diff --git a/packages/react/src/components/ComboBox/ComboBox.stories.js b/packages/react/src/components/ComboBox/ComboBox.stories.js
index dde72b5b4618..44551650bd08 100644
--- a/packages/react/src/components/ComboBox/ComboBox.stories.js
+++ b/packages/react/src/components/ComboBox/ComboBox.stories.js
@@ -74,6 +74,22 @@ export const Default = () => (
   </div>
 );
 
+export const ExperimentalAutoAlign = () => (
+  <div style={{ width: 400 }}>
+    <div style={{ height: 300 }}></div>
+    <ComboBox
+      onChange={() => {}}
+      id="carbon-combobox"
+      items={items}
+      itemToString={(item) => (item ? item.text : '')}
+      titleText="ComboBox title"
+      helperText="Combobox helper text"
+      autoAlign={true}
+    />
+    <div style={{ height: 800 }}></div>
+  </div>
+);
+
 export const AllowCustomValue = () => {
   const filterItems = (menu) => {
     return menu?.item?.toLowerCase().includes(menu?.inputValue?.toLowerCase());
diff --git a/packages/react/src/components/ComboBox/ComboBox.tsx b/packages/react/src/components/ComboBox/ComboBox.tsx
index a6c85a6323c9..a3963ab1e16c 100644
--- a/packages/react/src/components/ComboBox/ComboBox.tsx
+++ b/packages/react/src/components/ComboBox/ComboBox.tsx
@@ -43,6 +43,7 @@ import mergeRefs from '../../tools/mergeRefs';
 import deprecate from '../../prop-types/deprecate';
 import { usePrefix } from '../../internal/usePrefix';
 import { FormContext } from '../FluidForm';
+import { useFloating, flip, autoUpdate } from '@floating-ui/react';
 
 const {
   InputBlur,
@@ -150,6 +151,11 @@ export interface ComboBoxProps<ItemType>
    */
   ariaLabel?: string;
 
+  /**
+   * Will auto-align the dropdown on first render if it is not visible. This prop is currently experimental and is subject to future changes.
+   */
+  autoAlign?: boolean;
+
   /**
    * An optional className to add to the container node
    */
@@ -313,6 +319,7 @@ const ComboBox = forwardRef(
     const {
       ['aria-label']: ariaLabel = 'Choose an item',
       ariaLabel: deprecatedAriaLabel,
+      autoAlign = false,
       className: containerClassName,
       direction = 'bottom',
       disabled = false,
@@ -342,6 +349,41 @@ const ComboBox = forwardRef(
       slug,
       ...rest
     } = props;
+    const { refs, floatingStyles } = useFloating(
+      autoAlign
+        ? {
+            // placement: direction,
+
+            // The floating element is positioned relative to its nearest
+            // containing block (usually the viewport). It will in many cases also
+            // “break” the floating element out of a clipping ancestor.
+            // https://floating-ui.com/docs/misc#clipping
+            strategy: 'fixed',
+
+            // Middleware order matters, arrow should be last
+            middleware: [
+              flip({
+                fallbackAxisSideDirection: 'none',
+              }),
+            ],
+            whileElementsMounted: autoUpdate,
+          }
+        : {} // When autoAlign is turned off, floating-ui will not be used
+    );
+    const parentWidth = (refs?.reference?.current as HTMLElement)?.clientWidth;
+    useEffect(() => {
+      if (autoAlign) {
+        Object.keys(floatingStyles).forEach((style) => {
+          if (refs.floating.current) {
+            refs.floating.current.style[style] = floatingStyles[style];
+          }
+        });
+
+        if (parentWidth && refs.floating.current) {
+          refs.floating.current.style.width = parentWidth + 'px';
+        }
+      }
+    }, [floatingStyles, autoAlign, refs.floating, parentWidth]);
     const prefix = usePrefix();
     const { isFluid } = useContext(FormContext);
     const textInput = useRef<HTMLInputElement>(null);
@@ -631,6 +673,7 @@ const ComboBox = forwardRef(
           size={size}
           warn={warn}
           warnText={warnText}
+          ref={refs.setReference}
           warnTextId={warnTextId}>
           <div className={`${prefix}--list-box__field`}>
             <input
@@ -737,6 +780,7 @@ const ComboBox = forwardRef(
           </div>
           {normalizedSlug}
           <ListBox.Menu
+            ref={mergeRefs(getMenuProps().ref, refs.setFloating)}
             {...getMenuProps({
               'aria-label': deprecatedAriaLabel || ariaLabel,
             })}>
@@ -822,6 +866,11 @@ ComboBox.propTypes = {
     'This prop syntax has been deprecated. Please use the new `aria-label`.'
   ),
 
+  /**
+   * Will auto-align the dropdown on first render if it is not visible. This prop is currently experimental and is subject to future changes.
+   */
+  autoAlign: PropTypes.bool,
+
   /**
    * An optional className to add to the container node
    */