diff --git a/CHANGELOG.md b/CHANGELOG.md
index b1ea94db8fc0..e48783a88e8b 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -43,6 +43,7 @@ Ref: https://keepachangelog.com/en/1.0.0/
 * [#20939](https://github.com/cosmos/cosmos-sdk/pull/20939) Fix collection reverse iterator to include `pagination.key` in the result.
 * (client/grpc) [#20969](https://github.com/cosmos/cosmos-sdk/pull/20969) Fix `node.NewQueryServer` method not setting `cfg`.
 * (testutil/integration) [#21006](https://github.com/cosmos/cosmos-sdk/pull/21006) Fix `NewIntegrationApp` method not writing default genesis to state
+* (runtime) [#21080](https://github.com/cosmos/cosmos-sdk/pull/21080) Fix `app.yaml` / `app.json` incompatibility with `depinject v1.0.0`
 
 ## [v0.50.8](https://github.com/cosmos/cosmos-sdk/releases/tag/v0.50.8) - 2024-07-15
 
diff --git a/runtime/module.go b/runtime/module.go
index 9ab1bbf40816..d7d46cc75b90 100644
--- a/runtime/module.go
+++ b/runtime/module.go
@@ -127,7 +127,7 @@ func ProvideApp(interfaceRegistry codectypes.InterfaceRegistry) (
 type AppInputs struct {
 	depinject.In
 
-	AppConfig          *appv1alpha1.Config
+	AppConfig          *appv1alpha1.Config `optional:"true"`
 	Config             *runtimev1alpha1.Module
 	AppBuilder         *AppBuilder
 	Modules            map[string]appmodule.AppModule
diff --git a/runtime/services.go b/runtime/services.go
index 5dcd2bf3427d..3730b4a2af92 100644
--- a/runtime/services.go
+++ b/runtime/services.go
@@ -15,7 +15,11 @@ import (
 )
 
 func (a *App) registerRuntimeServices(cfg module.Configurator) error {
-	appv1alpha1.RegisterQueryServer(cfg.QueryServer(), services.NewAppQueryService(a.appConfig))
+	// no app config service if user is using app.yaml / app.json
+	// it is as in v0.52, this whole query service does not exist at all.
+	if a.appConfig != nil {
+		appv1alpha1.RegisterQueryServer(cfg.QueryServer(), services.NewAppQueryService(a.appConfig))
+	}
 	autocliv1.RegisterQueryServer(cfg.QueryServer(), services.NewAutoCLIQueryService(a.ModuleManager.Modules))
 
 	reflectionSvc, err := services.NewReflectionService()