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gorule-0000002.md

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layout id title type fail_mode status contact implementations examples
rule
GORULE:0000002
No 'NOT' annotations to binding ; GO:0005488 or 'protein binding ; GO:0005515'
report
hard
implemented
fail pass
comment format input
Fails because it has an annotation to GO:0005515 protein binding and a NOT qualifier.
gaf
PomBase SPAC23H4.18c rbx1 NOT GO:0005515 PMID:12167173 IPI PomBase:SPBC1718.01 F SCF complex, Cul4-RING and CLRC ubiquitin ligase ligase E3 subunit Rbx1 pip1 protein NCBITaxon:4896 20041130 PomBase
comment format input
Should pass
gaf
PomBase SPAC23H4.18c rbx1 GO:0005515 PMID:12167173 IPI PomBase:SPBC1718.01 F SCF complex, Cul4-RING and CLRC ubiquitin ligase ligase E3 subunit Rbx1 pip1 protein NCBITaxon:4896 20041130 PomBase

An annotation to binding ; GO:0005488 or protein binding ; GO:0005515 with the 'not' qualifier implies that the annotated protein cannot bind anything. There are no characterized examples of a protein with no interactions.

The presence of an identifier in the 'with' column or in an annotation extension would not justify a 'not' annotation either, since a qualifier add precision to the GO term; it does not imply that a protein does not have the activity designated by the GO term under the specific context specified by the annotation extension.

This rule only applies to direct annotations to GO:0005488 and GO:0005515; children of these terms can be qualified with 'not', as further information on the type of binding is then supplied in the GO term. For more information, see the binding guidelines on the GO wiki.