
@@ -317,7 +317,7 @@ def grpc_objc_library(
         deps: dependencies
         visibility: visibility, default to public
     """
-    
+
     native.objc_library(
         name = name,
         hdrs = hdrs,
@@ -329,7 +329,7 @@ def grpc_objc_library(
         includes = includes,
         visibility = visibility,
     )
-    
+
 def grpc_upb_proto_library(name, deps):
     upb_proto_library(name = name, deps = deps)
 
diff --git a/bazel/grpc_deps.bzl b/bazel/grpc_deps.bzl
index 07ed16ef3d2ed7..8c5b5cd3c1eae4 100644
--- a/bazel/grpc_deps.bzl
+++ b/bazel/grpc_deps.bzl
@@ -61,7 +61,7 @@ def grpc_deps():
         name = "gtest",
         actual = "@com_github_google_googletest//:gtest",
     )
-    
+
     native.bind(
         name = "benchmark",
         actual = "@com_github_google_benchmark//:benchmark",
@@ -117,9 +117,9 @@ def grpc_deps():
     if "com_google_protobuf" not in native.existing_rules():
         http_archive(
             name = "com_google_protobuf",
-            sha256 = "416212e14481cff8fd4849b1c1c1200a7f34808a54377e22d7447efdf54ad758",
-            strip_prefix = "protobuf-09745575a923640154bcf307fba8aedff47f240a",
-            url = "https://github.com/google/protobuf/archive/09745575a923640154bcf307fba8aedff47f240a.tar.gz",
+            sha256 = "758249b537abba2f21ebc2d02555bf080917f0f2f88f4cbe2903e0e28c4187ed",
+            strip_prefix = "protobuf-3.10.0",
+            url = "https://github.com/google/protobuf/archive/v3.10.0.tar.gz",
         )
 
     if "com_github_google_googletest" not in native.existing_rules():
diff --git a/bazel/grpc_python_deps.bzl b/bazel/grpc_python_deps.bzl
index 8f00e560c4ef9e..824c92fa95295c 100644
--- a/bazel/grpc_python_deps.bzl
+++ b/bazel/grpc_python_deps.bzl
@@ -4,21 +4,12 @@ load("@bazel_tools//tools/build_defs/repo:http.bzl", "http_archive")
 load("@com_github_grpc_grpc//third_party/py:python_configure.bzl", "python_configure")
 
 def grpc_python_deps():
-    native.bind(
-        name = "six",
-        actual = "@six_archive//:six",
-    )
-
-    # protobuf binds to the name "six", so we can't use it here.
-    # See https://github.com/bazelbuild/bazel/issues/1952 for why bind is
-    # horrible.
-    if "six_archive" not in native.existing_rules():
+    if "six" not in native.existing_rules():
         http_archive(
-            name = "six_archive",
-            strip_prefix = "six-1.12.0",
+            name = "six",
             build_file = "@com_github_grpc_grpc//third_party:six.BUILD",
             sha256 = "d16a0141ec1a18405cd4ce8b4613101da75da0e9a7aec5bdd4fa804d0e0eba73",
-            urls = ["https://files.pythonhosted.org/packages/dd/bf/4138e7bfb757de47d1f4b6994648ec67a51efe58fa907c1e11e350cddfca/six-1.12.0.tar.gz"],
+            urls = ["https://pypi.python.org/packages/source/s/six/six-1.12.0.tar.gz"],
         )
 
     if "enum34" not in native.existing_rules():
diff --git a/src/objective-c/examples/BUILD b/src/objective-c/examples/BUILD
index 4d838b17ba0f24..62f8040b5ead98 100644
--- a/src/objective-c/examples/BUILD
+++ b/src/objective-c/examples/BUILD
@@ -19,7 +19,7 @@ licenses(["notice"])  # 3-clause BSD
 package(default_visibility = ["//visibility:public"])
 
 load(
-    "//src/objective-c:grpc_objc_internal_library.bzl", 
+    "//src/objective-c:grpc_objc_internal_library.bzl",
     "grpc_objc_examples_library",
     "local_objc_grpc_library",
     "proto_library_objc_wrapper",
diff --git a/src/objective-c/grpc_objc_internal_library.bzl b/src/objective-c/grpc_objc_internal_library.bzl
index c90293d827dcdb..61b07150f057f8 100644
--- a/src/objective-c/grpc_objc_internal_library.bzl
+++ b/src/objective-c/grpc_objc_internal_library.bzl
@@ -23,6 +23,7 @@
 # each change must be ported from one to the other.
 #
 
+load("@rules_proto//proto:defs.bzl", "proto_library")
 load(
     "//bazel:generate_objc.bzl",
     "generate_objc",
@@ -39,7 +40,7 @@ def proto_library_objc_wrapper(
     """proto_library for adding dependencies to google/protobuf protos
     use_well_known_protos - ignored in open source version
     """
-    native.proto_library(
+    proto_library(
         name = name,
         srcs = srcs,
         deps = deps,
diff --git a/src/proto/grpc/channelz/BUILD b/src/proto/grpc/channelz/BUILD
index cfc8531de1b445..fe368069c9006e 100644
--- a/src/proto/grpc/channelz/BUILD
+++ b/src/proto/grpc/channelz/BUILD
@@ -12,10 +12,11 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-licenses(["notice"])  # Apache v2
-
+load("@rules_proto//proto:defs.bzl", "proto_library")
 load("//bazel:grpc_build_system.bzl", "grpc_proto_library", "grpc_package")
 
+licenses(["notice"])  # Apache v2
+
 grpc_package(name = "channelz", visibility = "public")
 
 grpc_proto_library(
diff --git a/src/proto/grpc/core/BUILD b/src/proto/grpc/core/BUILD
index 46de9fae187d9e..00ed887ab7ea9a 100644
--- a/src/proto/grpc/core/BUILD
+++ b/src/proto/grpc/core/BUILD
@@ -12,10 +12,11 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-licenses(["notice"])  # Apache v2
-
+load("@rules_proto//proto:defs.bzl", "proto_library")
 load("//bazel:grpc_build_system.bzl", "grpc_proto_library", "grpc_package")
 
+licenses(["notice"])  # Apache v2
+
 grpc_package(name = "core", visibility = "public")
 
 grpc_proto_library(
diff --git a/src/proto/grpc/gcp/BUILD b/src/proto/grpc/gcp/BUILD
index 1c22d89e464eb4..513f3f60f9f65b 100644
--- a/src/proto/grpc/gcp/BUILD
+++ b/src/proto/grpc/gcp/BUILD
@@ -12,6 +12,8 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
+load("@rules_proto//proto:defs.bzl", "proto_library")
+
 licenses(["notice"])  # Apache v2
 
 proto_library(
diff --git a/src/proto/grpc/health/v1/BUILD b/src/proto/grpc/health/v1/BUILD
index fc58e8a17701e7..812b01acb5fc80 100644
--- a/src/proto/grpc/health/v1/BUILD
+++ b/src/proto/grpc/health/v1/BUILD
@@ -12,10 +12,11 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-licenses(["notice"])  # Apache v2
-
+load("@rules_proto//proto:defs.bzl", "proto_library")
 load("//bazel:grpc_build_system.bzl", "grpc_proto_library", "grpc_package")
 
+licenses(["notice"])  # Apache v2
+
 grpc_package(name = "health", visibility = "public")
 
 grpc_proto_library(
diff --git a/src/proto/grpc/lb/v1/BUILD b/src/proto/grpc/lb/v1/BUILD
index 2a6e82a57e7620..a3006e022432d2 100644
--- a/src/proto/grpc/lb/v1/BUILD
+++ b/src/proto/grpc/lb/v1/BUILD
@@ -12,10 +12,11 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-licenses(["notice"])  # Apache v2
-
+load("@rules_proto//proto:defs.bzl", "proto_library")
 load("//bazel:grpc_build_system.bzl", "grpc_package", "grpc_proto_library")
 
+licenses(["notice"])  # Apache v2
+
 grpc_package(
     name = "lb",
     visibility = "public",
diff --git a/src/proto/grpc/reflection/v1alpha/BUILD b/src/proto/grpc/reflection/v1alpha/BUILD
index 5424c0d867e7ae..6ad826bd34d51c 100644
--- a/src/proto/grpc/reflection/v1alpha/BUILD
+++ b/src/proto/grpc/reflection/v1alpha/BUILD
@@ -12,10 +12,11 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-licenses(["notice"])  # Apache v2
-
+load("@rules_proto//proto:defs.bzl", "proto_library")
 load("//bazel:grpc_build_system.bzl", "grpc_proto_library", "grpc_package")
 
+licenses(["notice"])  # Apache v2
+
 grpc_package(name = "reflection", visibility = "public")
 
 grpc_proto_library(
diff --git a/src/proto/grpc/status/BUILD b/src/proto/grpc/status/BUILD
index 14315d36e36d07..7d63e027235e1c 100644
--- a/src/proto/grpc/status/BUILD
+++ b/src/proto/grpc/status/BUILD
@@ -12,10 +12,11 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-licenses(["notice"])  # Apache v2
-
+load("@rules_proto//proto:defs.bzl", "proto_library")
 load("//bazel:grpc_build_system.bzl", "grpc_proto_library", "grpc_package")
 
+licenses(["notice"])  # Apache v2
+
 grpc_package(name = "status", visibility = "public")
 
 grpc_proto_library(
diff --git a/src/proto/grpc/testing/BUILD b/src/proto/grpc/testing/BUILD
index 308d4b6ed99f08..ac67b819d77c6c 100644
--- a/src/proto/grpc/testing/BUILD
+++ b/src/proto/grpc/testing/BUILD
@@ -12,12 +12,13 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-licenses(["notice"])  # Apache v2
-
+load("@rules_proto//proto:defs.bzl", "proto_library")
 load("//bazel:grpc_build_system.bzl", "grpc_proto_library", "grpc_package")
 load("@grpc_python_dependencies//:requirements.bzl", "requirement")
 load("//bazel:python_rules.bzl", "py_proto_library", "py_grpc_library")
 
+licenses(["notice"])  # Apache v2
+
 grpc_package(
     name = "testing",
     visibility = "public",
diff --git a/src/proto/grpc/testing/duplicate/BUILD b/src/proto/grpc/testing/duplicate/BUILD
index 714c9a75185377..1d45f3fbec2d3c 100644
--- a/src/proto/grpc/testing/duplicate/BUILD
+++ b/src/proto/grpc/testing/duplicate/BUILD
@@ -12,10 +12,10 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-licenses(["notice"])  # Apache v2
-
 load("//bazel:grpc_build_system.bzl", "grpc_proto_library", "grpc_package")
 
+licenses(["notice"])  # Apache v2
+
 grpc_package(name = "duplicate", visibility = "public")
 
 grpc_proto_library(
diff --git a/src/proto/grpc/testing/proto2/BUILD.bazel b/src/proto/grpc/testing/proto2/BUILD.bazel
index 8acb233302aca5..4559d898123fa7 100644
--- a/src/proto/grpc/testing/proto2/BUILD.bazel
+++ b/src/proto/grpc/testing/proto2/BUILD.bazel
@@ -1,7 +1,8 @@
+load("@rules_proto//proto:defs.bzl", "proto_library")
 load("@grpc_python_dependencies//:requirements.bzl", "requirement")
+load("//bazel:python_rules.bzl", "py_proto_library")
 
 package(default_visibility = ["//visibility:public"])
-load("//bazel:python_rules.bzl", "py_proto_library")
 
 proto_library(
     name = "empty2_proto_descriptor",
diff --git a/src/proto/grpc/testing/xds/BUILD b/src/proto/grpc/testing/xds/BUILD
index b9fb013512b013..6cf43dae0b4be0 100644
--- a/src/proto/grpc/testing/xds/BUILD
+++ b/src/proto/grpc/testing/xds/BUILD
@@ -12,10 +12,11 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-licenses(["notice"])  # Apache v2
-
+load("@rules_proto//proto:defs.bzl", "proto_library")
 load("//bazel:grpc_build_system.bzl", "grpc_package", "grpc_proto_library")
 
+licenses(["notice"])  # Apache v2
+
 grpc_package(
     name = "xds",
     visibility = "public",
diff --git a/src/python/grpcio/grpc/BUILD.bazel b/src/python/grpcio/grpc/BUILD.bazel
index 1b5a018249a1b9..5a9867eb19adcf 100644
--- a/src/python/grpcio/grpc/BUILD.bazel
+++ b/src/python/grpcio/grpc/BUILD.bazel
@@ -14,7 +14,7 @@ py_library(
         "//src/python/grpcio/grpc/_cython:cygrpc",
         "//src/python/grpcio/grpc/experimental",
         "//src/python/grpcio/grpc/framework",
-        "@six_archive//:six",
+        "@six",
     ] + select({
         "//conditions:default": ["@enum34//:enum34",],
         "//:python3": [],
diff --git a/src/python/grpcio/grpc/framework/foundation/BUILD.bazel b/src/python/grpcio/grpc/framework/foundation/BUILD.bazel
index b539fa46da71a8..27503dd7614fa0 100644
--- a/src/python/grpcio/grpc/framework/foundation/BUILD.bazel
+++ b/src/python/grpcio/grpc/framework/foundation/BUILD.bazel
@@ -22,7 +22,7 @@ py_library(
     name = "callable_util",
     srcs = ["callable_util.py"],
     deps = [
-        "//external:six",
+        "@six",
     ] + select({
         "//conditions:default": ["@enum34//:enum34",],
         "//:python3": [],
@@ -33,7 +33,7 @@ py_library(
     name = "future",
     srcs = ["future.py"],
     deps = [
-        "//external:six",
+        "@six",
     ],
 )
 
@@ -58,6 +58,6 @@ py_library(
     name = "stream",
     srcs = ["stream.py"],
     deps = [
-        "//external:six",
+        "@six",
     ],
 )
diff --git a/src/python/grpcio/grpc/framework/interfaces/base/BUILD.bazel b/src/python/grpcio/grpc/framework/interfaces/base/BUILD.bazel
index 5d0c06950a84bf..4787f70ed7d4d2 100644
--- a/src/python/grpcio/grpc/framework/interfaces/base/BUILD.bazel
+++ b/src/python/grpcio/grpc/framework/interfaces/base/BUILD.bazel
@@ -14,7 +14,7 @@ py_library(
     srcs = ["base.py"],
     deps = [
         "//src/python/grpcio/grpc/framework/foundation:abandonment",
-        "//external:six",
+        "@six",
     ] + select({
         "//conditions:default": ["@enum34//:enum34",],
         "//:python3": [],
diff --git a/src/python/grpcio/grpc/framework/interfaces/face/BUILD.bazel b/src/python/grpcio/grpc/framework/interfaces/face/BUILD.bazel
index 3af1404eade7fc..00daac365172d6 100644
--- a/src/python/grpcio/grpc/framework/interfaces/face/BUILD.bazel
+++ b/src/python/grpcio/grpc/framework/interfaces/face/BUILD.bazel
@@ -15,7 +15,7 @@ py_library(
     deps = [
         "//src/python/grpcio/grpc/framework/foundation",
         "//src/python/grpcio/grpc/framework/common",
-        "//external:six",
+        "@six",
     ] + select({
         "//conditions:default": ["@enum34//:enum34",],
         "//:python3": [],
diff --git a/third_party/six.BUILD b/third_party/six.BUILD
index 60dc7811492d63..88c75520defbbe 100644
--- a/third_party/six.BUILD
+++ b/third_party/six.BUILD
@@ -1,6 +1,13 @@
+genrule(
+  name = "copy_six",
+  srcs = ["six-1.12.0/six.py"],
+  outs = ["__init__.py"],
+  cmd = "cp $< $(@)",
+)
+
 py_library(
-    name = "six",
-    srcs = ["six.py"],
-    srcs_version = "PY2AND3",
-    visibility = ["//visibility:public"],
+  name = "six",
+  srcs = ["__init__.py"],
+  srcs_version = "PY2AND3",
+  visibility = ["//visibility:public"],
 )