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medschool-hormones.tex
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medschool-hormones.tex
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\documentclass[12pt]{article}
\usepackage[margin=.5in,top=.2in,left=.2in,landscape]{geometry}
\usepackage{tikz-cd,mathtools}
\begin{document}
\pagestyle{empty}
\newcommand\headsub[3]{$\overbrace{\displaystyle\hspace{2cm}\mathclap{\text{#3}}\hspace{2cm}\vphantom{\sum^\infty}}^{\overset{\displaystyle\text{\Large #1}}{\displaystyle\text{#2}\vphantom{\int}}}$}
\newcommand\stackthree[3]{$\smash{\overset{\mathclap{\textstyle\text{\tiny#1}\phantom{\text{\tiny#2}}}}{\overset{\mathclap{\text{\tiny#2}\phantom{\text{\tiny#1}}}}{\displaystyle\vphantom{\sum}\text{\footnotesize#3}}}}$}
\[\begin{tikzcd}[math mode = false, row sep = .5in]
{}& $\mathclap{\overbrace{\hspace{10cm}}^{\displaystyle\text{Adrenal cortex}\vphantom\int}}$
&& $\mathclap{\overbrace{\hspace{4cm}}^{\displaystyle\text{Peripheral tissue}\vphantom\int}}$
\\[-.4in] \headsub{Zona Glamerulosa}{Mineralocorticoids}{Cholesterol}
\ar{d}[swap]{\stackthree{ACTH~\footnotesize$\oplus\!\!\to$}{Ketoconazole~\footnotesize$\ominus\!\!\to$}{Cholesterol desmolase} \quad}
&\headsub{Zona Fasciculata}{Glucocorticoids}{}
&\headsub{Zona Reticularis}{Androgens}{}
&\headsub{}{Estrogens, DHT}{}
\\Pregnenolone
\ar{d}[swap]{\Large\textbf D \quad}%[swap,text width=4cm]{3$\textstyle\beta$-hydroxysteroid dehydrogenase}
\ar{r}[outer sep = 1ex]{\Large\textbf A}%[anchor=center,rotate=90,xshift= 10ex]{17$\textstyle\alpha$-hydroxylase}
&17-hydroxypregnenolone
\dar[swap]{\Large\textbf D \quad}
\rar
& $\smash{\overset{\textstyle\text{(DHEA)}}{\text{Dehydroepiandrosterone}}}$
\dar[swap]{\Large\textbf D \quad}
\\\bf Progesterone
\ar{d}[swap]{\Large\textbf B \quad}%[swap,text width=4cm]{21-hydroxylase}
\ar{r}[outer sep = 1ex]{\Large\textbf A}%[anchor=center,rotate=90,xshift= -10ex]{17$\textstyle\alpha$-hydroxylase}
&17-hydroxyprogesterone
\dar[swap]{\Large\textbf B \quad}
\rar
& Androstenedione
\dar
\rar{Aromatase}
& Estrone
\dar
\\11-deoxycorticosterone
\ar{d}[swap]{\Large\textbf C \quad}%[swap,text width=4cm]{11$\textstyle\beta$-hydroxylase}
&11-deoxycortisol
\dar[swap]{\Large\textbf C \quad}
& Testosterone
\rar{Aromatase}
\ar[swap,bend right=18]{dr}{5$\textstyle\alpha$-reductase}
&\bf Estradiol
\\Corticosterone
\ar{d}[swap]{\stackthree{\hspace{2.5cm}}{Angiotensin~II~\footnotesize$\oplus\!\!\to$}{Aldosterone synthase} \quad}
&\bf Cortisol
&& $\smash{\underset{\textstyle\text{(DHT)}}{\text{Dihydrotestosterone}}}$
\\\bf Aldosterone
\end{tikzcd}\]
\vspace{13mm}\Large
\noindent\hspace{15mm}\textbf A \quad 17$\alpha$-hydroxylase
\noindent\hspace{15mm}\textbf B \quad 21-hydroxylase
\noindent\hspace{15mm}\textbf C \quad 11$\textstyle\beta$-hydroxylase
\noindent\hspace{15mm}\textbf D \quad 3$\beta$-hydroxysteroid dehydrogenase
\end{document}
\newpage
\newpage
$\rightharpoondown$
$\dashv$
ACTH $\longrightarrow$
$\rightarrow\!\oplus\rightarrow$
${}-{}\dashv$
\def\toplus{{%
\setbox0\hbox{$\longrightarrow$}%
\rlap{\hbox to \wd0{\hss$\oplus$\hss}}\box0
}}
\def\tominus{{%
\setbox0\hbox{$\longrightarrow$}%
\rlap{\hbox to \wd0{\hss$\ominus$\hss}}\box0
}}
$\toplus$
$\tominus$
\end{document}