diff --git a/docs/source/sources.rst b/docs/source/sources.rst
index 3ab48fc50..bc808b755 100644
--- a/docs/source/sources.rst
+++ b/docs/source/sources.rst
@@ -41,6 +41,13 @@ SBML extraction (:py:mod:`mira.sources.sbml`)
:members:
:show-inheritance:
+SBML Qual extraction (:py:mod:`mira.sources.sbml.qual_api`)
+-----------------------------------------------------------
+.. automodule:: mira.sources.sbml.qual_api
+ :members:
+ :show-inheritance:
+
+
BioModels client (:py:mod:`mira.sources.biomodels`)
---------------------------------------------------
.. automodule:: mira.sources.biomodels
diff --git a/mira/modeling/amr/regnet.py b/mira/modeling/amr/regnet.py
index b7f7d7af4..bf128d0eb 100644
--- a/mira/modeling/amr/regnet.py
+++ b/mira/modeling/amr/regnet.py
@@ -5,7 +5,6 @@
__all__ = ["AMRRegNetModel", "ModelSpecification",
"template_model_to_regnet_json"]
-
import json
import logging
from copy import deepcopy
@@ -47,7 +46,7 @@ def __init__(self, model: Model):
model.template_model.annotations.name else "Model"
self.model_description = model.template_model.annotations.description \
if model.template_model.annotations and \
- model.template_model.annotations.description else self.model_name
+ model.template_model.annotations.description else self.model_name
self.rates = []
self.observables = []
@@ -84,7 +83,7 @@ def __init__(self, model: Model):
self.states.append(state_data)
self._states_by_id[name] = state_data
- idx = 0
+ edge_id = 1
# It's possible that something is naturally degraded/replicated
# by multiple transitions so we need to collect and aggregate rates
intrinsic_by_var = defaultdict(list)
@@ -132,47 +131,70 @@ def __init__(self, model: Model):
# a regular transition in the regnet framework
# Possibilities are:
# - ControlledReplication / GroupedControlledProduction
- # - ControlledDegradation
+ # - ControlledDegradation / GroupedControlledDegradation
+ # - ControlledProduction if the control and produced concept are not the same
else:
- tid = f"t{idx + 1}"
- transition_dict = {'id': tid}
# If we have multiple controls then the thing that replicates
# is both a control and a produced variable.
if len(transition.control) > 1:
- indep_ctrl = {c.key for c in transition.control} - \
- {transition.produced[0].key}
- # There is one corner case where both controllers are also
- # the same as the produced variable, in which case.
- if not indep_ctrl:
- indep_ctrl = {transition.produced[0].key}
- transition_dict['source'] = vmap[sorted(indep_ctrl)[0]]
+ # GroupedControlledProduction
+ if is_production(transition.template) or is_replication(
+ transition.template
+ ):
+ indep_ctrl = {c.key for c in transition.control} - {
+ transition.produced[0].key
+ }
+ # There is one corner case where both controllers are also
+ # the same as the produced variable, in which case.
+ if not indep_ctrl:
+ indep_ctrl = {transition.produced[0].key}
+
+ for index, controller in enumerate(indep_ctrl):
+ self.create_edge(
+ transition,
+ vmap[controller],
+ vmap[transition.produced[0].key],
+ edge_id,
+ False if index == 0 else True
+ )
+
+ edge_id += 1
+ else:
+ # GroupedControlledDegradation
+ indep_ctrl = {c.key for c in transition.control} - {
+ transition.consumed[0].key
+ }
+ # There is one corner case where both controllers are also
+ # the same as the consumed variable, in which case.
+ if not indep_ctrl:
+ indep_ctrl = {transition.consumed[0].key}
+
+ for index, controller in enumerate(indep_ctrl):
+ self.create_edge(
+ transition,
+ vmap[controller],
+ vmap[transition.consumed[0].key],
+ edge_id,
+ False if index == 0 else True
+ )
+
+ edge_id += 1
else:
- transition_dict['source'] = vmap[transition.control[0].key]
- transition_dict['target'] = \
- vmap[transition.consumed[0].key if
- transition.consumed else transition.produced[0].key]
- transition_dict['sign'] = (is_production(transition.template) or
- is_replication(transition.template))
-
- # Include rate law
- if transition.template.rate_law:
- rate_law = transition.template.rate_law.args[0]
- pnames = transition.template.get_parameter_names()
- # We just choose an arbitrary one deterministically
- rate_const = sorted(pnames)[0] if pnames else None
-
- transition_dict['properties'] = {
- 'name': tid,
- 'rate_constant': rate_const,
- }
- self.rates.append({
- 'target': tid,
- 'expression': str(rate_law),
- 'expression_mathml': expression_to_mathml(rate_law)
- })
-
- self.transitions.append(transition_dict)
- idx += 1
+ # ControlledProduction if produced and controller are not the same
+ # ControlledDegradation
+ target = vmap[
+ transition.consumed[0].key
+ if transition.consumed
+ else transition.produced[0].key
+ ]
+ self.create_edge(
+ transition,
+ vmap[transition.control[0].key],
+ target,
+ edge_id,
+ False
+ )
+ edge_id += 1
for var, rates in intrinsic_by_var.items():
rate_law = sum(rates)
@@ -224,6 +246,55 @@ def __init__(self, model: Model):
self.time = None
add_metadata_annotations(self.metadata, model)
+ def create_edge(self, transition, source, target, edge_id, duplicate):
+ """Create and append a transition dictionary to the list of transitions
+
+ Parameters
+ ----------
+ transition : Transition
+ The Transition object
+ source : str
+ The name of the source of the transition
+ target : str
+ The name of the target of the transition
+ edge_id : int
+ The id to assign to the transition
+ duplicate : bool
+ A boolean that tells us whether the transition we are processing has already been
+ processed at least once. This is for the purpose of not adding duplicate rate laws
+ to the output amr.
+ """
+ tid = f"t{edge_id}"
+ transition_dict = {"id": tid}
+ transition_dict["source"] = source
+ transition_dict["target"] = target
+ transition_dict["sign"] = is_production(
+ transition.template
+ ) or is_replication(transition.template)
+
+ #
+ if transition.template.rate_law:
+ # If we are processing a duplicate rate, set the rate to 0
+ rate_law = transition.template.rate_law.args[0] if not duplicate \
+ else safe_parse_expr('0')
+ pnames = transition.template.get_parameter_names()
+ # We just choose an arbitrary one deterministically
+ rate_const = sorted(pnames)[0] if pnames else None
+
+ transition_dict["properties"] = {
+ "name": tid,
+ "rate_constant": rate_const,
+ }
+ self.rates.append(
+ {
+ "target": tid,
+ "expression": str(rate_law),
+ "expression_mathml": expression_to_mathml(rate_law),
+ }
+ )
+
+ self.transitions.append(transition_dict)
+
def to_json(
self,
name: str = None,
@@ -461,4 +532,3 @@ class ModelSpecification(BaseModel):
model: RegNetModel
semantics: Optional[Ode]
metadata: Optional[Dict]
-
diff --git a/mira/sources/sbml/__init__.py b/mira/sources/sbml/__init__.py
index 0a0e47b0b..27d5326ff 100644
--- a/mira/sources/sbml/__init__.py
+++ b/mira/sources/sbml/__init__.py
@@ -1 +1,2 @@
from .api import *
+from .qual_api import *
diff --git a/mira/sources/sbml/processor.py b/mira/sources/sbml/processor.py
index 04dd9ff00..8f37a9044 100644
--- a/mira/sources/sbml/processor.py
+++ b/mira/sources/sbml/processor.py
@@ -6,51 +6,15 @@
"""
import copy
-import csv
-from collections import defaultdict
-from copy import deepcopy
-import logging
import math
-from typing import Dict, Iterable, List, Mapping, Optional, Tuple
-
-import bioregistry
-import libsbml
-import sympy
-from lxml import etree
-from tqdm import tqdm
-
-from mira.metamodel import *
-from mira.resources import get_resource_file
-
-
-class TqdmLoggingHandler(logging.Handler):
- def __init__(self, level=logging.NOTSET):
- super().__init__(level)
-
- def emit(self, record):
- try:
- msg = self.format(record)
- tqdm.write(msg)
- self.flush()
- except Exception:
- self.handleError(record)
+from typing import Dict, Iterable, List, Mapping, Tuple
+from mira.sources.sbml.utils import *
logger = logging.getLogger(__name__)
logger.addHandler(TqdmLoggingHandler())
-PREFIX_MAP = {
- "rdf": "http://www.w3.org/1999/02/22-rdf-syntax-ns#",
- "dcterms": "http://purl.org/dc/terms/",
- "vCard": "http://www.w3.org/2001/vcard-rdf/3.0#",
- "vCard4": "http://www.w3.org/2006/vcard/ns#",
- "bqbiol": "http://biomodels.net/biology-qualifiers/",
- "bqmodel": "http://biomodels.net/model-qualifiers/",
- "CopasiMT": "http://www.copasi.org/RDF/MiriamTerms#",
- "copasi": "http://www.copasi.org/static/sbml",
- "jd": "http://www.sys-bio.org/sbml",
-}
-RESOURCE_KEY = "{http://www.w3.org/1999/02/22-rdf-syntax-ns#}resource"
+
#: This XPath query gets annotations on species for their structured
#: identifiers, typically given as MIRIAM URIs or URNs
IDENTIFIERS_XPATH = f"rdf:RDF/rdf:Description/bqbiol:is/rdf:Bag/rdf:li"
@@ -61,7 +25,9 @@ def emit(self, record):
#: This is an alternative XPath for groundings that use the isVersionOf
#: relation and are thus less specific than the one above but can be used
#: as fallback
-IDENTIFIERS_VERSION_XPATH = f"rdf:RDF/rdf:Description/bqbiol:isVersionOf/rdf:Bag/rdf:li"
+IDENTIFIERS_VERSION_XPATH = (
+ f"rdf:RDF/rdf:Description/bqbiol:isVersionOf/rdf:Bag/rdf:li"
+)
#: This XPath query gets annotations on species about their properties,
#: which typically help ad-hoc create subclasses that are more specific
PROPERTIES_XPATH = f"rdf:RDF/rdf:Description/bqbiol:hasProperty/rdf:Bag/rdf:li"
@@ -70,28 +36,6 @@ def emit(self, record):
IS_VERSION_XPATH = f"rdf:RDF/rdf:Description/bqbiol:hasProperty/rdf:Bag/rdf:li"
-class Converter:
- """Wrapper around a curies converter with lazy loading."""
-
- def __init__(self):
- self.converter = None
-
- def parse_uri(self, uri):
- """Parse a URI into a prefix/identifier pair."""
- if self.converter is None:
- self.converter = bioregistry.get_converter(include_prefixes=True)
- return self.converter.parse_uri(uri)
-
- def uri_to_curie(self, uri: str) -> Optional[str]:
- """Turn a URI into a CURIE."""
- if self.converter is None:
- self.converter = bioregistry.get_converter(include_prefixes=True)
- return self.converter.compress(uri)
-
-
-converter = Converter()
-
-
class SbmlProcessor:
"""Traverse an SBML document generated by libSBML and extract a MIRA
Template model."""
@@ -104,15 +48,19 @@ def __init__(self, sbml_model, model_id=None, reporter_ids=None):
def extract_model(self):
if self.model_id is None:
- self.model_id = get_model_id(self.sbml_model)
- model_annots = get_model_annotations(self.sbml_model)
+ self.model_id = get_model_id(self.sbml_model, converter=converter)
+ model_annots = get_model_annotations(
+ self.sbml_model, converter=converter, logger=logger
+ )
reporter_ids = set(self.reporter_ids or [])
concepts = self._extract_concepts()
def _lookup_concepts_filtered(species_ids) -> List[Concept]:
return [
- concepts[species_id] for species_id in species_ids
- if species_id not in reporter_ids and 'cumulative' not in species_id
+ concepts[species_id]
+ for species_id in species_ids
+ if species_id not in reporter_ids
+ and "cumulative" not in species_id
]
# Iterate thorugh all reactions and piecewise convert to templates
@@ -124,31 +72,36 @@ def _lookup_concepts_filtered(species_ids) -> List[Concept]:
all_parameters = {
parameter.id: {
- 'value': parameter.value,
- 'description': parameter.name,
- 'units': self.get_object_units(parameter)
+ "value": parameter.value,
+ "description": parameter.name,
+ "units": self.get_object_units(parameter),
}
for parameter in self.sbml_model.parameters
}
- parameter_symbols = \
- {parameter.id: sympy.Symbol(parameter.id)
- for parameter in self.sbml_model.parameters}
- compartment_symbols = {compartment.id: sympy.Symbol(compartment.id)
- for compartment in self.sbml_model.compartments}
+ parameter_symbols = {
+ parameter.id: sympy.Symbol(parameter.id)
+ for parameter in self.sbml_model.parameters
+ }
+ compartment_symbols = {
+ compartment.id: sympy.Symbol(compartment.id)
+ for compartment in self.sbml_model.compartments
+ }
# Add compartment volumes as parameters
for compartment in self.sbml_model.compartments:
- all_parameters[compartment.id] = {'value': compartment.volume,
- 'description': compartment.name,
- 'units': self.get_object_units(compartment)}
+ all_parameters[compartment.id] = {
+ "value": compartment.volume,
+ "description": compartment.name,
+ "units": self.get_object_units(compartment),
+ }
# Handle custom function definitions in the model
function_lambdas = {}
for fun_def in self.sbml_model.function_definitions:
- args = [fun_def.getArgument(i).getName()
- for i in range(fun_def.getNumArguments())]
- arg_symbols = {
- arg: sympy.Symbol(arg) for arg in args
- }
+ args = [
+ fun_def.getArgument(i).getName()
+ for i in range(fun_def.getNumArguments())
+ ]
+ arg_symbols = {arg: sympy.Symbol(arg) for arg in args}
signature = tuple(arg_symbols.values())
formula_str = get_formula_str(fun_def.getBody())
@@ -161,18 +114,28 @@ def _lookup_concepts_filtered(species_ids) -> List[Concept]:
# In formulas, the species ID appears instead of the species name
# and so we have to map these to symbols corresponding to the species name
species_id_map = {
- species.id: (sympy.Symbol(species.name)
- if (species.name and '(' not in species.name
- and '-' not in species.name
- and '+' not in species.name)
- else sympy.Symbol(species.id))
+ species.id: (
+ sympy.Symbol(species.name)
+ if (
+ species.name
+ and "(" not in species.name
+ and "-" not in species.name
+ and "+" not in species.name
+ )
+ else sympy.Symbol(species.id)
+ )
for species in self.sbml_model.species
}
- all_locals = {k: v for k, v in (list(parameter_symbols.items()) +
- list(compartment_symbols.items()) +
- list(function_lambdas.items()) +
- list(species_id_map.items()))}
+ all_locals = {
+ k: v
+ for k, v in (
+ list(parameter_symbols.items())
+ + list(compartment_symbols.items())
+ + list(function_lambdas.items())
+ + list(species_id_map.items())
+ )
+ }
# Handle custom assignment rules in the model
assignment_rules = {}
@@ -184,8 +147,12 @@ def _lookup_concepts_filtered(species_ids) -> List[Concept]:
all_implicit_modifiers = set()
implicit_modifiers = None
for reaction in self.sbml_model.reactions:
- modifier_species = [species.species for species in reaction.modifiers]
- reactant_species = [species.species for species in reaction.reactants]
+ modifier_species = [
+ species.species for species in reaction.modifiers
+ ]
+ reactant_species = [
+ species.species for species in reaction.reactants
+ ]
product_species = [species.species for species in reaction.products]
# In some models, modifiers are defined as both input and output
@@ -204,13 +171,14 @@ def _lookup_concepts_filtered(species_ids) -> List[Concept]:
# Some rate laws define parameters locally and so we need to
# extract them and add them to the global parameter list
for parameter in rate_law.parameters:
- all_parameters[parameter.id] = {'value': parameter.value,
- 'description': parameter.name if parameter.name else None,
- 'units': self.get_object_units(parameter)}
+ all_parameters[parameter.id] = {
+ "value": parameter.value,
+ "description": parameter.name if parameter.name else None,
+ "units": self.get_object_units(parameter),
+ }
parameter_symbols[parameter.id] = sympy.Symbol(parameter.id)
- rate_expr = safe_parse_expr(rate_law.formula,
- local_dict=all_locals)
+ rate_expr = safe_parse_expr(rate_law.formula, local_dict=all_locals)
# At this point we need to make sure we substitute the assignments
rate_expr = rate_expr.subs(assignment_rules)
@@ -221,21 +189,26 @@ def _lookup_concepts_filtered(species_ids) -> List[Concept]:
# and explicit 1.0 will be carried around in the rate expression
comp_one = False
if comp_symbol in rate_expr.free_symbols:
- if rate_expr not in rate_expr.diff(comp_symbol).free_symbols:
- if all_parameters[comp]['value'] == 1.0:
+ if (
+ rate_expr
+ not in rate_expr.diff(comp_symbol).free_symbols
+ ):
+ if all_parameters[comp]["value"] == 1.0:
comp_one = True
rate_expr /= comp_symbol
if not comp_one:
- rate_expr = rate_expr.subs(comp_symbol,
- all_parameters[comp]['value'])
+ rate_expr = rate_expr.subs(
+ comp_symbol, all_parameters[comp]["value"]
+ )
rate_law_variables = variables_from_sympy_expr(rate_expr)
# Implicit modifiers appear in the rate law but are not reactants and
# aren't listed explicitly as modifiers. They have to be proper species
# though (since the rate law also contains parameters).
- implicit_modifiers = ((set(rate_law_variables) & all_species)
- - (set(reactant_species) | set(modifier_species)))
+ implicit_modifiers = (set(rate_law_variables) & all_species) - (
+ set(reactant_species) | set(modifier_species)
+ )
# We extend modifiers with implicit ones
modifier_species += sorted(implicit_modifiers)
all_implicit_modifiers |= implicit_modifiers
@@ -286,29 +259,43 @@ def _lookup_concepts_filtered(species_ids) -> List[Concept]:
)
)
elif not reactants and not products:
- logger.debug(f"[{self.model_id} reaction:{reaction.id}] missing reactants and products")
+ logger.debug(
+ f"[{self.model_id} reaction:{reaction.id}] missing reactants and products"
+ )
continue
# We either have a production or a degradation
elif bool(products) != bool(reactants):
- kwargs = {'rate_law': rate_expr}
+ kwargs = {"rate_law": rate_expr}
if not modifiers:
contr = {}
elif len(modifiers) == 1:
- contr = {'controller': modifiers[0]}
+ contr = {"controller": modifiers[0]}
else:
- contr = {'controllers': modifiers}
+ contr = {"controllers": modifiers}
kwargs.update(contr)
if products:
- cls = NaturalProduction if not modifiers else \
- (ControlledProduction if len(modifiers) == 1
- else GroupedControlledProduction)
- kwargs.update({'outcome': products[0]})
+ cls = (
+ NaturalProduction
+ if not modifiers
+ else (
+ ControlledProduction
+ if len(modifiers) == 1
+ else GroupedControlledProduction
+ )
+ )
+ kwargs.update({"outcome": products[0]})
else:
- cls = NaturalDegradation if not modifiers else \
- (ControlledDegradation if len(modifiers) == 1
- else GroupedControlledDegradation)
- kwargs.update({'subject': reactants[0]})
+ cls = (
+ NaturalDegradation
+ if not modifiers
+ else (
+ ControlledDegradation
+ if len(modifiers) == 1
+ else GroupedControlledDegradation
+ )
+ )
+ kwargs.update({"subject": reactants[0]})
templates.append(cls(**kwargs))
else:
logger.debug(
@@ -327,21 +314,31 @@ def _lookup_concepts_filtered(species_ids) -> List[Concept]:
# initial concentration is of type float
initials[species.name] = Initial(
concept=concepts[species.getId()],
- expression=SympyExprStr(sympy.Float(species.initial_concentration)),
+ expression=SympyExprStr(
+ sympy.Float(species.initial_concentration)
+ ),
)
- param_objs = {k: Parameter(name=k, value=v['value'],
- description=v['description'],
- units=v['units'])
- for k, v in all_parameters.items()}
+ param_objs = {
+ k: Parameter(
+ name=k,
+ value=v["value"],
+ description=v["description"],
+ units=v["units"],
+ )
+ for k, v in all_parameters.items()
+ }
- template_model = TemplateModel(templates=templates,
- parameters=param_objs,
- initials=initials,
- annotations=model_annots)
+ template_model = TemplateModel(
+ templates=templates,
+ parameters=param_objs,
+ initials=initials,
+ annotations=model_annots,
+ )
# Replace constant concepts by their initial value
- template_model = replace_constant_concepts(template_model,
- implicit_modifiers)
+ template_model = replace_constant_concepts(
+ template_model, implicit_modifiers
+ )
return template_model
def _extract_concepts(self) -> Mapping[str, Concept]:
@@ -351,15 +348,16 @@ def _extract_concepts(self) -> Mapping[str, Concept]:
for species in self.sbml_model.getListOfSpecies():
# Extract the units for the species
units = self.get_object_units(species)
- concept = _extract_concept(species, model_id=self.model_id,
- units=units)
+ concept = _extract_concept(
+ species, model_id=self.model_id, units=units
+ )
concepts[species.getId()] = concept
return concepts
def get_object_units(self, object):
if object.units:
- if object.units == 'dimensionless':
+ if object.units == "dimensionless":
return Unit(expression=sympy.Integer(1))
else:
return Unit(expression=self.units[object.units])
@@ -367,168 +365,6 @@ def get_object_units(self, object):
return None
-def get_units(unit_definitions):
- """Return units from a list of unit definition blocks."""
- units = {}
- for unit_def in unit_definitions:
- units[unit_def.id] = process_unit_definition(unit_def)
- return units
-
-
-unit_symbol_mappings = {
- 'item': 'person',
- 'metre': 'meter',
- 'litre': 'liter',
-}
-
-unit_expression_mappings = {
- 86400.0 * sympy.Symbol('second'): sympy.Symbol('day'),
- 1 / (86400.0 * sympy.Symbol('second')): 1 / sympy.Symbol('day'),
- 1 / (86400.0 * sympy.Symbol('second') * sympy.Symbol('person')):
- 1 / (sympy.Symbol('day') * sympy.Symbol('person')),
- 31536000.0 * sympy.Symbol('second'): sympy.Symbol('year'),
- 1 / (31536000.0 * sympy.Symbol('second')): 1 / sympy.Symbol('year'),
- 1 / (31536000.0 * sympy.Symbol('second') * sympy.Symbol('person')):
- 1 / (sympy.Symbol('year') * sympy.Symbol('person')),
-}
-
-
-def process_unit_definition(unit_definition):
- """Process a unit definition block to extract an expression."""
- full_unit_expr = sympy.Integer(1)
- for unit in unit_definition.units:
- unit_symbol_str = SBML_UNITS[unit.kind]
- # We assume person instead of item here
- if unit_symbol_str in unit_symbol_mappings:
- unit_symbol_str = unit_symbol_mappings[unit_symbol_str]
- unit_symbol = sympy.Symbol(unit_symbol_str)
- # We do this to avoid the spurious factors in the expression
- if unit.multiplier != 1:
- unit_symbol *= unit.multiplier
- if unit.exponent != 1:
- unit_symbol **= unit.exponent
- if unit.scale != 0:
- unit_symbol *= 10 ** unit.scale
- full_unit_expr *= unit_symbol
- # We apply some mappings for canonical units we want to change
- # We use equals here since == in sympy is structural equality
- for k, v in unit_expression_mappings.items():
- if full_unit_expr.equals(k):
- full_unit_expr = v
- return full_unit_expr
-
-
-def get_model_annotations(sbml_model) -> Annotations:
- """Get the model annotations from the SBML model."""
- ann_xml = sbml_model.getAnnotationString()
- if not ann_xml:
- return None
- et = etree.fromstring(ann_xml)
- # Publication: bqmodel:isDescribedBy
- # Disease: bqbiol:is
- # Taxa: bqbiol:hasTaxon
- # Model type: bqbiol:hasProperty
- annot_structure = {
- 'publications': 'bqmodel:isDescribedBy',
- 'diseases': 'bqbiol:is',
- 'taxa': 'bqbiol:hasTaxon',
- 'model_type': 'bqbiol:hasProperty',
- 'pathway': 'bqbiol:isVersionOf', # points to pathways
- # bqbiol:isPartOf used to point to pathways
- # bqbiol:occursIn used to point to pathways - might be subtle distinction with process vs. pathway
- 'homolog_to': "bqbiol:isHomologTo",
- "base_model": "bqmodel:isDerivedFrom", # derived from other biomodel
- 'has_part': "bqbiol:hasPart", # points to pathways
- }
- annotations = defaultdict(list)
- for key, path in annot_structure.items():
- full_path = f'rdf:RDF/rdf:Description/{path}/rdf:Bag/rdf:li'
- tags = et.findall(full_path, namespaces=PREFIX_MAP)
- if not tags:
- continue
- for tag in tags:
- uri = tag.attrib.get(RESOURCE_KEY)
- if not uri:
- continue
- curie = converter.uri_to_curie(uri)
- if not curie:
- continue
- annotations[key].append(curie)
-
- model_id = get_model_id(sbml_model)
- if model_id and model_id.startswith("BIOMD"):
- license = "CC0"
- else:
- license = None
-
- # TODO smarter split up taxon into pathogens and host organisms
- hosts = []
- pathogens = []
- for curie in annotations.get("taxa", []):
- if curie == "ncbitaxon:9606":
- hosts.append(curie)
- else:
- pathogens.append(curie)
-
- model_types = []
- diseases = []
- logged_curie = set()
- for curie in annotations.get("model_type", []):
- if curie.startswith("mamo:"):
- model_types.append(curie)
- elif any(
- curie.startswith(f"{disease_prefix}:")
- for disease_prefix in ["mondo", "doid", "efo"]
- ) or _curie_is_ncit_disease(curie):
- diseases.append(bioregistry.normalize_curie(curie))
- elif curie not in logged_curie:
- logged_curie.add(curie)
- logger.debug(f"unhandled model_type: {curie}")
-
- return Annotations(
- name=sbml_model.getModel().getName(),
- description=None, # TODO
- license=license,
- authors=[], # TODO,
- references=annotations.get("publications", []),
- # no time_scale, time_start, time_end, locations from biomodels
- hosts=hosts,
- pathogens=pathogens,
- diseases=diseases,
- model_types=model_types,
- )
-
-
-def _curie_is_ncit_disease(curie: str) -> bool:
- prefix, identifier = bioregistry.parse_curie(curie)
- if prefix != "ncit":
- return False
- try:
- import pyobo
- except ImportError:
- return False
- else:
- # return pyobo.has_ancestor("ncit", identifier, "ncit", "C2991")
- return False
-
-
-def get_model_id(sbml_model):
- """Get the model ID from the SBML model annotation."""
- ann_xml = sbml_model.getAnnotationString()
- if not ann_xml:
- return None
- et = etree.fromstring(ann_xml)
- id_tags = et.findall('rdf:RDF/rdf:Description/bqmodel:is/rdf:Bag/rdf:li',
- namespaces=PREFIX_MAP)
- for id_tag in id_tags:
- uri = id_tag.attrib.get(RESOURCE_KEY)
- if uri:
- prefix, identifier = converter.parse_uri(uri)
- if prefix == 'biomodels.db' and identifier.startswith('BIOMD'):
- return identifier
- return None
-
-
def find_constant_concepts(template_model: TemplateModel) -> Iterable[str]:
# Find concepts that are unchanged, just appear as controllers or not at all
all_concepts = set()
@@ -536,9 +372,12 @@ def find_constant_concepts(template_model: TemplateModel) -> Iterable[str]:
for template in template_model.templates:
concepts_by_role = template.get_concepts_by_role()
for role, concepts in concepts_by_role.items():
- names = {c.name for c in concepts} if \
- isinstance(concepts, list) else {concepts.name}
- if role in {'subject', 'outcome'}:
+ names = (
+ {c.name for c in concepts}
+ if isinstance(concepts, list)
+ else {concepts.name}
+ )
+ if role in {"subject", "outcome"}:
changing_concepts |= names
all_concepts |= names
non_changing_concepts = all_concepts - changing_concepts
@@ -561,13 +400,14 @@ def replace_constant_concepts(template_model: TemplateModel, candidates=None):
# Fixme, do we need more grounding (identifiers, concept)
# for the concept here?
# Get the units of the concept here
- template_model.parameters[constant_concept] = \
- Parameter(name=constant_concept, value=float(initial_expression.args[0]))
+ template_model.parameters[constant_concept] = Parameter(
+ name=constant_concept, value=float(initial_expression.args[0])
+ )
new_templates = []
for template in template_model.templates:
- new_template = replace_controller_by_constant(template,
- constant_concept,
- initial_expression.args[0])
+ new_template = replace_controller_by_constant(
+ template, constant_concept, initial_expression.args[0]
+ )
if new_template:
new_templates.append(new_template)
else:
@@ -583,16 +423,22 @@ def replace_controller_by_constant(template, controller_name, value):
subject=template.subject,
outcome=template.outcome,
)
- new_template.rate_law = template.rate_law.subs(controller_name, value)
+ new_template.rate_law = template.rate_law.subs(
+ controller_name, value
+ )
return new_template
elif isinstance(template, GroupedControlledConversion):
if len(template.controllers) > 2:
new_template = GroupedControlledConversion(
subject=template.subject,
outcome=template.outcome,
- controllers=[c for c in template.controllers if c.name != controller_name],
+ controllers=[
+ c for c in template.controllers if c.name != controller_name
+ ],
+ )
+ new_template.rate_law = template.rate_law.subs(
+ controller_name, value
)
- new_template.rate_law = template.rate_law.subs(controller_name, value)
return new_template
else:
# If there are only two controllers, we can replace the
@@ -602,7 +448,9 @@ def replace_controller_by_constant(template, controller_name, value):
outcome=template.outcome,
controller=template.controllers[0],
)
- new_template.rate_law = template.rate_law.subs(controller_name, value)
+ new_template.rate_law = template.rate_law.subs(
+ controller_name, value
+ )
return new_template
# TODO: potentially handle other template types
return
@@ -621,30 +469,32 @@ def get_formula_str(ast_node):
if not name:
op = ast_node.getOperatorName()
if op:
- if op == 'times':
- op_str = '*'
- elif op == 'plus':
- op_str = '+'
- elif op == 'divide':
- op_str = '/'
- elif op == 'minus':
- op_str = '-'
+ if op == "times":
+ op_str = "*"
+ elif op == "plus":
+ op_str = "+"
+ elif op == "divide":
+ op_str = "/"
+ elif op == "minus":
+ op_str = "-"
else:
- print('Unknown op: %s' % op)
+ print("Unknown op: %s" % op)
assert False
# Special case where we have a unary minus
- if op == 'minus' and ast_node.isUMinus():
- return '-%s' % get_formula_str(ast_node.getChild(0))
+ if op == "minus" and ast_node.isUMinus():
+ return "-%s" % get_formula_str(ast_node.getChild(0))
# More general binary case
- return '(%s %s %s)' % (get_formula_str(ast_node.getChild(0)),
- op_str,
- get_formula_str(ast_node.getChild(1)))
+ return "(%s %s %s)" % (
+ get_formula_str(ast_node.getChild(0)),
+ op_str,
+ get_formula_str(ast_node.getChild(1)),
+ )
val = ast_node.getValue()
if val is not None:
return val
# Exponential doesn't show up as an operator but rather a name
- elif name in {'exp'}:
- return '%s(%s)' % (name, get_formula_str(ast_node.getChild(0)))
+ elif name in {"exp"}:
+ return "%s(%s)" % (name, get_formula_str(ast_node.getChild(0)))
else:
return name
@@ -689,7 +539,7 @@ def _extract_concept(species, units=None, model_id=None):
species_id = species.getId()
species_name = species.getName()
display_name = species_name
- if '(' in species_name:
+ if "(" in species_name:
species_name = species_id
# If we have curated a grounding for this species we return the concept
@@ -701,11 +551,13 @@ def _extract_concept(species, units=None, model_id=None):
display_name=display_name,
identifiers=copy.deepcopy(mapped_ids),
context=copy.deepcopy(mapped_context),
- units=units
+ units=units,
)
return concept
else:
- logger.debug(f"[{model_id} species:{species_id}] not found in grounding map")
+ logger.debug(
+ f"[{model_id} species:{species_id}] not found in grounding map"
+ )
# Otherwise we try to create a Concept with all its groundings and apply
# various normalizations and clean up.
@@ -715,50 +567,65 @@ def _extract_concept(species, units=None, model_id=None):
annotation_string = species.getAnnotationString()
if not annotation_string:
logger.debug(f"[{model_id} species:{species_id}] had no annotations")
- concept = Concept(name=species_name, display_name=display_name,
- identifiers={}, context={}, units=units)
+ concept = Concept(
+ name=species_name,
+ display_name=display_name,
+ identifiers={},
+ context={},
+ units=units,
+ )
return concept
annotation_tree = etree.fromstring(annotation_string)
rdf_properties = [
converter.parse_uri(desc.attrib[RESOURCE_KEY])
- for desc in
- annotation_tree.findall(PROPERTIES_XPATH, namespaces=PREFIX_MAP)
+ for desc in annotation_tree.findall(
+ PROPERTIES_XPATH, namespaces=PREFIX_MAP
+ )
]
# First we check identifiers with a specific relation representing
# equivalence
identifiers_list = []
- for element in annotation_tree.findall(IDENTIFIERS_XPATH,
- namespaces=PREFIX_MAP):
+ for element in annotation_tree.findall(
+ IDENTIFIERS_XPATH, namespaces=PREFIX_MAP
+ ):
curie = converter.parse_uri(element.attrib[RESOURCE_KEY])
identifiers_list.append(curie)
context = {}
- if ('ido', 'C101887') in identifiers_list:
- identifiers_list.remove(('ido', 'C101887'))
- identifiers_list.append(('ncit', 'C101887'))
- if ('ncit', 'C171133') in identifiers_list:
- identifiers_list.remove(('ncit', 'C171133'))
+ if ("ido", "C101887") in identifiers_list:
+ identifiers_list.remove(("ido", "C101887"))
+ identifiers_list.append(("ncit", "C101887"))
+ if ("ncit", "C171133") in identifiers_list:
+ identifiers_list.remove(("ncit", "C171133"))
# Reclassify asymptomatic as a disease status
- if ('ido', '0000569') in identifiers_list and \
- ('ido', '0000511') in identifiers_list:
- identifiers_list.remove(('ido', '0000569'))
- context['disease_status'] = 'ncit:C3833'
+ if ("ido", "0000569") in identifiers_list and (
+ "ido",
+ "0000511",
+ ) in identifiers_list:
+ identifiers_list.remove(("ido", "0000569"))
+ context["disease_status"] = "ncit:C3833"
# Exposed shouldn't be susceptible
- if ('ido', '0000514') in identifiers_list and \
- ('ido', '0000597') in identifiers_list:
- identifiers_list.remove(('ido', '0000514'))
+ if ("ido", "0000514") in identifiers_list and (
+ "ido",
+ "0000597",
+ ) in identifiers_list:
+ identifiers_list.remove(("ido", "0000514"))
# Break apoart hospitalized and ICU
- if ('ncit', 'C25179') in identifiers_list and \
- ('ncit', 'C53511') in identifiers_list:
- identifiers_list.remove(('ncit', 'C53511'))
- context['disease_status'] = 'ncit:C53511'
+ if ("ncit", "C25179") in identifiers_list and (
+ "ncit",
+ "C53511",
+ ) in identifiers_list:
+ identifiers_list.remove(("ncit", "C53511"))
+ context["disease_status"] = "ncit:C53511"
# Remove redundant term for deceased due to disease progression
- if ('ncit', 'C28554') in identifiers_list and \
- ('ncit', 'C168970') in identifiers_list:
- identifiers_list.remove(('ncit', 'C168970'))
+ if ("ncit", "C28554") in identifiers_list and (
+ "ncit",
+ "C168970",
+ ) in identifiers_list:
+ identifiers_list.remove(("ncit", "C168970"))
identifiers = dict(identifiers_list)
if len(identifiers) != len(identifiers_list):
@@ -766,43 +633,47 @@ def _extract_concept(species, units=None, model_id=None):
# We capture context here as a set of generic properties
for idx, rdf_property in enumerate(sorted(rdf_properties)):
- if rdf_property[0] == 'ncit' and rdf_property[1].startswith('000'):
- prop = ('ido', rdf_property[1])
- elif rdf_property[0] == 'ido' and rdf_property[1].startswith('C'):
- prop = ('ncit', rdf_property[1])
+ if rdf_property[0] == "ncit" and rdf_property[1].startswith("000"):
+ prop = ("ido", rdf_property[1])
+ elif rdf_property[0] == "ido" and rdf_property[1].startswith("C"):
+ prop = ("ncit", rdf_property[1])
else:
prop = rdf_property
context[f'property{"" if idx == 0 else idx}'] = ":".join(prop)
# As a fallback, we also check if identifiers are available with
# a less specific relation
if not identifiers:
- elements = sorted([
- converter.parse_uri(element.attrib[RESOURCE_KEY])
- for element in annotation_tree.findall(IDENTIFIERS_VERSION_XPATH,
- namespaces=PREFIX_MAP)
- ], reverse=True)
+ elements = sorted(
+ [
+ converter.parse_uri(element.attrib[RESOURCE_KEY])
+ for element in annotation_tree.findall(
+ IDENTIFIERS_VERSION_XPATH, namespaces=PREFIX_MAP
+ )
+ ],
+ reverse=True,
+ )
# This is generic COVID-19 infection, generally not needed
- if ('ncit', 'C171133') in elements:
- elements.remove(('ncit', 'C171133'))
+ if ("ncit", "C171133") in elements:
+ elements.remove(("ncit", "C171133"))
# Remap inconsistent groundings
- if ('ido', '0000569') in elements:
- elements.remove(('ido', '0000569'))
- elements.append(('ido', '0000511'))
- context['disease_status'] = 'ncit:C3833'
- elif ('ido', '0000573') in elements:
- elements.remove(('ido', '0000573'))
- elements.append(('ido', '0000511'))
- context['disease_status'] = 'ncit:C25269'
+ if ("ido", "0000569") in elements:
+ elements.remove(("ido", "0000569"))
+ elements.append(("ido", "0000511"))
+ context["disease_status"] = "ncit:C3833"
+ elif ("ido", "0000573") in elements:
+ elements.remove(("ido", "0000573"))
+ elements.append(("ido", "0000511"))
+ context["disease_status"] = "ncit:C25269"
# Make transmissibility a context instead of identity
- if ('ido', '0000463') in elements:
- if ('ncit', 'C49508') in elements:
- context['transmissibility'] = 'ncit:C49508'
- elements.remove(('ido', '0000463'))
- elements.remove(('ncit', 'C49508'))
- elif ('ncit', 'C171549') in elements:
- context['transmissibility'] = 'ncit:C171549'
- elements.remove(('ido', '0000463'))
- elements.remove(('ncit', 'C171549'))
+ if ("ido", "0000463") in elements:
+ if ("ncit", "C49508") in elements:
+ context["transmissibility"] = "ncit:C49508"
+ elements.remove(("ido", "0000463"))
+ elements.remove(("ncit", "C49508"))
+ elif ("ncit", "C171549") in elements:
+ context["transmissibility"] = "ncit:C171549"
+ elements.remove(("ido", "0000463"))
+ elements.remove(("ncit", "C171549"))
identifiers = dict(elements)
@@ -820,52 +691,31 @@ def _extract_concept(species, units=None, model_id=None):
return concept
-def grounding_normalize(concept):
- # A common curation mistake in BioModels: mixing up IDO and NCIT identifiers
- for k, v in deepcopy(concept.identifiers).items():
- if k == 'ncit' and v.startswith('000'):
- concept.identifiers.pop(k)
- concept.identifiers['ido'] = v
- elif k == 'ido' and v.startswith('C'):
- concept.identifiers.pop(k)
- concept.identifiers['ncit'] = v
- # Has property acquired immunity == immune population
- if not concept.get_curie()[0] and \
- concept.context == {'property': 'ido:0000621'}:
- concept.identifiers['ido'] = '0000592'
- concept.context = {}
- elif concept.get_curie() == ('ido', '0000514') and \
- concept.context == {'property': 'ido:0000468'}:
- concept.context = {}
- # Different ways of expression immune/recovered
- elif concept.get_curie() == ('ncit', 'C171133') and \
- concept.context == {'property': 'ido:0000621'}:
- concept.identifiers = {'ido': '0000592'}
- concept.context = {}
- # Different terms for dead/deceased
- elif concept.get_curie() == ('ncit', 'C168970'):
- concept.identifiers = {'ncit': 'C28554'}
- return concept
-
-
-def _get_copasi_identifiers(annotation_tree: etree, xpath: str) -> Dict[str, str]:
+def _get_copasi_identifiers(
+ annotation_tree: etree, xpath: str
+) -> Dict[str, str]:
# Use COPASI_IS or COPASI_IS_VERSION_OF for xpath depending on use case
return dict(
- tuple(el.attrib[RESOURCE_KEY].split(':')[-2:]) for el in
- annotation_tree.xpath(xpath, namespaces=PREFIX_MAP)
+ tuple(el.attrib[RESOURCE_KEY].split(":")[-2:])
+ for el in annotation_tree.xpath(xpath, namespaces=PREFIX_MAP)
)
def _get_copasi_props(annotation_tree: etree) -> List[Tuple[str, str]]:
return [
- tuple(el.attrib[RESOURCE_KEY].split(':')[-2:]) for el in
- annotation_tree.xpath(COPASI_HAS_PROPERTY, namespaces=PREFIX_MAP)
+ tuple(el.attrib[RESOURCE_KEY].split(":")[-2:])
+ for el in annotation_tree.xpath(
+ COPASI_HAS_PROPERTY, namespaces=PREFIX_MAP
+ )
]
-def _extract_all_copasi_attrib(species_annot_etree: etree) -> List[Tuple[str, str]]:
- descr_tags = species_annot_etree.xpath(COPASI_DESCR_XPATH,
- namespaces=PREFIX_MAP)
+def _extract_all_copasi_attrib(
+ species_annot_etree: etree,
+) -> List[Tuple[str, str]]:
+ descr_tags = species_annot_etree.xpath(
+ COPASI_DESCR_XPATH, namespaces=PREFIX_MAP
+ )
resources = []
for descr_tag in descr_tags:
for element in descr_tag.iter():
@@ -885,61 +735,3 @@ def _extract_all_copasi_attrib(species_annot_etree: etree) -> List[Tuple[str, st
assert value != "{}"
resources.append((key, value))
return resources
-
-
-def _get_grounding_map():
- def parse_identifier_grounding(grounding_str):
- # Example: ido:0000511/infected population from which we want to get
- # {'ido': '0000511'}
- if not grounding_str:
- return {}
- return dict(
- tuple(grounding.split('/')[0].split(':'))
- for grounding in grounding_str.split('|')
- )
-
- def parse_context_grounding(grounding_str):
- # Example: disease_severity=ncit:C25269/Symptomatic|
- # diagnosis=ncit:C113725/Undiagnosed
- # from which we want to get {'disease_severity': 'ncit:C25269',
- # 'diagnosis': 'ncit:C113725'}
- if not grounding_str:
- return {}
- return dict(
- tuple(grounding.split('/')[0].split('='))
- for grounding in grounding_str.split('|')
- )
-
- fname = get_resource_file('mapped_biomodels_groundings.csv')
- mappings = {}
- with open(fname, 'r') as fh:
- reader = csv.reader(fh)
- next(reader)
- for name, ids, context, model, mapped_ids, mapped_context in reader:
- mappings[(model, name)] = (
- parse_identifier_grounding(mapped_ids),
- parse_context_grounding(mapped_context)
- )
-
- return mappings
-
-
-grounding_map = _get_grounding_map()
-
-
-def get_sbml_units():
- """Build up a mapping of SBML unit kinds to their names.
-
- This is necessary because units are given as numbers.
- """
- module_contents = dir(libsbml)
- unit_kinds = {var: var.split('_')[-1].lower()
- for var in module_contents
- if var.startswith("UNIT_KIND")
- and var != "UNIT_KIND_INVALID"}
- unit_kinds = {getattr(libsbml, var): unit_name
- for var, unit_name in unit_kinds.items()}
- return unit_kinds
-
-
-SBML_UNITS = get_sbml_units()
diff --git a/mira/sources/sbml/qual_api.py b/mira/sources/sbml/qual_api.py
new file mode 100644
index 000000000..ef5c854b9
--- /dev/null
+++ b/mira/sources/sbml/qual_api.py
@@ -0,0 +1,165 @@
+from typing import Iterable, Optional
+
+from libsbml import SBMLReader
+
+from mira.metamodel import TemplateModel
+from .qual_processor import SbmlQualProcessor
+
+__all__ = [
+ "template_model_from_sbml_qual_file",
+ "template_model_from_sbml_qual_file_obj",
+ "template_model_from_sbml_qual_string",
+ "template_model_from_sbml_qual_model",
+ "sbml_qual_model_from_file",
+]
+
+
+def template_model_from_sbml_qual_file(
+ file_path,
+ *,
+ model_id: Optional[str] = None,
+ reporter_ids: Optional[Iterable[str]] = None,
+) -> TemplateModel:
+ """Extract a MIRA template model from a file containing SBML Qual XML.
+
+ Parameters
+ ----------
+ file_path :
+ The path to the SBML Qual file.
+ model_id :
+ The ID of the model to extract. (Optional) If not provided, an attempt
+ will be made to extract an ID from the SBML Qual file if it's a BIOMODELS
+ model.
+ reporter_ids :
+ An iterable of reporter IDs
+
+ Returns
+ -------
+ :
+ The extracted MIRA template model.
+ """
+ sbml_model, qual_model = sbml_qual_model_from_file(file_path)
+ return template_model_from_sbml_qual_model(
+ sbml_model, qual_model, model_id=model_id, reporter_ids=reporter_ids
+ )
+
+
+def template_model_from_sbml_qual_file_obj(
+ file,
+ *,
+ model_id: Optional[str] = None,
+ reporter_ids: Optional[Iterable[str]] = None,
+) -> TemplateModel:
+ """Extract a MIRA template model from a file object containing SBML Qual XML.
+
+ Parameters
+ ----------
+ file :
+ The open file object containing the SBML Qual XML.
+ model_id :
+ The ID of the model to extract. (Optional) If not provided, an attempt
+ will be made to extract an ID from the SBML Qual file if it's a BIOMODELS
+ model.
+ reporter_ids :
+ An iterable of reporter IDs
+
+ Returns
+ -------
+ :
+ The extracted MIRA template model.
+ """
+ return template_model_from_sbml_qual_string(
+ file.read().decode("utf-8"),
+ model_id=model_id,
+ reporter_ids=reporter_ids,
+ )
+
+
+def sbml_qual_model_from_file(fname):
+ """Return an SBML model object and SBML Qual model object from an SBML Qual file.
+
+ Parameters
+ ----------
+ fname :
+ The path to the SBML Qual file.
+
+ Returns
+ -------
+ :
+ An SBML model object.
+ :
+ An SBMl Qual Model object.
+ """
+ with open(fname, "rb") as fh:
+ sbml_string = fh.read().decode("utf-8")
+ sbml_document = SBMLReader().readSBMLFromString(sbml_string)
+ sbml_model = sbml_document.getModel()
+ qual_model_plugin = sbml_model.getPlugin("qual")
+ return sbml_model, qual_model_plugin
+
+
+def template_model_from_sbml_qual_string(
+ s: str,
+ *,
+ model_id: Optional[str] = None,
+ reporter_ids: Optional[Iterable[str]] = None,
+) -> TemplateModel:
+ """Extract a MIRA template model from a string representing SBML Qual XML.
+
+ Parameters
+ ----------
+ s :
+ The string containing the SBML Qual XML.
+ model_id :
+ The ID of the model to extract. (Optional) If not provided, an attempt
+ will be made to extract an ID from the SBML Qual xml if it's a BIOMODELS
+ model.
+ reporter_ids :
+ An iterable of reporter IDs
+
+ Returns
+ -------
+ :
+ The extracted TemplateModel.
+ """
+ sbml_document = SBMLReader().readSBMLFromString(s)
+ sbml_model = sbml_document.getModel()
+ qual_model_plugin = sbml_model.getPlugin("qual")
+ return template_model_from_sbml_qual_model(
+ sbml_model,
+ qual_model_plugin,
+ model_id=model_id,
+ reporter_ids=reporter_ids,
+ )
+
+
+def template_model_from_sbml_qual_model(
+ sbml_model,
+ qual_model,
+ *,
+ model_id: Optional[str] = None,
+ reporter_ids: Optional[Iterable[str]] = None,
+) -> TemplateModel:
+ """Extract a MIRA template model from an SBML Qual model object.
+
+ Parameters
+ ----------
+ sbml_model :
+ The SBML model object.
+ qual_model :
+ The SBML Qual model object
+ model_id :
+ The ID of the model to extract. (Optional) If not provided, an attempt
+ will be made to extract an ID from the SBML Qual model if it's a BIOMODELS
+ model.
+
+ Returns
+ -------
+ :
+ The extracted TemplateModel.
+ """
+ processor = SbmlQualProcessor(
+ sbml_model, qual_model, model_id=model_id, reporter_ids=reporter_ids
+ )
+ tm = processor.extract_model()
+ return tm
diff --git a/mira/sources/sbml/qual_processor.py b/mira/sources/sbml/qual_processor.py
new file mode 100644
index 000000000..ed2124bf9
--- /dev/null
+++ b/mira/sources/sbml/qual_processor.py
@@ -0,0 +1,406 @@
+"""
+This module extracts an equivalent MIRA template model from an SBML Qual document. As
+opposed to a regular SBML document, models derived from an SBML Qual document have empty
+unit_definitions, parameters, and compartment attributes.
+
+This module extracts templates, initials and concepts from SBML Qual documents.
+"""
+import copy
+import re
+from typing import List, Mapping
+from urllib.parse import unquote
+
+from mira.sources.sbml.utils import *
+
+from lxml import etree
+
+
+DESCRIPTION_XPATH = f".//bqbiol:isDescribedBy/rdf:Bag/rdf:li"
+ENCODED_XPATH = f".//bqbiol:isEncodedBy/rdf:Bag/rdf:li"
+
+logger = logging.getLogger(__name__)
+logger.addHandler(TqdmLoggingHandler())
+
+
+class SbmlQualProcessor:
+
+ """Traverse an SBML Qual document generated by libSBML and extract a MIRA Template model."""
+
+ def __init__(
+ self, sbml_model, qual_model_plugin, model_id=None, reporter_ids=None
+ ):
+ self.qual_model_plugin = qual_model_plugin
+ self.sbml_model = sbml_model
+ self.model_id = model_id
+ self.reporter_ids = reporter_ids
+
+ def extract_model(self):
+ if self.model_id is None:
+ self.model_id = get_model_id(self.sbml_model, converter=converter)
+ model_annots = get_model_annotations(
+ self.sbml_model, converter=converter, logger=logger
+ )
+ reporter_ids = set(self.reporter_ids or [])
+ concepts = self._extract_concepts()
+
+ def _lookup_concepts_filtered(species_ids) -> List[Concept]:
+ return [
+ concepts[species_id]
+ for species_id in species_ids
+ if species_id not in reporter_ids
+ and "cumulative" not in species_id
+ ]
+
+ templates: List[Template] = []
+
+ # each input to a transition can have a negative or positive sign or no sign
+ # qual:sign = positive in source file indicates it controls the production of something
+ # qual:sign = negative in source file indicates it controls the degradation of something
+ # if both positive and negative exists, it is production process, with a list of
+ # controllers from both the negative and positive side.
+ # if no sign is given, we default to positive sign
+
+ # Transitions always have at least one input and one output
+ # Since we always have at least one input, there will always be at least
+ # 1 controller (negative or positive). Will never have a natural template
+ for transition_id, transition in enumerate(
+ self.qual_model_plugin.transitions
+ ):
+ transition_name = transition.id
+
+ input_names = [
+ qual_species.qualitative_species
+ for qual_species in transition.getListOfInputs()
+ ]
+ output_names = [
+ qual_species.qualitative_species
+ for qual_species in transition.getListOfOutputs()
+ ]
+
+ # positive sign is anything other than 1, negative sign is 1 for inputs only
+ # outputs do not have a sign
+ positive_controller_names = [
+ qual_species.qualitative_species
+ for qual_species in transition.getListOfInputs()
+ if qual_species.getSign() != 1
+ ]
+
+ negative_controller_names = [
+ qual_species.qualitative_species
+ for qual_species in transition.getListOfInputs()
+ if qual_species.getSign() == 1
+ ]
+
+ input_concepts = _lookup_concepts_filtered(input_names)
+ output_concepts = _lookup_concepts_filtered(output_names)
+ positive_controller_concepts = _lookup_concepts_filtered(
+ positive_controller_names
+ )
+ negative_controller_concepts = _lookup_concepts_filtered(
+ negative_controller_names
+ )
+
+ if (
+ not positive_controller_concepts
+ and not negative_controller_concepts
+ ):
+ if len(input_concepts) == 1 and len(output_concepts) == 0:
+ templates.append(
+ NaturalDegradation(
+ subject=input_concepts[0],
+ name=transition_id,
+ display_name=transition_name,
+ )
+ )
+ elif len(input_concepts) == 0 and len(output_concepts) == 1:
+ templates.append(
+ NaturalProduction(
+ outcome=output_concepts[0],
+ name=transition_id,
+ display_name=transition_name,
+ )
+ )
+ elif len(input_concepts) == 1 and len(output_concepts) == 1:
+ templates.append(
+ NaturalConversion(
+ subject=input_concepts[0],
+ outcome=output_concepts[0],
+ name=transition_id,
+ display_name=transition_name,
+ )
+ )
+ else:
+ if (
+ len(positive_controller_concepts) >= 1
+ and len(negative_controller_concepts) == 0
+ ):
+ if len(positive_controller_concepts) == 1:
+ templates.append(
+ ControlledProduction(
+ controller=positive_controller_concepts[0],
+ outcome=output_concepts[0],
+ name=transition_id,
+ display_name=transition_name,
+ )
+ )
+ else:
+ templates.append(
+ GroupedControlledProduction(
+ controllers=positive_controller_concepts,
+ outcome=output_concepts[0],
+ name=transition_id,
+ display_name=transition_name,
+ )
+ )
+ elif (
+ len(positive_controller_concepts) == 0
+ and len(negative_controller_concepts) >= 1
+ ):
+ if len(negative_controller_concepts) == 1:
+ templates.append(
+ ControlledDegradation(
+ controller=negative_controller_concepts[0],
+ subject=input_concepts[0],
+ name=transition_id,
+ display_name=transition_name,
+ )
+ )
+ else:
+ templates.append(
+ GroupedControlledDegradation(
+ controllers=negative_controller_concepts,
+ subject=input_concepts[0],
+ name=transition_id,
+ display_name=transition_name,
+ )
+ )
+ elif (
+ len(positive_controller_concepts) >= 1
+ and len(negative_controller_concepts) >= 1
+ ):
+ templates.append(
+ GroupedControlledProduction(
+ controllers=positive_controller_concepts
+ + negative_controller_concepts,
+ outcome=output_concepts[0],
+ name=transition_id,
+ display_name=transition_name,
+ )
+ )
+
+ initials = {}
+ for qual_species in self.qual_model_plugin.qualitative_species:
+ initials[qual_species.id] = Initial(
+ concept=concepts[qual_species.id],
+ expression=qual_species.level,
+ )
+
+ template_model = TemplateModel(
+ templates=templates, initials=initials, annotations=model_annots
+ )
+ return template_model
+
+ def _extract_concepts(self) -> Mapping[str, Concept]:
+ concepts = {}
+ for species in self.qual_model_plugin.getListOfQualitativeSpecies():
+ units = self.get_object_units(species)
+ concept = _extract_concept(
+ species, model_id=self.model_id, units=units
+ )
+ concepts[species.id] = concept
+ return concepts
+
+ def get_object_units(self, object):
+ # QualitativeSpecies object does not have a units attribute
+ if hasattr(object, "units"):
+ if object.units == "dimensionless":
+ return Unit(expression=sympy.Integer(1))
+ else:
+ return Unit(expression=self.units[object.units])
+ else:
+ return None
+
+
+def _extract_concept(species, units=None, model_id=None):
+ """Extract a concept and its accompanying annotation from a qualitative species"""
+ # retrieve local name for species that is only used a reference in the sbml qual model
+ local_qual_name_reference = species.id
+ # retrieve name of the species that can be used for look up in external resources
+ external_name = species.name
+
+ if (model_id, external_name) in grounding_map:
+ mapped_ids, mapped_context = grounding_map[(model_id, external_name)]
+ concept = Concept(
+ name=local_qual_name_reference,
+ display_name=external_name,
+ identifiers=copy.deepcopy(mapped_ids),
+ context=copy.deepcopy(mapped_context),
+ units=units,
+ )
+ return concept
+ else:
+ logger.debug(
+ f"[{model_id} species:{external_name}] not found in grounding map"
+ )
+
+ old_annotation_string = species.getAnnotationString()
+
+ # current annotation misses a namespace for the rdf tag and cannot be used to create an etree
+ # we add a new tag arbitrarily named "element" and add a namespace to create valid xml
+ # such that it can be parsed by the etree.fromstring() method
+ new_annotation_string = (
+ """"""
+ + old_annotation_string
+ + ""
+ )
+
+ if not old_annotation_string:
+ logger.debug(f"[{model_id} species:{external_name}] had no annotations")
+ concept = Concept(
+ name=local_qual_name_reference,
+ display_name=external_name,
+ identifiers={},
+ context={},
+ units=units,
+ )
+ return concept
+
+ annotation_tree = etree.fromstring(new_annotation_string)
+
+ # Instead of URIs found in regular SBML, the resources found in the annotation strings for
+ # these qualitative species are already in CURIE format with the "urn" prefix and meta prefix
+ # attached. We remove the "urn" identifier and metaprefix later
+
+ description_strings_list = [
+ desc.attrib[RESOURCE_KEY]
+ for desc in annotation_tree.findall(
+ DESCRIPTION_XPATH, namespaces=PREFIX_MAP
+ )
+ ]
+
+ encoded_strings_list = [
+ desc.attrib[RESOURCE_KEY]
+ for desc in annotation_tree.findall(
+ ENCODED_XPATH, namespaces=PREFIX_MAP
+ )
+ ]
+
+ identifiers_curie_list, encoded_curies_list = [], []
+
+ # identifiers, typically given as MIRIAM URIs or URNs
+ # remove URNs, meta-prefixes and extract only prefixes and identifiers in tuple format
+ # for descriptions and encodings strings for a qualitative species
+ for description_string in description_strings_list:
+ # remove url quoting
+ description_string = unquote(description_string)
+
+ # for resources in the format of urn:{metaprefix}:hgnc.symbol:{identifier}
+ if "miriam" and "hgnc.symbol" in description_string:
+ pattern = r"hgnc\.symbol:(.*)"
+ match = re.search(pattern, description_string)
+ curie = ("hgnc", match.group(1))
+ identifiers_curie_list.append(curie)
+
+ # for all other resources
+ elif "miriam" in description_string:
+ pattern = r":([^:]+):([^:]+)$"
+ match = re.search(pattern, description_string)
+ curie = tuple(match.groups())
+ identifiers_curie_list.append(curie)
+
+ for encoded_string in encoded_strings_list:
+ encoded_string = unquote(encoded_string)
+ if "miriam" and "hgnc.symbol" in encoded_string:
+ pattern = r"hgnc\.symbol:(.*)"
+ match = re.search(pattern, encoded_string)
+ curie = ("hgnc", match.group(1))
+ encoded_curies_list.append(curie)
+
+ elif "miriam" in encoded_string:
+ pattern = r":([^:]+):([^:]+)$"
+ match = re.search(pattern, encoded_string)
+ curie = tuple(match.groups())
+ encoded_curies_list.append(curie)
+
+ context = {}
+
+ if ("ido", "C101887") in identifiers_curie_list:
+ identifiers_curie_list.remove(("ido", "C101887"))
+ identifiers_curie_list.append(("ncit", "C101887"))
+ if ("ncit", "C171133") in identifiers_curie_list:
+ identifiers_curie_list.remove(("ncit", "C171133"))
+ # Reclassify asymptomatic as a disease status
+ if ("ido", "0000569") in identifiers_curie_list and (
+ "ido",
+ "0000511",
+ ) in identifiers_curie_list:
+ identifiers_curie_list.remove(("ido", "0000569"))
+ context["disease_status"] = "ncit:C3833"
+ # Exposed shouldn't be susceptible
+ if ("ido", "0000514") in identifiers_curie_list and (
+ "ido",
+ "0000597",
+ ) in identifiers_curie_list:
+ identifiers_curie_list.remove(("ido", "0000514"))
+ # Break apart hospitalized and ICU
+ if ("ncit", "C25179") in identifiers_curie_list and (
+ "ncit",
+ "C53511",
+ ) in identifiers_curie_list:
+ identifiers_curie_list.remove(("ncit", "C53511"))
+ context["disease_status"] = "ncit:C53511"
+ # Remove redundant term for deceased due to disease progression
+ if ("ncit", "C28554") in identifiers_curie_list and (
+ "ncit",
+ "C168970",
+ ) in identifiers_curie_list:
+ identifiers_curie_list.remove(("ncit", "C168970"))
+
+ # Multiple semantically identical CURIEs with different prefixes associated with a species.
+ # Additionally, some species involve multiple agents and thus contain CURIEs for all agents
+ # involved. Deterministically choose the CURIE to use as the identifier for the concept by
+ # sorting the keys of the identifiers dictionary (prefix) alphabetically
+
+ # Sort the curie by prefix and then by the identifier
+ all_identifiers = dict(
+ sorted(
+ identifiers_curie_list,
+ reverse=True,
+ key=lambda curie_tuple: (curie_tuple[0], curie_tuple[1]),
+ )
+ )
+
+ if all_identifiers:
+ chosen_key = next(iter(all_identifiers))
+ identifiers = {chosen_key: all_identifiers[chosen_key]}
+ else:
+ identifiers = {}
+
+ # we capture context using the encoding curies as a set of generic properties
+ for idx, description_property in enumerate(sorted(encoded_curies_list)):
+ if description_property[0] == "ncit" and description_property[
+ 1
+ ].startswith("000"):
+ prop = ("ido", description_property[1])
+ elif description_property[0] == "ido" and description_property[
+ 1
+ ].startswith("C"):
+ prop = ("ncit", description_property[1])
+ else:
+ prop = description_property
+ context[f'property{"" if idx == 0 else idx}'] = ":".join(prop)
+
+ concept = Concept(
+ name=local_qual_name_reference,
+ display_name=external_name,
+ identifiers=identifiers,
+ context=context,
+ units=units,
+ )
+ concept = grounding_normalize(concept)
+ return concept
diff --git a/mira/sources/sbml/utils.py b/mira/sources/sbml/utils.py
new file mode 100644
index 000000000..b918eb549
--- /dev/null
+++ b/mira/sources/sbml/utils.py
@@ -0,0 +1,322 @@
+"""
+Module to define shared functionality between processing SBML and SBML Qual documents.
+"""
+
+
+import csv
+from collections import defaultdict
+from copy import deepcopy
+import logging
+from typing import Optional
+
+import bioregistry
+import libsbml
+import sympy
+from lxml import etree
+from tqdm import tqdm
+
+from mira.metamodel import *
+from mira.resources import get_resource_file
+
+
+class TqdmLoggingHandler(logging.Handler):
+ def __init__(self, level=logging.NOTSET):
+ super().__init__(level)
+
+ def emit(self, record):
+ try:
+ msg = self.format(record)
+ tqdm.write(msg)
+ self.flush()
+ except Exception:
+ self.handleError(record)
+
+
+PREFIX_MAP = {
+ "rdf": "http://www.w3.org/1999/02/22-rdf-syntax-ns#",
+ "dcterms": "http://purl.org/dc/terms/",
+ "vCard": "http://www.w3.org/2001/vcard-rdf/3.0#",
+ "vCard4": "http://www.w3.org/2006/vcard/ns#",
+ "bqbiol": "http://biomodels.net/biology-qualifiers/",
+ "bqmodel": "http://biomodels.net/model-qualifiers/",
+ "CopasiMT": "http://www.copasi.org/RDF/MiriamTerms#",
+ "copasi": "http://www.copasi.org/static/sbml",
+ "jd": "http://www.sys-bio.org/sbml",
+}
+
+RESOURCE_KEY = "{http://www.w3.org/1999/02/22-rdf-syntax-ns#}resource"
+
+
+class Converter:
+ """Wrapper around a curies converter with lazy loading."""
+
+ def __init__(self):
+ self.converter = None
+
+ def parse_uri(self, uri):
+ """Parse a URI into a prefix/identifier pair."""
+ if self.converter is None:
+ self.converter = bioregistry.get_converter(include_prefixes=True)
+ return self.converter.parse_uri(uri)
+
+ def uri_to_curie(self, uri: str) -> Optional[str]:
+ """Turn a URI into a CURIE."""
+ if self.converter is None:
+ self.converter = bioregistry.get_converter(include_prefixes=True)
+ return self.converter.compress(uri)
+
+
+converter = Converter()
+
+
+def get_model_annotations(sbml_model, *, converter, logger):
+ """Get the model annotations from an SBML model."""
+ ann_xml = sbml_model.getAnnotationString()
+ if not ann_xml:
+ return None
+ et = etree.fromstring(ann_xml)
+ annot_structure = {
+ "publications": "bqmodel:isDescribedBy",
+ "diseases": "bqbiol:is",
+ "taxa": "bqbiol:hasTaxon",
+ "model_type": "bqbiol:hasProperty",
+ "pathway": "bqbiol:isVersionOf", # points to pathways
+ # bqbiol:isPartOf used to point to pathways
+ # bqbiol:occursIn used to point to pathways - might be subtle distinction with process vs. pathway
+ "homolog_to": "bqbiol:isHomologTo",
+ "base_model": "bqmodel:isDerivedFrom", # derived from other biomodel
+ "has_part": "bqbiol:hasPart", # points to pathways
+ }
+ annotations = defaultdict(list)
+ for key, path in annot_structure.items():
+ full_path = f"rdf:RDF/rdf:Description/{path}/rdf:Bag/rdf:li"
+ tags = et.findall(full_path, namespaces=PREFIX_MAP)
+ if not tags:
+ continue
+ for tag in tags:
+ uri = tag.attrib.get(RESOURCE_KEY)
+ if not uri:
+ continue
+ curie = converter.uri_to_curie(uri)
+ if not curie:
+ continue
+ annotations[key].append(curie)
+
+ model_id = get_model_id(sbml_model, converter=converter)
+ if model_id and model_id.startswith("BIOMD"):
+ license = "CC0"
+ else:
+ license = None
+
+ # TODO smarter split up taxon into pathogens and host organisms
+ hosts = []
+ pathogens = []
+ for curie in annotations.get("taxa", []):
+ if curie == "ncbitaxon:9606":
+ hosts.append(curie)
+ else:
+ pathogens.append(curie)
+
+ model_types = []
+ diseases = []
+ logged_curie = set()
+ for curie in annotations.get("model_type", []):
+ if curie.startswith("mamo:"):
+ model_types.append(curie)
+ elif any(
+ curie.startswith(f"{disease_prefix}:")
+ for disease_prefix in ["mondo", "doid", "efo"]
+ ) or _curie_is_ncit_disease(curie):
+ diseases.append(bioregistry.normalize_curie(curie))
+ elif curie not in logged_curie:
+ logged_curie.add(curie)
+ logger.debug(f"unhandled model_type: {curie}")
+
+ return Annotations(
+ name=sbml_model.getModel().getName(),
+ description=None, # TODO
+ license=license,
+ authors=[], # TODO,
+ references=annotations.get("publications", []),
+ # no time_scale, time_start, time_end, locations from biomodels
+ hosts=hosts,
+ pathogens=pathogens,
+ diseases=diseases,
+ model_types=model_types,
+ )
+
+
+def get_model_id(sbml_model, *, converter):
+ """Get the model ID from the model annotation."""
+ ann_xml = sbml_model.getAnnotationString()
+ if not ann_xml:
+ return None
+ et = etree.fromstring(ann_xml)
+ id_tags = et.findall(
+ "rdf:RDF/rdf:Description/bqmodel:is/rdf:Bag/rdf:li",
+ namespaces=PREFIX_MAP,
+ )
+ for id_tag in id_tags:
+ uri = id_tag.attrib.get(RESOURCE_KEY)
+ if uri:
+ prefix, identifier = converter.parse_uri(uri)
+ if prefix == "biomodels.db" and identifier.startswith("BIOMD"):
+ return identifier
+ return None
+
+
+def _curie_is_ncit_disease(curie: str) -> bool:
+ prefix, identifier = bioregistry.parse_curie(curie)
+ if prefix != "ncit":
+ return False
+ try:
+ import pyobo
+ except ImportError:
+ return False
+ else:
+ # return pyobo.has_ancestor("ncit", identifier, "ncit", "C2991")
+ return False
+
+
+def get_grounding_map():
+ def parse_identifier_grounding(grounding_str):
+ # Example: ido:0000511/infected population from which we want to get
+ # {'ido': '0000511'}
+ if not grounding_str:
+ return {}
+ return dict(
+ tuple(grounding.split("/")[0].split(":"))
+ for grounding in grounding_str.split("|")
+ )
+
+ def parse_context_grounding(grounding_str):
+ # Example: disease_severity=ncit:C25269/Symptomatic|
+ # diagnosis=ncit:C113725/Undiagnosed
+ # from which we want to get {'disease_severity': 'ncit:C25269',
+ # 'diagnosis': 'ncit:C113725'}
+ if not grounding_str:
+ return {}
+ return dict(
+ tuple(grounding.split("/")[0].split("="))
+ for grounding in grounding_str.split("|")
+ )
+
+ fname = get_resource_file("mapped_biomodels_groundings.csv")
+ mappings = {}
+ with open(fname, "r") as fh:
+ reader = csv.reader(fh)
+ next(reader)
+ for name, ids, context, model, mapped_ids, mapped_context in reader:
+ mappings[(model, name)] = (
+ parse_identifier_grounding(mapped_ids),
+ parse_context_grounding(mapped_context),
+ )
+
+ return mappings
+
+
+grounding_map = get_grounding_map()
+
+
+def get_sbml_units():
+ """Build up a mapping of SBML unit kinds to their names.
+
+ This is necessary because units are given as numbers.
+ """
+ module_contents = dir(libsbml)
+ unit_kinds = {
+ var: var.split("_")[-1].lower()
+ for var in module_contents
+ if var.startswith("UNIT_KIND") and var != "UNIT_KIND_INVALID"
+ }
+ unit_kinds = {
+ getattr(libsbml, var): unit_name
+ for var, unit_name in unit_kinds.items()
+ }
+ return unit_kinds
+
+
+SBML_UNITS = get_sbml_units()
+
+
+def grounding_normalize(concept):
+ # A common curation mistake in BioModels: mixing up IDO and NCIT identifiers
+ for k, v in deepcopy(concept.identifiers).items():
+ if k == "ncit" and v.startswith("000"):
+ concept.identifiers.pop(k)
+ concept.identifiers["ido"] = v
+ elif k == "ido" and v.startswith("C"):
+ concept.identifiers.pop(k)
+ concept.identifiers["ncit"] = v
+ # Has property acquired immunity == immune population
+ if not concept.get_curie()[0] and concept.context == {
+ "property": "ido:0000621"
+ }:
+ concept.identifiers["ido"] = "0000592"
+ concept.context = {}
+ elif concept.get_curie() == ("ido", "0000514") and concept.context == {
+ "property": "ido:0000468"
+ }:
+ concept.context = {}
+ # Different ways of expression immune/recovered
+ elif concept.get_curie() == ("ncit", "C171133") and concept.context == {
+ "property": "ido:0000621"
+ }:
+ concept.identifiers = {"ido": "0000592"}
+ concept.context = {}
+ # Different terms for dead/deceased
+ elif concept.get_curie() == ("ncit", "C168970"):
+ concept.identifiers = {"ncit": "C28554"}
+ return concept
+
+
+def get_units(unit_definitions):
+ """Return units from a list of unit definition blocks."""
+ units = {}
+ for unit_def in unit_definitions:
+ units[unit_def.id] = process_unit_definition(unit_def)
+ return units
+
+
+def process_unit_definition(unit_definition):
+ """Process a unit definition block to extract an expression."""
+ full_unit_expr = sympy.Integer(1)
+ for unit in unit_definition.units:
+ unit_symbol_str = SBML_UNITS[unit.kind]
+ # We assume person instead of item here
+ if unit_symbol_str in unit_symbol_mappings:
+ unit_symbol_str = unit_symbol_mappings[unit_symbol_str]
+ unit_symbol = sympy.Symbol(unit_symbol_str)
+ # We do this to avoid the spurious factors in the expression
+ if unit.multiplier != 1:
+ unit_symbol *= unit.multiplier
+ if unit.exponent != 1:
+ unit_symbol **= unit.exponent
+ if unit.scale != 0:
+ unit_symbol *= 10**unit.scale
+ full_unit_expr *= unit_symbol
+ # We apply some mappings for canonical units we want to change
+ # We use equals here since == in sympy is structural equality
+ for k, v in unit_expression_mappings.items():
+ if full_unit_expr.equals(k):
+ full_unit_expr = v
+ return full_unit_expr
+
+
+unit_symbol_mappings = {
+ "item": "person",
+ "metre": "meter",
+ "litre": "liter",
+}
+unit_expression_mappings = {
+ 86400.0 * sympy.Symbol("second"): sympy.Symbol("day"),
+ 1 / (86400.0 * sympy.Symbol("second")): 1 / sympy.Symbol("day"),
+ 1
+ / (86400.0 * sympy.Symbol("second") * sympy.Symbol("person")): 1
+ / (sympy.Symbol("day") * sympy.Symbol("person")),
+ 31536000.0 * sympy.Symbol("second"): sympy.Symbol("year"),
+ 1 / (31536000.0 * sympy.Symbol("second")): 1 / sympy.Symbol("year"),
+ 1
+ / (31536000.0 * sympy.Symbol("second") * sympy.Symbol("person")): 1
+ / (sympy.Symbol("year") * sympy.Symbol("person")),
+}
diff --git a/notebooks/SBML Qual Demo.ipynb b/notebooks/SBML Qual Demo.ipynb
new file mode 100644
index 000000000..e216a632d
--- /dev/null
+++ b/notebooks/SBML Qual Demo.ipynb
@@ -0,0 +1,279 @@
+{
+ "cells": [
+ {
+ "cell_type": "code",
+ "execution_count": 1,
+ "id": "e462d2ab-9a9b-412e-a85c-6020cc89c226",
+ "metadata": {},
+ "outputs": [],
+ "source": [
+ "import requests\n",
+ "\n",
+ "from mira.sources.biomodels import get_sbml_model\n",
+ "from mira.sources.sbml.qual_api import template_model_from_sbml_qual_string\n",
+ "\n",
+ "MODEL_URL = \"https://git-r3lab.uni.lu/covid/models/-/raw/master/Executable%20Modules/SBML_qual_build/sbml/Orf3a_stable.sbml?ref_type=heads\"\n",
+ "BIOMODEL_ID = \"BIOMD0000000562\""
+ ]
+ },
+ {
+ "cell_type": "markdown",
+ "id": "c74ce658-5971-44d5-afdf-cf78c0526198",
+ "metadata": {},
+ "source": [
+ "## We load in biomodel BIOMD0000000562 from the biomodel's database and convert it to a semantically similar MIRA template model"
+ ]
+ },
+ {
+ "cell_type": "code",
+ "execution_count": 2,
+ "id": "fb528cb1-5a93-4092-858b-be3e7daa0779",
+ "metadata": {},
+ "outputs": [],
+ "source": [
+ "model_text = get_sbml_model(BIOMODEL_ID)\n",
+ "tm = template_model_from_sbml_qual_string(model_text)"
+ ]
+ },
+ {
+ "cell_type": "markdown",
+ "id": "a7283cf9-1821-4ba2-9cf9-c5eb94d15d68",
+ "metadata": {},
+ "source": [
+ "## Identify all concepts loaded in from the biomodel\n",
+ "\n",
+ "Qualitative species' annotations are not provided for models on the biomodel's website"
+ ]
+ },
+ {
+ "cell_type": "code",
+ "execution_count": 3,
+ "id": "6a446a48-7f96-4b63-8ef7-e27bb52a0cd0",
+ "metadata": {},
+ "outputs": [
+ {
+ "name": "stdout",
+ "output_type": "stream",
+ "text": [
+ "erk\n",
+ "ikk\n",
+ "gsk3\n",
+ "nfkb\n",
+ "ask1\n",
+ "ras\n",
+ "egf\n",
+ "egfr\n",
+ "traf2\n",
+ "ikb\n",
+ "map3k1\n",
+ "tnfr\n",
+ "ap1\n",
+ "mek\n",
+ "mkk4\n",
+ "ex\n",
+ "tnfa\n",
+ "raf1\n",
+ "map3k7\n",
+ "mkk7\n",
+ "cjun\n",
+ "sos\n",
+ "jnk\n",
+ "pi3k\n",
+ "p38\n",
+ "akt\n",
+ "ph\n",
+ "nik\n"
+ ]
+ }
+ ],
+ "source": [
+ "for initial in tm.initials:\n",
+ " print(initial)"
+ ]
+ },
+ {
+ "cell_type": "markdown",
+ "id": "70bcc3e5-0561-44da-b0f6-63546f23ee6f",
+ "metadata": {},
+ "source": [
+ "## Qualitative models do not have parameters"
+ ]
+ },
+ {
+ "cell_type": "code",
+ "execution_count": 4,
+ "id": "fe438910-9775-4a53-abf8-58627c2687b5",
+ "metadata": {},
+ "outputs": [
+ {
+ "data": {
+ "text/plain": [
+ "{}"
+ ]
+ },
+ "execution_count": 4,
+ "metadata": {},
+ "output_type": "execute_result"
+ }
+ ],
+ "source": [
+ "tm.parameters"
+ ]
+ },
+ {
+ "cell_type": "markdown",
+ "id": "4f106e1a-05ec-4da1-bf42-ab75dceaeb7d",
+ "metadata": {},
+ "source": [
+ "## Visualize the template model structure loaded in from a SBML Qual document from the biomodels website"
+ ]
+ },
+ {
+ "cell_type": "code",
+ "execution_count": 5,
+ "id": "748485f3-a5b9-42af-9279-35cce125ea08",
+ "metadata": {},
+ "outputs": [
+ {
+ "data": {
+ "image/png": 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+ "text/plain": [
+ ""
+ ]
+ },
+ "execution_count": 5,
+ "metadata": {},
+ "output_type": "execute_result"
+ }
+ ],
+ "source": [
+ "tm.draw_jupyter()"
+ ]
+ },
+ {
+ "cell_type": "markdown",
+ "id": "fe1a8c56-19ea-4636-8d7d-0ca4420af49e",
+ "metadata": {},
+ "source": [
+ "## We then convert an SBML Qual document from the Covid-19 disease map\n",
+ "\n",
+ "The specific file is here: https://git-r3lab.uni.lu/covid/models/-/blob/master/Executable%20Modules/SBML_qual_build/sbml/Orf3a_stable.sbml?ref_type=heads\n"
+ ]
+ },
+ {
+ "cell_type": "code",
+ "execution_count": 6,
+ "id": "1013581c-2a26-4f0c-b6e1-181fecd2b0c2",
+ "metadata": {},
+ "outputs": [
+ {
+ "data": {
+ "image/png": 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0aZKuvvpqde7cWdOnT1f79u21ZMkSZWRkaM6cORo2bBhBAQAuO8bz51aTz2Hs3r1bSUlJuvLKK/XSSy/pd7/7nVJTUzV37tyLHhTgwTZ1bjV5mwIAAAAgRUdHa/jw4Zo6daq++uorHTp0SB999JHi4uLkcrk0atQoNWrUSL1791ZSUpIWL16szMzMS14Xx2PnxvGYb2LbPze2fQAAAAAAAAC1CWEBAOAjWrRoodtvv10vv/yyNmzYoKysLDmdTv3xj39UcHCwZs+ercGDBysqKkqdO3fWvffeq7feekvbt29XSUnJr/77p0yZojZt2uixxx7T8uXLlZ2drYMHD+rhhx9Wenp62YVIz+smTpyoZcuWKTs7W7t379bo0aOVnp6umTNnqkmTJlWuo1evXtq9e7cOHDigjRs3KjU1Vf369bvg3+NS1DdlyhS1a9dO9957rz777DNlZWXp+PHjmj17tl544QVNnz6dNPMaYubMmbLZbLr11lt18OBBq8vBr/DRRx/p0Ucf1V/+8hclJiae9/vY553fZ1/OfZ7dbtc111yjuXPnXrTPBABcmNzcXC1dulTjx49Xy5YtNXDgQC1ZskRDhw5VcnKy0tLS9N5772n48OEKDg62ulwAtRjj+fP77Jp2DsPpdGr48OHq0KGDPvvsM02ZMkV79+7V1KlT1aJFi0v6d7NNnd9n17RtCgAAAMDZnR4ekJGRofnz58tms501PCArK+ui18Hx2Pl9Nsdjvodt//w+m20fAAAAAAAAQK1hAABqjbS0NOOTTz4xnnvuOWPYsGFGVFSUIckIDw83bDabkZiYaMyZM8dITU2t0ucfPXrUmDhxotGmTRsjMDDQaNasmXHnnXcau3fv/sXXRUZGGvHx8cbKlSvLXrNx40ZDUoXbM888YxiGccbzv/nNb8ret2vXLqNfv35GeHi40apVK+O111476+ed7WvwfOr7+9//Xml9Z3ve49ixY8akSZOMtm3bGoGBgUZ0dLQxZMgQIzk5+Rd/d76yq5+srCyjc+fORq9evYycnByry0EVOBwOIzg42HjkkUeq9H72edVvn/f8888bjRs3NgoLC6v0fgDAhUtNTTVmzpxpxMXFGYGBgUZAQIAxYMAA46WXXjJ+/PFHq8sDgAoSEhKMhIQEwzAYz1fH8XxVnDp1ypgzZ47RpUsXQ5Jhs9mMTz75xCgtLb1sNXiwTfnGNgUAAADg4sjIyDAWLVpkJCYmGjExMYafn59Rp04dIyYmxpg8ebLxySefGFlZWRfl7+J4jOOx2oTzW2z7AABUxcKFC/l+AwAAAAAf52cYhiEAQK1UUlKiXbt2KSUlRSkpKXK5XPr6669VWlqqZs2aKSYmRjExMbLb7brhhhsUFhZmdclAtbJnzx716dNH/fv316JFi+Tv7291SThPX375pQYNGqQRI0Zo7ty5/L/zEXv37lXbtm21dOlS/eY3v7G6HADwSfn5+XK5XHI4HHI4HEpJSVF4eLhuvPFGDR8+XCNGjPhVqxABwKV0xx13SJIWLVpkcSX4tQ4fPqz33ntPs2bN0tGjRzVq1Cg98cQT6tq1q9WlAQAAAAAqcejQIa1bt04Oh0NOp1Pff/+9AgIC1L17d8XFxclmsyk2Nlb16tWzulSgWuP8FgAAqIpFixZp1KhRom0EAAAAAHwXYQEAgApycnK0bdu2svCAdevW6dChQ6pTp47at29fFh5gs9nUsWNHGmxR661Zs0bx8fF69NFH9dJLL1ldDs7Djh07FBsbq759++qjjz5SQECA1SXhIoqNjVXTpk21cOFCq0sBAJ9gGIa+/fZbrVixQitWrJDT6VRhYaG6deum+Ph4DRkyRP3791dgYKDVpQLAOTGZuub78ccf9Y9//ENvv/22wsPDdd9992nChAlq0aKF1aUBAAAAAC5ARkaG1q9ff9bwAE+AQGhoqNWlAtUK57cAAEBVEBYAAAAAAL6PsAAAwDmlpaWVhQc4nU5t3bpV+fn5qlu3rrp161YWHnD99dcrOjra6nKBy+7DDz/UHXfcoRdeeEFPP/201eXgFxw4cEB2u10tWrRQcnKywsPDrS4JF9k///lPPfroo0pLS1NUVJTV5QBAjXTs2DGtWrVKDodDn332mQ4cOKBGjRrpxhtvVFxcnIYOHaqWLVtaXSYAXDAmU9dcTqdT06ZN0/Lly9WuXTs9+uijeuCBBxQWFmZ1aQAAAACAiyA9PV1Op/MXwwPsdrtCQkKsLhWwFOe3AABAVRAWAAAAAAC+j7AAAMAFKy4u1g8//FAWHpCSkqKdO3fKMAw1a9asLDwgJiZGvXv35oI9aoU33nhDDz/8sF555RUlJSVZXQ4qceTIkbKVj9euXUsjuY86efKkmjVrppdfflnjx4+3uhwAqBHy8vK0YcMGrV69Wl988YW2bt2qOnXqqG/fvoqPj9eQIUPUq1cv+fv7W10qAPwqTKauWQoLC7VgwQJNnz5d3377rWw2m5KSkjRy5EjVqVPH6vIAAAAAAJdQWlqaXC6XHA6HkpOTtWfPHsIDAHF+CwAAVA1hAQAAAADg+wgLAABcFFlZWdqyZUtZeMCmTZt09OhRBQYG6uqrr64QINCpUyf5+flZXTJw0b344ot6/vnn9f777+vOO++0uhx4OXnypAYOHKjMzEw5nU41bdrU6pJwCd11111KT0/XmjVrrC4FAKqlgoICbdq0SatXr9aqVau0efNmFRYW6uqrr9agQYMUHx+vgQMHql69elaXCgAXFZOpa4YjR47o3Xff1auvvqojR45oxIgRevzxx3XddddZXRoAAAAAwCLe4QFffPGF9u7dq9DQUPXq1Ut2u11xcXHq16+fgoODrS4VuKQ4vwUAAKqCsAAAAAAA8H0BVhcAAPANkZGRZQn+kmQYhn744Qdt3rxZmzdv1qZNm/Tuu++quLhYTZo0UZ8+fXTttdfq2muv1XXXXccK3/AJf/rTn5SVlaUxY8YoMjJSN998s9UlQeZqlLfffrvS09MJCqgl7rjjDt1+++3673//qxYtWlhdDgBYrqSkRNu2bZPD4ZDD4ZDL5VJ+fr6aNWsmu92uV199VfHx8WrdurXVpQIAarEff/xR//jHP/TOO+8oMDBQY8eO1RNPPKGWLVtaXRoAAAAAwGLNmzdXQkKCEhISJFUMD1iwYIGmTZumsLAw9ezZk/AAAAAAAAAAAABQ6/gZRMQBAC6TvLw8paSklAUIbNmyRfv27ZMkXX311RXCA3r27KnQ0FCLKwYunGEYuv/++7VgwQKtWLFCdrvd6pJqtZKSEo0aNUoOh0Nr1qxRjx49rC4Jl8GpU6fUtGlTvfDCC0pMTLS6HAC47IqKipSSkqK1a9dq9erVcjqdys3NVYsWLTRw4EDdeOONGjBggNq0aWN1qQBwWbHyWvXkdDo1bdo0LV++XG3bttWECRN0//33Kzw83OrSAAAAAAA1RGpqqpxOp1wul1asWKF9+/YpLCxMN9xwg2w2m+x2u/r376+goCCrSwV+Fc5vAQCAqli0aJFGjRol2kYAAAAAwHcRFgAAsFRmZqa++uorOZ1OpaSk6Msvv9Thw4dVp04dtW/fXjExMWW36667jov3qBFoUK8eDMPQAw88oHnz5umLL74guKGW+d3vfqfU1FS5XC6rSwGASy43N1dff/21XC6XnE6n1q9fr6ysLDVu3FixsbFlk2F79eolPz8/q8sFAMswmbr6KCws1IIFCzR9+nR9++23stlsSkpK0siRI1WnTh2rywMAAAAA1HDe4QGff/659u/fr/DwcPXt25fwANRonN8CAABVQVgAAAAAAPg+wgIAANVOWlqaUx+YygAAIABJREFUUlJSym5Op1OZmZkKDAxUt27dZLPZygIEOnXqRMMTqqX8/HzdfPPN2rVrl1atWqVOnTpZXVKt88QTT2jmzJn6+OOPNXToUKvLwWW2bNky3XLLLdqzZ49at25tdTkAcFGlpaXJ6XSW3b755huVlJToqquuKpvoarfb1aFDB6tLBYBqhcnU1jt69Kj++c9/6tVXX9WRI0c0YsQI/eEPf1CfPn2sLg0AAAAA4MNSU1PlcDjkdDq1Zs0aHThwgPAA1Eic3wIAAFVBWAAAAAAA+D7CAgAA1V5JSYl27dpVIUDgq6++UkFBgSIjI9WlSxfFxMSUXcBv0qSJ1SUDksxVfocNG6bvv/9eK1euVJcuXawuqdaYMmWKnnnmGb333nsaO3as1eXAAkVFRWratKmeeeYZTZo0yepyAKDKDMPQzp075XK5ysIBUlNTFRAQoO7du5cFA9hsNjVr1szqcgGgWmMytXV++uknvfrqq3rnnXcUGBiosWPH6vHHH1erVq2sLg0AAAAAUAt5hwesXr1aBw8eLAsPiIuLk81mU58+fRQYGGh1qUAFnN8CAABVQVgAAAAAAPg+wgIAADVSUVGRdu/eXdY0lZKSol27dqm0tFTNmjVTTExM2c1ms6lBgwZWl4xaKjc3V8OHD9eOHTvkcDjUtWtXq0vyeXPmzNE999yjl19+WRMnTrS6HFjo3nvv1Y4dO7R582arSwGA85aVlaUtW7aUjXE3bdqko0ePKiwsTD179iwLBrDb7YqKirK6XACoUZhMffk5nU7NmjVLH374oa688kpNmDBB999/v8LDw60uDQAAAACAMp7wAIfDodWrV+vo0aOKiIjQ9ddfT3gAqhXObwEAgKogLAAAAAAAfB9hAQAAn3Hy5El98803SklJUUpKipxOp/bs2SNJatu2rWw2W1mAQO/evRUSEmJxxagt8vLyNGzYMH333XdauXIlgQGX0JIlS3T77bfr2Wef1XPPPWd1ObDYihUrdNNNN+mnn35Su3b/n707j8uqzv///7w2FhcW2VHADRA0QRHN1BrS1BazbDE/00z7+mtKqyln6dZvWmamptXGaqxsGRtHZz6ZWVqpLQZOKqCoKKhhboiCsqns1/n+4cdrRMAEgQMXj/vtdm7Auc451/Oc63TZ+3Wd87oGmB0HABqorq7Wxo0btX79eq1bt07r1q3Trl27JEnR0dEaOXKkRo0apQsvvFDDhg2T3W43OTEAdG5cTN0+qqurtXTpUr3wwgtav369xowZo4ceekjTpk2TzWYzOx4AAAAAAD/pp5oHTJgwQcOGDZPVajU7KroY6lsAAKAlaBYAAAAAAO6PZgEAALe2f/9+rV+/Xhs2bND69euVnp6usrIyeXp6KjExUSNHjlRycrKSk5MVExPDh/loMydOnNCUKVO0ZcsWGga0ka+//lpXXHGFbr/9ds2dO9fsOOgAamtr1bt3bz388MN6/PHHzY4DAMrLy3M1BVi3bp02btyoqqoq+fv7uxoDnJoCAgLMjgsAboeLqdtWaWmp3nvvPb3wwgs6dOiQrrnmGj388MO68MILzY4GAAAAAMB5Ob15wFdffaUjR46oZ8+eGjVqFM0D0K6obwEAgJagWQAAAAAAuD+aBQAAupz8/HylpaUpNTVVGRkZyszMVEVFhXr27KmhQ4cqKSnJNcXHx8tisZgdGW7i9IYBq1at0tChQ82O5DY2bNig8ePH66qrrtKCBQu4EAcud999tzIzM5Wenm52FABdTH5+vjIyMlzT+vXrdfjwYdntdsXExCgpKUljx47VmDFjFBcXx79dANAOuJi6bezatUuvvfaa3n77bdntdt1666169NFHFRERYXY0AAAAAADaxOnNA1avXq2jR4/SPADtgvoWAABoCZoFAAAAAID7o1kAAKDLq6mpUVZWltLT011Tdna2amtr5e/vrxEjRigpKUkjRozQiBEjFBUVZXZkdGLHjx93NQxYuXKlEhMTzY7U6e3cuVPjxo3TBRdcoE8//VSenp5mR0IH8vnnn+uKK67Qnj17uFkJQJvZs2dPvcYA6enpOnLkiGw2m2JjY12NqEaMGKHhw4fL29vb7MgA0CVxMXXrSk1N1Zw5c/TRRx8pKipKDz74oO688051797d7GgAAAAAALQbp9Op7du3Ky0trV7zgKCgII0aNUpjx47VhAkTNHz4cL6oAOeN+hYAAGgJmgUAAAAAgPujWQAAAI2oqanRjh076t30tWHDBlVXV8vX11dDhgxx3fSVlJSkwYMHmx0ZnciJEyc0depUpaen65NPPtG4cePMjtShGYah8vJy+fj4NHhs//79Gjt2rEJDQ7V69WpuSkEDVVVVCg4O1rPPPqsHHnjA7DgA3MCPP/6ozMzMev+fWFRUJKvVqtjYWFejqaSkJCUmJqpHjx5mRwaALunEiROqqqqqN++2226TJL377rv15nt6eqpbt27tlq0zq66u1tKlS/Xiiy9q3bp1GjNmjB566CFNmzZNNpvN7HgAAAAAAJiurq5OOTk5ruYBq1atUnFxMc0D0GzUtwAAQGuhWQAAAAAAuD+aBQAAcI6OHz+ujRs31rsxLCcnR06nU/7+/kpKStKYMWOUlJSk5ORkhYaGmh0ZHVh1dbVuvvlmffLJJ/rHP/6hadOmNbrc7t271a9fv3ZO17GsXr1as2bN0hdffKGwsDDX/KKiIl188cWy2Wz69ttv1atXLxNToiObPn26jh49qpUrV5odBUAncnrzqG3btik7O1vr1q1TYWGhJCksLKxe86gxY8bwbxEAdCBvvvmm7rvvvnNa9o033tC9997bxok6t9LSUr333nt68cUXlZ+fr8svv1y/+93vdOGFF5odDQAAAACADq2urk6bNm1Samqq0tLStHLlSpWUlCg4OFiXXHKJxowZo7Fjx9I8AA1Q3wIAAK2FZgEAAAAA4P5oFgAAwHkoLy9XVlZWow0EzryBbNSoUQoODjY7MjqQuro63X///XrnnXc0b9483X777fUeT0tL0+TJk5WRkaGYmBiTUprvqquu0meffaaIiAh9/fXXGjBggMrLy3XppZfq6NGjSk1NrddEADjTP/7xD9166606dOiQ/P39zY4DoAMqLCxUVlaWNm3apKysLGVlZWn79u2qra2Vt7e3hgwZosTERCUkJLimnj17mh0bAHAWRUVFCg0NVV1d3VmXs9lsKigoUGBgYDsl61x++OEHzZkzR++8845sNptuvfVWPfLII4qMjDQ7GgAAAAAAnVJTzQNCQkJ08cUX0zwALtS3AABAa6FZAAAAAAC4P5oFAADQysrKyrR58+Z6DQS2b98uwzAaNBAYPXo0H9h2cYZh6A9/+IOeeuop/eUvf9EjjzwiScrLy9OIESNUXFysSZMm6fPPPzc5qTl2796tgQMHyul0yuFwyMfHRytWrNATTzyhzMxMfffdd4qNjTU7Jjq40tJSBQcHa/78+fr5z39udhwAJqqpqVFOTo6ys7NdTQGysrKUn58vSQoLC3M1AzjVHCAmJkY2m83k5ACAlpg8ebJWr16t2traRh+32WyaMGFClx1vnU1qaqrmzJmjjz76SFFRUbr77rt1zz33yM/Pz+xoAAAAAAC4lVPNA1atWqXU1FR99913Ki0tpXkAJFHfAgAArYNmAQAAAADg/mgWAABAOygtLdWWLVvqNRDYtm2bJDVoIDBmzBj16tXL5MRob3PmzNHMmTP12GOP6be//a1GjhypvLw81dTUSJKWLVumq666yuSU7W/mzJl6/fXXXcfBZrPJw8NDnp6e+uabb5SQkGByQnQWEydOlJ+fnxYvXmx2FADtwOl0avfu3dq6dau2bt2qLVu2KDs7W7m5uaqpqZHD4VBsbKwSEhI0dOhQDRs2TAkJCQoODjY7OgCgFS1YsEC33HKLnE5no49brVZ98MEHbt1QqqioSC+//LKeffbZn1y2pqZGH3/8sV566SV9//33SkpK0oMPPqj/+Z//kd1ub4e0AAAAAACgtrZWWVlZruYBa9asUVlZmUJDQzVu3DhNmDBBY8aM0eDBg82OinZAfQsAALQGmgUAAAAAgPujWQAAACYpKChQenq6a8rIyFBBQYGsVqtiYmI0fPhwJSUlafjw4Ro2bJh8fX3Njow2Nn/+fN19993q06eP8vPzXTfIW61W9enTRzt27JCnp6fJKdtPeXm5wsLCdPz48XrzrVarrFarFi1apGnTppmUDp3N3LlzNXv2bBUWFsrLy8vsOABaUXFxsbKzs7Vt2zZlZ2crIyNDWVlZOnbsmKSTjZkGDx6s+Ph4JSUluX739vY2OTkAoK0dP35cgYGBqqysbPRxT09PFRUVqUePHu2crH3k5+frZz/7mXbt2qWtW7cqPj6+0eXKysr07rvv6sUXX9SBAwd0xRVX6Le//a1Gjx7dzokBAAAAAMCZmmoeEBYWprFjx9I8wM119foWAABoHTQLAAAAAAD3R7MAAAA6kP3797saB2RmZiojI0OHDh2SxWLRwIED6zUQGD58uPz9/dssy7Fjx2S327mptp1NnjxZK1eubPDNADabTc8++6wef/xxk5K1v9dee02zZs1SXV1dg8csFossFoveeust3X777SakQ2dz4MABRURE6NNPP9UVV1xhdhwAzWQYhvbu3aucnBxt27ZNOTk52r59u7Kzs3X06FFJUmhoqIYMGeKaLrjgAsXHx3OBHAB0cTfeeKM+/vhjVzO2U+x2u6ZNm6ZFixaZlKxt5eXlKSUlRQcPHpQk3XLLLXrrrbcaLPPqq6/qnXfekc1m06233qpHHnlEkZGRZkQGAAAAAADn4PTmAatWrVJaWpoqKirqNQ+47LLL1K9fv/N6ngULFshut+umm25qpeRoqa5a3wIAAK2HZgEAAAAA4P5oFgAAQAeXn5+vjIwMZWRkuL4xd9u2bZJOflNuUlKSaxo5cqRCQkJa5Xk/+ugjPfLII3rllVc0derUVtkmzu7555/X7NmzmyzKe3t7a9euXQoPD2/nZO3P6XRq4MCB+vHHH8/6IYXFYtHLL7+shx56qB3TobNKTk7W8OHD9be//c3sKACaUFNTo127dmnbtm3Kzc11NQbIycnR8ePHJUkhISGKj4/XoEGDNHjwYMXHx2vo0KEKCAgwOT0AoCNaunSprr322gbjCovFoo8//lhXX321ScnaTk5Ojn72s5/p6NGjrovIHQ6H9u3bp5CQEKWmpmrOnDn66KOPFBkZqXvuuUf33HOP/Pz8TE4OAAAAAACa68zmAampqaqsrDzv5gHXXHONli5dqilTpmjevHkKDQ1toz3AT+mK9S0AANC6aBYAAAAAAO6PZgEAAHRCxcXFys7OdjURyMjI0Pbt22UYRoMGAsnJyS364P6JJ57Qs88+K8MwlJKSorlz5youLq4N9gaS9Nlnn+nqq6+W0+lschmHw6Ebb7xRCxYsaMdk5li+fLmuvPLKsy5js9lUV1encePGacmSJdwkip/09NNP680339T+/ftlsVjMjgN0acXFxdqxY4d27Nih7du3KycnR9u2bVNeXp5qampktVrVt29fDRo0yNUYIC4uTnFxcfL39zc7PgCgE6murlZgYKDKy8vrze/Zs6cKCwvl6elpUrK2kZmZqQkTJqi8vFy1tbWu+Q6HQ7fffrvS09OVkZGhMWPGaNasWbrmmmtks9lMTAwAAAAAAFrTuTQPmDhxovr27dvkNpxOp/z9/VVWViaHwyEvLy/NnTtXv/jFL9pvR+DS1epbAACg9dEsAAAAAADcH80CAABwEyUlJdq6des5NRAYPHiw+vfvf9btTZo0SStXrpRhGHI4HKqrq9Mdd9yhP/3pT9yU3crS09M1btw4VVZW/uSyFotFaWlpGj16dDskM8/48eO1Zs2aeje3nHLqJu/o6Gg988wzuuGGG9o7Hjqp9PR0JScna9OmTUpISDA7DuD2qqqqtHPnTldTgJ07dyo3N1c7duxQYWGhJMnDw0MxMTGuZgDx8fGKjY3VoEGD5O3tbfIeAADcxZ133qkPPvhANTU1kk7eOH/LLbforbfeMjlZ6/ruu+90+eWXq7KyUnV1dQ0e9/X11cSJE/Xoo49q5MiRJiQEAAAAAADtraKiQhkZGUpLS9OqVav03Xf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+ "text/plain": [
+ ""
+ ]
+ },
+ "execution_count": 6,
+ "metadata": {},
+ "output_type": "execute_result"
+ }
+ ],
+ "source": [
+ "model_text = requests.get(MODEL_URL).text\n",
+ "tm = template_model_from_sbml_qual_string(model_text)\n",
+ "tm.draw_jupyter()"
+ ]
+ },
+ {
+ "cell_type": "markdown",
+ "id": "e8fb68bf-2fb0-4168-a8c5-345062e638e9",
+ "metadata": {},
+ "source": [
+ "## We identify all concepts and their identifiers from the model that is apart of the Covid-19 disease map\n",
+ "\n",
+ "Qualitative species' annotations have been provided for most of the species' in the model"
+ ]
+ },
+ {
+ "cell_type": "code",
+ "execution_count": 7,
+ "id": "272b8133-3f48-4bba-ab67-7375bcca0483",
+ "metadata": {},
+ "outputs": [
+ {
+ "name": "stdout",
+ "output_type": "stream",
+ "text": [
+ "Hops Complex_complex | {'uniprot': 'J9TC74'}\n",
+ "IKBKG/IKBKB/CHUK_complex | {'hgnc': '1974'}\n",
+ "LPS/TLR4/MYD88_complex | {'hgnc': '11850'}\n",
+ "P65/P015_complex | {'hgnc': '7794'}\n",
+ "LPS/TNF α/IL-1_complex | {'hgnc': '11916'}\n",
+ "TAB2/TAB3/TAK1_complex | {'hgnc': '17075'}\n",
+ "TRIM27/TRIM21_complex | {'hgnc': '11312'}\n",
+ "TLR7/8/9_complex | {'hgnc': '15631'}\n",
+ "TRIM30a/TRIM38_complex | {'hgnc': '10059'}\n",
+ "NEMO/IKKA/IKKB_complex | {'hgnc': '1974'}\n",
+ "TRIM14/TRIM23_complex | {'hgnc': '16283'}\n",
+ "NFKB1:NFKNIA_complex | {}\n",
+ "Orf3a | {}\n",
+ "TRIM59 | {'pubmed': '22588174'}\n",
+ "NLRP3 | {'hgnc': '16400'}\n",
+ "PYCARD_ubiquitinated_ubiquitinated_ubiquitinated | {'pubmed': '32172672'}\n",
+ "TRAF3 | {'hgnc': '12033'}\n",
+ "CASP1 | {'hgnc': '1499'}\n",
+ "TRAF6 | {'hgnc': '12036'}\n",
+ "double-stranded RNA_rna | {}\n",
+ "ssRNA_rna | {}\n",
+ "TICAM1 | {'hgnc': '18348'}\n",
+ "MYD88 | {'hgnc': '7562'}\n",
+ "TRIM38 | {'hgnc': '10059'}\n",
+ "TRIM22 | {'hgnc': '16379'}\n",
+ "NFKBIA_phosphorylated_ubiquitinated_ubiquitinated_ubiquitinated | {'hgnc': '7797'}\n",
+ "TRIM29 | {'hgnc': '17274'}\n",
+ "TRIM23 | {'hgnc': '660'}\n",
+ "TRIM9 | {'hgnc': '16288'}\n",
+ "BTRC | {'hgnc': '1144'}\n",
+ "TRIM39 | {'hgnc': '10065'}\n",
+ "CACTIN | {'hgnc': '29938'}\n",
+ "NFKB1 | {'hgnc': '7794'}\n",
+ "S | {'uniprot': 'P0DTC2'}\n",
+ "E | {'ncbiprotein': '1796318600'}\n",
+ "SERPINF2 | {'hgnc': '9075'}\n",
+ "IFNB1 | {'hgnc': '5434'}\n",
+ "IL1b | {'hgnc': '5992'}\n",
+ "TLR3 | {'hgnc': '11849'}\n",
+ "ORF8b | {'ncbiprotein': 'BCD58760'}\n",
+ "IRF6 | {}\n",
+ "TLR4 | {}\n"
+ ]
+ }
+ ],
+ "source": [
+ "for initial in tm.initials.values():\n",
+ " print(f\"{initial.concept.display_name} | {initial.concept.identifiers}\")"
+ ]
+ }
+ ],
+ "metadata": {
+ "kernelspec": {
+ "display_name": "Python 3 (ipykernel)",
+ "language": "python",
+ "name": "python3"
+ },
+ "language_info": {
+ "codemirror_mode": {
+ "name": "ipython",
+ "version": 3
+ },
+ "file_extension": ".py",
+ "mimetype": "text/x-python",
+ "name": "python",
+ "nbconvert_exporter": "python",
+ "pygments_lexer": "ipython3",
+ "version": "3.10.12"
+ }
+ },
+ "nbformat": 4,
+ "nbformat_minor": 5
+}
diff --git a/notebooks/evaluation_2024.03/epi_scenario5/scenario5_regnet.json b/notebooks/evaluation_2024.03/epi_scenario5/scenario5_regnet.json
index 0a21ae62c..2cde7b44f 100644
--- a/notebooks/evaluation_2024.03/epi_scenario5/scenario5_regnet.json
+++ b/notebooks/evaluation_2024.03/epi_scenario5/scenario5_regnet.json
@@ -145,7 +145,7 @@
},
{
"id": "t3",
- "source": "I",
+ "source": "Lactose",
"target": "I_Lactose",
"sign": true,
"properties": {
@@ -156,8 +156,8 @@
{
"id": "t4",
"source": "I",
- "target": "Lactose",
- "sign": false,
+ "target": "I_Lactose",
+ "sign": true,
"properties": {
"name": "t4",
"rate_constant": "k_3"
@@ -165,8 +165,8 @@
},
{
"id": "t5",
- "source": "Lactose",
- "target": "I",
+ "source": "I",
+ "target": "Lactose",
"sign": false,
"properties": {
"name": "t5",
@@ -175,18 +175,18 @@
},
{
"id": "t6",
- "source": "I_Lactose",
+ "source": "Lactose",
"target": "I",
- "sign": true,
+ "sign": false,
"properties": {
"name": "t6",
- "rate_constant": "k_4"
+ "rate_constant": "k_3"
}
},
{
"id": "t7",
"source": "I_Lactose",
- "target": "Lactose",
+ "target": "I",
"sign": true,
"properties": {
"name": "t7",
@@ -195,171 +195,201 @@
},
{
"id": "t8",
+ "source": "I_Lactose",
+ "target": "Lactose",
+ "sign": true,
+ "properties": {
+ "name": "t8",
+ "rate_constant": "k_4"
+ }
+ },
+ {
+ "id": "t9",
"source": "I",
"target": "I_Op",
"sign": true,
"properties": {
- "name": "t8",
+ "name": "t9",
"rate_constant": "k_5"
}
},
{
- "id": "t9",
+ "id": "t10",
+ "source": "Op",
+ "target": "I_Op",
+ "sign": true,
+ "properties": {
+ "name": "t10",
+ "rate_constant": "k_5"
+ }
+ },
+ {
+ "id": "t11",
"source": "I",
"target": "Op",
"sign": false,
"properties": {
- "name": "t9",
+ "name": "t11",
"rate_constant": "k_5"
}
},
{
- "id": "t10",
+ "id": "t12",
"source": "Op",
"target": "I",
"sign": false,
"properties": {
- "name": "t10",
+ "name": "t12",
"rate_constant": "k_5"
}
},
{
- "id": "t11",
+ "id": "t13",
"source": "I_Op",
"target": "I",
"sign": true,
"properties": {
- "name": "t11",
+ "name": "t13",
"rate_constant": "k_6"
}
},
{
- "id": "t12",
+ "id": "t14",
"source": "I_Op",
"target": "Op",
"sign": true,
"properties": {
- "name": "t12",
+ "name": "t14",
"rate_constant": "k_6"
}
},
{
- "id": "t13",
+ "id": "t15",
+ "source": "RNAP",
+ "target": "RNAP_Op",
+ "sign": true,
+ "properties": {
+ "name": "t15",
+ "rate_constant": "k_7"
+ }
+ },
+ {
+ "id": "t16",
"source": "Op",
"target": "RNAP_Op",
"sign": true,
"properties": {
- "name": "t13",
+ "name": "t16",
"rate_constant": "k_7"
}
},
{
- "id": "t14",
+ "id": "t17",
"source": "RNAP",
"target": "Op",
"sign": false,
"properties": {
- "name": "t14",
+ "name": "t17",
"rate_constant": "k_7"
}
},
{
- "id": "t15",
+ "id": "t18",
"source": "Op",
"target": "RNAP",
"sign": false,
"properties": {
- "name": "t15",
+ "name": "t18",
"rate_constant": "k_7"
}
},
{
- "id": "t16",
+ "id": "t19",
"source": "RNAP_Op",
"target": "RNAP",
"sign": true,
"properties": {
- "name": "t16",
+ "name": "t19",
"rate_constant": "k_8"
}
},
{
- "id": "t17",
+ "id": "t20",
"source": "RNAP_Op",
"target": "Op",
"sign": true,
"properties": {
- "name": "t17",
+ "name": "t20",
"rate_constant": "k_8"
}
},
{
- "id": "t18",
+ "id": "t21",
"source": "RNAP_Op",
"target": "RNAP",
"sign": true,
"properties": {
- "name": "t18",
+ "name": "t21",
"rate_constant": "k_9"
}
},
{
- "id": "t19",
+ "id": "t22",
"source": "RNAP_Op",
"target": "Op",
"sign": true,
"properties": {
- "name": "t19",
+ "name": "t22",
"rate_constant": "k_9"
}
},
{
- "id": "t20",
+ "id": "t23",
"source": "RNAP_Op",
"target": "r_lac",
"sign": true,
"properties": {
- "name": "t20",
+ "name": "t23",
"rate_constant": "k_9"
}
},
{
- "id": "t21",
+ "id": "t24",
"source": "r_lac",
"target": "Z",
"sign": true,
"properties": {
- "name": "t21",
+ "name": "t24",
"rate_constant": "k_10"
}
},
{
- "id": "t22",
+ "id": "t25",
"source": "Z",
"target": "Lactose",
"sign": false,
"properties": {
- "name": "t22",
+ "name": "t25",
"rate_constant": "k_11"
}
},
{
- "id": "t23",
+ "id": "t26",
"source": "Lactose",
"target": "Z",
"sign": false,
"properties": {
- "name": "t23",
+ "name": "t26",
"rate_constant": "k_11"
}
},
{
- "id": "t24",
+ "id": "t27",
"source": "I_Lactose",
"target": "Lactose",
"sign": true,
"properties": {
- "name": "t24",
+ "name": "t27",
"rate_constant": "k_14"
}
}
@@ -451,8 +481,8 @@
},
{
"target": "t4",
- "expression": "I*Lactose*k_3",
- "expression_mathml": "ILactosek_3"
+ "expression": "0",
+ "expression_mathml": "0"
},
{
"target": "t5",
@@ -461,8 +491,8 @@
},
{
"target": "t6",
- "expression": "I_Lactose*k_4",
- "expression_mathml": "I_Lactosek_4"
+ "expression": "I*Lactose*k_3",
+ "expression_mathml": "ILactosek_3"
},
{
"target": "t7",
@@ -471,8 +501,8 @@
},
{
"target": "t8",
- "expression": "I*Op*k_5",
- "expression_mathml": "IOpk_5"
+ "expression": "I_Lactose*k_4",
+ "expression_mathml": "I_Lactosek_4"
},
{
"target": "t9",
@@ -481,76 +511,91 @@
},
{
"target": "t10",
+ "expression": "0",
+ "expression_mathml": "0"
+ },
+ {
+ "target": "t11",
"expression": "I*Op*k_5",
"expression_mathml": "IOpk_5"
},
{
- "target": "t11",
+ "target": "t12",
+ "expression": "I*Op*k_5",
+ "expression_mathml": "IOpk_5"
+ },
+ {
+ "target": "t13",
"expression": "I_Op*k_6",
"expression_mathml": "I_Opk_6"
},
{
- "target": "t12",
+ "target": "t14",
"expression": "I_Op*k_6",
"expression_mathml": "I_Opk_6"
},
{
- "target": "t13",
+ "target": "t15",
"expression": "Op*RNAP*k_7",
"expression_mathml": "OpRNAPk_7"
},
{
- "target": "t14",
+ "target": "t16",
+ "expression": "0",
+ "expression_mathml": "0"
+ },
+ {
+ "target": "t17",
"expression": "Op*RNAP*k_7",
"expression_mathml": "OpRNAPk_7"
},
{
- "target": "t15",
+ "target": "t18",
"expression": "Op*RNAP*k_7",
"expression_mathml": "OpRNAPk_7"
},
{
- "target": "t16",
+ "target": "t19",
"expression": "RNAP_Op*k_8",
"expression_mathml": "RNAP_Opk_8"
},
{
- "target": "t17",
+ "target": "t20",
"expression": "RNAP_Op*k_8",
"expression_mathml": "RNAP_Opk_8"
},
{
- "target": "t18",
+ "target": "t21",
"expression": "RNAP_Op*k_9",
"expression_mathml": "RNAP_Opk_9"
},
{
- "target": "t19",
+ "target": "t22",
"expression": "RNAP_Op*k_9",
"expression_mathml": "RNAP_Opk_9"
},
{
- "target": "t20",
+ "target": "t23",
"expression": "RNAP_Op*k_9",
"expression_mathml": "RNAP_Opk_9"
},
{
- "target": "t21",
+ "target": "t24",
"expression": "k_10*r_lac",
"expression_mathml": "k_10r_lac"
},
{
- "target": "t22",
+ "target": "t25",
"expression": "Lactose*Z*k_11",
"expression_mathml": "LactoseZk_11"
},
{
- "target": "t23",
+ "target": "t26",
"expression": "Lactose*Z*k_11",
"expression_mathml": "LactoseZk_11"
},
{
- "target": "t24",
+ "target": "t27",
"expression": "I_Lactose*k_14",
"expression_mathml": "I_Lactosek_14"
},
diff --git a/notebooks/hackathon_2024.02/scenario6/scenario6_chen_regnet.json b/notebooks/hackathon_2024.02/scenario6/scenario6_chen_regnet.json
index f2e9b9e92..ed15f71e8 100644
--- a/notebooks/hackathon_2024.02/scenario6/scenario6_chen_regnet.json
+++ b/notebooks/hackathon_2024.02/scenario6/scenario6_chen_regnet.json
@@ -203,21 +203,6 @@
"semantics": {
"ode": {
"rates": [
- {
- "target": "r_1",
- "expression": "V_0*r_1",
- "expression_mathml": "V_0r_1"
- },
- {
- "target": "r_2",
- "expression": "V_1*r_2",
- "expression_mathml": "V_1r_2"
- },
- {
- "target": "r_3",
- "expression": "V_2*r_3",
- "expression_mathml": "V_2r_3"
- },
{
"target": "t1",
"expression": "L_0*r_1",
@@ -233,21 +218,6 @@
"expression": "L_2*r_3",
"expression_mathml": "L_2r_3"
},
- {
- "target": "p_1",
- "expression": "U_0*p_1",
- "expression_mathml": "U_0p_1"
- },
- {
- "target": "p_2",
- "expression": "U_1*p_2",
- "expression_mathml": "U_1p_2"
- },
- {
- "target": "p_3",
- "expression": "U_2*p_3",
- "expression_mathml": "U_2p_3"
- },
{
"target": "t4",
"expression": "C_0*p_1",
@@ -262,6 +232,36 @@
"target": "t6",
"expression": "C_2*p_1",
"expression_mathml": "C_2p_1"
+ },
+ {
+ "target": "r_1",
+ "expression": "V_0*r_1",
+ "expression_mathml": "V_0r_1"
+ },
+ {
+ "target": "r_2",
+ "expression": "V_1*r_2",
+ "expression_mathml": "V_1r_2"
+ },
+ {
+ "target": "r_3",
+ "expression": "V_2*r_3",
+ "expression_mathml": "V_2r_3"
+ },
+ {
+ "target": "p_1",
+ "expression": "U_0*p_1",
+ "expression_mathml": "U_0p_1"
+ },
+ {
+ "target": "p_2",
+ "expression": "U_1*p_2",
+ "expression_mathml": "U_1p_2"
+ },
+ {
+ "target": "p_3",
+ "expression": "U_2*p_3",
+ "expression_mathml": "U_2p_3"
}
],
"observables": [],
diff --git a/notebooks/hackathon_2024.02/scenario6/scenario6_hunt_regnet.json b/notebooks/hackathon_2024.02/scenario6/scenario6_hunt_regnet.json
index b1fa6dc36..db8d836a8 100644
--- a/notebooks/hackathon_2024.02/scenario6/scenario6_hunt_regnet.json
+++ b/notebooks/hackathon_2024.02/scenario6/scenario6_hunt_regnet.json
@@ -126,49 +126,69 @@
"id": "t5",
"source": "p_2",
"target": "r_2",
- "sign": false,
+ "sign": true,
"properties": {
"name": "t5",
- "rate_constant": "V_1"
+ "rate_constant": "C_1"
}
},
{
"id": "t6",
+ "source": "p_2",
+ "target": "r_2",
+ "sign": false,
+ "properties": {
+ "name": "t6",
+ "rate_constant": "V_1"
+ }
+ },
+ {
+ "id": "t7",
"source": "r_2",
"target": "p_2",
"sign": true,
"properties": {
- "name": "t6",
+ "name": "t7",
"rate_constant": "L_1"
}
},
{
- "id": "t7",
+ "id": "t8",
"source": "p_1",
"target": "r_3",
"sign": true,
"properties": {
- "name": "t7",
+ "name": "t8",
"rate_constant": "C_2"
}
},
{
- "id": "t8",
+ "id": "t9",
+ "source": "p_3",
+ "target": "r_3",
+ "sign": true,
+ "properties": {
+ "name": "t9",
+ "rate_constant": "C_2"
+ }
+ },
+ {
+ "id": "t10",
"source": "p_2",
"target": "r_3",
"sign": false,
"properties": {
- "name": "t8",
+ "name": "t10",
"rate_constant": "V_2"
}
},
{
- "id": "t9",
+ "id": "t11",
"source": "r_3",
"target": "p_3",
"sign": true,
"properties": {
- "name": "t9",
+ "name": "t11",
"rate_constant": "L_2"
}
}
@@ -278,11 +298,6 @@
"expression": "L_0*r_1/(1 + p_1/d_0)",
"expression_mathml": "L_0r_11p_1d_0"
},
- {
- "target": "p_1",
- "expression": "U_0*p_1",
- "expression_mathml": "U_0p_1"
- },
{
"target": "t4",
"expression": "C_1*p_1/(1 + p_2/a_1)",
@@ -290,34 +305,49 @@
},
{
"target": "t5",
+ "expression": "0",
+ "expression_mathml": "0"
+ },
+ {
+ "target": "t6",
"expression": "V_1*r_2/(1 + p_2/b_1)",
"expression_mathml": "V_1r_21p_2b_1"
},
{
- "target": "t6",
+ "target": "t7",
"expression": "L_1*r_2/(1 + p_2/d_1)",
"expression_mathml": "L_1r_21p_2d_1"
},
{
- "target": "p_2",
- "expression": "U_1*p_2",
- "expression_mathml": "U_1p_2"
- },
- {
- "target": "t7",
+ "target": "t8",
"expression": "C_2*p_1/(1 + p_3/a_2)",
"expression_mathml": "C_2p_11p_3a_2"
},
{
- "target": "t8",
+ "target": "t9",
+ "expression": "0",
+ "expression_mathml": "0"
+ },
+ {
+ "target": "t10",
"expression": "V_2*r_3/(1 + p_2/b_2)",
"expression_mathml": "V_2r_31p_2b_2"
},
{
- "target": "t9",
+ "target": "t11",
"expression": "L_2*r_3/(1 + p_3/d_2)",
"expression_mathml": "L_2r_31p_3d_2"
},
+ {
+ "target": "p_1",
+ "expression": "U_0*p_1",
+ "expression_mathml": "U_0p_1"
+ },
+ {
+ "target": "p_2",
+ "expression": "U_1*p_2",
+ "expression_mathml": "U_1p_2"
+ },
{
"target": "p_3",
"expression": "U_2*p_3",
diff --git a/scripts/covid19_diseasemaps/process_covid19_diseasemaps_sbml.py b/scripts/covid19_diseasemaps/process_covid19_diseasemaps_sbml.py
new file mode 100644
index 000000000..3e4a4d97f
--- /dev/null
+++ b/scripts/covid19_diseasemaps/process_covid19_diseasemaps_sbml.py
@@ -0,0 +1,57 @@
+import json
+import tqdm
+import requests
+
+from mira.sources.sbml import template_model_from_sbml_qual_string
+from mira.modeling.amr.regnet import template_model_to_regnet_json
+from mira.sources.biomodels import get_sbml_model
+
+
+
+models = [
+ "Apoptosis",
+ "Coagulation-pathway",
+ "ER_Stress",
+ "ETC",
+ "E_protein",
+ "HMOX1_Pathway",
+ "IFN-lambda",
+ "Interferon1",
+ "JNK_pathway",
+ "Kynurenine_pathway",
+ "NLRP3_Activation",
+ "Nsp14",
+ "Nsp4_Nsp6",
+ "Nsp9_protein",
+ "Orf10_Cul2_pathway",
+ "Orf3a",
+ "PAMP_signaling",
+ "Pyrimidine_deprivation",
+ "RTC-and-transcription",
+ "Renin_angiotensin",
+ "TGFB_pathway",
+ "Virus_replication_cycle",
+]
+
+
+SBML_URL_BASE = (
+ "https://git-r3lab.uni.lu/covid/models/-/raw/master/"
+ "Executable%20Modules/SBML_qual_build/sbml"
+)
+
+
+if __name__ == "__main__":
+ for model in tqdm.tqdm(models):
+ url = f"{SBML_URL_BASE}/{model}_stable.sbml"
+ model_text = requests.get(url).text
+ tm = template_model_from_sbml_qual_string(model_text)
+ regnet = template_model_to_regnet_json(tm)
+ with open(f"regnet_amr_sbml/{model}.json", "w") as fh:
+ json.dump(regnet, fh, indent=1)
+
+ model_id = "BIOMD0000000562"
+ model_text = get_sbml_model(model_id)
+ tm = template_model_from_sbml_qual_string(model_text)
+ regnet = template_model_to_regnet_json(tm)
+ with open(f"regnet_amr_sbml/{model_id}.json", "w") as fh:
+ json.dump(regnet, fh, indent=1)
diff --git a/scripts/covid19_diseasemaps/regnet_amr_sbml/Apoptosis.json b/scripts/covid19_diseasemaps/regnet_amr_sbml/Apoptosis.json
new file mode 100644
index 000000000..8eca998fb
--- /dev/null
+++ b/scripts/covid19_diseasemaps/regnet_amr_sbml/Apoptosis.json
@@ -0,0 +1,625 @@
+{
+ "header": {
+ "name": "Model",
+ "schema": "https://raw.githubusercontent.com/DARPA-ASKEM/Model-Representations/regnet_v0.2/regnet/regnet_schema.json",
+ "schema_name": "regnet",
+ "description": "Model",
+ "model_version": "0.1"
+ },
+ "model": {
+ "vertices": [
+ {
+ "id": "Orf7a",
+ "name": "Orf7a",
+ "grounding": {
+ "identifiers": {
+ "ncbigene": "1489674"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "E",
+ "name": "E",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32785274"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "BAD",
+ "name": "BAD",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "Q92934"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "FASLG",
+ "name": "FASLG",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P48023"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "FAS/FASL_complex",
+ "name": "FAS/FASL_complex",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P25445"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TNF",
+ "name": "TNF",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P01375"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TNF/TNFRSF1A_complex",
+ "name": "TNF/TNFRSF1A_complex",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P01375"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "BCL2/MCL1/BCL2L1_complex",
+ "name": "BCL2/MCL1/BCL2L1_complex",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P10415"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "FADD",
+ "name": "FADD",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "Q13158"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TRADD",
+ "name": "TRADD",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "Q15628"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TRADD/FADD_complex",
+ "name": "TRADD/FADD_complex",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "Q13158"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CYCS",
+ "name": "CYCS",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P99999"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "APAF1",
+ "name": "APAF1",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "O14727"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CASP9_cell",
+ "name": "CASP9_cell",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P55211"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "AKT1",
+ "name": "AKT1",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P31749"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Apoptosome_complex",
+ "name": "Apoptosome_complex",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "O14727"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "M",
+ "name": "M",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "16845612"
+ },
+ "context": {
+ "property": "ncbiprotein:APO40582"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "BAD/BBC3/BCL2L11_complex",
+ "name": "BAD/BBC3/BCL2L11_complex",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "O43521"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "BID",
+ "name": "BID",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P55957"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "BAX",
+ "name": "BAX",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "Q07812"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf3a",
+ "name": "Orf3a",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32555321"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MAPK14",
+ "name": "MAPK14",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "Q16539"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CASP9_cell_active",
+ "name": "CASP9_cell_active",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CASP8",
+ "name": "CASP8",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "Q14790"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CASP7",
+ "name": "CASP7",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P55210"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CASP3",
+ "name": "CASP3",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P42574"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf6",
+ "name": "Orf6",
+ "grounding": {
+ "identifiers": {
+ "ncbigene": "1489673"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "S",
+ "name": "S",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32075877"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf8a",
+ "name": "Orf8a",
+ "grounding": {
+ "identifiers": {
+ "ncbigene": "1489676"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "N",
+ "name": "N",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "16112641"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf3b",
+ "name": "Orf3b",
+ "grounding": {
+ "identifiers": {
+ "ncbigene": "1489670"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf9b",
+ "name": "Orf9b",
+ "grounding": {
+ "identifiers": {
+ "ncbigene": "1489679"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Apoptosis_phenotype",
+ "name": "Apoptosis_phenotype",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "31226023"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ }
+ ],
+ "edges": [
+ {
+ "id": "t1",
+ "source": "BAD",
+ "target": "Orf7a",
+ "sign": false
+ },
+ {
+ "id": "t2",
+ "source": "E",
+ "target": "Orf7a",
+ "sign": false
+ },
+ {
+ "id": "t3",
+ "source": "FASLG",
+ "target": "FAS/FASL_complex",
+ "sign": true
+ },
+ {
+ "id": "t4",
+ "source": "TNF",
+ "target": "TNF/TNFRSF1A_complex",
+ "sign": true
+ },
+ {
+ "id": "t5",
+ "source": "BCL2/MCL1/BCL2L1_complex",
+ "target": "BCL2/MCL1/BCL2L1_complex",
+ "sign": false
+ },
+ {
+ "id": "t6",
+ "source": "TNF/TNFRSF1A_complex",
+ "target": "TRADD/FADD_complex",
+ "sign": true
+ },
+ {
+ "id": "t7",
+ "source": "FADD",
+ "target": "TRADD/FADD_complex",
+ "sign": true
+ },
+ {
+ "id": "t8",
+ "source": "TRADD",
+ "target": "TRADD/FADD_complex",
+ "sign": true
+ },
+ {
+ "id": "t9",
+ "source": "CYCS",
+ "target": "Apoptosome_complex",
+ "sign": true
+ },
+ {
+ "id": "t10",
+ "source": "CASP9_cell",
+ "target": "Apoptosome_complex",
+ "sign": true
+ },
+ {
+ "id": "t11",
+ "source": "APAF1",
+ "target": "Apoptosome_complex",
+ "sign": true
+ },
+ {
+ "id": "t12",
+ "source": "AKT1",
+ "target": "Apoptosome_complex",
+ "sign": true
+ },
+ {
+ "id": "t13",
+ "source": "M",
+ "target": "M",
+ "sign": false
+ },
+ {
+ "id": "t14",
+ "source": "FAS/FASL_complex",
+ "target": "FADD",
+ "sign": true
+ },
+ {
+ "id": "t15",
+ "source": "AKT1",
+ "target": "AKT1",
+ "sign": false
+ },
+ {
+ "id": "t16",
+ "source": "BCL2/MCL1/BCL2L1_complex",
+ "target": "BAX",
+ "sign": true
+ },
+ {
+ "id": "t17",
+ "source": "BAD/BBC3/BCL2L11_complex",
+ "target": "BAX",
+ "sign": true
+ },
+ {
+ "id": "t18",
+ "source": "BID",
+ "target": "BAX",
+ "sign": true
+ },
+ {
+ "id": "t19",
+ "source": "Orf3a",
+ "target": "MAPK14",
+ "sign": true
+ },
+ {
+ "id": "t20",
+ "source": "MAPK14",
+ "target": "CYCS",
+ "sign": true
+ },
+ {
+ "id": "t21",
+ "source": "BAX",
+ "target": "CYCS",
+ "sign": true
+ },
+ {
+ "id": "t22",
+ "source": "CASP9_cell_active",
+ "target": "CASP7",
+ "sign": true
+ },
+ {
+ "id": "t23",
+ "source": "CASP8",
+ "target": "CASP7",
+ "sign": true
+ },
+ {
+ "id": "t24",
+ "source": "Apoptosome_complex",
+ "target": "CASP9_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t25",
+ "source": "AKT1",
+ "target": "CASP9_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t26",
+ "source": "CASP8",
+ "target": "CASP3",
+ "sign": true
+ },
+ {
+ "id": "t27",
+ "source": "CASP9_cell_active",
+ "target": "CASP3",
+ "sign": true
+ },
+ {
+ "id": "t28",
+ "source": "FADD",
+ "target": "CASP8",
+ "sign": true
+ },
+ {
+ "id": "t29",
+ "source": "TRADD/FADD_complex",
+ "target": "CASP8",
+ "sign": true
+ },
+ {
+ "id": "t30",
+ "source": "Orf3a",
+ "target": "CASP8",
+ "sign": true
+ },
+ {
+ "id": "t31",
+ "source": "N",
+ "target": "Apoptosis_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t32",
+ "source": "S",
+ "target": "Apoptosis_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t33",
+ "source": "Orf9b",
+ "target": "Apoptosis_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t34",
+ "source": "CASP3",
+ "target": "Apoptosis_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t35",
+ "source": "CASP7",
+ "target": "Apoptosis_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t36",
+ "source": "Orf8a",
+ "target": "Apoptosis_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t37",
+ "source": "Orf3b",
+ "target": "Apoptosis_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t38",
+ "source": "Orf6",
+ "target": "Apoptosis_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t39",
+ "source": "CASP8",
+ "target": "BID",
+ "sign": true
+ }
+ ],
+ "parameters": []
+ },
+ "semantics": {
+ "ode": {
+ "rates": [],
+ "observables": [],
+ "time": {
+ "id": "t"
+ }
+ }
+ },
+ "metadata": {
+ "annotations": {}
+ }
+}
\ No newline at end of file
diff --git a/scripts/covid19_diseasemaps/regnet_amr_sbml/BIOMD0000000562.json b/scripts/covid19_diseasemaps/regnet_amr_sbml/BIOMD0000000562.json
new file mode 100644
index 000000000..94184185c
--- /dev/null
+++ b/scripts/covid19_diseasemaps/regnet_amr_sbml/BIOMD0000000562.json
@@ -0,0 +1,469 @@
+{
+ "header": {
+ "name": "Chaouiya2013 - EGF and TNFalpha mediated signalling pathway",
+ "schema": "https://raw.githubusercontent.com/DARPA-ASKEM/Model-Representations/regnet_v0.2/regnet/regnet_schema.json",
+ "schema_name": "regnet",
+ "description": "Chaouiya2013 - EGF and TNFalpha mediated signalling pathway",
+ "model_version": "0.1"
+ },
+ "model": {
+ "vertices": [
+ {
+ "id": "nik",
+ "name": "nik",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ikk",
+ "name": "ikk",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "mkk4",
+ "name": "mkk4",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "p38",
+ "name": "p38",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ask1",
+ "name": "ask1",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "map3k1",
+ "name": "map3k1",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "mkk7",
+ "name": "mkk7",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "map3k7",
+ "name": "map3k7",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "jnk",
+ "name": "jnk",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "tnfr",
+ "name": "tnfr",
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+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "traf2",
+ "name": "traf2",
+ "grounding": {
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+ "context": {}
+ },
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+ },
+ {
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+ "context": {}
+ },
+ "initial": 3.0
+ },
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+ },
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+ },
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+ },
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+ },
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+ },
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+ },
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+ },
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+ },
+ {
+ "id": "akt",
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+ },
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+ },
+ {
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+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
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+ },
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+ },
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+ }
+ ],
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+ },
+ {
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+ "source": "raf1",
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+ },
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+ },
+ {
+ "id": "t29",
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+ "target": "sos",
+ "sign": true
+ },
+ {
+ "id": "t30",
+ "source": "egfr",
+ "target": "sos",
+ "sign": true
+ }
+ ],
+ "parameters": []
+ },
+ "semantics": {
+ "ode": {
+ "rates": [],
+ "observables": [],
+ "time": {
+ "id": "t"
+ }
+ }
+ },
+ "metadata": {
+ "annotations": {
+ "license": "CC0",
+ "authors": [],
+ "references": [
+ "pubmed:24321545"
+ ],
+ "time_scale": null,
+ "time_start": null,
+ "time_end": null,
+ "locations": [],
+ "pathogens": [],
+ "diseases": [],
+ "hosts": [
+ "ncbitaxon:9606"
+ ],
+ "model_types": [
+ "mamo:0000030"
+ ]
+ }
+ }
+}
\ No newline at end of file
diff --git a/scripts/covid19_diseasemaps/regnet_amr_sbml/Coagulation-pathway.json b/scripts/covid19_diseasemaps/regnet_amr_sbml/Coagulation-pathway.json
new file mode 100644
index 000000000..5154e2841
--- /dev/null
+++ b/scripts/covid19_diseasemaps/regnet_amr_sbml/Coagulation-pathway.json
@@ -0,0 +1,2701 @@
+{
+ "header": {
+ "name": "Model",
+ "schema": "https://raw.githubusercontent.com/DARPA-ASKEM/Model-Representations/regnet_v0.2/regnet/regnet_schema.json",
+ "schema_name": "regnet",
+ "description": "Model",
+ "model_version": "0.1"
+ },
+ "model": {
+ "vertices": [
+ {
+ "id": "KLKB1",
+ "name": "KLKB1",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:6371"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "KNG1",
+ "name": "KNG1",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "KNG1:KLKB1_complex",
+ "name": "KNG1:KLKB1_complex",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "F10a",
+ "name": "F10a",
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+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:F10"
+ }
+ },
+ "initial": 3.0
+ },
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+ "name": "F5a",
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+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:F5"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "F5a:F10a_complex",
+ "name": "F5a:F10a_complex",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "F9a",
+ "name": "F9a",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:F9"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "F8a",
+ "name": "F8a",
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+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:F8"
+ }
+ },
+ "initial": 3.0
+ },
+ {
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+ "name": "F8:F9_complex",
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+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
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+ },
+ "context": {
+ "property": "hgnc:8593"
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+ },
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+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SARS-CoV-2 infection_phenotype",
+ "name": "SARS-CoV-2 infection_phenotype",
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+ "identifiers": {
+ "taxonomy": "2697049"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PLAT:SERPINE1_complex",
+ "name": "PLAT:SERPINE1_complex",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Fibrinogen_complex",
+ "name": "Fibrinogen_complex",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Antithrombin",
+ "name": "Antithrombin",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Thrombin_blood_active",
+ "name": "Thrombin_blood_active",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TAT complex_complex",
+ "name": "TAT complex_complex",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Thrombomodulin",
+ "name": "Thrombomodulin",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:11784"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Thrombin:Thrombomodulin_complex",
+ "name": "Thrombin:Thrombomodulin_complex",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9986"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "C5b:C6:C7_complex",
+ "name": "C5b:C6:C7_complex",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "C8A:C8B:C8G_complex",
+ "name": "C8A:C8B:C8G_complex",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "C5b:C6:C7:C8A:C8B:C8G_complex",
+ "name": "C5b:C6:C7:C8A:C8B:C8G_complex",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "C3b",
+ "name": "C3b",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:C3"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "C3b:Bb_complex",
+ "name": "C3b:Bb_complex",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "C3b:Bb:C3b_complex",
+ "name": "C3b:Bb:C3b_complex",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
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+ "name": "C5b:C6_complex",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
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+ "name": "C7",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "HGNC:1346"
+ }
+ },
+ "initial": 3.0
+ },
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+ "name": "C9",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:1358"
+ }
+ },
+ "initial": 3.0
+ },
+ {
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+ "name": "C5b-9_complex_endothelium, vascular",
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+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
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+ "name": "C5b",
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+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:C5"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "C6",
+ "name": "C6",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:1339"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "C4b",
+ "name": "C4b",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:1324"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "C2a",
+ "name": "C2a",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:C2"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "C2a:C4b_complex",
+ "name": "C2a:C4b_complex",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ACE2_blood",
+ "name": "ACE2_blood",
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+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:13557"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "S",
+ "name": "S",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "2697049"
+ },
+ "context": {
+ "property": "uniprot:P0DTC2",
+ "property1": "uniprot:P59594"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ACE2:Spike_complex",
+ "name": "ACE2:Spike_complex",
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+ "identifiers": {
+ "taxonomy": "2697049"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
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+ "name": "Plasmin",
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+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:PLG"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SERPINF2",
+ "name": "SERPINF2",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:9075"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SERPINF2:Plasmin_complex",
+ "name": "SERPINF2:Plasmin_complex",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "GP6",
+ "name": "GP6",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "HGNC:14388"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Fibrinogen:GP6_complex",
+ "name": "Fibrinogen:GP6_complex",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "GP6:alpha2:beta1_complex",
+ "name": "GP6:alpha2:beta1_complex",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "10090"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "VWF",
+ "name": "VWF",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:12726",
+ "property1": "hgnc:12726"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "GP6:alpha2beta1:VWF_complex",
+ "name": "GP6:alpha2beta1:VWF_complex",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "10090"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ITGA2:ITGAB1_complex",
+ "name": "ITGA2:ITGAB1_complex",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "F12",
+ "name": "F12",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:3530"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "F12a",
+ "name": "F12a",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:F12"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "F10",
+ "name": "F10",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:3528"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "F8",
+ "name": "F8",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:3546"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Bradykinin",
+ "name": "Bradykinin",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ACE",
+ "name": "ACE",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:2707"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PROC",
+ "name": "PROC",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:9451"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Small peptide",
+ "name": "Small peptide",
+ "grounding": {
+ "identifiers": {
+ "mesh": "D010446"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "F11",
+ "name": "F11",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "F11a",
+ "name": "F11a",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:F11"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "F9",
+ "name": "F9",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:35531"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Thrombin_blood",
+ "name": "Thrombin_blood",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Heparin_simple_molecule",
+ "name": "Heparin_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "angiotensin I_simple_molecule",
+ "name": "angiotensin I_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "angiotensin II_simple_molecule",
+ "name": "angiotensin II_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
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+ "name": "AGT",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:333"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "REN",
+ "name": "REN",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:REN"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Prorenin",
+ "name": "Prorenin",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:9958"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Kallikrein",
+ "name": "Kallikrein",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:KLKB1"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "aldosterone_simple_molecule_blood",
+ "name": "aldosterone_simple_molecule_blood",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "27584"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "F5",
+ "name": "F5",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:3541"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Prothrombin",
+ "name": "Prothrombin",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Fibrin polymer",
+ "name": "Fibrin polymer",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TAFI",
+ "name": "TAFI",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:1546",
+ "property1": "hgnc:1546"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "D-dimer",
+ "name": "D-dimer",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Plasminogen",
+ "name": "Plasminogen",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:9071"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PLAT_blood_active",
+ "name": "PLAT_blood_active",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:9051"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PLAU",
+ "name": "PLAU",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:9052",
+ "property1": "hgnc:9052"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "angiotensin I-7_simple_molecule",
+ "name": "angiotensin I-7_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IL6",
+ "name": "IL6",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:6018"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "AGTR1_blood",
+ "name": "AGTR1_blood",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "336"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "cytokine storm_phenotype",
+ "name": "cytokine storm_phenotype",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TNF",
+ "name": "TNF",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:11892"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IL1B",
+ "name": "IL1B",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:5992"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Kininogen",
+ "name": "Kininogen",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:KNG1"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "C5",
+ "name": "C5",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:1331"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "C5a",
+ "name": "C5a",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:C5"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IL8",
+ "name": "IL8",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:6025"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IL2RA",
+ "name": "IL2RA",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:6008"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CRP",
+ "name": "CRP",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:2367"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "C4d",
+ "name": "C4d",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Thrombosis_phenotype_blood",
+ "name": "Thrombosis_phenotype_blood",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "C3",
+ "name": "C3",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:1318"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "C3a",
+ "name": "C3a",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:C3"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MBL2",
+ "name": "MBL2",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:6902"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MASP1",
+ "name": "MASP1",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:6901",
+ "property1": "hgnc:6901"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "C4",
+ "name": "C4",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MASP2",
+ "name": "MASP2",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:6902",
+ "property1": "hgnc:6902"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "C4a",
+ "name": "C4a",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:1323"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "C2",
+ "name": "C2",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:1248"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "C2b",
+ "name": "C2b",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:C2"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CFI",
+ "name": "CFI",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:2771"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "C4d deposition_phenotype",
+ "name": "C4d deposition_phenotype",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "septal capillary necrosis_phenotype",
+ "name": "septal capillary necrosis_phenotype",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "C5b-9 deposition_phenotype",
+ "name": "C5b-9 deposition_phenotype",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ACE2_endothelium, vascular",
+ "name": "ACE2_endothelium, vascular",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:13557"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Fibrin monomer",
+ "name": "Fibrin monomer",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Bradykinin(1-5)",
+ "name": "Bradykinin(1-5)",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "apoptosis_phenotype",
+ "name": "apoptosis_phenotype",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "platelet aggregation_phenotype",
+ "name": "platelet aggregation_phenotype",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MASP2 deposition_phenotype",
+ "name": "MASP2 deposition_phenotype",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "F13a",
+ "name": "F13a",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {
+ "property": "hgnc:F13"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "platelet activation_phenotype",
+ "name": "platelet activation_phenotype",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "AGTR1_platelet",
+ "name": "AGTR1_platelet",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "336"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MAS1",
+ "name": "MAS1",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:6899"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "thrombus formation_phenotype",
+ "name": "thrombus formation_phenotype",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SARS-CoV-2 viral entry_phenotype",
+ "name": "SARS-CoV-2 viral entry_phenotype",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "2697049"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "K+_ion",
+ "name": "K+_ion",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "29103"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ACTH_simple_molecule",
+ "name": "ACTH_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "9201"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "aldosterone_simple_molecule_endothelium, vascular",
+ "name": "aldosterone_simple_molecule_endothelium, vascular",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "27584"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NR3C2",
+ "name": "NR3C2",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:7979"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "vascular remodeling_phenotype",
+ "name": "vascular remodeling_phenotype",
+ "grounding": {
+ "identifiers": {
+ "GO": "0001974"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Hypokalemia_phenotype",
+ "name": "Hypokalemia_phenotype",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Thrombosis_phenotype_human host",
+ "name": "Thrombosis_phenotype_human host",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "9606"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "vascular inflammation_phenotype",
+ "name": "vascular inflammation_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ }
+ ],
+ "edges": [
+ {
+ "id": "t1",
+ "source": "KNG1",
+ "target": "KNG1:KLKB1_complex",
+ "sign": true
+ },
+ {
+ "id": "t2",
+ "source": "KLKB1",
+ "target": "KNG1:KLKB1_complex",
+ "sign": true
+ },
+ {
+ "id": "t3",
+ "source": "F10a",
+ "target": "F5a:F10a_complex",
+ "sign": true
+ },
+ {
+ "id": "t4",
+ "source": "F5a",
+ "target": "F5a:F10a_complex",
+ "sign": true
+ },
+ {
+ "id": "t5",
+ "source": "F8a",
+ "target": "F8:F9_complex",
+ "sign": true
+ },
+ {
+ "id": "t6",
+ "source": "F9a",
+ "target": "F8:F9_complex",
+ "sign": true
+ },
+ {
+ "id": "t7",
+ "source": "SARS-CoV-2 infection_phenotype",
+ "target": "PLAT:SERPINE1_complex",
+ "sign": true
+ },
+ {
+ "id": "t8",
+ "source": "SERPINE1",
+ "target": "PLAT:SERPINE1_complex",
+ "sign": true
+ },
+ {
+ "id": "t9",
+ "source": "PLAT_blood",
+ "target": "PLAT:SERPINE1_complex",
+ "sign": true
+ },
+ {
+ "id": "t10",
+ "source": "SARS-CoV-2 infection_phenotype",
+ "target": "Fibrinogen_complex",
+ "sign": true
+ },
+ {
+ "id": "t11",
+ "source": "SARS-CoV-2 infection_phenotype",
+ "target": "TAT complex_complex",
+ "sign": true
+ },
+ {
+ "id": "t12",
+ "source": "Thrombin_blood_active",
+ "target": "TAT complex_complex",
+ "sign": true
+ },
+ {
+ "id": "t13",
+ "source": "Antithrombin",
+ "target": "TAT complex_complex",
+ "sign": true
+ },
+ {
+ "id": "t14",
+ "source": "Thrombin_blood_active",
+ "target": "Thrombin:Thrombomodulin_complex",
+ "sign": true
+ },
+ {
+ "id": "t15",
+ "source": "Thrombomodulin",
+ "target": "Thrombin:Thrombomodulin_complex",
+ "sign": true
+ },
+ {
+ "id": "t16",
+ "source": "C8A:C8B:C8G_complex",
+ "target": "C5b:C6:C7:C8A:C8B:C8G_complex",
+ "sign": true
+ },
+ {
+ "id": "t17",
+ "source": "C5b:C6:C7_complex",
+ "target": "C5b:C6:C7:C8A:C8B:C8G_complex",
+ "sign": true
+ },
+ {
+ "id": "t18",
+ "source": "C3b",
+ "target": "C3b:Bb:C3b_complex",
+ "sign": true
+ },
+ {
+ "id": "t19",
+ "source": "C3b:Bb_complex",
+ "target": "C3b:Bb:C3b_complex",
+ "sign": true
+ },
+ {
+ "id": "t20",
+ "source": "C7",
+ "target": "C5b:C6:C7_complex",
+ "sign": true
+ },
+ {
+ "id": "t21",
+ "source": "C5b:C6_complex",
+ "target": "C5b:C6:C7_complex",
+ "sign": true
+ },
+ {
+ "id": "t22",
+ "source": "SARS-CoV-2 infection_phenotype",
+ "target": "C5b-9_complex_endothelium, vascular",
+ "sign": true
+ },
+ {
+ "id": "t23",
+ "source": "C9",
+ "target": "C5b-9_complex_endothelium, vascular",
+ "sign": true
+ },
+ {
+ "id": "t24",
+ "source": "C5b:C6:C7:C8A:C8B:C8G_complex",
+ "target": "C5b-9_complex_endothelium, vascular",
+ "sign": true
+ },
+ {
+ "id": "t25",
+ "source": "C5b",
+ "target": "C5b:C6_complex",
+ "sign": true
+ },
+ {
+ "id": "t26",
+ "source": "C6",
+ "target": "C5b:C6_complex",
+ "sign": true
+ },
+ {
+ "id": "t27",
+ "source": "C2a",
+ "target": "C2a:C4b_complex",
+ "sign": true
+ },
+ {
+ "id": "t28",
+ "source": "C4b",
+ "target": "C2a:C4b_complex",
+ "sign": true
+ },
+ {
+ "id": "t29",
+ "source": "S",
+ "target": "ACE2:Spike_complex",
+ "sign": true
+ },
+ {
+ "id": "t30",
+ "source": "ACE2_blood",
+ "target": "ACE2:Spike_complex",
+ "sign": true
+ },
+ {
+ "id": "t31",
+ "source": "SERPINF2",
+ "target": "SERPINF2:Plasmin_complex",
+ "sign": true
+ },
+ {
+ "id": "t32",
+ "source": "SARS-CoV-2 infection_phenotype",
+ "target": "SERPINF2:Plasmin_complex",
+ "sign": true
+ },
+ {
+ "id": "t33",
+ "source": "Plasmin",
+ "target": "SERPINF2:Plasmin_complex",
+ "sign": true
+ },
+ {
+ "id": "t34",
+ "source": "GP6",
+ "target": "Fibrinogen:GP6_complex",
+ "sign": true
+ },
+ {
+ "id": "t35",
+ "source": "Fibrinogen_complex",
+ "target": "Fibrinogen:GP6_complex",
+ "sign": true
+ },
+ {
+ "id": "t36",
+ "source": "GP6:alpha2:beta1_complex",
+ "target": "GP6:alpha2beta1:VWF_complex",
+ "sign": true
+ },
+ {
+ "id": "t37",
+ "source": "VWF",
+ "target": "GP6:alpha2beta1:VWF_complex",
+ "sign": true
+ },
+ {
+ "id": "t38",
+ "source": "ITGA2:ITGAB1_complex",
+ "target": "GP6:alpha2:beta1_complex",
+ "sign": true
+ },
+ {
+ "id": "t39",
+ "source": "GP6",
+ "target": "GP6:alpha2:beta1_complex",
+ "sign": true
+ },
+ {
+ "id": "t40",
+ "source": "S",
+ "target": "C5b-9_complex_endothelium, vascular",
+ "sign": true
+ },
+ {
+ "id": "t41",
+ "source": "KLKB1",
+ "target": "F12a",
+ "sign": true
+ },
+ {
+ "id": "t42",
+ "source": "F12",
+ "target": "F12a",
+ "sign": true
+ },
+ {
+ "id": "t43",
+ "source": "ACE",
+ "target": "Small peptide",
+ "sign": true
+ },
+ {
+ "id": "t44",
+ "source": "F10",
+ "target": "Small peptide",
+ "sign": true
+ },
+ {
+ "id": "t45",
+ "source": "F12",
+ "target": "Small peptide",
+ "sign": true
+ },
+ {
+ "id": "t46",
+ "source": "Bradykinin",
+ "target": "Small peptide",
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+ },
+ {
+ "id": "t47",
+ "source": "F8",
+ "target": "Small peptide",
+ "sign": true
+ },
+ {
+ "id": "t48",
+ "source": "KLKB1",
+ "target": "Small peptide",
+ "sign": true
+ },
+ {
+ "id": "t49",
+ "source": "PROC",
+ "target": "Small peptide",
+ "sign": true
+ },
+ {
+ "id": "t50",
+ "source": "Thrombin_blood_active",
+ "target": "Small peptide",
+ "sign": true
+ },
+ {
+ "id": "t51",
+ "source": "Antithrombin",
+ "target": "Small peptide",
+ "sign": true
+ },
+ {
+ "id": "t52",
+ "source": "F9a",
+ "target": "Small peptide",
+ "sign": true
+ },
+ {
+ "id": "t53",
+ "source": "F12a",
+ "target": "F11",
+ "sign": true
+ },
+ {
+ "id": "t54",
+ "source": "Thrombin_blood_active",
+ "target": "F11",
+ "sign": true
+ },
+ {
+ "id": "t55",
+ "source": "F12a",
+ "target": "F11a",
+ "sign": true
+ },
+ {
+ "id": "t56",
+ "source": "Thrombin_blood_active",
+ "target": "F11a",
+ "sign": true
+ },
+ {
+ "id": "t57",
+ "source": "F11a",
+ "target": "F9a",
+ "sign": true
+ },
+ {
+ "id": "t58",
+ "source": "F9",
+ "target": "F9a",
+ "sign": true
+ },
+ {
+ "id": "t59",
+ "source": "F9a",
+ "target": "F10a",
+ "sign": true
+ },
+ {
+ "id": "t60",
+ "source": "Antithrombin",
+ "target": "F10a",
+ "sign": true
+ },
+ {
+ "id": "t61",
+ "source": "F10",
+ "target": "F10a",
+ "sign": true
+ },
+ {
+ "id": "t62",
+ "source": "SARS-CoV-2 infection_phenotype",
+ "target": "F8",
+ "sign": true
+ },
+ {
+ "id": "t63",
+ "source": "F8",
+ "target": "F8a",
+ "sign": true
+ },
+ {
+ "id": "t64",
+ "source": "Thrombin_blood_active",
+ "target": "F8a",
+ "sign": true
+ },
+ {
+ "id": "t65",
+ "source": "PROC",
+ "target": "F8a",
+ "sign": true
+ },
+ {
+ "id": "t66",
+ "source": "Thrombin_blood",
+ "target": "Thrombin_blood_active",
+ "sign": true
+ },
+ {
+ "id": "t67",
+ "source": "Heparin_simple_molecule",
+ "target": "Thrombin_blood_active",
+ "sign": true
+ },
+ {
+ "id": "t68",
+ "source": "Antithrombin",
+ "target": "Thrombin_blood_active",
+ "sign": true
+ },
+ {
+ "id": "t69",
+ "source": "ACE",
+ "target": "angiotensin II_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t70",
+ "source": "angiotensin I_simple_molecule",
+ "target": "angiotensin II_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t71",
+ "source": "SARS-CoV-2 infection_phenotype",
+ "target": "angiotensin II_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t72",
+ "source": "AGT",
+ "target": "angiotensin I_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t73",
+ "source": "REN",
+ "target": "angiotensin I_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t74",
+ "source": "Prorenin",
+ "target": "REN",
+ "sign": true
+ },
+ {
+ "id": "t75",
+ "source": "Kallikrein",
+ "target": "REN",
+ "sign": true
+ },
+ {
+ "id": "t76",
+ "source": "aldosterone_simple_molecule_blood",
+ "target": "ACE",
+ "sign": true
+ },
+ {
+ "id": "t77",
+ "source": "F5",
+ "target": "F5a",
+ "sign": true
+ },
+ {
+ "id": "t78",
+ "source": "PROC",
+ "target": "F5a",
+ "sign": true
+ },
+ {
+ "id": "t79",
+ "source": "Thrombin:Thrombomodulin_complex",
+ "target": "F5a",
+ "sign": true
+ },
+ {
+ "id": "t80",
+ "source": "SARS-CoV-2 infection_phenotype",
+ "target": "SARS-CoV-2 infection_phenotype",
+ "sign": false
+ },
+ {
+ "id": "t81",
+ "source": "F5a:F10a_complex",
+ "target": "Thrombin_blood",
+ "sign": true
+ },
+ {
+ "id": "t82",
+ "source": "Prothrombin",
+ "target": "Thrombin_blood",
+ "sign": true
+ },
+ {
+ "id": "t83",
+ "source": "SARS-CoV-2 infection_phenotype",
+ "target": "PROC",
+ "sign": true
+ },
+ {
+ "id": "t84",
+ "source": "SARS-CoV-2 infection_phenotype",
+ "target": "D-dimer",
+ "sign": true
+ },
+ {
+ "id": "t85",
+ "source": "Plasmin",
+ "target": "D-dimer",
+ "sign": true
+ },
+ {
+ "id": "t86",
+ "source": "TAFI",
+ "target": "D-dimer",
+ "sign": true
+ },
+ {
+ "id": "t87",
+ "source": "Fibrin polymer",
+ "target": "D-dimer",
+ "sign": true
+ },
+ {
+ "id": "t88",
+ "source": "C5b-9_complex_endothelium, vascular",
+ "target": "Plasminogen",
+ "sign": true
+ },
+ {
+ "id": "t89",
+ "source": "F11a",
+ "target": "Plasmin",
+ "sign": true
+ },
+ {
+ "id": "t90",
+ "source": "Plasminogen",
+ "target": "Plasmin",
+ "sign": true
+ },
+ {
+ "id": "t91",
+ "source": "PLAT_blood_active",
+ "target": "Plasmin",
+ "sign": true
+ },
+ {
+ "id": "t92",
+ "source": "PLAU",
+ "target": "Plasmin",
+ "sign": true
+ },
+ {
+ "id": "t93",
+ "source": "KLKB1",
+ "target": "Plasmin",
+ "sign": true
+ },
+ {
+ "id": "t94",
+ "source": "Bradykinin",
+ "target": "PLAT_blood_active",
+ "sign": true
+ },
+ {
+ "id": "t95",
+ "source": "SERPINE1",
+ "target": "PLAT_blood_active",
+ "sign": true
+ },
+ {
+ "id": "t96",
+ "source": "angiotensin II_simple_molecule",
+ "target": "PLAT_blood_active",
+ "sign": true
+ },
+ {
+ "id": "t97",
+ "source": "angiotensin I-7_simple_molecule",
+ "target": "PLAT_blood_active",
+ "sign": true
+ },
+ {
+ "id": "t98",
+ "source": "PLAT_blood",
+ "target": "PLAT_blood_active",
+ "sign": true
+ },
+ {
+ "id": "t99",
+ "source": "PROC",
+ "target": "PLAT_blood_active",
+ "sign": true
+ },
+ {
+ "id": "t100",
+ "source": "angiotensin II_simple_molecule",
+ "target": "SERPINE1",
+ "sign": true
+ },
+ {
+ "id": "t101",
+ "source": "angiotensin I-7_simple_molecule",
+ "target": "SERPINE1",
+ "sign": true
+ },
+ {
+ "id": "t102",
+ "source": "IL6",
+ "target": "SERPINE1",
+ "sign": true
+ },
+ {
+ "id": "t103",
+ "source": "AGTR1_blood",
+ "target": "SERPINE1",
+ "sign": true
+ },
+ {
+ "id": "t104",
+ "source": "aldosterone_simple_molecule_blood",
+ "target": "SERPINE1",
+ "sign": true
+ },
+ {
+ "id": "t105",
+ "source": "Thrombin_blood_active",
+ "target": "TAFI",
+ "sign": true
+ },
+ {
+ "id": "t106",
+ "source": "SERPINE1",
+ "target": "SERPINE1",
+ "sign": false
+ },
+ {
+ "id": "t107",
+ "source": "SARS-CoV-2 infection_phenotype",
+ "target": "TNF",
+ "sign": true
+ },
+ {
+ "id": "t108",
+ "source": "cytokine storm_phenotype",
+ "target": "TNF",
+ "sign": true
+ },
+ {
+ "id": "t109",
+ "source": "SARS-CoV-2 infection_phenotype",
+ "target": "IL6",
+ "sign": true
+ },
+ {
+ "id": "t110",
+ "source": "cytokine storm_phenotype",
+ "target": "IL6",
+ "sign": true
+ },
+ {
+ "id": "t111",
+ "source": "SARS-CoV-2 infection_phenotype",
+ "target": "IL1B",
+ "sign": true
+ },
+ {
+ "id": "t112",
+ "source": "cytokine storm_phenotype",
+ "target": "IL1B",
+ "sign": true
+ },
+ {
+ "id": "t113",
+ "source": "KNG1:KLKB1_complex",
+ "target": "Kininogen",
+ "sign": true
+ },
+ {
+ "id": "t114",
+ "source": "F12a",
+ "target": "Kallikrein",
+ "sign": true
+ },
+ {
+ "id": "t115",
+ "source": "KLKB1",
+ "target": "Kallikrein",
+ "sign": true
+ },
+ {
+ "id": "t116",
+ "source": "KNG1:KLKB1_complex",
+ "target": "Kallikrein",
+ "sign": true
+ },
+ {
+ "id": "t117",
+ "source": "C3b:Bb:C3b_complex",
+ "target": "C5a",
+ "sign": true
+ },
+ {
+ "id": "t118",
+ "source": "SARS-CoV-2 infection_phenotype",
+ "target": "C5a",
+ "sign": true
+ },
+ {
+ "id": "t119",
+ "source": "C5",
+ "target": "C5a",
+ "sign": true
+ },
+ {
+ "id": "t120",
+ "source": "Plasmin",
+ "target": "C5a",
+ "sign": true
+ },
+ {
+ "id": "t121",
+ "source": "C2a:C4b_complex",
+ "target": "C5a",
+ "sign": true
+ },
+ {
+ "id": "t122",
+ "source": "C5b-9_complex_endothelium, vascular",
+ "target": "Thrombosis_phenotype_blood",
+ "sign": true
+ },
+ {
+ "id": "t123",
+ "source": "TNF",
+ "target": "Thrombosis_phenotype_blood",
+ "sign": true
+ },
+ {
+ "id": "t124",
+ "source": "angiotensin II_simple_molecule",
+ "target": "Thrombosis_phenotype_blood",
+ "sign": true
+ },
+ {
+ "id": "t125",
+ "source": "IL1B",
+ "target": "Thrombosis_phenotype_blood",
+ "sign": true
+ },
+ {
+ "id": "t126",
+ "source": "C4d",
+ "target": "Thrombosis_phenotype_blood",
+ "sign": true
+ },
+ {
+ "id": "t127",
+ "source": "IL6",
+ "target": "Thrombosis_phenotype_blood",
+ "sign": true
+ },
+ {
+ "id": "t128",
+ "source": "CRP",
+ "target": "Thrombosis_phenotype_blood",
+ "sign": true
+ },
+ {
+ "id": "t129",
+ "source": "IL2RA",
+ "target": "Thrombosis_phenotype_blood",
+ "sign": true
+ },
+ {
+ "id": "t130",
+ "source": "VWF",
+ "target": "Thrombosis_phenotype_blood",
+ "sign": true
+ },
+ {
+ "id": "t131",
+ "source": "IL8",
+ "target": "Thrombosis_phenotype_blood",
+ "sign": true
+ },
+ {
+ "id": "t132",
+ "source": "SARS-CoV-2 infection_phenotype",
+ "target": "Thrombomodulin",
+ "sign": true
+ },
+ {
+ "id": "t133",
+ "source": "SARS-CoV-2 infection_phenotype",
+ "target": "IL8",
+ "sign": true
+ },
+ {
+ "id": "t134",
+ "source": "cytokine storm_phenotype",
+ "target": "IL8",
+ "sign": true
+ },
+ {
+ "id": "t135",
+ "source": "SARS-CoV-2 infection_phenotype",
+ "target": "IL2RA",
+ "sign": true
+ },
+ {
+ "id": "t136",
+ "source": "cytokine storm_phenotype",
+ "target": "IL2RA",
+ "sign": true
+ },
+ {
+ "id": "t137",
+ "source": "C3",
+ "target": "C3a",
+ "sign": true
+ },
+ {
+ "id": "t138",
+ "source": "C2a:C4b_complex",
+ "target": "C3a",
+ "sign": true
+ },
+ {
+ "id": "t139",
+ "source": "C3b:Bb_complex",
+ "target": "C3a",
+ "sign": true
+ },
+ {
+ "id": "t140",
+ "source": "C3",
+ "target": "C3b",
+ "sign": true
+ },
+ {
+ "id": "t141",
+ "source": "C2a:C4b_complex",
+ "target": "C3b",
+ "sign": true
+ },
+ {
+ "id": "t142",
+ "source": "C3b:Bb_complex",
+ "target": "C3b",
+ "sign": true
+ },
+ {
+ "id": "t143",
+ "source": "C3b:Bb:C3b_complex",
+ "target": "C5b",
+ "sign": true
+ },
+ {
+ "id": "t144",
+ "source": "C5",
+ "target": "C5b",
+ "sign": true
+ },
+ {
+ "id": "t145",
+ "source": "C2a:C4b_complex",
+ "target": "C5b",
+ "sign": true
+ },
+ {
+ "id": "t146",
+ "source": "MBL2",
+ "target": "MASP1",
+ "sign": true
+ },
+ {
+ "id": "t147",
+ "source": "MASP2",
+ "target": "C4a",
+ "sign": true
+ },
+ {
+ "id": "t148",
+ "source": "C4",
+ "target": "C4a",
+ "sign": true
+ },
+ {
+ "id": "t149",
+ "source": "MASP2",
+ "target": "C4b",
+ "sign": true
+ },
+ {
+ "id": "t150",
+ "source": "C4",
+ "target": "C4b",
+ "sign": true
+ },
+ {
+ "id": "t151",
+ "source": "MASP1",
+ "target": "C2a",
+ "sign": true
+ },
+ {
+ "id": "t152",
+ "source": "C2",
+ "target": "C2a",
+ "sign": true
+ },
+ {
+ "id": "t153",
+ "source": "MASP1",
+ "target": "C2b",
+ "sign": true
+ },
+ {
+ "id": "t154",
+ "source": "C2",
+ "target": "C2b",
+ "sign": true
+ },
+ {
+ "id": "t155",
+ "source": "SARS-CoV-2 infection_phenotype",
+ "target": "C4d",
+ "sign": true
+ },
+ {
+ "id": "t156",
+ "source": "CFI",
+ "target": "C4d",
+ "sign": true
+ },
+ {
+ "id": "t157",
+ "source": "C4b",
+ "target": "C4d",
+ "sign": true
+ },
+ {
+ "id": "t158",
+ "source": "S",
+ "target": "C4d",
+ "sign": true
+ },
+ {
+ "id": "t159",
+ "source": "C4d",
+ "target": "C4d deposition_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t160",
+ "source": "C4d deposition_phenotype",
+ "target": "septal capillary necrosis_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t161",
+ "source": "C5b-9_complex_endothelium, vascular",
+ "target": "C5b-9 deposition_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t162",
+ "source": "SARS-CoV-2 infection_phenotype",
+ "target": "ACE2_endothelium, vascular",
+ "sign": true
+ },
+ {
+ "id": "t163",
+ "source": "ACE2_blood",
+ "target": "ACE2_endothelium, vascular",
+ "sign": true
+ },
+ {
+ "id": "t164",
+ "source": "SARS-CoV-2 infection_phenotype",
+ "target": "Fibrin monomer",
+ "sign": true
+ },
+ {
+ "id": "t165",
+ "source": "Thrombin_blood",
+ "target": "Fibrin monomer",
+ "sign": true
+ },
+ {
+ "id": "t166",
+ "source": "Fibrinogen_complex",
+ "target": "Fibrin monomer",
+ "sign": true
+ },
+ {
+ "id": "t167",
+ "source": "Thrombin:Thrombomodulin_complex",
+ "target": "Fibrin monomer",
+ "sign": true
+ },
+ {
+ "id": "t168",
+ "source": "ACE2_endothelium, vascular",
+ "target": "angiotensin I-7_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t169",
+ "source": "angiotensin II_simple_molecule",
+ "target": "angiotensin I-7_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t170",
+ "source": "KNG1:KLKB1_complex",
+ "target": "Bradykinin",
+ "sign": true
+ },
+ {
+ "id": "t171",
+ "source": "Bradykinin",
+ "target": "Bradykinin(1-5)",
+ "sign": true
+ },
+ {
+ "id": "t172",
+ "source": "ACE",
+ "target": "Bradykinin(1-5)",
+ "sign": true
+ },
+ {
+ "id": "t173",
+ "source": "C5b-9 deposition_phenotype",
+ "target": "apoptosis_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t174",
+ "source": "C5b-9 deposition_phenotype",
+ "target": "platelet aggregation_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t175",
+ "source": "SARS-CoV-2 infection_phenotype",
+ "target": "CRP",
+ "sign": true
+ },
+ {
+ "id": "t176",
+ "source": "SARS-CoV-2 infection_phenotype",
+ "target": "VWF",
+ "sign": true
+ },
+ {
+ "id": "t177",
+ "source": "MASP2",
+ "target": "MASP2 deposition_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t178",
+ "source": "F13a",
+ "target": "Fibrin polymer",
+ "sign": true
+ },
+ {
+ "id": "t179",
+ "source": "Fibrin monomer",
+ "target": "Fibrin polymer",
+ "sign": true
+ },
+ {
+ "id": "t180",
+ "source": "GP6:alpha2beta1:VWF_complex",
+ "target": "platelet activation_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t181",
+ "source": "Fibrinogen:GP6_complex",
+ "target": "platelet activation_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t182",
+ "source": "MAS1",
+ "target": "thrombus formation_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t183",
+ "source": "platelet activation_phenotype",
+ "target": "thrombus formation_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t184",
+ "source": "AGTR1_platelet",
+ "target": "thrombus formation_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t185",
+ "source": "SARS-CoV-2 infection_phenotype",
+ "target": "MASP2",
+ "sign": true
+ },
+ {
+ "id": "t186",
+ "source": "angiotensin I-7_simple_molecule",
+ "target": "MAS1",
+ "sign": true
+ },
+ {
+ "id": "t187",
+ "source": "angiotensin II_simple_molecule",
+ "target": "AGTR1_platelet",
+ "sign": true
+ },
+ {
+ "id": "t188",
+ "source": "ACE2:Spike_complex",
+ "target": "SARS-CoV-2 viral entry_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t189",
+ "source": "SARS-CoV-2 infection_phenotype",
+ "target": "aldosterone_simple_molecule_blood",
+ "sign": true
+ },
+ {
+ "id": "t190",
+ "source": "angiotensin II_simple_molecule",
+ "target": "aldosterone_simple_molecule_blood",
+ "sign": true
+ },
+ {
+ "id": "t191",
+ "source": "K+_ion",
+ "target": "aldosterone_simple_molecule_blood",
+ "sign": true
+ },
+ {
+ "id": "t192",
+ "source": "AGTR1_blood",
+ "target": "aldosterone_simple_molecule_blood",
+ "sign": true
+ },
+ {
+ "id": "t193",
+ "source": "ACTH_simple_molecule",
+ "target": "aldosterone_simple_molecule_blood",
+ "sign": true
+ },
+ {
+ "id": "t194",
+ "source": "aldosterone_simple_molecule_blood",
+ "target": "aldosterone_simple_molecule_endothelium, vascular",
+ "sign": true
+ },
+ {
+ "id": "t195",
+ "source": "aldosterone_simple_molecule_endothelium, vascular",
+ "target": "NR3C2",
+ "sign": true
+ },
+ {
+ "id": "t196",
+ "source": "AGTR1_blood",
+ "target": "NR3C2",
+ "sign": true
+ },
+ {
+ "id": "t197",
+ "source": "aldosterone_simple_molecule_endothelium, vascular",
+ "target": "vascular remodeling_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t198",
+ "source": "angiotensin II_simple_molecule",
+ "target": "AGTR1_blood",
+ "sign": true
+ },
+ {
+ "id": "t199",
+ "source": "Hypokalemia_phenotype",
+ "target": "Hypokalemia_phenotype",
+ "sign": false
+ },
+ {
+ "id": "t200",
+ "source": "AGTR1_blood",
+ "target": "Thrombosis_phenotype_human host",
+ "sign": true
+ },
+ {
+ "id": "t201",
+ "source": "NR3C2",
+ "target": "Thrombosis_phenotype_human host",
+ "sign": true
+ },
+ {
+ "id": "t202",
+ "source": "aldosterone_simple_molecule_endothelium, vascular",
+ "target": "vascular inflammation_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t203",
+ "source": "SARS-CoV-2 infection_phenotype",
+ "target": "Hypokalemia_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t204",
+ "source": "aldosterone_simple_molecule_blood",
+ "target": "Hypokalemia_phenotype",
+ "sign": true
+ }
+ ],
+ "parameters": []
+ },
+ "semantics": {
+ "ode": {
+ "rates": [],
+ "observables": [],
+ "time": {
+ "id": "t"
+ }
+ }
+ },
+ "metadata": {
+ "annotations": {}
+ }
+}
\ No newline at end of file
diff --git a/scripts/covid19_diseasemaps/regnet_amr_sbml/ER_Stress.json b/scripts/covid19_diseasemaps/regnet_amr_sbml/ER_Stress.json
new file mode 100644
index 000000000..509484473
--- /dev/null
+++ b/scripts/covid19_diseasemaps/regnet_amr_sbml/ER_Stress.json
@@ -0,0 +1,3521 @@
+{
+ "header": {
+ "name": "Model",
+ "schema": "https://raw.githubusercontent.com/DARPA-ASKEM/Model-Representations/regnet_v0.2/regnet/regnet_schema.json",
+ "schema_name": "regnet",
+ "description": "Model",
+ "model_version": "0.1"
+ },
+ "model": {
+ "vertices": [
+ {
+ "id": "EIF2S1_phosphorylated",
+ "name": "EIF2S1_phosphorylated",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:EIF2S1"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "EIF2S2",
+ "name": "EIF2S2",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:EIF2S2"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "EIF2S3:GDP_complex",
+ "name": "EIF2S3:GDP_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "EIF2-P:GDP_complex",
+ "name": "EIF2-P:GDP_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ERN1:Unfolded_space_protein_complex",
+ "name": "ERN1:Unfolded_space_protein_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TRAF2",
+ "name": "TRAF2",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:TRAF2"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "BAK1:ERN1_complex",
+ "name": "BAK1:ERN1_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "BAX:ERN1_complex",
+ "name": "BAX:ERN1_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "BAX_endoplasmic reticulum",
+ "name": "BAX_endoplasmic reticulum",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:BAX"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "BAK1",
+ "name": "BAK1",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:BAK1"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "BCL2",
+ "name": "BCL2",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:BCL2"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "BCL2L1",
+ "name": "BCL2L1",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:BCL2L1"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Persistant_space_ER_space_Stress_phenotype_endoplasmic reticulum",
+ "name": "Persistant_space_ER_space_Stress_phenotype_endoplasmic reticulum",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TRAF2:ERN1_complex",
+ "name": "TRAF2:ERN1_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SIGMAR1_mitochondria-associated endoplasmic reticulum membrane",
+ "name": "SIGMAR1_mitochondria-associated endoplasmic reticulum membrane",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "17981125"
+ },
+ "context": {
+ "property": "hgnc:8157",
+ "property1": "taxonomy:10029"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ITPR3",
+ "name": "ITPR3",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "17981125"
+ },
+ "context": {
+ "property": "hgnc:6182"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ER_space_stress_phenotype",
+ "name": "ER_space_stress_phenotype",
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+ },
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+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Ca2+space_ER_space_depletion_phenotype",
+ "name": "Ca2+space_ER_space_depletion_phenotype",
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+ },
+ "context": {
+ "property": "taxonomy:10029"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SIGMAR1:ITPR3_complex",
+ "name": "SIGMAR1:ITPR3_complex",
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+ "pubmed": "17981125"
+ },
+ "context": {
+ "property": "taxonomy:10029"
+ }
+ },
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+ },
+ {
+ "id": "Met-tRNA_rna",
+ "name": "Met-tRNA_rna",
+ "grounding": {
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+ "context": {
+ "property": "hgnc:34779"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "EIF2:GDP_complex",
+ "name": "EIF2:GDP_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Ternary_space_Complex_complex",
+ "name": "Ternary_space_Complex_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "GDP_simple_molecule",
+ "name": "GDP_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "EIF2:GDP:Met-tRNA_complex",
+ "name": "EIF2:GDP:Met-tRNA_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CASP8:CASP8-ubq:FADD_complex",
+ "name": "CASP8:CASP8-ubq:FADD_complex",
+ "grounding": {
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+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SQSTM1_space_",
+ "name": "SQSTM1_space_",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:SQSTM1"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MAP1LC3A",
+ "name": "MAP1LC3A",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:MAP1LC3A"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ATG5",
+ "name": "ATG5",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:ATG5"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TRIM13",
+ "name": "TRIM13",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:TRIM13"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CASP8:FADD:MAP1LC3A:SQSTM1:ATG5_complex",
+ "name": "CASP8:FADD:MAP1LC3A:SQSTM1:ATG5_complex",
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+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ERN1_endoplasmic reticulum",
+ "name": "ERN1_endoplasmic reticulum",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:ERN1"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Unfolded_space_protein",
+ "name": "Unfolded_space_protein",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SIGMAR1_endoplasmic reticulum",
+ "name": "SIGMAR1_endoplasmic reticulum",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:8157"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "HSPA5_endoplasmic reticulum",
+ "name": "HSPA5_endoplasmic reticulum",
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+ "context": {
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+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SIGMAR1:HSPA5_complex",
+ "name": "SIGMAR1:HSPA5_complex",
+ "grounding": {
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+ },
+ "context": {
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+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "VAPB",
+ "name": "VAPB",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:12649"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "RMDN3",
+ "name": "RMDN3",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:25550"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "VAPB:RMDN3_complex",
+ "name": "VAPB:RMDN3_complex",
+ "grounding": {
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+ "pubmed": "28132811"
+ },
+ "context": {
+ "property": "taxonomy:9606"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "GTP_simple_molecule",
+ "name": "GTP_simple_molecule",
+ "grounding": {
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+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "EIF2B_complex",
+ "name": "EIF2B_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PACS2_early_space_endosome",
+ "name": "PACS2_early_space_endosome",
+ "grounding": {
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+ },
+ "context": {
+ "property": "hgnc:23794"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ADAM17_early_space_endosome",
+ "name": "ADAM17_early_space_endosome",
+ "grounding": {
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+ },
+ "context": {
+ "property": "hgnc:195"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PACS2-ADAM17_space_interaction_complex",
+ "name": "PACS2-ADAM17_space_interaction_complex",
+ "grounding": {
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+ "pubmed": "26108729"
+ },
+ "context": {
+ "property": "taxonomy:9606"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "BCAP31",
+ "name": "BCAP31",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:16695"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "FIS1",
+ "name": "FIS1",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:21689"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "FIS1:BCAP31_complex",
+ "name": "FIS1:BCAP31_complex",
+ "grounding": {
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+ "pubmed": "15692567"
+ },
+ "context": {
+ "property": "taxonomy:9606"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MFN2_endoplasmic reticulum",
+ "name": "MFN2_endoplasmic reticulum",
+ "grounding": {
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+ "pubmed": "19052620"
+ },
+ "context": {
+ "property": "hgnc:16877"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MFN2_mitochondrion",
+ "name": "MFN2_mitochondrion",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:16877"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MFN2:MFN2_complex",
+ "name": "MFN2:MFN2_complex",
+ "grounding": {
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+ "pubmed": "19052620"
+ },
+ "context": {
+ "property": "taxonomy:9606"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "BBC3",
+ "name": "BBC3",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:BBC3"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Persistant_space_ER_space_Stress_phenotype_cell",
+ "name": "Persistant_space_ER_space_Stress_phenotype_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ERN1:BBC3_complex",
+ "name": "ERN1:BBC3_complex",
+ "grounding": {
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+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "EIF2S1",
+ "name": "EIF2S1",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:EIF2S1"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MFN1",
+ "name": "MFN1",
+ "grounding": {
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+ "context": {
+ "property": "hgnc:1826"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MFN1:MFN2_complex",
+ "name": "MFN1:MFN2_complex",
+ "grounding": {
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+ "pubmed": "19052620"
+ },
+ "context": {
+ "property": "taxonomy:9606"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MCU",
+ "name": "MCU",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "24231807"
+ },
+ "context": {
+ "property": "hgnc:23526",
+ "property1": "taxonomy:9606"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SMDT1",
+ "name": "SMDT1",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "24231807"
+ },
+ "context": {
+ "property": "hgnc:25055",
+ "property1": "taxonomy:9606"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MCU2",
+ "name": "MCU2",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "24231807"
+ },
+ "context": {
+ "property": "hgnc:31830",
+ "property1": "taxonomy:9606"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MCU1",
+ "name": "MCU1",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "24231807"
+ },
+ "context": {
+ "property": "hgnc:1530",
+ "property1": "taxonomy:9606"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MCU:MICU1:MICU2:SMDT1_complex",
+ "name": "MCU:MICU1:MICU2:SMDT1_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "24231807"
+ },
+ "context": {
+ "property": "taxonomy:9606"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "BCL2L11_endoplasmic reticulum",
+ "name": "BCL2L11_endoplasmic reticulum",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:BCL2L11"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ERN1:BCL2L11_complex",
+ "name": "ERN1:BCL2L11_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CAPN1",
+ "name": "CAPN1",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:CAPN1"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Ca2+_ion_cell",
+ "name": "Ca2+_ion_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "high_space_Ca2+space_cytosolic_space_concentration_phenotype",
+ "name": "high_space_Ca2+space_cytosolic_space_concentration_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CAPN1:Ca2+_complex",
+ "name": "CAPN1:Ca2+_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "EIF2AK3",
+ "name": "EIF2AK3",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:EIF2AK3"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "EIF2AK3:EIF2AK3_complex",
+ "name": "EIF2AK3:EIF2AK3_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Mitochondrial_space_calcium_space_uniporter_space_complex_complex",
+ "name": "Mitochondrial_space_calcium_space_uniporter_space_complex_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "26968367"
+ },
+ "context": {
+ "property": "taxonomy:9606"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ACE2",
+ "name": "ACE2",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "15692567"
+ },
+ "context": {
+ "property": "HGNC:13557"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "S",
+ "name": "S",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P0DTC2",
+ "property1": "uniprot:P59594",
+ "property2": "uniprot:W6A028"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ACE2:Spike_complex",
+ "name": "ACE2:Spike_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "HSPA5_default_compartment",
+ "name": "HSPA5_default_compartment",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "30978349"
+ },
+ "context": {
+ "property": "HGNC:5238"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "HSPA5-Spike interaction_complex",
+ "name": "HSPA5-Spike interaction_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32340551"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ACE2,_space_membrane-bound",
+ "name": "ACE2,_space_membrane-bound",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "19411314"
+ },
+ "context": {
+ "property": "hgnc:ACE2"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ACE2,_space_soluble",
+ "name": "ACE2,_space_soluble",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "19411314"
+ },
+ "context": {
+ "property": "hgnc:ACE2"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ACE2-SARS-CoV interaction_complex",
+ "name": "ACE2-SARS-CoV interaction_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "19411314"
+ },
+ "context": {
+ "property": "taxonomy:9606",
+ "property1": "uniprot:P59594"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PPP1R15A_gene",
+ "name": "PPP1R15A_gene",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ATF4",
+ "name": "ATF4",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:ATF4"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "DDIT3",
+ "name": "DDIT3",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:DDIT3"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PPP1R15A_rna",
+ "name": "PPP1R15A_rna",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:PPP1R15A"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "BAX_phosphorylated",
+ "name": "BAX_phosphorylated",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:BAX"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "release_space_of_space_ER_space_Ca2+_phenotype",
+ "name": "release_space_of_space_ER_space_Ca2+_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ATF6_endoplasmic reticulum",
+ "name": "ATF6_endoplasmic reticulum",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:ATF6"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ER_space_Stress_phenotype",
+ "name": "ER_space_Stress_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ATF6_Golgi apparatus",
+ "name": "ATF6_Golgi apparatus",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:ATF6"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MBTPS2",
+ "name": "MBTPS2",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:MBTPS2"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MBTPS1",
+ "name": "MBTPS1",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:MBTPS1"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "retrograde_space_transport_space_from_space_ER_space_to_space_cytosol_phenotype",
+ "name": "retrograde_space_transport_space_from_space_ER_space_to_space_cytosol_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MAPK14_phosphorylated",
+ "name": "MAPK14_phosphorylated",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:MAPK14"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "DDIT3_phosphorylated",
+ "name": "DDIT3_phosphorylated",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:DDIT3"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "endoplasmic_space_reticulum_space_organization_phenotype",
+ "name": "endoplasmic_space_reticulum_space_organization_phenotype",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "19052620"
+ },
+ "context": {
+ "property": "taxonomy:9606"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ATF6:HSPA5_complex",
+ "name": "ATF6:HSPA5_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "HSPA5_rna",
+ "name": "HSPA5_rna",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:HSPA5"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ITPR",
+ "name": "ITPR",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:ITPR1",
+ "property1": "hgnc:ITPR2",
+ "property2": "hgnc:ITPR3"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TMBIM6",
+ "name": "TMBIM6",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:TMBIM6"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ERO1A_endoplasmic reticulum",
+ "name": "ERO1A_endoplasmic reticulum",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:ERO1A"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "HSPA5_gene",
+ "name": "HSPA5_gene",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "XBP1",
+ "name": "XBP1",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:XBP1"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "accumulation_space_of_space_misfolded_space_protein_space_in_space_ER_phenotype",
+ "name": "accumulation_space_of_space_misfolded_space_protein_space_in_space_ER_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "UPR_phenotype",
+ "name": "UPR_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Ca2+space_mitochondrial_space_concentration_phenotype",
+ "name": "Ca2+space_mitochondrial_space_concentration_phenotype",
+ "grounding": {
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+ "pubmed": "28132811"
+ },
+ "context": {
+ "property": "taxonomy:9606"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PACS2_endoplasmic reticulum",
+ "name": "PACS2_endoplasmic reticulum",
+ "grounding": {
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+ "pubmed": "15692567"
+ },
+ "context": {
+ "property": "hgnc:23794"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "DNAJC3_rna",
+ "name": "DNAJC3_rna",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:DNAJC3"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "DNAJC3",
+ "name": "DNAJC3",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:DNAJC3"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "DDIT3_gene",
+ "name": "DDIT3_gene",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ATF6_nucleus",
+ "name": "ATF6_nucleus",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:ATF6"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "DDIT3_rna",
+ "name": "DDIT3_rna",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:DDIT3"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ATF4_gene",
+ "name": "ATF4_gene",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ATF4_rna",
+ "name": "ATF4_rna",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:ATF4"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "BCL2L11_phosphorylated",
+ "name": "BCL2L11_phosphorylated",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:BCL2L11"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PPP2CA",
+ "name": "PPP2CA",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:PPP2CA"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "BCL2L11_cell",
+ "name": "BCL2L11_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:BCL2L11"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TRIB3_gene",
+ "name": "TRIB3_gene",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TRIB3_rna",
+ "name": "TRIB3_rna",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:TRIB3"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Ca2+_ion_endoplasmic reticulum",
+ "name": "Ca2+_ion_endoplasmic reticulum",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ITPR3:HSPA9:VDAC1_complex",
+ "name": "ITPR3:HSPA9:VDAC1_complex",
+ "grounding": {
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+ "pubmed": "29491369"
+ },
+ "context": {
+ "property": "taxonomy:9606"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Ca2+_ion_mitochondrion",
+ "name": "Ca2+_ion_mitochondrion",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ERO1A_cell",
+ "name": "ERO1A_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:ERO1A"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PPP1R15A",
+ "name": "PPP1R15A",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:PPP1R15A"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "EIF2AK1",
+ "name": "EIF2AK1",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:EIF2AK1"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CASP9",
+ "name": "CASP9",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:CSAP9"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "cleaved~CASP4",
+ "name": "cleaved~CASP4",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:CASP4"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "cleaved~CASP9",
+ "name": "cleaved~CASP9",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:CASP9"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "mitochondrion-endoplasmic_space_reticulum_space_membrane_space_tethering_space__phenotype",
+ "name": "mitochondrion-endoplasmic_space_reticulum_space_membrane_space_tethering_space__phenotype",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "19052620"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "mitochondrial_space_fission_phenotype",
+ "name": "mitochondrial_space_fission_phenotype",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "15692567"
+ },
+ "context": {
+ "property": "taxonomy:9606"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "mitochondria_space_fragmentation_phenotype",
+ "name": "mitochondria_space_fragmentation_phenotype",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "15692567"
+ },
+ "context": {
+ "property": "taxonomy:9606"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "mitochondrial_space_outer_space_membrane_space_depolarization_phenotype",
+ "name": "mitochondrial_space_outer_space_membrane_space_depolarization_phenotype",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "21183955"
+ },
+ "context": {
+ "property": "taxonomy:9606"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "XBP1_gene",
+ "name": "XBP1_gene",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "XBP1_rna",
+ "name": "XBP1_rna",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:XBP1"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ERAD_phenotype",
+ "name": "ERAD_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "BCL2_gene",
+ "name": "BCL2_gene",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "BCL2_rna",
+ "name": "BCL2_rna",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:BCL2"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "hyperoxidation_phenotype",
+ "name": "hyperoxidation_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "protein_space_ubiquitination_space_and_space_destruction_phenotype",
+ "name": "protein_space_ubiquitination_space_and_space_destruction_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CDK5",
+ "name": "CDK5",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:CDK5"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MAPK14",
+ "name": "MAPK14",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:MAPK14"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MAP3K5_phosphorylated",
+ "name": "MAP3K5_phosphorylated",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:MAP3K5"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ERO1A_rna",
+ "name": "ERO1A_rna",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:ERO1A"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Apoptosis_phenotype_cell",
+ "name": "Apoptosis_phenotype_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Cell_space_survival_phenotype",
+ "name": "Cell_space_survival_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "p20",
+ "name": "p20",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:BCAP31"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "unfolded_space_protein_space_response_space_(UPR)_phenotype",
+ "name": "unfolded_space_protein_space_response_space_(UPR)_phenotype",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "22511781"
+ },
+ "context": {
+ "property": "taxonomy:10090"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "EIF2AK2",
+ "name": "EIF2AK2",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:EIF2AK2"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "presence_space_of_space_dsRNA_phenotype",
+ "name": "presence_space_of_space_dsRNA_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Ca2+_ion_mitochondrial matrix",
+ "name": "Ca2+_ion_mitochondrial matrix",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "24231807"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "BAX_cell",
+ "name": "BAX_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:BAX"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MAPK8_phosphorylated",
+ "name": "MAPK8_phosphorylated",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:MAPK8"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MAPK8",
+ "name": "MAPK8",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:MAPK8"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MAP3K4_phosphorylated",
+ "name": "MAP3K4_phosphorylated",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:MAP3K4"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Translation_space_initiation_phenotype",
+ "name": "Translation_space_initiation_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "BID",
+ "name": "BID",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:BID"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "BID_phosphorylated",
+ "name": "BID_phosphorylated",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:BID"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TRIB3",
+ "name": "TRIB3",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:TRIB3"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CASP4",
+ "name": "CASP4",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:CASP4"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "HYOU1_rna",
+ "name": "HYOU1_rna",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:HYOU1"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "HYOU1",
+ "name": "HYOU1",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:HYOU1"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CASP3",
+ "name": "CASP3",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:CASP3"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "cleaved~CASP3",
+ "name": "cleaved~CASP3",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:CASP3"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "GCN2:ATP_complex",
+ "name": "GCN2:ATP_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "AP-1",
+ "name": "AP-1",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:FOS",
+ "property1": "hgnc:FOSB",
+ "property2": "hgnc:FOSL1",
+ "property3": "hgnc:FOSL2",
+ "property4": "hgnc:JUN",
+ "property5": "hgnc:JUNB",
+ "property6": "hgnc:JUND"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "AP-1_phosphorylated_phosphorylated",
+ "name": "AP-1_phosphorylated_phosphorylated",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:FOS",
+ "property1": "hgnc:FOSB",
+ "property2": "hgnc:FOSL1",
+ "property3": "hgnc:FOSL2",
+ "property4": "hgnc:JUN",
+ "property5": "hgnc:JUNB",
+ "property6": "hgnc:JUND"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "RYR1",
+ "name": "RYR1",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:RYR1"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Apoptosis_phenotype_endoplasmic reticulum",
+ "name": "Apoptosis_phenotype_endoplasmic reticulum",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "15692567"
+ },
+ "context": {
+ "property": "taxonomy:9606"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MAP3K5",
+ "name": "MAP3K5",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:MAP3K5"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "DNAJC3_gene",
+ "name": "DNAJC3_gene",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MFN2_rna",
+ "name": "MFN2_rna",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:MFN2"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ADAM17_cell",
+ "name": "ADAM17_cell",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32264791"
+ },
+ "context": {
+ "property": "HGNC:195"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MFN2_gene",
+ "name": "MFN2_gene",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "mitochondrial_space_calcium_space_ion_space_transmembrane_space_transport_phenotype",
+ "name": "mitochondrial_space_calcium_space_ion_space_transmembrane_space_transport_phenotype",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "24231807"
+ },
+ "context": {
+ "property": "taxonomy:9606"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "endoplasmic_space_reticulum_space_calcium_space_ion_space_homeostasis_phenotype",
+ "name": "endoplasmic_space_reticulum_space_calcium_space_ion_space_homeostasis_phenotype",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "22511781"
+ },
+ "context": {
+ "property": "taxonomy:10090"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MAP3K4",
+ "name": "MAP3K4",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:MAP3K4"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "HYOU1_gene",
+ "name": "HYOU1_gene",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ERO1A_gene",
+ "name": "ERO1A_gene",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SARS-CoV infection_phenotype",
+ "name": "SARS-CoV infection_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "viral entry into host cell_phenotype",
+ "name": "viral entry into host cell_phenotype",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "19411314"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "viral RNA genome replication_phenotype",
+ "name": "viral RNA genome replication_phenotype",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "14647384"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ }
+ ],
+ "edges": [
+ {
+ "id": "t1",
+ "source": "EIF2S3:GDP_complex",
+ "target": "EIF2-P:GDP_complex",
+ "sign": true
+ },
+ {
+ "id": "t2",
+ "source": "EIF2S2",
+ "target": "EIF2-P:GDP_complex",
+ "sign": true
+ },
+ {
+ "id": "t3",
+ "source": "EIF2S1_phosphorylated",
+ "target": "EIF2-P:GDP_complex",
+ "sign": true
+ },
+ {
+ "id": "t4",
+ "source": "Persistant_space_ER_space_Stress_phenotype_endoplasmic reticulum",
+ "target": "TRAF2:ERN1_complex",
+ "sign": true
+ },
+ {
+ "id": "t5",
+ "source": "BCL2",
+ "target": "TRAF2:ERN1_complex",
+ "sign": true
+ },
+ {
+ "id": "t6",
+ "source": "ERN1:Unfolded_space_protein_complex",
+ "target": "TRAF2:ERN1_complex",
+ "sign": true
+ },
+ {
+ "id": "t7",
+ "source": "BCL2L1",
+ "target": "TRAF2:ERN1_complex",
+ "sign": true
+ },
+ {
+ "id": "t8",
+ "source": "TRAF2",
+ "target": "TRAF2:ERN1_complex",
+ "sign": true
+ },
+ {
+ "id": "t9",
+ "source": "BAK1",
+ "target": "TRAF2:ERN1_complex",
+ "sign": true
+ },
+ {
+ "id": "t10",
+ "source": "BAX:ERN1_complex",
+ "target": "TRAF2:ERN1_complex",
+ "sign": true
+ },
+ {
+ "id": "t11",
+ "source": "BAX_endoplasmic reticulum",
+ "target": "TRAF2:ERN1_complex",
+ "sign": true
+ },
+ {
+ "id": "t12",
+ "source": "BAK1:ERN1_complex",
+ "target": "TRAF2:ERN1_complex",
+ "sign": true
+ },
+ {
+ "id": "t13",
+ "source": "SIGMAR1_mitochondria-associated endoplasmic reticulum membrane",
+ "target": "SIGMAR1:ITPR3_complex",
+ "sign": true
+ },
+ {
+ "id": "t14",
+ "source": "ITPR3",
+ "target": "SIGMAR1:ITPR3_complex",
+ "sign": true
+ },
+ {
+ "id": "t15",
+ "source": "ER_space_stress_phenotype",
+ "target": "SIGMAR1:ITPR3_complex",
+ "sign": true
+ },
+ {
+ "id": "t16",
+ "source": "Ca2+space_ER_space_depletion_phenotype",
+ "target": "SIGMAR1:ITPR3_complex",
+ "sign": true
+ },
+ {
+ "id": "t17",
+ "source": "Ternary_space_Complex_complex",
+ "target": "EIF2:GDP:Met-tRNA_complex",
+ "sign": true
+ },
+ {
+ "id": "t18",
+ "source": "GDP_simple_molecule",
+ "target": "EIF2:GDP:Met-tRNA_complex",
+ "sign": true
+ },
+ {
+ "id": "t19",
+ "source": "Met-tRNA_rna",
+ "target": "EIF2:GDP:Met-tRNA_complex",
+ "sign": true
+ },
+ {
+ "id": "t20",
+ "source": "EIF2:GDP_complex",
+ "target": "EIF2:GDP:Met-tRNA_complex",
+ "sign": true
+ },
+ {
+ "id": "t21",
+ "source": "CASP8:CASP8-ubq:FADD_complex",
+ "target": "CASP8:FADD:MAP1LC3A:SQSTM1:ATG5_complex",
+ "sign": true
+ },
+ {
+ "id": "t22",
+ "source": "Persistant_space_ER_space_Stress_phenotype_endoplasmic reticulum",
+ "target": "CASP8:FADD:MAP1LC3A:SQSTM1:ATG5_complex",
+ "sign": true
+ },
+ {
+ "id": "t23",
+ "source": "ATG5",
+ "target": "CASP8:FADD:MAP1LC3A:SQSTM1:ATG5_complex",
+ "sign": true
+ },
+ {
+ "id": "t24",
+ "source": "TRIM13",
+ "target": "CASP8:FADD:MAP1LC3A:SQSTM1:ATG5_complex",
+ "sign": true
+ },
+ {
+ "id": "t25",
+ "source": "MAP1LC3A",
+ "target": "CASP8:FADD:MAP1LC3A:SQSTM1:ATG5_complex",
+ "sign": true
+ },
+ {
+ "id": "t26",
+ "source": "SQSTM1_space_",
+ "target": "CASP8:FADD:MAP1LC3A:SQSTM1:ATG5_complex",
+ "sign": true
+ },
+ {
+ "id": "t27",
+ "source": "ERN1_endoplasmic reticulum",
+ "target": "ERN1:Unfolded_space_protein_complex",
+ "sign": true
+ },
+ {
+ "id": "t28",
+ "source": "Unfolded_space_protein",
+ "target": "ERN1:Unfolded_space_protein_complex",
+ "sign": true
+ },
+ {
+ "id": "t29",
+ "source": "HSPA5_endoplasmic reticulum",
+ "target": "SIGMAR1:HSPA5_complex",
+ "sign": true
+ },
+ {
+ "id": "t30",
+ "source": "SIGMAR1_endoplasmic reticulum",
+ "target": "SIGMAR1:HSPA5_complex",
+ "sign": true
+ },
+ {
+ "id": "t31",
+ "source": "RMDN3",
+ "target": "VAPB:RMDN3_complex",
+ "sign": true
+ },
+ {
+ "id": "t32",
+ "source": "VAPB",
+ "target": "VAPB:RMDN3_complex",
+ "sign": true
+ },
+ {
+ "id": "t33",
+ "source": "EIF2:GDP:Met-tRNA_complex",
+ "target": "Ternary_space_Complex_complex",
+ "sign": true
+ },
+ {
+ "id": "t34",
+ "source": "GTP_simple_molecule",
+ "target": "Ternary_space_Complex_complex",
+ "sign": true
+ },
+ {
+ "id": "t35",
+ "source": "EIF2B_complex",
+ "target": "Ternary_space_Complex_complex",
+ "sign": true
+ },
+ {
+ "id": "t36",
+ "source": "ADAM17_early_space_endosome",
+ "target": "PACS2-ADAM17_space_interaction_complex",
+ "sign": true
+ },
+ {
+ "id": "t37",
+ "source": "PACS2_early_space_endosome",
+ "target": "PACS2-ADAM17_space_interaction_complex",
+ "sign": true
+ },
+ {
+ "id": "t38",
+ "source": "BCAP31",
+ "target": "FIS1:BCAP31_complex",
+ "sign": true
+ },
+ {
+ "id": "t39",
+ "source": "FIS1",
+ "target": "FIS1:BCAP31_complex",
+ "sign": true
+ },
+ {
+ "id": "t40",
+ "source": "MFN2_mitochondrion",
+ "target": "MFN2:MFN2_complex",
+ "sign": true
+ },
+ {
+ "id": "t41",
+ "source": "MFN2_endoplasmic reticulum",
+ "target": "MFN2:MFN2_complex",
+ "sign": true
+ },
+ {
+ "id": "t42",
+ "source": "Persistant_space_ER_space_Stress_phenotype_cell",
+ "target": "ERN1:BBC3_complex",
+ "sign": true
+ },
+ {
+ "id": "t43",
+ "source": "ERN1_endoplasmic reticulum",
+ "target": "ERN1:BBC3_complex",
+ "sign": true
+ },
+ {
+ "id": "t44",
+ "source": "BBC3",
+ "target": "ERN1:BBC3_complex",
+ "sign": true
+ },
+ {
+ "id": "t45",
+ "source": "EIF2S3:GDP_complex",
+ "target": "EIF2:GDP_complex",
+ "sign": true
+ },
+ {
+ "id": "t46",
+ "source": "EIF2S2",
+ "target": "EIF2:GDP_complex",
+ "sign": true
+ },
+ {
+ "id": "t47",
+ "source": "EIF2S1",
+ "target": "EIF2:GDP_complex",
+ "sign": true
+ },
+ {
+ "id": "t48",
+ "source": "MFN1",
+ "target": "MFN1:MFN2_complex",
+ "sign": true
+ },
+ {
+ "id": "t49",
+ "source": "MFN2_endoplasmic reticulum",
+ "target": "MFN1:MFN2_complex",
+ "sign": true
+ },
+ {
+ "id": "t50",
+ "source": "MCU1",
+ "target": "MCU:MICU1:MICU2:SMDT1_complex",
+ "sign": true
+ },
+ {
+ "id": "t51",
+ "source": "MCU2",
+ "target": "MCU:MICU1:MICU2:SMDT1_complex",
+ "sign": true
+ },
+ {
+ "id": "t52",
+ "source": "MCU",
+ "target": "MCU:MICU1:MICU2:SMDT1_complex",
+ "sign": true
+ },
+ {
+ "id": "t53",
+ "source": "SMDT1",
+ "target": "MCU:MICU1:MICU2:SMDT1_complex",
+ "sign": true
+ },
+ {
+ "id": "t54",
+ "source": "Persistant_space_ER_space_Stress_phenotype_cell",
+ "target": "ERN1:BCL2L11_complex",
+ "sign": true
+ },
+ {
+ "id": "t55",
+ "source": "ERN1_endoplasmic reticulum",
+ "target": "ERN1:BCL2L11_complex",
+ "sign": true
+ },
+ {
+ "id": "t56",
+ "source": "BCL2L11_endoplasmic reticulum",
+ "target": "ERN1:BCL2L11_complex",
+ "sign": true
+ },
+ {
+ "id": "t57",
+ "source": "high_space_Ca2+space_cytosolic_space_concentration_phenotype",
+ "target": "CAPN1:Ca2+_complex",
+ "sign": true
+ },
+ {
+ "id": "t58",
+ "source": "CAPN1",
+ "target": "CAPN1:Ca2+_complex",
+ "sign": true
+ },
+ {
+ "id": "t59",
+ "source": "Ca2+_ion_cell",
+ "target": "CAPN1:Ca2+_complex",
+ "sign": true
+ },
+ {
+ "id": "t60",
+ "source": "EIF2AK3",
+ "target": "EIF2AK3:EIF2AK3_complex",
+ "sign": true
+ },
+ {
+ "id": "t61",
+ "source": "Persistant_space_ER_space_Stress_phenotype_endoplasmic reticulum",
+ "target": "EIF2AK3:EIF2AK3_complex",
+ "sign": true
+ },
+ {
+ "id": "t62",
+ "source": "Unfolded_space_protein",
+ "target": "EIF2AK3:EIF2AK3_complex",
+ "sign": true
+ },
+ {
+ "id": "t63",
+ "source": "MCU:MICU1:MICU2:SMDT1_complex",
+ "target": "Mitochondrial_space_calcium_space_uniporter_space_complex_complex",
+ "sign": true
+ },
+ {
+ "id": "t64",
+ "source": "S",
+ "target": "ACE2:Spike_complex",
+ "sign": true
+ },
+ {
+ "id": "t65",
+ "source": "ACE2",
+ "target": "ACE2:Spike_complex",
+ "sign": true
+ },
+ {
+ "id": "t66",
+ "source": "S",
+ "target": "HSPA5-Spike interaction_complex",
+ "sign": true
+ },
+ {
+ "id": "t67",
+ "source": "HSPA5_default_compartment",
+ "target": "HSPA5-Spike interaction_complex",
+ "sign": true
+ },
+ {
+ "id": "t68",
+ "source": "ACE2,_space_soluble",
+ "target": "ACE2-SARS-CoV interaction_complex",
+ "sign": true
+ },
+ {
+ "id": "t69",
+ "source": "ACE2,_space_membrane-bound",
+ "target": "ACE2-SARS-CoV interaction_complex",
+ "sign": true
+ },
+ {
+ "id": "t70",
+ "source": "S",
+ "target": "ACE2-SARS-CoV interaction_complex",
+ "sign": true
+ },
+ {
+ "id": "t71",
+ "source": "DDIT3",
+ "target": "PPP1R15A_rna",
+ "sign": true
+ },
+ {
+ "id": "t72",
+ "source": "ATF4",
+ "target": "PPP1R15A_rna",
+ "sign": true
+ },
+ {
+ "id": "t73",
+ "source": "PPP1R15A_gene",
+ "target": "PPP1R15A_rna",
+ "sign": true
+ },
+ {
+ "id": "t74",
+ "source": "BAX_phosphorylated",
+ "target": "release_space_of_space_ER_space_Ca2+_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t75",
+ "source": "MBTPS1",
+ "target": "ATF6_Golgi apparatus",
+ "sign": true
+ },
+ {
+ "id": "t76",
+ "source": "MBTPS2",
+ "target": "ATF6_Golgi apparatus",
+ "sign": true
+ },
+ {
+ "id": "t77",
+ "source": "ER_space_Stress_phenotype",
+ "target": "ATF6_Golgi apparatus",
+ "sign": true
+ },
+ {
+ "id": "t78",
+ "source": "ATF6_endoplasmic reticulum",
+ "target": "ATF6_Golgi apparatus",
+ "sign": true
+ },
+ {
+ "id": "t79",
+ "source": "retrograde_space_transport_space_from_space_ER_space_to_space_cytosol_phenotype",
+ "target": "ATF6_Golgi apparatus",
+ "sign": true
+ },
+ {
+ "id": "t80",
+ "source": "DDIT3",
+ "target": "DDIT3_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t81",
+ "source": "MAPK14_phosphorylated",
+ "target": "DDIT3_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t82",
+ "source": "TRAF2:ERN1_complex",
+ "target": "TRAF2",
+ "sign": true
+ },
+ {
+ "id": "t83",
+ "source": "MFN2_endoplasmic reticulum",
+ "target": "endoplasmic_space_reticulum_space_organization_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t84",
+ "source": "Ca2+space_ER_space_depletion_phenotype",
+ "target": "HSPA5_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t85",
+ "source": "Unfolded_space_protein",
+ "target": "HSPA5_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t86",
+ "source": "SIGMAR1:HSPA5_complex",
+ "target": "HSPA5_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t87",
+ "source": "ATF6:HSPA5_complex",
+ "target": "HSPA5_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t88",
+ "source": "HSPA5_rna",
+ "target": "HSPA5_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t89",
+ "source": "ER_space_stress_phenotype",
+ "target": "HSPA5_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t90",
+ "source": "ACE2",
+ "target": "HSPA5_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t91",
+ "source": "ERO1A_endoplasmic reticulum",
+ "target": "ITPR",
+ "sign": true
+ },
+ {
+ "id": "t92",
+ "source": "TMBIM6",
+ "target": "ITPR",
+ "sign": true
+ },
+ {
+ "id": "t93",
+ "source": "Ternary_space_Complex_complex",
+ "target": "GTP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t94",
+ "source": "GDP_simple_molecule",
+ "target": "GTP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t95",
+ "source": "HSPA5_gene",
+ "target": "HSPA5_rna",
+ "sign": true
+ },
+ {
+ "id": "t96",
+ "source": "S",
+ "target": "HSPA5_rna",
+ "sign": true
+ },
+ {
+ "id": "t97",
+ "source": "ACE2",
+ "target": "HSPA5_rna",
+ "sign": true
+ },
+ {
+ "id": "t98",
+ "source": "EIF2AK3:EIF2AK3_complex",
+ "target": "UPR_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t99",
+ "source": "XBP1",
+ "target": "UPR_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t100",
+ "source": "ATF6_Golgi apparatus",
+ "target": "UPR_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t101",
+ "source": "TRAF2:ERN1_complex",
+ "target": "UPR_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t102",
+ "source": "accumulation_space_of_space_misfolded_space_protein_space_in_space_ER_phenotype",
+ "target": "UPR_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t103",
+ "source": "RMDN3",
+ "target": "Ca2+space_mitochondrial_space_concentration_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t104",
+ "source": "VAPB",
+ "target": "Ca2+space_mitochondrial_space_concentration_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t105",
+ "source": "FIS1",
+ "target": "Ca2+space_mitochondrial_space_concentration_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t106",
+ "source": "PACS2_endoplasmic reticulum",
+ "target": "PACS2_endoplasmic reticulum",
+ "sign": false
+ },
+ {
+ "id": "t107",
+ "source": "accumulation_space_of_space_misfolded_space_protein_space_in_space_ER_phenotype",
+ "target": "ER_space_Stress_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t108",
+ "source": "ATF6:HSPA5_complex",
+ "target": "ATF6_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t109",
+ "source": "Unfolded_space_protein",
+ "target": "ATF6_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t110",
+ "source": "DNAJC3_rna",
+ "target": "DNAJC3",
+ "sign": true
+ },
+ {
+ "id": "t111",
+ "source": "DDIT3_gene",
+ "target": "DDIT3_rna",
+ "sign": true
+ },
+ {
+ "id": "t112",
+ "source": "XBP1",
+ "target": "DDIT3_rna",
+ "sign": true
+ },
+ {
+ "id": "t113",
+ "source": "ATF4",
+ "target": "DDIT3_rna",
+ "sign": true
+ },
+ {
+ "id": "t114",
+ "source": "Persistant_space_ER_space_Stress_phenotype_cell",
+ "target": "DDIT3_rna",
+ "sign": true
+ },
+ {
+ "id": "t115",
+ "source": "ATF6_nucleus",
+ "target": "DDIT3_rna",
+ "sign": true
+ },
+ {
+ "id": "t116",
+ "source": "ATF4_gene",
+ "target": "ATF4_rna",
+ "sign": true
+ },
+ {
+ "id": "t117",
+ "source": "EIF2-P:GDP_complex",
+ "target": "ATF4_rna",
+ "sign": true
+ },
+ {
+ "id": "t118",
+ "source": "PPP2CA",
+ "target": "BCL2L11_cell",
+ "sign": true
+ },
+ {
+ "id": "t119",
+ "source": "BCL2L11_phosphorylated",
+ "target": "BCL2L11_cell",
+ "sign": true
+ },
+ {
+ "id": "t120",
+ "source": "TRIB3_gene",
+ "target": "TRIB3_rna",
+ "sign": true
+ },
+ {
+ "id": "t121",
+ "source": "DDIT3",
+ "target": "TRIB3_rna",
+ "sign": true
+ },
+ {
+ "id": "t122",
+ "source": "SIGMAR1:ITPR3_complex",
+ "target": "Ca2+_ion_mitochondrion",
+ "sign": true
+ },
+ {
+ "id": "t123",
+ "source": "Ca2+_ion_endoplasmic reticulum",
+ "target": "Ca2+_ion_mitochondrion",
+ "sign": true
+ },
+ {
+ "id": "t124",
+ "source": "ITPR3:HSPA9:VDAC1_complex",
+ "target": "Ca2+_ion_mitochondrion",
+ "sign": true
+ },
+ {
+ "id": "t125",
+ "source": "ERO1A_cell",
+ "target": "ERO1A_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t126",
+ "source": "EIF2S1_phosphorylated",
+ "target": "EIF2S1",
+ "sign": true
+ },
+ {
+ "id": "t127",
+ "source": "EIF2AK1",
+ "target": "EIF2S1",
+ "sign": true
+ },
+ {
+ "id": "t128",
+ "source": "PPP1R15A",
+ "target": "EIF2S1",
+ "sign": true
+ },
+ {
+ "id": "t129",
+ "source": "CASP9",
+ "target": "cleaved~CASP9",
+ "sign": true
+ },
+ {
+ "id": "t130",
+ "source": "cleaved~CASP4",
+ "target": "cleaved~CASP9",
+ "sign": true
+ },
+ {
+ "id": "t131",
+ "source": "ITPR3",
+ "target": "RMDN3",
+ "sign": false
+ },
+ {
+ "id": "t132",
+ "source": "VAPB",
+ "target": "RMDN3",
+ "sign": false
+ },
+ {
+ "id": "t133",
+ "source": "mitochondrion-endoplasmic_space_reticulum_space_membrane_space_tethering_space__phenotype",
+ "target": "RMDN3",
+ "sign": false
+ },
+ {
+ "id": "t134",
+ "source": "PPP1R15A_rna",
+ "target": "PPP1R15A",
+ "sign": true
+ },
+ {
+ "id": "t135",
+ "source": "mitochondrial_space_fission_phenotype",
+ "target": "mitochondria_space_fragmentation_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t136",
+ "source": "FIS1",
+ "target": "mitochondrial_space_outer_space_membrane_space_depolarization_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t137",
+ "source": "ER_space_stress_phenotype",
+ "target": "SIGMAR1_mitochondria-associated endoplasmic reticulum membrane",
+ "sign": true
+ },
+ {
+ "id": "t138",
+ "source": "Ca2+space_ER_space_depletion_phenotype",
+ "target": "SIGMAR1_mitochondria-associated endoplasmic reticulum membrane",
+ "sign": true
+ },
+ {
+ "id": "t139",
+ "source": "SIGMAR1:HSPA5_complex",
+ "target": "SIGMAR1_mitochondria-associated endoplasmic reticulum membrane",
+ "sign": true
+ },
+ {
+ "id": "t140",
+ "source": "XBP1_gene",
+ "target": "XBP1_rna",
+ "sign": true
+ },
+ {
+ "id": "t141",
+ "source": "ERN1:BCL2L11_complex",
+ "target": "XBP1_rna",
+ "sign": true
+ },
+ {
+ "id": "t142",
+ "source": "TRAF2:ERN1_complex",
+ "target": "XBP1_rna",
+ "sign": true
+ },
+ {
+ "id": "t143",
+ "source": "ATF6_nucleus",
+ "target": "XBP1_rna",
+ "sign": true
+ },
+ {
+ "id": "t144",
+ "source": "ERN1:BBC3_complex",
+ "target": "XBP1_rna",
+ "sign": true
+ },
+ {
+ "id": "t145",
+ "source": "ERAD_phenotype",
+ "target": "accumulation_space_of_space_misfolded_space_protein_space_in_space_ER_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t146",
+ "source": "Unfolded_space_protein",
+ "target": "accumulation_space_of_space_misfolded_space_protein_space_in_space_ER_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t147",
+ "source": "DDIT3_phosphorylated",
+ "target": "BCL2_rna",
+ "sign": true
+ },
+ {
+ "id": "t148",
+ "source": "BCL2_gene",
+ "target": "BCL2_rna",
+ "sign": true
+ },
+ {
+ "id": "t149",
+ "source": "ERO1A_endoplasmic reticulum",
+ "target": "hyperoxidation_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t150",
+ "source": "retrograde_space_transport_space_from_space_ER_space_to_space_cytosol_phenotype",
+ "target": "protein_space_ubiquitination_space_and_space_destruction_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t151",
+ "source": "ER_space_Stress_phenotype",
+ "target": "CDK5",
+ "sign": true
+ },
+ {
+ "id": "t152",
+ "source": "MAP3K5_phosphorylated",
+ "target": "MAPK14_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t153",
+ "source": "MAPK14",
+ "target": "MAPK14_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t154",
+ "source": "ERO1A_rna",
+ "target": "ERO1A_cell",
+ "sign": true
+ },
+ {
+ "id": "t155",
+ "source": "Apoptosis_phenotype_cell",
+ "target": "Cell_space_survival_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t156",
+ "source": "MFN2_endoplasmic reticulum",
+ "target": "unfolded_space_protein_space_response_space_(UPR)_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t157",
+ "source": "ER_space_stress_phenotype",
+ "target": "unfolded_space_protein_space_response_space_(UPR)_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t158",
+ "source": "p20",
+ "target": "unfolded_space_protein_space_response_space_(UPR)_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t159",
+ "source": "DNAJC3",
+ "target": "EIF2AK2",
+ "sign": true
+ },
+ {
+ "id": "t160",
+ "source": "presence_space_of_space_dsRNA_phenotype",
+ "target": "EIF2AK2",
+ "sign": true
+ },
+ {
+ "id": "t161",
+ "source": "Ca2+_ion_mitochondrion",
+ "target": "Ca2+_ion_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t162",
+ "source": "Mitochondrial_space_calcium_space_uniporter_space_complex_complex",
+ "target": "Ca2+_ion_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t163",
+ "source": "BAX_cell",
+ "target": "BAX_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t164",
+ "source": "MAPK14_phosphorylated",
+ "target": "BAX_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t165",
+ "source": "MAPK8_phosphorylated",
+ "target": "BAX_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t166",
+ "source": "ATF6_endoplasmic reticulum",
+ "target": "retrograde_space_transport_space_from_space_ER_space_to_space_cytosol_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t167",
+ "source": "EIF2AK3:EIF2AK3_complex",
+ "target": "retrograde_space_transport_space_from_space_ER_space_to_space_cytosol_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t168",
+ "source": "MAPK8",
+ "target": "MAPK8_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t169",
+ "source": "MAP3K5_phosphorylated",
+ "target": "MAPK8_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t170",
+ "source": "MAP3K4_phosphorylated",
+ "target": "MAPK8_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t171",
+ "source": "XBP1_rna",
+ "target": "XBP1",
+ "sign": true
+ },
+ {
+ "id": "t172",
+ "source": "Ternary_space_Complex_complex",
+ "target": "Translation_space_initiation_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t173",
+ "source": "BID",
+ "target": "BID_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t174",
+ "source": "MAPK8_phosphorylated",
+ "target": "BID_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t175",
+ "source": "TRIB3_rna",
+ "target": "TRIB3",
+ "sign": true
+ },
+ {
+ "id": "t176",
+ "source": "CASP4",
+ "target": "cleaved~CASP4",
+ "sign": true
+ },
+ {
+ "id": "t177",
+ "source": "CAPN1:Ca2+_complex",
+ "target": "cleaved~CASP4",
+ "sign": true
+ },
+ {
+ "id": "t178",
+ "source": "SIGMAR1_mitochondria-associated endoplasmic reticulum membrane",
+ "target": "ER_space_stress_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t179",
+ "source": "MFN2_endoplasmic reticulum",
+ "target": "ER_space_stress_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t180",
+ "source": "ACE2",
+ "target": "ER_space_stress_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t181",
+ "source": "HYOU1_rna",
+ "target": "HYOU1",
+ "sign": true
+ },
+ {
+ "id": "t182",
+ "source": "CASP3",
+ "target": "cleaved~CASP3",
+ "sign": true
+ },
+ {
+ "id": "t183",
+ "source": "cleaved~CASP4",
+ "target": "cleaved~CASP3",
+ "sign": true
+ },
+ {
+ "id": "t184",
+ "source": "EIF2AK3:EIF2AK3_complex",
+ "target": "EIF2S1_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t185",
+ "source": "EIF2AK2",
+ "target": "EIF2S1_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t186",
+ "source": "DNAJC3",
+ "target": "EIF2S1_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t187",
+ "source": "EIF2S1",
+ "target": "EIF2S1_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t188",
+ "source": "GCN2:ATP_complex",
+ "target": "EIF2S1_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t189",
+ "source": "MFN1:MFN2_complex",
+ "target": "mitochondrion-endoplasmic_space_reticulum_space_membrane_space_tethering_space__phenotype",
+ "sign": true
+ },
+ {
+ "id": "t190",
+ "source": "VAPB:RMDN3_complex",
+ "target": "mitochondrion-endoplasmic_space_reticulum_space_membrane_space_tethering_space__phenotype",
+ "sign": true
+ },
+ {
+ "id": "t191",
+ "source": "PACS2_endoplasmic reticulum",
+ "target": "mitochondrion-endoplasmic_space_reticulum_space_membrane_space_tethering_space__phenotype",
+ "sign": true
+ },
+ {
+ "id": "t192",
+ "source": "FIS1:BCAP31_complex",
+ "target": "mitochondrion-endoplasmic_space_reticulum_space_membrane_space_tethering_space__phenotype",
+ "sign": true
+ },
+ {
+ "id": "t193",
+ "source": "MFN2:MFN2_complex",
+ "target": "mitochondrion-endoplasmic_space_reticulum_space_membrane_space_tethering_space__phenotype",
+ "sign": true
+ },
+ {
+ "id": "t194",
+ "source": "AP-1",
+ "target": "AP-1_phosphorylated_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t195",
+ "source": "DDIT3",
+ "target": "AP-1_phosphorylated_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t196",
+ "source": "MAPK8_phosphorylated",
+ "target": "AP-1_phosphorylated_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t197",
+ "source": "EIF2:GDP:Met-tRNA_complex",
+ "target": "GDP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t198",
+ "source": "GTP_simple_molecule",
+ "target": "GDP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t199",
+ "source": "EIF2B_complex",
+ "target": "GDP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t200",
+ "source": "TMBIM6",
+ "target": "Ca2+_ion_cell",
+ "sign": true
+ },
+ {
+ "id": "t201",
+ "source": "ITPR",
+ "target": "Ca2+_ion_cell",
+ "sign": true
+ },
+ {
+ "id": "t202",
+ "source": "Ca2+_ion_endoplasmic reticulum",
+ "target": "Ca2+_ion_cell",
+ "sign": true
+ },
+ {
+ "id": "t203",
+ "source": "RYR1",
+ "target": "Ca2+_ion_cell",
+ "sign": true
+ },
+ {
+ "id": "t204",
+ "source": "BCAP31",
+ "target": "p20",
+ "sign": true
+ },
+ {
+ "id": "t205",
+ "source": "PACS2_endoplasmic reticulum",
+ "target": "p20",
+ "sign": true
+ },
+ {
+ "id": "t206",
+ "source": "Apoptosis_phenotype_endoplasmic reticulum",
+ "target": "p20",
+ "sign": true
+ },
+ {
+ "id": "t207",
+ "source": "ATF4_rna",
+ "target": "ATF4",
+ "sign": true
+ },
+ {
+ "id": "t208",
+ "source": "MAP3K5",
+ "target": "MAP3K5_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t209",
+ "source": "TRAF2",
+ "target": "MAP3K5_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t210",
+ "source": "TRAF2:ERN1_complex",
+ "target": "MAP3K5_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t211",
+ "source": "SIGMAR1_mitochondria-associated endoplasmic reticulum membrane",
+ "target": "Apoptosis_phenotype_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t212",
+ "source": "ER_space_stress_phenotype",
+ "target": "Apoptosis_phenotype_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t213",
+ "source": "MFN2_endoplasmic reticulum",
+ "target": "Apoptosis_phenotype_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t214",
+ "source": "ATF6_nucleus",
+ "target": "DNAJC3_rna",
+ "sign": true
+ },
+ {
+ "id": "t215",
+ "source": "DNAJC3_gene",
+ "target": "DNAJC3_rna",
+ "sign": true
+ },
+ {
+ "id": "t216",
+ "source": "DDIT3_rna",
+ "target": "DDIT3",
+ "sign": true
+ },
+ {
+ "id": "t217",
+ "source": "MFN2_rna",
+ "target": "MFN2_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t218",
+ "source": "ER_space_stress_phenotype",
+ "target": "MFN2_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t219",
+ "source": "PACS2-ADAM17_space_interaction_complex",
+ "target": "ADAM17_cell",
+ "sign": true
+ },
+ {
+ "id": "t220",
+ "source": "XBP1",
+ "target": "ERAD_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t221",
+ "source": "MFN2_gene",
+ "target": "MFN2_rna",
+ "sign": true
+ },
+ {
+ "id": "t222",
+ "source": "CASP8:FADD:MAP1LC3A:SQSTM1:ATG5_complex",
+ "target": "Apoptosis_phenotype_cell",
+ "sign": true
+ },
+ {
+ "id": "t223",
+ "source": "cleaved~CASP9",
+ "target": "Apoptosis_phenotype_cell",
+ "sign": true
+ },
+ {
+ "id": "t224",
+ "source": "DDIT3_phosphorylated",
+ "target": "Apoptosis_phenotype_cell",
+ "sign": true
+ },
+ {
+ "id": "t225",
+ "source": "BID_phosphorylated",
+ "target": "Apoptosis_phenotype_cell",
+ "sign": true
+ },
+ {
+ "id": "t226",
+ "source": "BAX_phosphorylated",
+ "target": "Apoptosis_phenotype_cell",
+ "sign": true
+ },
+ {
+ "id": "t227",
+ "source": "TRIB3",
+ "target": "Apoptosis_phenotype_cell",
+ "sign": true
+ },
+ {
+ "id": "t228",
+ "source": "MAPK14_phosphorylated",
+ "target": "Apoptosis_phenotype_cell",
+ "sign": true
+ },
+ {
+ "id": "t229",
+ "source": "cleaved~CASP3",
+ "target": "Apoptosis_phenotype_cell",
+ "sign": true
+ },
+ {
+ "id": "t230",
+ "source": "BCL2L11_phosphorylated",
+ "target": "Apoptosis_phenotype_cell",
+ "sign": true
+ },
+ {
+ "id": "t231",
+ "source": "Cell_space_survival_phenotype",
+ "target": "Apoptosis_phenotype_cell",
+ "sign": true
+ },
+ {
+ "id": "t232",
+ "source": "Mitochondrial_space_calcium_space_uniporter_space_complex_complex",
+ "target": "mitochondrial_space_calcium_space_ion_space_transmembrane_space_transport_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t233",
+ "source": "ADAM17_cell",
+ "target": "ACE2,_space_soluble",
+ "sign": true
+ },
+ {
+ "id": "t234",
+ "source": "ACE2",
+ "target": "ACE2,_space_soluble",
+ "sign": true
+ },
+ {
+ "id": "t235",
+ "source": "ER_space_Stress_phenotype",
+ "target": "Persistant_space_ER_space_Stress_phenotype_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t236",
+ "source": "release_space_of_space_ER_space_Ca2+_phenotype",
+ "target": "high_space_Ca2+space_cytosolic_space_concentration_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t237",
+ "source": "Ca2+_ion_cell",
+ "target": "high_space_Ca2+space_cytosolic_space_concentration_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t238",
+ "source": "ATF6_Golgi apparatus",
+ "target": "ATF6_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t239",
+ "source": "HSPA5_endoplasmic reticulum",
+ "target": "endoplasmic_space_reticulum_space_calcium_space_ion_space_homeostasis_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t240",
+ "source": "MFN2_endoplasmic reticulum",
+ "target": "endoplasmic_space_reticulum_space_calcium_space_ion_space_homeostasis_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t241",
+ "source": "MAP3K4",
+ "target": "MAP3K4_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t242",
+ "source": "CDK5",
+ "target": "MAP3K4_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t243",
+ "source": "RMDN3",
+ "target": "VAPB",
+ "sign": false
+ },
+ {
+ "id": "t244",
+ "source": "HYOU1_gene",
+ "target": "HYOU1_rna",
+ "sign": true
+ },
+ {
+ "id": "t245",
+ "source": "ATF6_nucleus",
+ "target": "HYOU1_rna",
+ "sign": true
+ },
+ {
+ "id": "t246",
+ "source": "BCL2L11_cell",
+ "target": "BCL2L11_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t247",
+ "source": "MAPK8_phosphorylated",
+ "target": "BCL2L11_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t248",
+ "source": "ERO1A_gene",
+ "target": "ERO1A_rna",
+ "sign": true
+ },
+ {
+ "id": "t249",
+ "source": "ATF6_nucleus",
+ "target": "ERO1A_rna",
+ "sign": true
+ },
+ {
+ "id": "t250",
+ "source": "DDIT3",
+ "target": "ERO1A_rna",
+ "sign": true
+ },
+ {
+ "id": "t251",
+ "source": "ADAM17_cell",
+ "target": "ACE2,_space_membrane-bound",
+ "sign": true
+ },
+ {
+ "id": "t252",
+ "source": "ACE2",
+ "target": "ACE2,_space_membrane-bound",
+ "sign": true
+ },
+ {
+ "id": "t253",
+ "source": "ACE2",
+ "target": "ACE2",
+ "sign": false
+ },
+ {
+ "id": "t254",
+ "source": "SARS-CoV infection_phenotype",
+ "target": "viral entry into host cell_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t255",
+ "source": "ACE2-SARS-CoV interaction_complex",
+ "target": "viral entry into host cell_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t256",
+ "source": "ACE2,_space_soluble",
+ "target": "viral entry into host cell_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t257",
+ "source": "HSPA5-Spike interaction_complex",
+ "target": "viral entry into host cell_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t258",
+ "source": "viral entry into host cell_phenotype",
+ "target": "viral entry into host cell_phenotype",
+ "sign": false
+ },
+ {
+ "id": "t259",
+ "source": "ACE2",
+ "target": "viral RNA genome replication_phenotype",
+ "sign": true
+ }
+ ],
+ "parameters": []
+ },
+ "semantics": {
+ "ode": {
+ "rates": [],
+ "observables": [],
+ "time": {
+ "id": "t"
+ }
+ }
+ },
+ "metadata": {
+ "annotations": {}
+ }
+}
\ No newline at end of file
diff --git a/scripts/covid19_diseasemaps/regnet_amr_sbml/ETC.json b/scripts/covid19_diseasemaps/regnet_amr_sbml/ETC.json
new file mode 100644
index 000000000..746958cc9
--- /dev/null
+++ b/scripts/covid19_diseasemaps/regnet_amr_sbml/ETC.json
@@ -0,0 +1,1856 @@
+{
+ "header": {
+ "name": "Model",
+ "schema": "https://raw.githubusercontent.com/DARPA-ASKEM/Model-Representations/regnet_v0.2/regnet/regnet_schema.json",
+ "schema_name": "regnet",
+ "description": "Model",
+ "model_version": "0.1"
+ },
+ "model": {
+ "vertices": [
+ {
+ "id": "Nsp4_mitochondrion",
+ "name": "Nsp4_mitochondrion",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TIM_space_complex_complex",
+ "name": "TIM_space_complex_complex",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P62072"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TIM_space_complex:Nsp4_complex",
+ "name": "TIM_space_complex:Nsp4_complex",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "Q9Y584"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "F-ATPase_complex_mitochondrial matrix",
+ "name": "F-ATPase_complex_mitochondrial matrix",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "29440398"
+ },
+ "context": {
+ "property": "uniprot:O75964"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "H+_ion_mitochondrion",
+ "name": "H+_ion_mitochondrion",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "29235"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp6",
+ "name": "Nsp6",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "ncbiprotein:YP_009742613"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ATP_space_Synthase_complex",
+ "name": "ATP_space_Synthase_complex",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P00846"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "mt_space_mRNA_rna",
+ "name": "mt_space_mRNA_rna",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Mt_space_translation_complex",
+ "name": "Mt_space_translation_complex",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P43897"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Mt_space_ribosomal_space_proteins_complex",
+ "name": "Mt_space_ribosomal_space_proteins_complex",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P09001"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp8-affected Mt ribosomal proteins_complex",
+ "name": "Nsp8-affected Mt ribosomal proteins_complex",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P82663"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "mtDNA_space_encoded_space_OXPHOS_space_units_complex_mitochondrial matrix",
+ "name": "mtDNA_space_encoded_space_OXPHOS_space_units_complex_mitochondrial matrix",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "23149385"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NADH_simple_molecule",
+ "name": "NADH_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Complex_space_1_complex",
+ "name": "Complex_space_1_complex",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "O00217"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NDUFA1",
+ "name": "NDUFA1",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "O15239"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NDUFB9",
+ "name": "NDUFB9",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "Q9Y6M9"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "OXPHOS_space_factors_complex",
+ "name": "OXPHOS_space_factors_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "23149385"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ATP5MG",
+ "name": "ATP5MG",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "O75964"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "F-ATPase_complex_mitochondrial matrix",
+ "name": "F-ATPase_complex_mitochondrial matrix",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "21524994"
+ },
+ "context": {
+ "property": "GO:0005753",
+ "property1": "uniprot:O75964"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ACAD9",
+ "name": "ACAD9",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "Q9H845"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ECSIT",
+ "name": "ECSIT",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "Q9BQ95"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NDUFAF7",
+ "name": "NDUFAF7",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "Q7L592"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "complex_space_2_complex_mitochondrial matrix",
+ "name": "complex_space_2_complex_mitochondrial matrix",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "O14521"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Q_simple_molecule_mitochondrial matrix",
+ "name": "Q_simple_molecule_mitochondrial matrix",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "16389"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SIRT3",
+ "name": "SIRT3",
+ "grounding": {
+ "identifiers": {
+ "refseq": "NM_001017524"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "complex_space_3_complex",
+ "name": "complex_space_3_complex",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "O14949"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TCA_phenotype",
+ "name": "TCA_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "GO:0006099"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "mt_space_DNA_gene",
+ "name": "mt_space_DNA_gene",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "GO:0000262"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Mt-tRNA_space_synthetase_complex",
+ "name": "Mt-tRNA_space_synthetase_complex",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P41250"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TRMT1",
+ "name": "TRMT1",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "Q9NXH9"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MT_space_tRNAs_complex",
+ "name": "MT_space_tRNAs_complex",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "A0A0C5B5G6"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp8",
+ "name": "Nsp8",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "ncbiprotein:YP_009742615"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "paraquat_simple_molecule",
+ "name": "paraquat_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "34905"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "O2_simple_molecule",
+ "name": "O2_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:15379"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "paraquat_space_dication_complex",
+ "name": "paraquat_space_dication_complex",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "34905"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CYCS_mitochondrial matrix",
+ "name": "CYCS_mitochondrial matrix",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "complex_space_4_complex",
+ "name": "complex_space_4_complex",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P00395"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp4_cell",
+ "name": "Nsp4_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "DNAJC11",
+ "name": "DNAJC11",
+ "grounding": {
+ "identifiers": {
+ "refseq": "NM_018198"
+ },
+ "context": {
+ "property": "uniprot:Q9NVH1"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp4:DNAJC11_complex",
+ "name": "Nsp4:DNAJC11_complex",
+ "grounding": {
+ "identifiers": {
+ "refseq": "NM_018198"
+ },
+ "context": {
+ "property": "ncbiprotein:BCD58761",
+ "property1": "taxonomy:2697049",
+ "property2": "uniprot:Q9NVH1"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "F-ATPase:Nsp6_complex",
+ "name": "F-ATPase:Nsp6_complex",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P03901"
+ },
+ "context": {
+ "property": "taxonomy:2697049"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "hydroxide_simple_molecule",
+ "name": "hydroxide_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "16234"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Fe2+_ion",
+ "name": "Fe2+_ion",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "29033"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "H2O2_simple_molecule",
+ "name": "H2O2_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Fe3+_ion",
+ "name": "Fe3+_ion",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "29034"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "superoxide_simple_molecule",
+ "name": "superoxide_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "1842"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TFAM",
+ "name": "TFAM",
+ "grounding": {
+ "identifiers": {
+ "refseq": "NM_003201"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MT_space_transcription_complex",
+ "name": "MT_space_transcription_complex",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "O00411"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "damaged_space_mt_space_DNA_gene",
+ "name": "damaged_space_mt_space_DNA_gene",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf9c",
+ "name": "Orf9c",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "ncbiprotein:AIA62288"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "H+_ion_mitochondrial matrix",
+ "name": "H+_ion_mitochondrial matrix",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SOD1",
+ "name": "SOD1",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P00441"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SOD2",
+ "name": "SOD2",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P04179"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "mt_space_DNA_space_replication_phenotype",
+ "name": "mt_space_DNA_space_replication_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Mt-DNA_space_repair_complex",
+ "name": "Mt-DNA_space_repair_complex",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P0DP91"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Mt-dNTP_space_pool_complex",
+ "name": "Mt-dNTP_space_pool_complex",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "O00142"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "mt_space_DNA_space_damage_phenotype",
+ "name": "mt_space_DNA_space_damage_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "glutathione_simple_molecule",
+ "name": "glutathione_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "16856"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "GPX4",
+ "name": "GPX4",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P36969"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "GPX1",
+ "name": "GPX1",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P07203"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CAT",
+ "name": "CAT",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P04040"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TXN2",
+ "name": "TXN2",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "Q99757"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PRDX_complex",
+ "name": "PRDX_complex",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P30041"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "H2O_simple_molecule",
+ "name": "H2O_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ubiquinol_simple_molecule_mitochondrial matrix",
+ "name": "ubiquinol_simple_molecule_mitochondrial matrix",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "17976"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ROS_simple_molecule",
+ "name": "ROS_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "26523"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NADPH_simple_molecule",
+ "name": "NADPH_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TXNRD2",
+ "name": "TXNRD2",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "Q9NNW7"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "glutathione_space_disulfide_simple_molecule",
+ "name": "glutathione_space_disulfide_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "58297"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "GSR",
+ "name": "GSR",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P00390"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NADP(+)_simple_molecule",
+ "name": "NADP(+)_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "HO_simple_molecule",
+ "name": "HO_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "49648"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ADP_simple_molecule",
+ "name": "ADP_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Pi_simple_molecule",
+ "name": "Pi_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ATP_simple_molecule",
+ "name": "ATP_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Mt_space_replication_complex",
+ "name": "Mt_space_replication_complex",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P54098"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TOM_space_complex_complex_mitochondrion",
+ "name": "TOM_space_complex_complex_mitochondrion",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "O94826"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TIM23_space_complex_complex",
+ "name": "TIM23_space_complex_complex",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "O14925"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf9b",
+ "name": "Orf9b",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "ncbiprotein:APO40587"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "precursor_space_protein_space_N-terminus_space_binding",
+ "name": "precursor_space_protein_space_N-terminus_space_binding",
+ "grounding": {
+ "identifiers": {
+ "GO": "0047485"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NAD+_simple_molecule",
+ "name": "NAD+_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "O2-_simple_molecule",
+ "name": "O2-_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "29356"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp7",
+ "name": "Nsp7",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "ncbiprotein:YP_009725303"
+ }
+ },
+ "initial": 3.0
+ }
+ ],
+ "edges": [
+ {
+ "id": "t1",
+ "source": "TIM_space_complex_complex",
+ "target": "TIM_space_complex:Nsp4_complex",
+ "sign": true
+ },
+ {
+ "id": "t2",
+ "source": "Nsp4_mitochondrion",
+ "target": "TIM_space_complex:Nsp4_complex",
+ "sign": true
+ },
+ {
+ "id": "t3",
+ "source": "Nsp6",
+ "target": "ATP_space_Synthase_complex",
+ "sign": true
+ },
+ {
+ "id": "t4",
+ "source": "H+_ion_mitochondrion",
+ "target": "ATP_space_Synthase_complex",
+ "sign": true
+ },
+ {
+ "id": "t5",
+ "source": "F-ATPase_complex_mitochondrial matrix",
+ "target": "ATP_space_Synthase_complex",
+ "sign": true
+ },
+ {
+ "id": "t6",
+ "source": "Mt_space_ribosomal_space_proteins_complex",
+ "target": "mtDNA_space_encoded_space_OXPHOS_space_units_complex_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t7",
+ "source": "mt_space_mRNA_rna",
+ "target": "mtDNA_space_encoded_space_OXPHOS_space_units_complex_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t8",
+ "source": "Mt_space_translation_complex",
+ "target": "mtDNA_space_encoded_space_OXPHOS_space_units_complex_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t9",
+ "source": "Nsp8-affected Mt ribosomal proteins_complex",
+ "target": "mtDNA_space_encoded_space_OXPHOS_space_units_complex_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t10",
+ "source": "mtDNA_space_encoded_space_OXPHOS_space_units_complex_mitochondrial matrix",
+ "target": "Complex_space_1_complex",
+ "sign": true
+ },
+ {
+ "id": "t11",
+ "source": "OXPHOS_space_factors_complex",
+ "target": "Complex_space_1_complex",
+ "sign": true
+ },
+ {
+ "id": "t12",
+ "source": "NDUFB9",
+ "target": "Complex_space_1_complex",
+ "sign": true
+ },
+ {
+ "id": "t13",
+ "source": "NADH_simple_molecule",
+ "target": "Complex_space_1_complex",
+ "sign": true
+ },
+ {
+ "id": "t14",
+ "source": "NDUFA1",
+ "target": "Complex_space_1_complex",
+ "sign": true
+ },
+ {
+ "id": "t15",
+ "source": "ATP5MG",
+ "target": "F-ATPase_complex_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t16",
+ "source": "F-ATPase_complex_mitochondrial matrix",
+ "target": "F-ATPase_complex_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t17",
+ "source": "NDUFAF7",
+ "target": "OXPHOS_space_factors_complex",
+ "sign": true
+ },
+ {
+ "id": "t18",
+ "source": "ECSIT",
+ "target": "OXPHOS_space_factors_complex",
+ "sign": true
+ },
+ {
+ "id": "t19",
+ "source": "ACAD9",
+ "target": "OXPHOS_space_factors_complex",
+ "sign": true
+ },
+ {
+ "id": "t20",
+ "source": "Complex_space_1_complex",
+ "target": "complex_space_2_complex_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t21",
+ "source": "SIRT3",
+ "target": "complex_space_2_complex_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t22",
+ "source": "OXPHOS_space_factors_complex",
+ "target": "complex_space_2_complex_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t23",
+ "source": "Q_simple_molecule_mitochondrial matrix",
+ "target": "complex_space_2_complex_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t24",
+ "source": "Complex_space_1_complex",
+ "target": "complex_space_3_complex",
+ "sign": true
+ },
+ {
+ "id": "t25",
+ "source": "OXPHOS_space_factors_complex",
+ "target": "complex_space_3_complex",
+ "sign": true
+ },
+ {
+ "id": "t26",
+ "source": "Q_simple_molecule_mitochondrial matrix",
+ "target": "complex_space_3_complex",
+ "sign": true
+ },
+ {
+ "id": "t27",
+ "source": "mtDNA_space_encoded_space_OXPHOS_space_units_complex_mitochondrial matrix",
+ "target": "complex_space_3_complex",
+ "sign": true
+ },
+ {
+ "id": "t28",
+ "source": "TCA_phenotype",
+ "target": "complex_space_2_complex_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t29",
+ "source": "Mt-tRNA_space_synthetase_complex",
+ "target": "MT_space_tRNAs_complex",
+ "sign": true
+ },
+ {
+ "id": "t30",
+ "source": "mt_space_DNA_gene",
+ "target": "MT_space_tRNAs_complex",
+ "sign": true
+ },
+ {
+ "id": "t31",
+ "source": "TRMT1",
+ "target": "MT_space_tRNAs_complex",
+ "sign": true
+ },
+ {
+ "id": "t32",
+ "source": "Nsp8",
+ "target": "Nsp8",
+ "sign": false
+ },
+ {
+ "id": "t33",
+ "source": "O2_simple_molecule",
+ "target": "paraquat_space_dication_complex",
+ "sign": true
+ },
+ {
+ "id": "t34",
+ "source": "paraquat_simple_molecule",
+ "target": "paraquat_space_dication_complex",
+ "sign": true
+ },
+ {
+ "id": "t35",
+ "source": "complex_space_3_complex",
+ "target": "complex_space_4_complex",
+ "sign": true
+ },
+ {
+ "id": "t36",
+ "source": "CYCS_mitochondrial matrix",
+ "target": "complex_space_4_complex",
+ "sign": true
+ },
+ {
+ "id": "t37",
+ "source": "OXPHOS_space_factors_complex",
+ "target": "complex_space_4_complex",
+ "sign": true
+ },
+ {
+ "id": "t38",
+ "source": "mtDNA_space_encoded_space_OXPHOS_space_units_complex_mitochondrial matrix",
+ "target": "complex_space_4_complex",
+ "sign": true
+ },
+ {
+ "id": "t39",
+ "source": "Nsp4_cell",
+ "target": "Nsp4:DNAJC11_complex",
+ "sign": true
+ },
+ {
+ "id": "t40",
+ "source": "DNAJC11",
+ "target": "Nsp4:DNAJC11_complex",
+ "sign": true
+ },
+ {
+ "id": "t41",
+ "source": "ATP5MG",
+ "target": "F-ATPase:Nsp6_complex",
+ "sign": true
+ },
+ {
+ "id": "t42",
+ "source": "Nsp6",
+ "target": "F-ATPase:Nsp6_complex",
+ "sign": true
+ },
+ {
+ "id": "t43",
+ "source": "Fe2+_ion",
+ "target": "Fe3+_ion",
+ "sign": true
+ },
+ {
+ "id": "t44",
+ "source": "H2O2_simple_molecule",
+ "target": "Fe3+_ion",
+ "sign": true
+ },
+ {
+ "id": "t45",
+ "source": "hydroxide_simple_molecule",
+ "target": "Fe3+_ion",
+ "sign": true
+ },
+ {
+ "id": "t46",
+ "source": "superoxide_simple_molecule",
+ "target": "paraquat_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t47",
+ "source": "Complex_space_1_complex",
+ "target": "paraquat_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t48",
+ "source": "paraquat_space_dication_complex",
+ "target": "paraquat_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t49",
+ "source": "MT_space_transcription_complex",
+ "target": "mt_space_mRNA_rna",
+ "sign": true
+ },
+ {
+ "id": "t50",
+ "source": "TFAM",
+ "target": "mt_space_mRNA_rna",
+ "sign": true
+ },
+ {
+ "id": "t51",
+ "source": "damaged_space_mt_space_DNA_gene",
+ "target": "mt_space_mRNA_rna",
+ "sign": true
+ },
+ {
+ "id": "t52",
+ "source": "mt_space_DNA_gene",
+ "target": "mt_space_mRNA_rna",
+ "sign": true
+ },
+ {
+ "id": "t53",
+ "source": "Orf9c",
+ "target": "Orf9c",
+ "sign": false
+ },
+ {
+ "id": "t54",
+ "source": "superoxide_simple_molecule",
+ "target": "H2O2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t55",
+ "source": "SOD2",
+ "target": "H2O2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t56",
+ "source": "SOD1",
+ "target": "H2O2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t57",
+ "source": "H+_ion_mitochondrial matrix",
+ "target": "H2O2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t58",
+ "source": "H2O2_simple_molecule",
+ "target": "H+_ion_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t59",
+ "source": "hydroxide_simple_molecule",
+ "target": "H+_ion_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t60",
+ "source": "ATP_space_Synthase_complex",
+ "target": "H+_ion_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t61",
+ "source": "Fe3+_ion",
+ "target": "H+_ion_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t62",
+ "source": "superoxide_simple_molecule",
+ "target": "H+_ion_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t63",
+ "source": "NADH_simple_molecule",
+ "target": "H+_ion_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t64",
+ "source": "Complex_space_1_complex",
+ "target": "H+_ion_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t65",
+ "source": "TFAM",
+ "target": "mt_space_DNA_gene",
+ "sign": true
+ },
+ {
+ "id": "t66",
+ "source": "Mt-DNA_space_repair_complex",
+ "target": "mt_space_DNA_gene",
+ "sign": true
+ },
+ {
+ "id": "t67",
+ "source": "mt_space_DNA_space_replication_phenotype",
+ "target": "mt_space_DNA_gene",
+ "sign": true
+ },
+ {
+ "id": "t68",
+ "source": "damaged_space_mt_space_DNA_gene",
+ "target": "mt_space_DNA_gene",
+ "sign": true
+ },
+ {
+ "id": "t69",
+ "source": "Mt-dNTP_space_pool_complex",
+ "target": "mt_space_DNA_gene",
+ "sign": true
+ },
+ {
+ "id": "t70",
+ "source": "mt_space_DNA_space_damage_phenotype",
+ "target": "mt_space_DNA_gene",
+ "sign": true
+ },
+ {
+ "id": "t71",
+ "source": "superoxide_simple_molecule",
+ "target": "Fe2+_ion",
+ "sign": true
+ },
+ {
+ "id": "t72",
+ "source": "Fe3+_ion",
+ "target": "Fe2+_ion",
+ "sign": true
+ },
+ {
+ "id": "t73",
+ "source": "TXN2",
+ "target": "H2O_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t74",
+ "source": "PRDX_complex",
+ "target": "H2O_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t75",
+ "source": "GPX1",
+ "target": "H2O_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t76",
+ "source": "H2O2_simple_molecule",
+ "target": "H2O_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t77",
+ "source": "hydroxide_simple_molecule",
+ "target": "H2O_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t78",
+ "source": "glutathione_simple_molecule",
+ "target": "H2O_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t79",
+ "source": "GPX4",
+ "target": "H2O_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t80",
+ "source": "CAT",
+ "target": "H2O_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t81",
+ "source": "O2_simple_molecule",
+ "target": "Q_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t82",
+ "source": "H+_ion_mitochondrial matrix",
+ "target": "Q_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t83",
+ "source": "ubiquinol_simple_molecule_mitochondrial matrix",
+ "target": "Q_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t84",
+ "source": "complex_space_3_complex",
+ "target": "Q_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t85",
+ "source": "CYCS_mitochondrial matrix",
+ "target": "Q_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t86",
+ "source": "superoxide_simple_molecule",
+ "target": "ROS_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t87",
+ "source": "H2O2_simple_molecule",
+ "target": "ROS_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t88",
+ "source": "hydroxide_simple_molecule",
+ "target": "ROS_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t89",
+ "source": "TXNRD2",
+ "target": "TXN2",
+ "sign": true
+ },
+ {
+ "id": "t90",
+ "source": "NADPH_simple_molecule",
+ "target": "TXN2",
+ "sign": true
+ },
+ {
+ "id": "t91",
+ "source": "H2O2_simple_molecule",
+ "target": "TXN2",
+ "sign": true
+ },
+ {
+ "id": "t92",
+ "source": "PRDX_complex",
+ "target": "TXN2",
+ "sign": true
+ },
+ {
+ "id": "t93",
+ "source": "TXN2",
+ "target": "NADP(+)_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t94",
+ "source": "glutathione_space_disulfide_simple_molecule",
+ "target": "NADP(+)_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t95",
+ "source": "NADPH_simple_molecule",
+ "target": "NADP(+)_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t96",
+ "source": "TXNRD2",
+ "target": "NADP(+)_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t97",
+ "source": "GSR",
+ "target": "NADP(+)_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t98",
+ "source": "Fe2+_ion",
+ "target": "HO_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t99",
+ "source": "H2O2_simple_molecule",
+ "target": "HO_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t100",
+ "source": "hydroxide_simple_molecule",
+ "target": "HO_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t101",
+ "source": "superoxide_simple_molecule",
+ "target": "O2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t102",
+ "source": "Fe3+_ion",
+ "target": "O2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t103",
+ "source": "O2_simple_molecule",
+ "target": "H+_ion_mitochondrion",
+ "sign": true
+ },
+ {
+ "id": "t104",
+ "source": "H+_ion_mitochondrial matrix",
+ "target": "H+_ion_mitochondrion",
+ "sign": true
+ },
+ {
+ "id": "t105",
+ "source": "ubiquinol_simple_molecule_mitochondrial matrix",
+ "target": "H+_ion_mitochondrion",
+ "sign": true
+ },
+ {
+ "id": "t106",
+ "source": "complex_space_3_complex",
+ "target": "H+_ion_mitochondrion",
+ "sign": true
+ },
+ {
+ "id": "t107",
+ "source": "CYCS_mitochondrial matrix",
+ "target": "H+_ion_mitochondrion",
+ "sign": true
+ },
+ {
+ "id": "t108",
+ "source": "Complex_space_1_complex",
+ "target": "H+_ion_mitochondrion",
+ "sign": true
+ },
+ {
+ "id": "t109",
+ "source": "O2_simple_molecule",
+ "target": "superoxide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t110",
+ "source": "H2O2_simple_molecule",
+ "target": "superoxide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t111",
+ "source": "hydroxide_simple_molecule",
+ "target": "superoxide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t112",
+ "source": "paraquat_simple_molecule",
+ "target": "superoxide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t113",
+ "source": "Orf9c",
+ "target": "Orf9c",
+ "sign": false
+ },
+ {
+ "id": "t114",
+ "source": "mt_space_DNA_space_damage_phenotype",
+ "target": "damaged_space_mt_space_DNA_gene",
+ "sign": true
+ },
+ {
+ "id": "t115",
+ "source": "mt_space_DNA_gene",
+ "target": "damaged_space_mt_space_DNA_gene",
+ "sign": true
+ },
+ {
+ "id": "t116",
+ "source": "Fe2+_ion",
+ "target": "hydroxide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t117",
+ "source": "H2O2_simple_molecule",
+ "target": "hydroxide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t118",
+ "source": "H+_ion_mitochondrial matrix",
+ "target": "ATP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t119",
+ "source": "ADP_simple_molecule",
+ "target": "ATP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t120",
+ "source": "Pi_simple_molecule",
+ "target": "ATP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t121",
+ "source": "ATP_space_Synthase_complex",
+ "target": "ATP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t122",
+ "source": "Complex_space_1_complex",
+ "target": "ubiquinol_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t123",
+ "source": "complex_space_2_complex_mitochondrial matrix",
+ "target": "ubiquinol_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t124",
+ "source": "Q_simple_molecule_mitochondrial matrix",
+ "target": "ubiquinol_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t125",
+ "source": "Mt-dNTP_space_pool_complex",
+ "target": "mt_space_DNA_space_replication_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t126",
+ "source": "TFAM",
+ "target": "mt_space_DNA_space_replication_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t127",
+ "source": "Mt_space_replication_complex",
+ "target": "mt_space_DNA_space_replication_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t128",
+ "source": "glutathione_space_disulfide_simple_molecule",
+ "target": "glutathione_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t129",
+ "source": "NADPH_simple_molecule",
+ "target": "glutathione_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t130",
+ "source": "GSR",
+ "target": "glutathione_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t131",
+ "source": "Orf9c",
+ "target": "Orf9c",
+ "sign": false
+ },
+ {
+ "id": "t132",
+ "source": "H2O2_simple_molecule",
+ "target": "glutathione_space_disulfide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t133",
+ "source": "glutathione_simple_molecule",
+ "target": "glutathione_space_disulfide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t134",
+ "source": "GPX4",
+ "target": "glutathione_space_disulfide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t135",
+ "source": "GPX1",
+ "target": "glutathione_space_disulfide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t136",
+ "source": "TOM_space_complex_complex_mitochondrion",
+ "target": "precursor_space_protein_space_N-terminus_space_binding",
+ "sign": true
+ },
+ {
+ "id": "t137",
+ "source": "TIM23_space_complex_complex",
+ "target": "precursor_space_protein_space_N-terminus_space_binding",
+ "sign": true
+ },
+ {
+ "id": "t138",
+ "source": "TIM_space_complex:Nsp4_complex",
+ "target": "precursor_space_protein_space_N-terminus_space_binding",
+ "sign": true
+ },
+ {
+ "id": "t139",
+ "source": "TIM_space_complex_complex",
+ "target": "precursor_space_protein_space_N-terminus_space_binding",
+ "sign": true
+ },
+ {
+ "id": "t140",
+ "source": "Orf9b",
+ "target": "precursor_space_protein_space_N-terminus_space_binding",
+ "sign": true
+ },
+ {
+ "id": "t141",
+ "source": "Orf9c",
+ "target": "Orf9c",
+ "sign": false
+ },
+ {
+ "id": "t142",
+ "source": "SIRT3",
+ "target": "SOD2",
+ "sign": true
+ },
+ {
+ "id": "t143",
+ "source": "NADH_simple_molecule",
+ "target": "NAD+_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t144",
+ "source": "Complex_space_1_complex",
+ "target": "NAD+_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t145",
+ "source": "O2_simple_molecule",
+ "target": "O2-_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t146",
+ "source": "H+_ion_mitochondrial matrix",
+ "target": "O2-_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t147",
+ "source": "ubiquinol_simple_molecule_mitochondrial matrix",
+ "target": "O2-_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t148",
+ "source": "complex_space_3_complex",
+ "target": "O2-_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t149",
+ "source": "CYCS_mitochondrial matrix",
+ "target": "O2-_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t150",
+ "source": "Nsp7",
+ "target": "Nsp7",
+ "sign": false
+ },
+ {
+ "id": "t151",
+ "source": "Nsp4_cell",
+ "target": "Nsp4_mitochondrion",
+ "sign": true
+ },
+ {
+ "id": "t152",
+ "source": "TOM_space_complex_complex_mitochondrion",
+ "target": "Nsp4_mitochondrion",
+ "sign": true
+ },
+ {
+ "id": "t153",
+ "source": "complex_space_3_complex",
+ "target": "CYCS_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t154",
+ "source": "H+_ion_mitochondrial matrix",
+ "target": "CYCS_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t155",
+ "source": "O2_simple_molecule",
+ "target": "CYCS_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t156",
+ "source": "ubiquinol_simple_molecule_mitochondrial matrix",
+ "target": "CYCS_mitochondrial matrix",
+ "sign": true
+ }
+ ],
+ "parameters": []
+ },
+ "semantics": {
+ "ode": {
+ "rates": [],
+ "observables": [],
+ "time": {
+ "id": "t"
+ }
+ }
+ },
+ "metadata": {
+ "annotations": {}
+ }
+}
\ No newline at end of file
diff --git a/scripts/covid19_diseasemaps/regnet_amr_sbml/E_protein.json b/scripts/covid19_diseasemaps/regnet_amr_sbml/E_protein.json
new file mode 100644
index 000000000..bea08f12a
--- /dev/null
+++ b/scripts/covid19_diseasemaps/regnet_amr_sbml/E_protein.json
@@ -0,0 +1,561 @@
+{
+ "header": {
+ "name": "Model",
+ "schema": "https://raw.githubusercontent.com/DARPA-ASKEM/Model-Representations/regnet_v0.2/regnet/regnet_schema.json",
+ "schema_name": "regnet",
+ "description": "Model",
+ "model_version": "0.1"
+ },
+ "model": {
+ "vertices": [
+ {
+ "id": "histone_complex_nucleus",
+ "name": "histone_complex_nucleus",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "BRD4",
+ "name": "BRD4",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "BRD2",
+ "name": "BRD2",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "H4C14",
+ "name": "H4C14",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "H4-16",
+ "name": "H4-16",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "H4C1",
+ "name": "H4C1",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "H3C15",
+ "name": "H3C15",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "H3C1",
+ "name": "H3C1",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "H4C9",
+ "name": "H4C9",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "H2BC21",
+ "name": "H2BC21",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "H2A",
+ "name": "H2A",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MPP5",
+ "name": "MPP5",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0,
+ "sign": true
+ },
+ {
+ "id": "CRB3",
+ "name": "CRB3",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0,
+ "sign": true
+ },
+ {
+ "id": "PATJ",
+ "name": "PATJ",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0,
+ "sign": true
+ },
+ {
+ "id": "CRB3:PALS1:PATJ complex_complex",
+ "name": "CRB3:PALS1:PATJ complex_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ASIC1",
+ "name": "ASIC1",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "STOML3",
+ "name": "STOML3",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "E_cell",
+ "name": "E_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "ncbiprotein:BCD58755"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ASIC1 trimer:H+:STOML3_complex",
+ "name": "ASIC1 trimer:H+:STOML3_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "E-PALS1_complex",
+ "name": "E-PALS1_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CDK9",
+ "name": "CDK9",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CCNT1",
+ "name": "CCNT1",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "P-TEFb_complex",
+ "name": "P-TEFb_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "E_nucleus",
+ "name": "E_nucleus",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TBP",
+ "name": "TBP",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "JQ-1_simple_molecule",
+ "name": "JQ-1_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "H+_ion",
+ "name": "H+_ion",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ATP1A:ATP1B:FXYDs_complex",
+ "name": "ATP1A:ATP1B:FXYDs_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "K+_ion",
+ "name": "K+_ion",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Na+_ion",
+ "name": "Na+_ion",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Activity of sodium channels_phenotype",
+ "name": "Activity of sodium channels_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Maintenance of tight junction_phenotype",
+ "name": "Maintenance of tight junction_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "RNA Polymerase II-dependent Transcription _phenotype",
+ "name": "RNA Polymerase II-dependent Transcription _phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Chromatin organization_phenotype",
+ "name": "Chromatin organization_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ }
+ ],
+ "edges": [
+ {
+ "id": "t1",
+ "source": "BRD4",
+ "target": "histone_complex_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t2",
+ "source": "BRD2",
+ "target": "histone_complex_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t3",
+ "source": "H4-16",
+ "target": "histone_complex_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t4",
+ "source": "H2BC21",
+ "target": "histone_complex_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t5",
+ "source": "H4C1",
+ "target": "histone_complex_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t6",
+ "source": "H4C14",
+ "target": "histone_complex_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t7",
+ "source": "H4C9",
+ "target": "histone_complex_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t8",
+ "source": "H3C1",
+ "target": "histone_complex_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t9",
+ "source": "H3C15",
+ "target": "histone_complex_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t10",
+ "source": "H2A",
+ "target": "histone_complex_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t11",
+ "source": "PATJ",
+ "target": "CRB3:PALS1:PATJ complex_complex",
+ "sign": true
+ },
+ {
+ "id": "t12",
+ "source": "CRB3",
+ "target": "CRB3:PALS1:PATJ complex_complex",
+ "sign": true
+ },
+ {
+ "id": "t13",
+ "source": "MPP5",
+ "target": "CRB3:PALS1:PATJ complex_complex",
+ "sign": true
+ },
+ {
+ "id": "t14",
+ "source": "ASIC1",
+ "target": "ASIC1 trimer:H+:STOML3_complex",
+ "sign": true
+ },
+ {
+ "id": "t15",
+ "source": "STOML3",
+ "target": "ASIC1 trimer:H+:STOML3_complex",
+ "sign": true
+ },
+ {
+ "id": "t16",
+ "source": "E_cell",
+ "target": "ASIC1 trimer:H+:STOML3_complex",
+ "sign": true
+ },
+ {
+ "id": "t17",
+ "source": "E_cell",
+ "target": "E_cell",
+ "sign": false
+ },
+ {
+ "id": "t18",
+ "source": "E_cell",
+ "target": "E-PALS1_complex",
+ "sign": true
+ },
+ {
+ "id": "t19",
+ "source": "MPP5",
+ "target": "E-PALS1_complex",
+ "sign": true
+ },
+ {
+ "id": "t20",
+ "source": "CDK9",
+ "target": "P-TEFb_complex",
+ "sign": true
+ },
+ {
+ "id": "t21",
+ "source": "CCNT1",
+ "target": "P-TEFb_complex",
+ "sign": true
+ },
+ {
+ "id": "t22",
+ "source": "BRD4",
+ "target": "CDK9",
+ "sign": true
+ },
+ {
+ "id": "t23",
+ "source": "BRD4",
+ "target": "CCNT1",
+ "sign": true
+ },
+ {
+ "id": "t24",
+ "source": "E_nucleus",
+ "target": "BRD4",
+ "sign": true
+ },
+ {
+ "id": "t25",
+ "source": "BRD2",
+ "target": "TBP",
+ "sign": true
+ },
+ {
+ "id": "t26",
+ "source": "E_nucleus",
+ "target": "BRD2",
+ "sign": true
+ },
+ {
+ "id": "t27",
+ "source": "JQ-1_simple_molecule",
+ "target": "BRD2",
+ "sign": true
+ },
+ {
+ "id": "t28",
+ "source": "H+_ion",
+ "target": "ASIC1",
+ "sign": true
+ },
+ {
+ "id": "t29",
+ "source": "ATP1A:ATP1B:FXYDs_complex",
+ "target": "K+_ion",
+ "sign": true
+ },
+ {
+ "id": "t30",
+ "source": "ATP1A:ATP1B:FXYDs_complex",
+ "target": "Na+_ion",
+ "sign": true
+ },
+ {
+ "id": "t31",
+ "source": "ASIC1 trimer:H+:STOML3_complex",
+ "target": "Activity of sodium channels_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t32",
+ "source": "STOML3",
+ "target": "Activity of sodium channels_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t33",
+ "source": "ATP1A:ATP1B:FXYDs_complex",
+ "target": "Activity of sodium channels_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t34",
+ "source": "CRB3:PALS1:PATJ complex_complex",
+ "target": "Maintenance of tight junction_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t35",
+ "source": "E-PALS1_complex",
+ "target": "Maintenance of tight junction_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t36",
+ "source": "P-TEFb_complex",
+ "target": "RNA Polymerase II-dependent Transcription _phenotype",
+ "sign": true
+ },
+ {
+ "id": "t37",
+ "source": "histone_complex_nucleus",
+ "target": "Chromatin organization_phenotype",
+ "sign": true
+ }
+ ],
+ "parameters": []
+ },
+ "semantics": {
+ "ode": {
+ "rates": [],
+ "observables": [],
+ "time": {
+ "id": "t"
+ }
+ }
+ },
+ "metadata": {
+ "annotations": {}
+ }
+}
\ No newline at end of file
diff --git a/scripts/covid19_diseasemaps/regnet_amr_sbml/HMOX1_Pathway.json b/scripts/covid19_diseasemaps/regnet_amr_sbml/HMOX1_Pathway.json
new file mode 100644
index 000000000..5689054f9
--- /dev/null
+++ b/scripts/covid19_diseasemaps/regnet_amr_sbml/HMOX1_Pathway.json
@@ -0,0 +1,3147 @@
+{
+ "header": {
+ "name": "Model",
+ "schema": "https://raw.githubusercontent.com/DARPA-ASKEM/Model-Representations/regnet_v0.2/regnet/regnet_schema.json",
+ "schema_name": "regnet",
+ "description": "Model",
+ "model_version": "0.1"
+ },
+ "model": {
+ "vertices": [
+ {
+ "id": "NRF2_phosphorylated_nucleus",
+ "name": "NRF2_phosphorylated_nucleus",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:Q16236"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MAF",
+ "name": "MAF",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:O75444"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nrf2/Maf_complex",
+ "name": "Nrf2/Maf_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "BACH1",
+ "name": "BACH1",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "ncbigene:571",
+ "property1": "uniprot:O14867"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "BACH1/Maf_complex",
+ "name": "BACH1/Maf_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "E2_ubiquitinated",
+ "name": "E2_ubiquitinated",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "interpro:IPR000608"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Ubiquitin Ligase Complex_complex_cell",
+ "name": "Ubiquitin Ligase Complex_complex_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P62877",
+ "property1": "uniprot:Q13618",
+ "property2": "uniprot:Q14145",
+ "property3": "uniprot:Q15843",
+ "property4": "uniprot:Q16236"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Ubiquitin Ligase Complex_complex_cell",
+ "name": "Ubiquitin Ligase Complex_complex_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "interpro:IPR000608",
+ "property1": "uniprot:P62877",
+ "property2": "uniprot:Q13618",
+ "property3": "uniprot:Q14145",
+ "property4": "uniprot:Q15843",
+ "property5": "uniprot:Q16236"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Ubiquitin Ligase Complex_complex_cell",
+ "name": "Ubiquitin Ligase Complex_complex_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "interpro:IPR000608",
+ "property1": "uniprot:P0CG48",
+ "property2": "uniprot:P62877",
+ "property3": "uniprot:Q13618",
+ "property4": "uniprot:Q14145",
+ "property5": "uniprot:Q15843",
+ "property6": "uniprot:Q16236"
+ }
+ },
+ "initial": 3.0,
+ "sign": true
+ },
+ {
+ "id": "NRF2_empty",
+ "name": "NRF2_empty",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:Q16236"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "KEAP1",
+ "name": "KEAP1",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:Q14145"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Dimethly fumarate_drug",
+ "name": "Dimethly fumarate_drug",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:76004"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NRF2:KEAP1_complex",
+ "name": "NRF2:KEAP1_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:Q14145",
+ "property1": "uniprot:Q16236"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CUL3:RBX1_complex",
+ "name": "CUL3:RBX1_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P62877",
+ "property1": "uniprot:Q13618"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Neddylated CUL3:RBX1_complex",
+ "name": "Neddylated CUL3:RBX1_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P62877",
+ "property1": "uniprot:Q13618",
+ "property2": "uniprot:Q15843"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SLC40A1_rna",
+ "name": "SLC40A1_rna",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "ncbigene:30061",
+ "property1": "ncbigene:30061"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SLC40A1:CP:Cu2+_complex",
+ "name": "SLC40A1:CP:Cu2+_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:29036",
+ "property1": "uniprot:P00450",
+ "property2": "uniprot:Q9NP59"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CAND1",
+ "name": "CAND1",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:Q86VP6"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Fe3+_ion_default_compartment",
+ "name": "Fe3+_ion_default_compartment",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:29034"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Transferrin",
+ "name": "Transferrin",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P02787"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "holoTF_complex",
+ "name": "holoTF_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:29034",
+ "property1": "uniprot:P02787"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TFRC",
+ "name": "TFRC",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P02786"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TFRC:holoTF_complex_cell",
+ "name": "TFRC:holoTF_complex_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:29034",
+ "property1": "uniprot:P02786",
+ "property2": "uniprot:P02787"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TFRC:holoTF_complex_endosome",
+ "name": "TFRC:holoTF_complex_endosome",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:29034",
+ "property1": "uniprot:P02786",
+ "property2": "uniprot:P02787"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TFRC:TF_complex_endosome",
+ "name": "TFRC:TF_complex_endosome",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P02786",
+ "property1": "uniprot:P02787"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TFRC:TF_complex_cell",
+ "name": "TFRC:TF_complex_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P02786",
+ "property1": "uniprot:P02787"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NLRP3_cell",
+ "name": "NLRP3_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:Q96P20"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TXNIP",
+ "name": "TXNIP",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:Q9H3M7"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TXNIP:NLRP3_complex",
+ "name": "TXNIP:NLRP3_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:Q96P20",
+ "property1": "uniprot:Q9H3M7"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SUGT1:HSP90AB1_complex",
+ "name": "SUGT1:HSP90AB1_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P08238",
+ "property1": "uniprot:P08238",
+ "property2": "uniprot:Q9Y2Z0",
+ "property3": "uniprot:Q9Y2Z0"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NLRP3:SUGT1:HSP90_complex",
+ "name": "NLRP3:SUGT1:HSP90_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P08238",
+ "property1": "uniprot:Q96P20",
+ "property2": "uniprot:Q9Y2Z0"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "BLVRA_rna",
+ "name": "BLVRA_rna",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "ncbigene:644",
+ "property1": "ncbigene:644"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "BLVRA:Zn2+_complex",
+ "name": "BLVRA:Zn2+_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:29805",
+ "property1": "uniprot:P53004"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TXN_cell",
+ "name": "TXN_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P10599"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Thioredoxin:TXNIP_complex",
+ "name": "Thioredoxin:TXNIP_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P10599",
+ "property1": "uniprot:Q9H3M7"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Pyrin trimer_complex",
+ "name": "Pyrin trimer_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:O15553"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PSTPIP1",
+ "name": "PSTPIP1",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:O43586"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PSTPIP1 trimer:Pyrin trimer_complex",
+ "name": "PSTPIP1 trimer:Pyrin trimer_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:O15553",
+ "property1": "uniprot:O43586"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NLRP3_cell_active",
+ "name": "NLRP3_cell_active",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ASC",
+ "name": "ASC",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:Q9ULZ3"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NLRP3 oligomer:ASC:Caspase1_complex",
+ "name": "NLRP3 oligomer:ASC:Caspase1_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P29466",
+ "property1": "uniprot:Q9ULZ3"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CTSG",
+ "name": "CTSG",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P08311"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NLRP3 oligomer:ASC_complex",
+ "name": "NLRP3 oligomer:ASC_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:36080",
+ "property1": "uniprot:Q9ULZ3"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Pyrin trimer:ASC_complex",
+ "name": "Pyrin trimer:ASC_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:O15553",
+ "property1": "uniprot:Q9ULZ3"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CASP1_cell",
+ "name": "CASP1_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P29466"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "FTH1_rna",
+ "name": "FTH1_rna",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "ncbigene:2495",
+ "property1": "ncbigene:2495"
+ }
+ },
+ "initial": 3.0
+ },
+ {
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+ },
+ {
+ "id": "Ferritin_complex",
+ "name": "Ferritin_complex",
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+ }
+ },
+ "initial": 3.0
+ },
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+ }
+ },
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+ },
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+ },
+ {
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+ "name": "ALB/BIL_complex",
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+ "property1": "uniprot:P02768"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CASP1(120-197):CASP1(317-404)_complex",
+ "name": "CASP1(120-197):CASP1(317-404)_complex",
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+ "property1": "uniprot:P29466"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Caspase-1 Tetramer_complex",
+ "name": "Caspase-1 Tetramer_complex",
+ "grounding": {
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+ "context": {
+ "property": "uniprot:P29466",
+ "property1": "uniprot:P29466"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Heme_simple_molecule_mitochondrial matrix",
+ "name": "Heme_simple_molecule_mitochondrial matrix",
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+ }
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+ },
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+ {
+ "id": "Heme_simple_molecule_cell",
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+ }
+ },
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+ },
+ {
+ "id": "O2_simple_molecule_cell",
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+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NADPH_simple_molecule",
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+ }
+ },
+ "initial": 3.0
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+ "id": "HMOX1_cell_active",
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+ },
+ {
+ "id": "Biliverdin_simple_molecule",
+ "name": "Biliverdin_simple_molecule",
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+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PRIN9_simple_molecule_mitochondrial matrix",
+ "name": "PRIN9_simple_molecule_mitochondrial matrix",
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+ },
+ {
+ "id": "Fe2+_ion_mitochondrial matrix",
+ "name": "Fe2+_ion_mitochondrial matrix",
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+ },
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+ {
+ "id": "FECH",
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+ {
+ "id": "Pb2+_ion",
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+ },
+ "initial": 3.0
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+ {
+ "id": "dALA_simple_molecule_cell",
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+ },
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+ },
+ {
+ "id": "ALAD:Zn2+_complex",
+ "name": "ALAD:Zn2+_complex",
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+ "property1": "uniprot:P13716"
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+ },
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+ },
+ {
+ "id": "H2O_simple_molecule_cell",
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+ }
+ },
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+ },
+ {
+ "id": "BLVRB",
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+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NADP+_simple_molecule",
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+ }
+ },
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+ "id": "Fe2+_ion_default_compartment",
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+ {
+ "id": "SLC11A2",
+ "name": "SLC11A2",
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+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Fe2+_ion_cell",
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+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Fe2+_ion_endosome",
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+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MCOLN1",
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+ },
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+ },
+ {
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+ "property1": "ncbigene:3162"
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+ },
+ {
+ "id": "HMOX1_cell",
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+ }
+ },
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+ },
+ {
+ "id": "CO_simple_molecule",
+ "name": "CO_simple_molecule",
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+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Bilirubin_simple_molecule_cell",
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+ {
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+ "property1": "ncbigene:645"
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+ },
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+ {
+ "id": "ABCC1",
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+ },
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+ {
+ "id": "ORF9c",
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+ },
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+ {
+ "id": "NRF2_phosphorylated_cell",
+ "name": "NRF2_phosphorylated_cell",
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+ }
+ },
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+ },
+ {
+ "id": "miRNA-155_rna",
+ "name": "miRNA-155_rna",
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+ },
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+ {
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+ {
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+ {
+ "id": "SUCC-CoA_simple_molecule",
+ "name": "SUCC-CoA_simple_molecule",
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+ }
+ },
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+ },
+ {
+ "id": "Gly_simple_molecule",
+ "name": "Gly_simple_molecule",
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+ },
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+ {
+ "id": "ALAS1:ALAS2_complex",
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+ "initial": 3.0
+ },
+ {
+ "id": "Panhematin_drug",
+ "name": "Panhematin_drug",
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+ }
+ },
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+ "id": "dALA_simple_molecule_mitochondrial matrix",
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+ {
+ "id": "CO2_simple_molecule_mitochondrial matrix",
+ "name": "CO2_simple_molecule_mitochondrial matrix",
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+ {
+ "id": "CoA-SH_simple_molecule",
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+ }
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+ {
+ "id": "PBG_simple_molecule",
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+ }
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+ {
+ "id": "HMBS:DIPY_complex",
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+ "property1": "uniprot:P08397"
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+ {
+ "id": "HMBL_simple_molecule",
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+ }
+ },
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+ {
+ "id": "NH4+_ion",
+ "name": "NH4+_ion",
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+ }
+ },
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+ {
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+ },
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+ },
+ {
+ "id": "URO3_simple_molecule",
+ "name": "URO3_simple_molecule",
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+ }
+ },
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+ {
+ "id": "UROD",
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+ },
+ "initial": 3.0
+ },
+ {
+ "id": "COPRO3_simple_molecule_cell",
+ "name": "COPRO3_simple_molecule_cell",
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+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "COPRO3_simple_molecule_mitochondrion",
+ "name": "COPRO3_simple_molecule_mitochondrion",
+ "grounding": {
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+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "O2_simple_molecule_mitochondrion",
+ "name": "O2_simple_molecule_mitochondrion",
+ "grounding": {
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+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CPOX",
+ "name": "CPOX",
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+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PPGEN9_simple_molecule",
+ "name": "PPGEN9_simple_molecule",
+ "grounding": {
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+ "context": {
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+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PPO:FAD_complex",
+ "name": "PPO:FAD_complex",
+ "grounding": {
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+ "property1": "uniprot:P50336"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CO2_simple_molecule_mitochondrion",
+ "name": "CO2_simple_molecule_mitochondrion",
+ "grounding": {
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+ "context": {
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+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "H2O2_simple_molecule",
+ "name": "H2O2_simple_molecule",
+ "grounding": {
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+ "context": {
+ "property": "CHEBI:16240"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Lipid Peroxide_simple_molecule",
+ "name": "Lipid Peroxide_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:61051"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Ferroptosis_phenotype",
+ "name": "Ferroptosis_phenotype",
+ "grounding": {
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+ "context": {
+ "property": "GO:0097707"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Poly-unsaturated fatty acid_simple_molecule",
+ "name": "Poly-unsaturated fatty acid_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:26208"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Reactive Oxygen Species_simple_molecule",
+ "name": "Reactive Oxygen Species_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:26523"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SLC40A1:HEPH:Cu2+_complex",
+ "name": "SLC40A1:HEPH:Cu2+_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:28694",
+ "property1": "uniprot:Q9BQS7",
+ "property2": "uniprot:Q9NP59"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "e-_ion_default_compartment",
+ "name": "e-_ion_default_compartment",
+ "grounding": {
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+ "context": {
+ "property": "CHEBI:10545"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CYBRD1:Heme_complex",
+ "name": "CYBRD1:Heme_complex",
+ "grounding": {
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+ "context": {
+ "property": "CHEBI:30413",
+ "property1": "uniprot:Q53TN4"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "O2_simple_molecule_default_compartment",
+ "name": "O2_simple_molecule_default_compartment",
+ "grounding": {
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+ "context": {
+ "property": "CHEBI:15379"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "H+_ion_default_compartment",
+ "name": "H+_ion_default_compartment",
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+ "context": {
+ "property": "CHEBI:15378"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Fe(3+)O(OH)_simple_molecule",
+ "name": "Fe(3+)O(OH)_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:78619"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "H2O_simple_molecule_default_compartment",
+ "name": "H2O_simple_molecule_default_compartment",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:15377"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "GPX4",
+ "name": "GPX4",
+ "grounding": {
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+ "context": {
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+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Lipid alcohol_simple_molecule",
+ "name": "Lipid alcohol_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:24026"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ORF3a",
+ "name": "ORF3a",
+ "grounding": {
+ "identifiers": {},
+ "context": {
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+ "property1": "uniprot:P0DTC3"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PKC",
+ "name": "PKC",
+ "grounding": {
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+ "context": {}
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+ "initial": 3.0
+ },
+ {
+ "id": "CK2",
+ "name": "CK2",
+ "grounding": {
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+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "FLVCR1-1",
+ "name": "FLVCR1-1",
+ "grounding": {
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+ "context": {
+ "property": "uniprot:Q9Y5Y0"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ATP_simple_molecule",
+ "name": "ATP_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:30616"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ABCG2",
+ "name": "ABCG2",
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+ "context": {
+ "property": "uniprot:Q9UNQ0"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Heme_simple_molecule_default_compartment",
+ "name": "Heme_simple_molecule_default_compartment",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:30413"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ADP_simple_molecule",
+ "name": "ADP_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:456216"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Pi_simple_molecule",
+ "name": "Pi_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:18367"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Fe3+_ion_endosome",
+ "name": "Fe3+_ion_endosome",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:29034"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "e-_ion_endosome",
+ "name": "e-_ion_endosome",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:10545"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "STEAP3",
+ "name": "STEAP3",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:Q658P3"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NRF2_ubiquitinated",
+ "name": "NRF2_ubiquitinated",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NLRP3_rna",
+ "name": "NLRP3_rna",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "ncbigene:114548",
+ "property1": "ncbigene:114548"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nf-KB Complex_complex",
+ "name": "Nf-KB Complex_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P19838",
+ "property1": "uniprot:Q00653",
+ "property2": "uniprot:Q04206"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "proIL-1B_cell",
+ "name": "proIL-1B_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P01584"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "proIL-18_cell",
+ "name": "proIL-18_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:Q14116"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IL-1B_cell",
+ "name": "IL-1B_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P01584"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IL-18_cell",
+ "name": "IL-18_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:Q14116"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IL-1B_default_compartment",
+ "name": "IL-1B_default_compartment",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P01584"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IL-18_default_compartment",
+ "name": "IL-18_default_compartment",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:Q14116"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SARS E",
+ "name": "SARS E",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P59637"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PAMPs_phenotype",
+ "name": "PAMPs_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "GO:0002221"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "DAMPs_phenotype",
+ "name": "DAMPs_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "GO:0002221"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SARS Orf3a",
+ "name": "SARS Orf3a",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P59632"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NLRP3 Elicitor Small Molecules_simple_molecule",
+ "name": "NLRP3 Elicitor Small Molecules_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:16336",
+ "property1": "CHEBI:30563",
+ "property2": "CHEBI:46661"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NLRP3 Elicitor Proteins",
+ "name": "NLRP3 Elicitor Proteins",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P05067",
+ "property1": "uniprot:P09616"
+ }
+ },
+ "initial": 3.0
+ }
+ ],
+ "edges": [
+ {
+ "id": "t1",
+ "source": "NRF2_phosphorylated_nucleus",
+ "target": "Nrf2/Maf_complex",
+ "sign": true
+ },
+ {
+ "id": "t2",
+ "source": "MAF",
+ "target": "Nrf2/Maf_complex",
+ "sign": true
+ },
+ {
+ "id": "t3",
+ "source": "MAF",
+ "target": "BACH1/Maf_complex",
+ "sign": true
+ },
+ {
+ "id": "t4",
+ "source": "BACH1",
+ "target": "BACH1/Maf_complex",
+ "sign": true
+ },
+ {
+ "id": "t5",
+ "source": "Ubiquitin Ligase Complex_complex_cell",
+ "target": "Ubiquitin Ligase Complex_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t6",
+ "source": "E2_ubiquitinated",
+ "target": "Ubiquitin Ligase Complex_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t7",
+ "source": "Ubiquitin Ligase Complex_complex_cell",
+ "target": "Ubiquitin Ligase Complex_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t8",
+ "source": "NRF2_empty",
+ "target": "NRF2:KEAP1_complex",
+ "sign": true
+ },
+ {
+ "id": "t9",
+ "source": "KEAP1",
+ "target": "NRF2:KEAP1_complex",
+ "sign": true
+ },
+ {
+ "id": "t10",
+ "source": "Dimethly fumarate_drug",
+ "target": "NRF2:KEAP1_complex",
+ "sign": true
+ },
+ {
+ "id": "t11",
+ "source": "CUL3:RBX1_complex",
+ "target": "Neddylated CUL3:RBX1_complex",
+ "sign": true
+ },
+ {
+ "id": "t12",
+ "source": "SLC40A1_rna",
+ "target": "SLC40A1:CP:Cu2+_complex",
+ "sign": true
+ },
+ {
+ "id": "t13",
+ "source": "CAND1",
+ "target": "Ubiquitin Ligase Complex_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t14",
+ "source": "Neddylated CUL3:RBX1_complex",
+ "target": "Ubiquitin Ligase Complex_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t15",
+ "source": "NRF2:KEAP1_complex",
+ "target": "Ubiquitin Ligase Complex_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t16",
+ "source": "Fe3+_ion_default_compartment",
+ "target": "holoTF_complex",
+ "sign": true
+ },
+ {
+ "id": "t17",
+ "source": "Transferrin",
+ "target": "holoTF_complex",
+ "sign": true
+ },
+ {
+ "id": "t18",
+ "source": "TFRC",
+ "target": "TFRC:holoTF_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t19",
+ "source": "holoTF_complex",
+ "target": "TFRC:holoTF_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t20",
+ "source": "TFRC:holoTF_complex_cell",
+ "target": "TFRC:holoTF_complex_endosome",
+ "sign": true
+ },
+ {
+ "id": "t21",
+ "source": "TFRC:holoTF_complex_endosome",
+ "target": "TFRC:TF_complex_endosome",
+ "sign": true
+ },
+ {
+ "id": "t22",
+ "source": "TFRC:TF_complex_endosome",
+ "target": "TFRC:TF_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t23",
+ "source": "NLRP3_cell",
+ "target": "TXNIP:NLRP3_complex",
+ "sign": true
+ },
+ {
+ "id": "t24",
+ "source": "TXNIP",
+ "target": "TXNIP:NLRP3_complex",
+ "sign": true
+ },
+ {
+ "id": "t25",
+ "source": "NLRP3_cell",
+ "target": "NLRP3:SUGT1:HSP90_complex",
+ "sign": true
+ },
+ {
+ "id": "t26",
+ "source": "SUGT1:HSP90AB1_complex",
+ "target": "NLRP3:SUGT1:HSP90_complex",
+ "sign": true
+ },
+ {
+ "id": "t27",
+ "source": "NLRP3:SUGT1:HSP90_complex",
+ "target": "SUGT1:HSP90AB1_complex",
+ "sign": true
+ },
+ {
+ "id": "t28",
+ "source": "BLVRA_rna",
+ "target": "BLVRA:Zn2+_complex",
+ "sign": true
+ },
+ {
+ "id": "t29",
+ "source": "TXNIP",
+ "target": "Thioredoxin:TXNIP_complex",
+ "sign": true
+ },
+ {
+ "id": "t30",
+ "source": "TXN_cell",
+ "target": "Thioredoxin:TXNIP_complex",
+ "sign": true
+ },
+ {
+ "id": "t31",
+ "source": "PSTPIP1",
+ "target": "PSTPIP1 trimer:Pyrin trimer_complex",
+ "sign": true
+ },
+ {
+ "id": "t32",
+ "source": "Pyrin trimer_complex",
+ "target": "PSTPIP1 trimer:Pyrin trimer_complex",
+ "sign": true
+ },
+ {
+ "id": "t33",
+ "source": "ASC",
+ "target": "NLRP3 oligomer:ASC_complex",
+ "sign": true
+ },
+ {
+ "id": "t34",
+ "source": "NLRP3_cell_active",
+ "target": "NLRP3 oligomer:ASC_complex",
+ "sign": true
+ },
+ {
+ "id": "t35",
+ "source": "NLRP3 oligomer:ASC:Caspase1_complex",
+ "target": "NLRP3 oligomer:ASC_complex",
+ "sign": true
+ },
+ {
+ "id": "t36",
+ "source": "CTSG",
+ "target": "NLRP3 oligomer:ASC_complex",
+ "sign": true
+ },
+ {
+ "id": "t37",
+ "source": "ASC",
+ "target": "Pyrin trimer:ASC_complex",
+ "sign": true
+ },
+ {
+ "id": "t38",
+ "source": "Pyrin trimer_complex",
+ "target": "Pyrin trimer:ASC_complex",
+ "sign": true
+ },
+ {
+ "id": "t39",
+ "source": "NLRP3 oligomer:ASC_complex",
+ "target": "NLRP3 oligomer:ASC:Caspase1_complex",
+ "sign": true
+ },
+ {
+ "id": "t40",
+ "source": "CASP1_cell",
+ "target": "NLRP3 oligomer:ASC:Caspase1_complex",
+ "sign": true
+ },
+ {
+ "id": "t41",
+ "source": "FTH1_rna",
+ "target": "Ferritin_complex",
+ "sign": true
+ },
+ {
+ "id": "t42",
+ "source": "FTL_rna",
+ "target": "Ferritin_complex",
+ "sign": true
+ },
+ {
+ "id": "t43",
+ "source": "Bilirubin_simple_molecule_default_compartment",
+ "target": "ALB/BIL_complex",
+ "sign": true
+ },
+ {
+ "id": "t44",
+ "source": "ALB",
+ "target": "ALB/BIL_complex",
+ "sign": true
+ },
+ {
+ "id": "t45",
+ "source": "CASP1(120-197):CASP1(317-404)_complex",
+ "target": "Caspase-1 Tetramer_complex",
+ "sign": true
+ },
+ {
+ "id": "t46",
+ "source": "CASP1_cell",
+ "target": "CASP1(120-197):CASP1(317-404)_complex",
+ "sign": true
+ },
+ {
+ "id": "t47",
+ "source": "Heme_simple_molecule_mitochondrial matrix",
+ "target": "Heme_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t48",
+ "source": "FLVCR1-2",
+ "target": "Heme_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t49",
+ "source": "NADPH_simple_molecule",
+ "target": "Biliverdin_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t50",
+ "source": "O2_simple_molecule_cell",
+ "target": "Biliverdin_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t51",
+ "source": "Heme_simple_molecule_cell",
+ "target": "Biliverdin_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t52",
+ "source": "HMOX1_cell_active",
+ "target": "Biliverdin_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t53",
+ "source": "FECH",
+ "target": "Heme_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t54",
+ "source": "Fe2+_ion_mitochondrial matrix",
+ "target": "Heme_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t55",
+ "source": "Pb2+_ion",
+ "target": "Heme_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t56",
+ "source": "PRIN9_simple_molecule_mitochondrial matrix",
+ "target": "Heme_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t57",
+ "source": "dALA_simple_molecule_cell",
+ "target": "H2O_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t58",
+ "source": "Heme_simple_molecule_cell",
+ "target": "H2O_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t59",
+ "source": "O2_simple_molecule_cell",
+ "target": "H2O_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t60",
+ "source": "NADPH_simple_molecule",
+ "target": "H2O_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t61",
+ "source": "HMOX1_cell_active",
+ "target": "H2O_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t62",
+ "source": "ALAD:Zn2+_complex",
+ "target": "H2O_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t63",
+ "source": "Biliverdin_simple_molecule",
+ "target": "NADP+_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t64",
+ "source": "BLVRA:Zn2+_complex",
+ "target": "NADP+_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t65",
+ "source": "Heme_simple_molecule_cell",
+ "target": "NADP+_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t66",
+ "source": "O2_simple_molecule_cell",
+ "target": "NADP+_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t67",
+ "source": "NADPH_simple_molecule",
+ "target": "NADP+_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t68",
+ "source": "BLVRB",
+ "target": "NADP+_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t69",
+ "source": "HMOX1_cell_active",
+ "target": "NADP+_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t70",
+ "source": "SLC11A2",
+ "target": "Fe2+_ion_cell",
+ "sign": true
+ },
+ {
+ "id": "t71",
+ "source": "Heme_simple_molecule_cell",
+ "target": "Fe2+_ion_cell",
+ "sign": true
+ },
+ {
+ "id": "t72",
+ "source": "Fe2+_ion_default_compartment",
+ "target": "Fe2+_ion_cell",
+ "sign": true
+ },
+ {
+ "id": "t73",
+ "source": "O2_simple_molecule_cell",
+ "target": "Fe2+_ion_cell",
+ "sign": true
+ },
+ {
+ "id": "t74",
+ "source": "Fe2+_ion_endosome",
+ "target": "Fe2+_ion_cell",
+ "sign": true
+ },
+ {
+ "id": "t75",
+ "source": "NADPH_simple_molecule",
+ "target": "Fe2+_ion_cell",
+ "sign": true
+ },
+ {
+ "id": "t76",
+ "source": "MCOLN1",
+ "target": "Fe2+_ion_cell",
+ "sign": true
+ },
+ {
+ "id": "t77",
+ "source": "HMOX1_cell_active",
+ "target": "Fe2+_ion_cell",
+ "sign": true
+ },
+ {
+ "id": "t78",
+ "source": "HMOX1_rna",
+ "target": "HMOX1_cell",
+ "sign": true
+ },
+ {
+ "id": "t79",
+ "source": "NADPH_simple_molecule",
+ "target": "CO_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t80",
+ "source": "O2_simple_molecule_cell",
+ "target": "CO_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t81",
+ "source": "Heme_simple_molecule_cell",
+ "target": "CO_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t82",
+ "source": "HMOX1_cell_active",
+ "target": "CO_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t83",
+ "source": "Biliverdin_simple_molecule",
+ "target": "Bilirubin_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t84",
+ "source": "NADPH_simple_molecule",
+ "target": "Bilirubin_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t85",
+ "source": "BLVRB",
+ "target": "Bilirubin_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t86",
+ "source": "BLVRA:Zn2+_complex",
+ "target": "Bilirubin_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t87",
+ "source": "BLVRB_rna",
+ "target": "BLVRB",
+ "sign": true
+ },
+ {
+ "id": "t88",
+ "source": "Bilirubin_simple_molecule_cell",
+ "target": "Bilirubin_simple_molecule_default_compartment",
+ "sign": true
+ },
+ {
+ "id": "t89",
+ "source": "ABCC1",
+ "target": "Bilirubin_simple_molecule_default_compartment",
+ "sign": true
+ },
+ {
+ "id": "t90",
+ "source": "ORF9c",
+ "target": "ABCC1",
+ "sign": true
+ },
+ {
+ "id": "t91",
+ "source": "NRF2_phosphorylated_cell",
+ "target": "NRF2_phosphorylated_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t92",
+ "source": "miRNA-155_rna",
+ "target": "miRNA-155_rna",
+ "sign": false
+ },
+ {
+ "id": "t93",
+ "source": "BACH1/Maf_complex",
+ "target": "HMOX1_rna",
+ "sign": true
+ },
+ {
+ "id": "t94",
+ "source": "Nrf2/Maf_complex",
+ "target": "HMOX1_rna",
+ "sign": true
+ },
+ {
+ "id": "t95",
+ "source": "FECH_rna",
+ "target": "FECH",
+ "sign": true
+ },
+ {
+ "id": "t96",
+ "source": "PRIN9_simple_molecule_mitochondrion",
+ "target": "PRIN9_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t97",
+ "source": "FECH",
+ "target": "H+_ion_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t98",
+ "source": "Fe2+_ion_mitochondrial matrix",
+ "target": "H+_ion_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t99",
+ "source": "Pb2+_ion",
+ "target": "H+_ion_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t100",
+ "source": "PRIN9_simple_molecule_mitochondrial matrix",
+ "target": "H+_ion_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t101",
+ "source": "Panhematin_drug",
+ "target": "dALA_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t102",
+ "source": "Heme_simple_molecule_mitochondrial matrix",
+ "target": "dALA_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t103",
+ "source": "H+_ion_mitochondrial matrix",
+ "target": "dALA_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t104",
+ "source": "Gly_simple_molecule",
+ "target": "dALA_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t105",
+ "source": "ALAS1:ALAS2_complex",
+ "target": "dALA_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t106",
+ "source": "SUCC-CoA_simple_molecule",
+ "target": "dALA_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t107",
+ "source": "Panhematin_drug",
+ "target": "CO2_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t108",
+ "source": "Heme_simple_molecule_mitochondrial matrix",
+ "target": "CO2_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t109",
+ "source": "H+_ion_mitochondrial matrix",
+ "target": "CO2_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t110",
+ "source": "Gly_simple_molecule",
+ "target": "CO2_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t111",
+ "source": "ALAS1:ALAS2_complex",
+ "target": "CO2_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t112",
+ "source": "SUCC-CoA_simple_molecule",
+ "target": "CO2_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t113",
+ "source": "Panhematin_drug",
+ "target": "CoA-SH_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t114",
+ "source": "Heme_simple_molecule_mitochondrial matrix",
+ "target": "CoA-SH_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t115",
+ "source": "H+_ion_mitochondrial matrix",
+ "target": "CoA-SH_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t116",
+ "source": "Gly_simple_molecule",
+ "target": "CoA-SH_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t117",
+ "source": "ALAS1:ALAS2_complex",
+ "target": "CoA-SH_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t118",
+ "source": "SUCC-CoA_simple_molecule",
+ "target": "CoA-SH_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t119",
+ "source": "dALA_simple_molecule_mitochondrial matrix",
+ "target": "dALA_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t120",
+ "source": "ALAD:Zn2+_complex",
+ "target": "PBG_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t121",
+ "source": "dALA_simple_molecule_cell",
+ "target": "PBG_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t122",
+ "source": "ALAD:Zn2+_complex",
+ "target": "H+_ion_cell",
+ "sign": true
+ },
+ {
+ "id": "t123",
+ "source": "dALA_simple_molecule_cell",
+ "target": "H+_ion_cell",
+ "sign": true
+ },
+ {
+ "id": "t124",
+ "source": "HMBS:DIPY_complex",
+ "target": "HMBL_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t125",
+ "source": "H2O_simple_molecule_cell",
+ "target": "HMBL_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t126",
+ "source": "PBG_simple_molecule",
+ "target": "HMBL_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t127",
+ "source": "HMBS:DIPY_complex",
+ "target": "NH4+_ion",
+ "sign": true
+ },
+ {
+ "id": "t128",
+ "source": "H2O_simple_molecule_cell",
+ "target": "NH4+_ion",
+ "sign": true
+ },
+ {
+ "id": "t129",
+ "source": "PBG_simple_molecule",
+ "target": "NH4+_ion",
+ "sign": true
+ },
+ {
+ "id": "t130",
+ "source": "HMBL_simple_molecule",
+ "target": "URO3_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t131",
+ "source": "UROS",
+ "target": "URO3_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t132",
+ "source": "UROD",
+ "target": "COPRO3_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t133",
+ "source": "URO3_simple_molecule",
+ "target": "COPRO3_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t134",
+ "source": "COPRO3_simple_molecule_cell",
+ "target": "COPRO3_simple_molecule_mitochondrion",
+ "sign": true
+ },
+ {
+ "id": "t135",
+ "source": "CPOX",
+ "target": "PPGEN9_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t136",
+ "source": "COPRO3_simple_molecule_mitochondrion",
+ "target": "PPGEN9_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t137",
+ "source": "O2_simple_molecule_mitochondrion",
+ "target": "PPGEN9_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t138",
+ "source": "PPO:FAD_complex",
+ "target": "PRIN9_simple_molecule_mitochondrion",
+ "sign": true
+ },
+ {
+ "id": "t139",
+ "source": "PPGEN9_simple_molecule",
+ "target": "PRIN9_simple_molecule_mitochondrion",
+ "sign": true
+ },
+ {
+ "id": "t140",
+ "source": "O2_simple_molecule_mitochondrion",
+ "target": "PRIN9_simple_molecule_mitochondrion",
+ "sign": true
+ },
+ {
+ "id": "t141",
+ "source": "CPOX",
+ "target": "CO2_simple_molecule_mitochondrion",
+ "sign": true
+ },
+ {
+ "id": "t142",
+ "source": "COPRO3_simple_molecule_mitochondrion",
+ "target": "CO2_simple_molecule_mitochondrion",
+ "sign": true
+ },
+ {
+ "id": "t143",
+ "source": "O2_simple_molecule_mitochondrion",
+ "target": "CO2_simple_molecule_mitochondrion",
+ "sign": true
+ },
+ {
+ "id": "t144",
+ "source": "CPOX",
+ "target": "H2O2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t145",
+ "source": "PPO:FAD_complex",
+ "target": "H2O2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t146",
+ "source": "PPGEN9_simple_molecule",
+ "target": "H2O2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t147",
+ "source": "COPRO3_simple_molecule_mitochondrion",
+ "target": "H2O2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t148",
+ "source": "O2_simple_molecule_mitochondrion",
+ "target": "H2O2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t149",
+ "source": "Lipid Peroxide_simple_molecule",
+ "target": "Ferroptosis_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t150",
+ "source": "Reactive Oxygen Species_simple_molecule",
+ "target": "Lipid Peroxide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t151",
+ "source": "Poly-unsaturated fatty acid_simple_molecule",
+ "target": "Lipid Peroxide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t152",
+ "source": "e-_ion_default_compartment",
+ "target": "Fe2+_ion_default_compartment",
+ "sign": true
+ },
+ {
+ "id": "t153",
+ "source": "Fe2+_ion_cell",
+ "target": "Fe2+_ion_default_compartment",
+ "sign": true
+ },
+ {
+ "id": "t154",
+ "source": "SLC40A1:CP:Cu2+_complex",
+ "target": "Fe2+_ion_default_compartment",
+ "sign": true
+ },
+ {
+ "id": "t155",
+ "source": "SLC40A1:HEPH:Cu2+_complex",
+ "target": "Fe2+_ion_default_compartment",
+ "sign": true
+ },
+ {
+ "id": "t156",
+ "source": "CYBRD1:Heme_complex",
+ "target": "Fe2+_ion_default_compartment",
+ "sign": true
+ },
+ {
+ "id": "t157",
+ "source": "Fe3+_ion_default_compartment",
+ "target": "Fe2+_ion_default_compartment",
+ "sign": true
+ },
+ {
+ "id": "t158",
+ "source": "O2_simple_molecule_default_compartment",
+ "target": "Fe3+_ion_default_compartment",
+ "sign": true
+ },
+ {
+ "id": "t159",
+ "source": "Fe2+_ion_default_compartment",
+ "target": "Fe3+_ion_default_compartment",
+ "sign": true
+ },
+ {
+ "id": "t160",
+ "source": "SLC40A1:CP:Cu2+_complex",
+ "target": "Fe3+_ion_default_compartment",
+ "sign": true
+ },
+ {
+ "id": "t161",
+ "source": "SLC40A1:HEPH:Cu2+_complex",
+ "target": "Fe3+_ion_default_compartment",
+ "sign": true
+ },
+ {
+ "id": "t162",
+ "source": "H+_ion_default_compartment",
+ "target": "Fe3+_ion_default_compartment",
+ "sign": true
+ },
+ {
+ "id": "t163",
+ "source": "NRF2_phosphorylated_nucleus",
+ "target": "SLC40A1_rna",
+ "sign": true
+ },
+ {
+ "id": "t164",
+ "source": "NRF2_phosphorylated_nucleus",
+ "target": "FTH1_rna",
+ "sign": true
+ },
+ {
+ "id": "t165",
+ "source": "NRF2_phosphorylated_nucleus",
+ "target": "FTL_rna",
+ "sign": true
+ },
+ {
+ "id": "t166",
+ "source": "NRF2_phosphorylated_nucleus",
+ "target": "FECH_rna",
+ "sign": true
+ },
+ {
+ "id": "t167",
+ "source": "NRF2_phosphorylated_nucleus",
+ "target": "BLVRA_rna",
+ "sign": true
+ },
+ {
+ "id": "t168",
+ "source": "NRF2_phosphorylated_nucleus",
+ "target": "BLVRB_rna",
+ "sign": true
+ },
+ {
+ "id": "t169",
+ "source": "Fe2+_ion_cell",
+ "target": "Fe(3+)O(OH)_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t170",
+ "source": "Ferritin_complex",
+ "target": "Fe(3+)O(OH)_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t171",
+ "source": "O2_simple_molecule_cell",
+ "target": "Fe(3+)O(OH)_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t172",
+ "source": "H+_ion_cell",
+ "target": "Fe(3+)O(OH)_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t173",
+ "source": "O2_simple_molecule_default_compartment",
+ "target": "H2O_simple_molecule_default_compartment",
+ "sign": true
+ },
+ {
+ "id": "t174",
+ "source": "Fe2+_ion_default_compartment",
+ "target": "H2O_simple_molecule_default_compartment",
+ "sign": true
+ },
+ {
+ "id": "t175",
+ "source": "SLC40A1:CP:Cu2+_complex",
+ "target": "H2O_simple_molecule_default_compartment",
+ "sign": true
+ },
+ {
+ "id": "t176",
+ "source": "SLC40A1:HEPH:Cu2+_complex",
+ "target": "H2O_simple_molecule_default_compartment",
+ "sign": true
+ },
+ {
+ "id": "t177",
+ "source": "H+_ion_default_compartment",
+ "target": "H2O_simple_molecule_default_compartment",
+ "sign": true
+ },
+ {
+ "id": "t178",
+ "source": "Fe2+_ion_cell",
+ "target": "Reactive Oxygen Species_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t179",
+ "source": "CO_simple_molecule",
+ "target": "Reactive Oxygen Species_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t180",
+ "source": "Lipid Peroxide_simple_molecule",
+ "target": "Lipid alcohol_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t181",
+ "source": "GPX4",
+ "target": "Lipid alcohol_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t182",
+ "source": "ORF3a",
+ "target": "HMOX1_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t183",
+ "source": "HMOX1_cell",
+ "target": "HMOX1_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t184",
+ "source": "NRF2_empty",
+ "target": "NRF2_phosphorylated_cell",
+ "sign": true
+ },
+ {
+ "id": "t185",
+ "source": "CK2",
+ "target": "NRF2_phosphorylated_cell",
+ "sign": true
+ },
+ {
+ "id": "t186",
+ "source": "PKC",
+ "target": "NRF2_phosphorylated_cell",
+ "sign": true
+ },
+ {
+ "id": "t187",
+ "source": "ATP_simple_molecule",
+ "target": "Heme_simple_molecule_default_compartment",
+ "sign": true
+ },
+ {
+ "id": "t188",
+ "source": "Heme_simple_molecule_cell",
+ "target": "Heme_simple_molecule_default_compartment",
+ "sign": true
+ },
+ {
+ "id": "t189",
+ "source": "H2O_simple_molecule_cell",
+ "target": "Heme_simple_molecule_default_compartment",
+ "sign": true
+ },
+ {
+ "id": "t190",
+ "source": "FLVCR1-1",
+ "target": "Heme_simple_molecule_default_compartment",
+ "sign": true
+ },
+ {
+ "id": "t191",
+ "source": "ABCG2",
+ "target": "Heme_simple_molecule_default_compartment",
+ "sign": true
+ },
+ {
+ "id": "t192",
+ "source": "ABCG2",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t193",
+ "source": "ATP_simple_molecule",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t194",
+ "source": "H2O_simple_molecule_cell",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t195",
+ "source": "Heme_simple_molecule_cell",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t196",
+ "source": "ABCG2",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t197",
+ "source": "ATP_simple_molecule",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t198",
+ "source": "H2O_simple_molecule_cell",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t199",
+ "source": "Heme_simple_molecule_cell",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t200",
+ "source": "TFRC:TF_complex_cell",
+ "target": "Transferrin",
+ "sign": true
+ },
+ {
+ "id": "t201",
+ "source": "TFRC:TF_complex_cell",
+ "target": "TFRC",
+ "sign": true
+ },
+ {
+ "id": "t202",
+ "source": "TFRC:holoTF_complex_endosome",
+ "target": "Fe3+_ion_endosome",
+ "sign": true
+ },
+ {
+ "id": "t203",
+ "source": "e-_ion_endosome",
+ "target": "Fe2+_ion_endosome",
+ "sign": true
+ },
+ {
+ "id": "t204",
+ "source": "STEAP3",
+ "target": "Fe2+_ion_endosome",
+ "sign": true
+ },
+ {
+ "id": "t205",
+ "source": "Fe3+_ion_endosome",
+ "target": "Fe2+_ion_endosome",
+ "sign": true
+ },
+ {
+ "id": "t206",
+ "source": "Ubiquitin Ligase Complex_complex_cell",
+ "target": "NRF2_ubiquitinated",
+ "sign": true
+ },
+ {
+ "id": "t207",
+ "source": "NLRP3_rna",
+ "target": "NLRP3_cell",
+ "sign": true
+ },
+ {
+ "id": "t208",
+ "source": "NLRP3:SUGT1:HSP90_complex",
+ "target": "NLRP3_cell",
+ "sign": true
+ },
+ {
+ "id": "t209",
+ "source": "Thioredoxin:TXNIP_complex",
+ "target": "TXNIP",
+ "sign": true
+ },
+ {
+ "id": "t210",
+ "source": "Reactive Oxygen Species_simple_molecule",
+ "target": "TXNIP",
+ "sign": true
+ },
+ {
+ "id": "t211",
+ "source": "Thioredoxin:TXNIP_complex",
+ "target": "TXN_cell",
+ "sign": true
+ },
+ {
+ "id": "t212",
+ "source": "Reactive Oxygen Species_simple_molecule",
+ "target": "TXN_cell",
+ "sign": true
+ },
+ {
+ "id": "t213",
+ "source": "Nf-KB Complex_complex",
+ "target": "NLRP3_rna",
+ "sign": true
+ },
+ {
+ "id": "t214",
+ "source": "NLRP3 oligomer:ASC:Caspase1_complex",
+ "target": "CASP1_cell",
+ "sign": true
+ },
+ {
+ "id": "t215",
+ "source": "CTSG",
+ "target": "CASP1_cell",
+ "sign": true
+ },
+ {
+ "id": "t216",
+ "source": "NLRP3 oligomer:ASC:Caspase1_complex",
+ "target": "CASP1_cell",
+ "sign": true
+ },
+ {
+ "id": "t217",
+ "source": "CTSG",
+ "target": "CASP1_cell",
+ "sign": true
+ },
+ {
+ "id": "t218",
+ "source": "NLRP3 oligomer:ASC:Caspase1_complex",
+ "target": "CASP1_cell",
+ "sign": true
+ },
+ {
+ "id": "t219",
+ "source": "CTSG",
+ "target": "CASP1_cell",
+ "sign": true
+ },
+ {
+ "id": "t220",
+ "source": "NLRP3 oligomer:ASC:Caspase1_complex",
+ "target": "CASP1_cell",
+ "sign": true
+ },
+ {
+ "id": "t221",
+ "source": "CTSG",
+ "target": "CASP1_cell",
+ "sign": true
+ },
+ {
+ "id": "t222",
+ "source": "Caspase-1 Tetramer_complex",
+ "target": "proIL-1B_cell",
+ "sign": true
+ },
+ {
+ "id": "t223",
+ "source": "Caspase-1 Tetramer_complex",
+ "target": "proIL-18_cell",
+ "sign": true
+ },
+ {
+ "id": "t224",
+ "source": "Caspase-1 Tetramer_complex",
+ "target": "IL-1B_cell",
+ "sign": true
+ },
+ {
+ "id": "t225",
+ "source": "proIL-1B_cell",
+ "target": "IL-1B_cell",
+ "sign": true
+ },
+ {
+ "id": "t226",
+ "source": "proIL-18_cell",
+ "target": "IL-18_cell",
+ "sign": true
+ },
+ {
+ "id": "t227",
+ "source": "Caspase-1 Tetramer_complex",
+ "target": "IL-18_cell",
+ "sign": true
+ },
+ {
+ "id": "t228",
+ "source": "IL-1B_cell",
+ "target": "IL-1B_default_compartment",
+ "sign": true
+ },
+ {
+ "id": "t229",
+ "source": "IL-18_cell",
+ "target": "IL-18_default_compartment",
+ "sign": true
+ },
+ {
+ "id": "t230",
+ "source": "NLRP3 Elicitor Proteins",
+ "target": "NLRP3_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t231",
+ "source": "DAMPs_phenotype",
+ "target": "NLRP3_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t232",
+ "source": "PAMPs_phenotype",
+ "target": "NLRP3_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t233",
+ "source": "Reactive Oxygen Species_simple_molecule",
+ "target": "NLRP3_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t234",
+ "source": "NLRP3 Elicitor Small Molecules_simple_molecule",
+ "target": "NLRP3_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t235",
+ "source": "SARS E",
+ "target": "NLRP3_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t236",
+ "source": "NLRP3_cell",
+ "target": "NLRP3_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t237",
+ "source": "TXNIP:NLRP3_complex",
+ "target": "NLRP3_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t238",
+ "source": "SARS Orf3a",
+ "target": "NLRP3_cell_active",
+ "sign": true
+ }
+ ],
+ "parameters": []
+ },
+ "semantics": {
+ "ode": {
+ "rates": [],
+ "observables": [],
+ "time": {
+ "id": "t"
+ }
+ }
+ },
+ "metadata": {
+ "annotations": {}
+ }
+}
\ No newline at end of file
diff --git a/scripts/covid19_diseasemaps/regnet_amr_sbml/IFN-lambda.json b/scripts/covid19_diseasemaps/regnet_amr_sbml/IFN-lambda.json
new file mode 100644
index 000000000..41a0b06c5
--- /dev/null
+++ b/scripts/covid19_diseasemaps/regnet_amr_sbml/IFN-lambda.json
@@ -0,0 +1,728 @@
+{
+ "header": {
+ "name": "Model",
+ "schema": "https://raw.githubusercontent.com/DARPA-ASKEM/Model-Representations/regnet_v0.2/regnet/regnet_schema.json",
+ "schema_name": "regnet",
+ "description": "Model",
+ "model_version": "0.1"
+ },
+ "model": {
+ "vertices": [
+ {
+ "id": "receptor complex_complex_cell",
+ "name": "receptor complex_complex_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0,
+ "sign": true
+ },
+ {
+ "id": "Ifn lambda_complex",
+ "name": "Ifn lambda_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ISGF3 precursor_complex",
+ "name": "ISGF3 precursor_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IRF9",
+ "name": "IRF9",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ISGF3_complex",
+ "name": "ISGF3_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SOCS3",
+ "name": "SOCS3",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "STAT3",
+ "name": "STAT3",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Inhibited ISGF3 precursor_complex",
+ "name": "Inhibited ISGF3 precursor_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IRF3_phosphorylated",
+ "name": "IRF3_phosphorylated",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "p38-NFkB_complex",
+ "name": "p38-NFkB_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ribosomal 40S subunit_complex",
+ "name": "ribosomal 40S subunit_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp1",
+ "name": "Nsp1",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "inhibited ribosomal 40S SU_complex",
+ "name": "inhibited ribosomal 40S SU_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "80S ribosome_complex",
+ "name": "80S ribosome_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "inhibited 80S ribosome_complex",
+ "name": "inhibited 80S ribosome_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "RIG-I-mitoMAVS_complex",
+ "name": "RIG-I-mitoMAVS_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IKK-TBK1_complex",
+ "name": "IKK-TBK1_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "RIG-I-MAVS_complex_mitochondrion",
+ "name": "RIG-I-MAVS_complex_mitochondrion",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "RIG-I:dsRNA_complex_mitochondrion",
+ "name": "RIG-I:dsRNA_complex_mitochondrion",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MAVS",
+ "name": "MAVS",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "STAT1_phosphorylated",
+ "name": "STAT1_phosphorylated",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "STAT2_phosphorylated",
+ "name": "STAT2_phosphorylated",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "dsRNA_rna",
+ "name": "dsRNA_rna",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "RIG-I-MAVS_complex_peroxisome",
+ "name": "RIG-I-MAVS_complex_peroxisome",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ribosomal 60S subunit_complex",
+ "name": "ribosomal 60S subunit_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "M",
+ "name": "M",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "RIG-I",
+ "name": "RIG-I",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "RIG-1 M-Protein_complex",
+ "name": "RIG-1 M-Protein_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PLPro",
+ "name": "PLPro",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Riplet:TRIM25_complex",
+ "name": "Riplet:TRIM25_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ISGs_rna",
+ "name": "ISGs_rna",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IFNs_complex",
+ "name": "IFNs_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SOCS1",
+ "name": "SOCS1",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "antiviral proteins_complex",
+ "name": "antiviral proteins_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IFN-III",
+ "name": "IFN-III",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IFN-sensitive-response-element_gene",
+ "name": "IFN-sensitive-response-element_gene",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "viral RNA_rna",
+ "name": "viral RNA_rna",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "nsp14",
+ "name": "nsp14",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "viral RNA+N-methyl-Guanine_rna",
+ "name": "viral RNA+N-methyl-Guanine_rna",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "nsp16",
+ "name": "nsp16",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "5'cap-viral-RNA_rna",
+ "name": "5'cap-viral-RNA_rna",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "dsRNA_vesicle_rna",
+ "name": "dsRNA_vesicle_rna",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "RNA_rna",
+ "name": "RNA_rna",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IRF1_phosphorylated",
+ "name": "IRF1_phosphorylated",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IFN-III_rna",
+ "name": "IFN-III_rna",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ }
+ ],
+ "edges": [
+ {
+ "id": "t1",
+ "source": "Ifn lambda_complex",
+ "target": "receptor complex_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t2",
+ "source": "ISGF3 precursor_complex",
+ "target": "ISGF3_complex",
+ "sign": true
+ },
+ {
+ "id": "t3",
+ "source": "IRF9",
+ "target": "ISGF3_complex",
+ "sign": true
+ },
+ {
+ "id": "t4",
+ "source": "SOCS3",
+ "target": "receptor complex_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t5",
+ "source": "ISGF3 precursor_complex",
+ "target": "Inhibited ISGF3 precursor_complex",
+ "sign": true
+ },
+ {
+ "id": "t6",
+ "source": "STAT3",
+ "target": "Inhibited ISGF3 precursor_complex",
+ "sign": true
+ },
+ {
+ "id": "t7",
+ "source": "IRF3_phosphorylated",
+ "target": "p38-NFkB_complex",
+ "sign": true
+ },
+ {
+ "id": "t8",
+ "source": "ribosomal 40S subunit_complex",
+ "target": "inhibited ribosomal 40S SU_complex",
+ "sign": true
+ },
+ {
+ "id": "t9",
+ "source": "Nsp1",
+ "target": "inhibited ribosomal 40S SU_complex",
+ "sign": true
+ },
+ {
+ "id": "t10",
+ "source": "80S ribosome_complex",
+ "target": "inhibited 80S ribosome_complex",
+ "sign": true
+ },
+ {
+ "id": "t11",
+ "source": "Nsp1",
+ "target": "inhibited 80S ribosome_complex",
+ "sign": true
+ },
+ {
+ "id": "t12",
+ "source": "IKK-TBK1_complex",
+ "target": "RIG-I-MAVS_complex_mitochondrion",
+ "sign": true
+ },
+ {
+ "id": "t13",
+ "source": "RIG-I-mitoMAVS_complex",
+ "target": "RIG-I-MAVS_complex_mitochondrion",
+ "sign": true
+ },
+ {
+ "id": "t14",
+ "source": "RIG-I:dsRNA_complex_mitochondrion",
+ "target": "RIG-I-mitoMAVS_complex",
+ "sign": true
+ },
+ {
+ "id": "t15",
+ "source": "MAVS",
+ "target": "RIG-I-mitoMAVS_complex",
+ "sign": true
+ },
+ {
+ "id": "t16",
+ "source": "STAT2_phosphorylated",
+ "target": "ISGF3 precursor_complex",
+ "sign": true
+ },
+ {
+ "id": "t17",
+ "source": "STAT1_phosphorylated",
+ "target": "ISGF3 precursor_complex",
+ "sign": true
+ },
+ {
+ "id": "t18",
+ "source": "dsRNA_rna",
+ "target": "RIG-I-MAVS_complex_peroxisome",
+ "sign": true
+ },
+ {
+ "id": "t19",
+ "source": "ribosomal 40S subunit_complex",
+ "target": "80S ribosome_complex",
+ "sign": true
+ },
+ {
+ "id": "t20",
+ "source": "ribosomal 60S subunit_complex",
+ "target": "80S ribosome_complex",
+ "sign": true
+ },
+ {
+ "id": "t21",
+ "source": "RIG-I",
+ "target": "RIG-1 M-Protein_complex",
+ "sign": true
+ },
+ {
+ "id": "t22",
+ "source": "M",
+ "target": "RIG-1 M-Protein_complex",
+ "sign": true
+ },
+ {
+ "id": "t23",
+ "source": "RIG-I",
+ "target": "RIG-I:dsRNA_complex_mitochondrion",
+ "sign": true
+ },
+ {
+ "id": "t24",
+ "source": "PLPro",
+ "target": "RIG-I:dsRNA_complex_mitochondrion",
+ "sign": true
+ },
+ {
+ "id": "t25",
+ "source": "dsRNA_rna",
+ "target": "RIG-I:dsRNA_complex_mitochondrion",
+ "sign": true
+ },
+ {
+ "id": "t26",
+ "source": "Riplet:TRIM25_complex",
+ "target": "RIG-I:dsRNA_complex_mitochondrion",
+ "sign": true
+ },
+ {
+ "id": "t27",
+ "source": "80S ribosome_complex",
+ "target": "IFNs_complex",
+ "sign": true
+ },
+ {
+ "id": "t28",
+ "source": "ISGs_rna",
+ "target": "IFNs_complex",
+ "sign": true
+ },
+ {
+ "id": "t29",
+ "source": "SOCS1",
+ "target": "receptor complex_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t30",
+ "source": "80S ribosome_complex",
+ "target": "antiviral proteins_complex",
+ "sign": true
+ },
+ {
+ "id": "t31",
+ "source": "ISGs_rna",
+ "target": "antiviral proteins_complex",
+ "sign": true
+ },
+ {
+ "id": "t32",
+ "source": "IFN-III",
+ "target": "Ifn lambda_complex",
+ "sign": true
+ },
+ {
+ "id": "t33",
+ "source": "receptor complex_complex_cell",
+ "target": "Ifn lambda_complex",
+ "sign": true
+ },
+ {
+ "id": "t34",
+ "source": "receptor complex_complex_cell",
+ "target": "STAT1_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t35",
+ "source": "receptor complex_complex_cell",
+ "target": "STAT2_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t36",
+ "source": "ISGF3_complex",
+ "target": "ISGs_rna",
+ "sign": true
+ },
+ {
+ "id": "t37",
+ "source": "IFN-sensitive-response-element_gene",
+ "target": "ISGs_rna",
+ "sign": true
+ },
+ {
+ "id": "t38",
+ "source": "nsp14",
+ "target": "viral RNA+N-methyl-Guanine_rna",
+ "sign": true
+ },
+ {
+ "id": "t39",
+ "source": "viral RNA_rna",
+ "target": "viral RNA+N-methyl-Guanine_rna",
+ "sign": true
+ },
+ {
+ "id": "t40",
+ "source": "viral RNA+N-methyl-Guanine_rna",
+ "target": "5'cap-viral-RNA_rna",
+ "sign": true
+ },
+ {
+ "id": "t41",
+ "source": "nsp16",
+ "target": "5'cap-viral-RNA_rna",
+ "sign": true
+ },
+ {
+ "id": "t42",
+ "source": "RNA_rna",
+ "target": "dsRNA_rna",
+ "sign": true
+ },
+ {
+ "id": "t43",
+ "source": "dsRNA_vesicle_rna",
+ "target": "dsRNA_rna",
+ "sign": true
+ },
+ {
+ "id": "t44",
+ "source": "RIG-I-MAVS_complex_mitochondrion",
+ "target": "IRF3_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t45",
+ "source": "RIG-I-MAVS_complex_peroxisome",
+ "target": "IRF1_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t46",
+ "source": "IRF1_phosphorylated",
+ "target": "IFN-III_rna",
+ "sign": true
+ },
+ {
+ "id": "t47",
+ "source": "p38-NFkB_complex",
+ "target": "IFN-III_rna",
+ "sign": true
+ },
+ {
+ "id": "t48",
+ "source": "IFN-III_rna",
+ "target": "IFN-III",
+ "sign": true
+ },
+ {
+ "id": "t49",
+ "source": "dsRNA_rna",
+ "target": "dsRNA_vesicle_rna",
+ "sign": true
+ }
+ ],
+ "parameters": []
+ },
+ "semantics": {
+ "ode": {
+ "rates": [],
+ "observables": [],
+ "time": {
+ "id": "t"
+ }
+ }
+ },
+ "metadata": {
+ "annotations": {}
+ }
+}
\ No newline at end of file
diff --git a/scripts/covid19_diseasemaps/regnet_amr_sbml/Interferon1.json b/scripts/covid19_diseasemaps/regnet_amr_sbml/Interferon1.json
new file mode 100644
index 000000000..337e373b3
--- /dev/null
+++ b/scripts/covid19_diseasemaps/regnet_amr_sbml/Interferon1.json
@@ -0,0 +1,2379 @@
+{
+ "header": {
+ "name": "Model",
+ "schema": "https://raw.githubusercontent.com/DARPA-ASKEM/Model-Representations/regnet_v0.2/regnet/regnet_schema.json",
+ "schema_name": "regnet",
+ "description": "Model",
+ "model_version": "0.1"
+ },
+ "model": {
+ "vertices": [
+ {
+ "id": "IFNAR_complex",
+ "name": "IFNAR_complex",
+ "grounding": {
+ "identifiers": {
+ "wikipathways": "WP4868"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IFNA1_extracellular space",
+ "name": "IFNA1_extracellular space",
+ "grounding": {
+ "identifiers": {
+ "wikipathways": "WP4868"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IFNA1_extracellular space",
+ "name": "IFNA1_extracellular space",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "31226023"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IFNA1_IFNAR_complex",
+ "name": "IFNA1_IFNAR_complex",
+ "grounding": {
+ "identifiers": {
+ "wikipathways": "WP4868"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IRAK1/4",
+ "name": "IRAK1/4",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TRIF",
+ "name": "TRIF",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TLR4_TRIF_TRAM_complex",
+ "name": "TLR4_TRIF_TRAM_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IFNB1_extracellular space",
+ "name": "IFNB1_extracellular space",
+ "grounding": {
+ "identifiers": {
+ "wikipathways": "WP4868"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IFNB1_extracellular space",
+ "name": "IFNB1_extracellular space",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "31226023"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IFNB1_IFNAR_complex",
+ "name": "IFNB1_IFNAR_complex",
+ "grounding": {
+ "identifiers": {
+ "wikipathways": "WP4868"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "STAT1_phosphorylated",
+ "name": "STAT1_phosphorylated",
+ "grounding": {
+ "identifiers": {
+ "wikipathways": "WP4868"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IRF9",
+ "name": "IRF9",
+ "grounding": {
+ "identifiers": {
+ "wikipathways": "WP4868"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "STAT2_phosphorylated",
+ "name": "STAT2_phosphorylated",
+ "grounding": {
+ "identifiers": {
+ "wikipathways": "WP4868"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TREML4",
+ "name": "TREML4",
+ "grounding": {
+ "identifiers": {
+ "wikipathways": "WP4868"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "JAK1_TYK2_complex",
+ "name": "JAK1_TYK2_complex",
+ "grounding": {
+ "identifiers": {
+ "wikipathways": "WP4868"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf6",
+ "name": "Orf6",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "31226023"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp5",
+ "name": "Nsp5",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "STAT1/2_IRF9_complex",
+ "name": "STAT1/2_IRF9_complex",
+ "grounding": {
+ "identifiers": {
+ "wikipathways": "WP4868"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ISRE_complex",
+ "name": "ISRE_complex",
+ "grounding": {
+ "identifiers": {
+ "wikipathways": "WP4868"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "JAK1",
+ "name": "JAK1",
+ "grounding": {
+ "identifiers": {
+ "wikipathways": "WP4868"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TYK2",
+ "name": "TYK2",
+ "grounding": {
+ "identifiers": {
+ "wikipathways": "WP4868"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "JUN",
+ "name": "JUN",
+ "grounding": {
+ "identifiers": {
+ "wikipathways": "WP4868"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "FOS",
+ "name": "FOS",
+ "grounding": {
+ "identifiers": {
+ "wikipathways": "WP4868"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "E",
+ "name": "E",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "31226023"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MAPK8/14_complex",
+ "name": "MAPK8/14_complex",
+ "grounding": {
+ "identifiers": {
+ "wikipathways": "WP4868"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "AP-1_complex_cell",
+ "name": "AP-1_complex_cell",
+ "grounding": {
+ "identifiers": {
+ "wikipathways": "WP4868"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IkB_p50_p65_complex_cell",
+ "name": "IkB_p50_p65_complex_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "p50_p65_complex_cell",
+ "name": "p50_p65_complex_cell",
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+ {
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+ {
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+ {
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+ {
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+ {
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+ {
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+ {
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+ {
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+ "initial": 3.0
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+ {
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+ {
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+ {
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+ {
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+ {
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+ {
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+ {
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+ {
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+ {
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+ {
+ "id": "IRF3_homodimer_complex_nucleus",
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+ {
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+ {
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+ {
+ "id": "IRF7_homodimer_complex",
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+ {
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+ "initial": 3.0
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+ {
+ "id": "GRL0617_drug",
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+ {
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+ {
+ "id": "IFNB1_rna",
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+ {
+ "id": "IFNB1_cell",
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+ {
+ "id": "IFNA1_rna",
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+ {
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+ {
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+ {
+ "id": "EIF2AK_rna",
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+ {
+ "id": "OAS1_cell",
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+ "initial": 3.0
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+ {
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+ "initial": 3.0
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+ {
+ "id": "Nsp13",
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+ {
+ "id": "Nsp1",
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+ {
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+ {
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+ {
+ "id": "Nsp6",
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+ {
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+ {
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+ {
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+ {
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+ {
+ "id": "ISG expression_antiviral response_phenotype",
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+ {
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+ {
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+ "initial": 3.0
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+ {
+ "id": "TRIM25",
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+ "initial": 3.0
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+ {
+ "id": "RNF135",
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+ "initial": 3.0
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+ {
+ "id": "Viral replication_phenotype",
+ "name": "Viral replication_phenotype",
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+ "context": {
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+ },
+ "initial": 3.0
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+ {
+ "id": "Proinflammatory cytokine expression_Inflammation_phenotype",
+ "name": "Proinflammatory cytokine expression_Inflammation_phenotype",
+ "grounding": {
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+ },
+ "initial": 3.0
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+ {
+ "id": "type I IFN response_phenotype",
+ "name": "type I IFN response_phenotype",
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+ "initial": 3.0
+ },
+ {
+ "id": "IkB_phosphorylated",
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+ "initial": 3.0
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+ {
+ "id": "ISG15_rna",
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+ ],
+ "edges": [
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+ "source": "IFNA1_extracellular space",
+ "target": "IFNA1_IFNAR_complex",
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+ {
+ "id": "t2",
+ "source": "IFNAR_complex",
+ "target": "IFNA1_IFNAR_complex",
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+ {
+ "id": "t3",
+ "source": "IFNA1_extracellular space",
+ "target": "IFNA1_IFNAR_complex",
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+ {
+ "id": "t4",
+ "source": "TRIF",
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+ {
+ "id": "t5",
+ "source": "IRAK1/4",
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+ {
+ "id": "t6",
+ "source": "IFNB1_extracellular space",
+ "target": "IFNB1_IFNAR_complex",
+ "sign": true
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+ {
+ "id": "t7",
+ "source": "IFNAR_complex",
+ "target": "IFNB1_IFNAR_complex",
+ "sign": true
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+ {
+ "id": "t8",
+ "source": "IFNB1_extracellular space",
+ "target": "IFNB1_IFNAR_complex",
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+ {
+ "id": "t9",
+ "source": "IRF9",
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+ {
+ "id": "t10",
+ "source": "STAT2_phosphorylated",
+ "target": "STAT1/2_IRF9_complex",
+ "sign": true
+ },
+ {
+ "id": "t11",
+ "source": "Orf6",
+ "target": "STAT1/2_IRF9_complex",
+ "sign": true
+ },
+ {
+ "id": "t12",
+ "source": "Nsp5",
+ "target": "STAT1/2_IRF9_complex",
+ "sign": true
+ },
+ {
+ "id": "t13",
+ "source": "JAK1_TYK2_complex",
+ "target": "STAT1/2_IRF9_complex",
+ "sign": true
+ },
+ {
+ "id": "t14",
+ "source": "TREML4",
+ "target": "STAT1/2_IRF9_complex",
+ "sign": true
+ },
+ {
+ "id": "t15",
+ "source": "STAT1_phosphorylated",
+ "target": "STAT1/2_IRF9_complex",
+ "sign": true
+ },
+ {
+ "id": "t16",
+ "source": "STAT1/2_IRF9_complex",
+ "target": "ISRE_complex",
+ "sign": true
+ },
+ {
+ "id": "t17",
+ "source": "Orf6",
+ "target": "ISRE_complex",
+ "sign": true
+ },
+ {
+ "id": "t18",
+ "source": "JAK1",
+ "target": "JAK1_TYK2_complex",
+ "sign": true
+ },
+ {
+ "id": "t19",
+ "source": "TYK2",
+ "target": "JAK1_TYK2_complex",
+ "sign": true
+ },
+ {
+ "id": "t20",
+ "source": "IFNB1_IFNAR_complex",
+ "target": "JAK1_TYK2_complex",
+ "sign": true
+ },
+ {
+ "id": "t21",
+ "source": "IFNA1_IFNAR_complex",
+ "target": "JAK1_TYK2_complex",
+ "sign": true
+ },
+ {
+ "id": "t22",
+ "source": "MAPK8/14_complex",
+ "target": "AP-1_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t23",
+ "source": "FOS",
+ "target": "AP-1_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t24",
+ "source": "JUN",
+ "target": "AP-1_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t25",
+ "source": "E",
+ "target": "AP-1_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t26",
+ "source": "IkB_p50_p65_complex_cell",
+ "target": "p50_p65_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t27",
+ "source": "OAS1_cell_active",
+ "target": "OAS1_EIF2AK_complex",
+ "sign": true
+ },
+ {
+ "id": "t28",
+ "source": "EIF2AK",
+ "target": "OAS1_EIF2AK_complex",
+ "sign": true
+ },
+ {
+ "id": "t29",
+ "source": "OAS3_cell_active",
+ "target": "OAS1_EIF2AK_complex",
+ "sign": true
+ },
+ {
+ "id": "t30",
+ "source": "OAS2_cell_active",
+ "target": "OAS1_EIF2AK_complex",
+ "sign": true
+ },
+ {
+ "id": "t31",
+ "source": "Azithromycin_drug",
+ "target": "TBK1_IKBKE_complex",
+ "sign": true
+ },
+ {
+ "id": "t32",
+ "source": "TRAF3",
+ "target": "TBK1_IKBKE_complex",
+ "sign": true
+ },
+ {
+ "id": "t33",
+ "source": "NAP1",
+ "target": "TBK1_IKBKE_complex",
+ "sign": true
+ },
+ {
+ "id": "t34",
+ "source": "IKBKE",
+ "target": "TBK1_IKBKE_complex",
+ "sign": true
+ },
+ {
+ "id": "t35",
+ "source": "TBK1",
+ "target": "TBK1_IKBKE_complex",
+ "sign": true
+ },
+ {
+ "id": "t36",
+ "source": "Nsp3",
+ "target": "TBK1_IKBKE_complex",
+ "sign": true
+ },
+ {
+ "id": "t37",
+ "source": "TLR7",
+ "target": "MYD88_TRAM_complex",
+ "sign": true
+ },
+ {
+ "id": "t38",
+ "source": "TLR9",
+ "target": "MYD88_TRAM_complex",
+ "sign": true
+ },
+ {
+ "id": "t39",
+ "source": "Viral dsRNA_rna_endosome",
+ "target": "MYD88_TRAM_complex",
+ "sign": true
+ },
+ {
+ "id": "t40",
+ "source": "MYD88",
+ "target": "MYD88_TRAM_complex",
+ "sign": true
+ },
+ {
+ "id": "t41",
+ "source": "IRAK1/4",
+ "target": "MYD88_TRAM_complex",
+ "sign": true
+ },
+ {
+ "id": "t42",
+ "source": "TREML4",
+ "target": "MYD88_TRAM_complex",
+ "sign": true
+ },
+ {
+ "id": "t43",
+ "source": "TRAF3_TBK1_IKBKE_complex_cell_active",
+ "target": "TRAF3_TANK_TBK1_IKKepsilon_complex",
+ "sign": true
+ },
+ {
+ "id": "t44",
+ "source": "M",
+ "target": "TRAF3_TANK_TBK1_IKKepsilon_complex",
+ "sign": true
+ },
+ {
+ "id": "t45",
+ "source": "MAVS",
+ "target": "TRAF3_TANK_TBK1_IKKepsilon_complex",
+ "sign": true
+ },
+ {
+ "id": "t46",
+ "source": "TANK",
+ "target": "TRAF3_TANK_TBK1_IKKepsilon_complex",
+ "sign": true
+ },
+ {
+ "id": "t47",
+ "source": "TLR3_TRIF_complex",
+ "target": "TRAF3_TANK_TBK1_IKKepsilon_complex",
+ "sign": true
+ },
+ {
+ "id": "t48",
+ "source": "TBK1_IKBKE_complex",
+ "target": "TRAF3_TBK1_IKBKE_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t49",
+ "source": "pp1ab",
+ "target": "TRAF3_TBK1_IKBKE_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t50",
+ "source": "TRAF3",
+ "target": "TRAF3_TBK1_IKBKE_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t51",
+ "source": "pp1ab",
+ "target": "TRAF3_TBK1_IKBKE_complex_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t52",
+ "source": "STING1_ubiquitinated",
+ "target": "TRAF3_TBK1_IKBKE_complex_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t53",
+ "source": "TRAF3_TBK1_IKBKE_complex_cell",
+ "target": "TRAF3_TBK1_IKBKE_complex_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t54",
+ "source": "Nsp16",
+ "target": "RIG1_MDA5_complex",
+ "sign": true
+ },
+ {
+ "id": "t55",
+ "source": "M",
+ "target": "RIG1_MDA5_complex",
+ "sign": true
+ },
+ {
+ "id": "t56",
+ "source": "Nsp14",
+ "target": "RIG1_MDA5_complex",
+ "sign": true
+ },
+ {
+ "id": "t57",
+ "source": "DDX58_ubiquitinated",
+ "target": "RIG1_MDA5_complex",
+ "sign": true
+ },
+ {
+ "id": "t58",
+ "source": "IFIH1",
+ "target": "RIG1_MDA5_complex",
+ "sign": true
+ },
+ {
+ "id": "t59",
+ "source": "Nsp10",
+ "target": "RIG1_MDA5_complex",
+ "sign": true
+ },
+ {
+ "id": "t60",
+ "source": "Viral dsRNA_rna_cell",
+ "target": "RIG1_MDA5_complex",
+ "sign": true
+ },
+ {
+ "id": "t61",
+ "source": "Nsp15",
+ "target": "RIG1_MDA5_complex",
+ "sign": true
+ },
+ {
+ "id": "t62",
+ "source": "N",
+ "target": "RIG1_MDA5_complex",
+ "sign": true
+ },
+ {
+ "id": "t63",
+ "source": "MNS_drug",
+ "target": "NLRP3_inflammasome_complex",
+ "sign": true
+ },
+ {
+ "id": "t64",
+ "source": "p50_p65_complex_nucleus",
+ "target": "NLRP3_inflammasome_complex",
+ "sign": true
+ },
+ {
+ "id": "t65",
+ "source": "E",
+ "target": "NLRP3_inflammasome_complex",
+ "sign": true
+ },
+ {
+ "id": "t66",
+ "source": "MAPK14",
+ "target": "MAPK8/14_complex",
+ "sign": true
+ },
+ {
+ "id": "t67",
+ "source": "MAP3K7",
+ "target": "MAPK8/14_complex",
+ "sign": true
+ },
+ {
+ "id": "t68",
+ "source": "TBK1",
+ "target": "MAPK8/14_complex",
+ "sign": true
+ },
+ {
+ "id": "t69",
+ "source": "MAPK8",
+ "target": "MAPK8/14_complex",
+ "sign": true
+ },
+ {
+ "id": "t70",
+ "source": "AP-1_complex_cell",
+ "target": "AP-1_complex_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t71",
+ "source": "p50_p65_complex_cell",
+ "target": "p50_p65_complex_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t72",
+ "source": "Viral dsRNA_rna_endosome",
+ "target": "TLR3_TRIF_complex",
+ "sign": true
+ },
+ {
+ "id": "t73",
+ "source": "TRIF",
+ "target": "TLR3_TRIF_complex",
+ "sign": true
+ },
+ {
+ "id": "t74",
+ "source": "Azithromycin_drug",
+ "target": "TLR3_TRIF_complex",
+ "sign": true
+ },
+ {
+ "id": "t75",
+ "source": "RIP1",
+ "target": "TLR3_TRIF_RIPK1_complex",
+ "sign": true
+ },
+ {
+ "id": "t76",
+ "source": "TLR3_TRIF_complex",
+ "target": "TLR3_TRIF_RIPK1_complex",
+ "sign": true
+ },
+ {
+ "id": "t77",
+ "source": "TAB2",
+ "target": "TAB1/2_TRAF6_TAK1_complex",
+ "sign": true
+ },
+ {
+ "id": "t78",
+ "source": "TRAF6_ubiquitinated",
+ "target": "TAB1/2_TRAF6_TAK1_complex",
+ "sign": true
+ },
+ {
+ "id": "t79",
+ "source": "TLR3_TRIF_RIPK1_complex",
+ "target": "TAB1/2_TRAF6_TAK1_complex",
+ "sign": true
+ },
+ {
+ "id": "t80",
+ "source": "TAK1",
+ "target": "TAB1/2_TRAF6_TAK1_complex",
+ "sign": true
+ },
+ {
+ "id": "t81",
+ "source": "TAB1",
+ "target": "TAB1/2_TRAF6_TAK1_complex",
+ "sign": true
+ },
+ {
+ "id": "t82",
+ "source": "NEMO",
+ "target": "IKKa_IKKb_NEMO_complex",
+ "sign": true
+ },
+ {
+ "id": "t83",
+ "source": "IKKa",
+ "target": "IKKa_IKKb_NEMO_complex",
+ "sign": true
+ },
+ {
+ "id": "t84",
+ "source": "IKKb",
+ "target": "IKKa_IKKb_NEMO_complex",
+ "sign": true
+ },
+ {
+ "id": "t85",
+ "source": "TAB1/2_TRAF6_TAK1_complex",
+ "target": "IKKa_IKKb_NEMO_complex",
+ "sign": true
+ },
+ {
+ "id": "t86",
+ "source": "NFKB1",
+ "target": "IkB_p50_p65_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t87",
+ "source": "IkB",
+ "target": "IkB_p50_p65_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t88",
+ "source": "RELA",
+ "target": "IkB_p50_p65_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t89",
+ "source": "IKKa_IKKb_NEMO_complex",
+ "target": "IkB_p50_p65_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t90",
+ "source": "IRF3_homodimer_complex_cell",
+ "target": "IRF3_homodimer_complex_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t91",
+ "source": "Orf6",
+ "target": "IRF3_homodimer_complex_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t92",
+ "source": "IRF3_phosphorylated",
+ "target": "IRF3_homodimer_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t93",
+ "source": "IRF7_phosphorylated",
+ "target": "IRF7_homodimer_complex",
+ "sign": true
+ },
+ {
+ "id": "t94",
+ "source": "GRL0617_drug",
+ "target": "ISG15_Nsp3_complex",
+ "sign": true
+ },
+ {
+ "id": "t95",
+ "source": "ISG15",
+ "target": "ISG15_Nsp3_complex",
+ "sign": true
+ },
+ {
+ "id": "t96",
+ "source": "Nsp3",
+ "target": "ISG15_Nsp3_complex",
+ "sign": true
+ },
+ {
+ "id": "t97",
+ "source": "IFNB1_rna",
+ "target": "IFNB1_cell",
+ "sign": true
+ },
+ {
+ "id": "t98",
+ "source": "IFNB1_cell",
+ "target": "IFNB1_extracellular space",
+ "sign": true
+ },
+ {
+ "id": "t99",
+ "source": "IFNA1_rna",
+ "target": "IFNA1_cell",
+ "sign": true
+ },
+ {
+ "id": "t100",
+ "source": "IFNA1_cell",
+ "target": "IFNA1_extracellular space",
+ "sign": true
+ },
+ {
+ "id": "t101",
+ "source": "IRF7_homodimer_complex",
+ "target": "IFNB1_rna",
+ "sign": true
+ },
+ {
+ "id": "t102",
+ "source": "p50_p65_complex_nucleus",
+ "target": "IFNB1_rna",
+ "sign": true
+ },
+ {
+ "id": "t103",
+ "source": "Azithromycin_drug",
+ "target": "IFNB1_rna",
+ "sign": true
+ },
+ {
+ "id": "t104",
+ "source": "AP-1_complex_nucleus",
+ "target": "IFNB1_rna",
+ "sign": true
+ },
+ {
+ "id": "t105",
+ "source": "IRF3_homodimer_complex_nucleus",
+ "target": "IFNB1_rna",
+ "sign": true
+ },
+ {
+ "id": "t106",
+ "source": "AP-1_complex_nucleus",
+ "target": "IFNA1_rna",
+ "sign": true
+ },
+ {
+ "id": "t107",
+ "source": "IRF7_homodimer_complex",
+ "target": "IFNA1_rna",
+ "sign": true
+ },
+ {
+ "id": "t108",
+ "source": "p50_p65_complex_nucleus",
+ "target": "IFNA1_rna",
+ "sign": true
+ },
+ {
+ "id": "t109",
+ "source": "IRF3_homodimer_complex_nucleus",
+ "target": "OAS1_rna",
+ "sign": true
+ },
+ {
+ "id": "t110",
+ "source": "ISRE_complex",
+ "target": "OAS1_rna",
+ "sign": true
+ },
+ {
+ "id": "t111",
+ "source": "IRF3_homodimer_complex_nucleus",
+ "target": "EIF2AK_rna",
+ "sign": true
+ },
+ {
+ "id": "t112",
+ "source": "ISRE_complex",
+ "target": "EIF2AK_rna",
+ "sign": true
+ },
+ {
+ "id": "t113",
+ "source": "OAS1_cell",
+ "target": "OAS1_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t114",
+ "source": "Nsp15",
+ "target": "OAS1_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t115",
+ "source": "EIF2AK_rna",
+ "target": "EIF2AK",
+ "sign": true
+ },
+ {
+ "id": "t116",
+ "source": "Nsp15",
+ "target": "EIF2AK",
+ "sign": true
+ },
+ {
+ "id": "t117",
+ "source": "ITCH",
+ "target": "TRAF6_ubiquitinated",
+ "sign": true
+ },
+ {
+ "id": "t118",
+ "source": "MYD88_TRAM_complex",
+ "target": "TRAF6_ubiquitinated",
+ "sign": true
+ },
+ {
+ "id": "t119",
+ "source": "Nsp3",
+ "target": "TRAF6_ubiquitinated",
+ "sign": true
+ },
+ {
+ "id": "t120",
+ "source": "Nsp13",
+ "target": "TBK1",
+ "sign": true
+ },
+ {
+ "id": "t121",
+ "source": "STING1_ubiquitinated",
+ "target": "TBK1",
+ "sign": true
+ },
+ {
+ "id": "t122",
+ "source": "MAVS",
+ "target": "TBK1",
+ "sign": true
+ },
+ {
+ "id": "t123",
+ "source": "IKBKE",
+ "target": "TBK1",
+ "sign": true
+ },
+ {
+ "id": "t124",
+ "source": "M",
+ "target": "Nsp1",
+ "sign": false
+ },
+ {
+ "id": "t125",
+ "source": "Orf3a",
+ "target": "Nsp1",
+ "sign": false
+ },
+ {
+ "id": "t126",
+ "source": "Nsp6",
+ "target": "Nsp1",
+ "sign": false
+ },
+ {
+ "id": "t127",
+ "source": "Nsp13",
+ "target": "Nsp1",
+ "sign": false
+ },
+ {
+ "id": "t128",
+ "source": "Orf7b",
+ "target": "Nsp1",
+ "sign": false
+ },
+ {
+ "id": "t129",
+ "source": "Nsp13",
+ "target": "Orf7a",
+ "sign": false
+ },
+ {
+ "id": "t130",
+ "source": "Nsp6",
+ "target": "Orf7a",
+ "sign": false
+ },
+ {
+ "id": "t131",
+ "source": "Orf7b",
+ "target": "Orf7a",
+ "sign": false
+ },
+ {
+ "id": "t132",
+ "source": "IRF3_homodimer_complex_nucleus",
+ "target": "OAS2_rna",
+ "sign": true
+ },
+ {
+ "id": "t133",
+ "source": "ISRE_complex",
+ "target": "OAS2_rna",
+ "sign": true
+ },
+ {
+ "id": "t134",
+ "source": "OAS2_cell",
+ "target": "OAS2_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t135",
+ "source": "Nsp15",
+ "target": "OAS2_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t136",
+ "source": "IRF3_homodimer_complex_nucleus",
+ "target": "OAS3_rna",
+ "sign": true
+ },
+ {
+ "id": "t137",
+ "source": "ISRE_complex",
+ "target": "OAS3_rna",
+ "sign": true
+ },
+ {
+ "id": "t138",
+ "source": "OAS3_cell",
+ "target": "OAS3_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t139",
+ "source": "Nsp15",
+ "target": "OAS3_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t140",
+ "source": "OAS1_EIF2AK_complex",
+ "target": "ISG expression_antiviral response_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t141",
+ "source": "ISG15",
+ "target": "ISG expression_antiviral response_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t142",
+ "source": "p50_p65_complex_nucleus",
+ "target": "ISG expression_antiviral response_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t143",
+ "source": "Azithromycin_drug",
+ "target": "ISG expression_antiviral response_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t144",
+ "source": "Nsp3",
+ "target": "ISG expression_antiviral response_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t145",
+ "source": "MYD88_TRAM_complex",
+ "target": "TRAF3",
+ "sign": true
+ },
+ {
+ "id": "t146",
+ "source": "Nsp3",
+ "target": "TRAF3",
+ "sign": true
+ },
+ {
+ "id": "t147",
+ "source": "TRAF6_ubiquitinated",
+ "target": "MAP3K7",
+ "sign": true
+ },
+ {
+ "id": "t148",
+ "source": "TBK1",
+ "target": "IKBKE",
+ "sign": true
+ },
+ {
+ "id": "t149",
+ "source": "Nsp3",
+ "target": "IKBKE",
+ "sign": true
+ },
+ {
+ "id": "t150",
+ "source": "Nsp6",
+ "target": "IRF3_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t151",
+ "source": "MAVS",
+ "target": "IRF3_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t152",
+ "source": "Orf8_complex",
+ "target": "IRF3_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t153",
+ "source": "TRAF3_TANK_TBK1_IKKepsilon_complex",
+ "target": "IRF3_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t154",
+ "source": "Nsp3",
+ "target": "IRF3_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t155",
+ "source": "Orf6",
+ "target": "IRF3_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t156",
+ "source": "N",
+ "target": "IRF3_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t157",
+ "source": "Nsp15",
+ "target": "IRF3_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t158",
+ "source": "pp1ab",
+ "target": "IRF3_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t159",
+ "source": "ITCH",
+ "target": "MAVS",
+ "sign": true
+ },
+ {
+ "id": "t160",
+ "source": "Orf9b",
+ "target": "MAVS",
+ "sign": true
+ },
+ {
+ "id": "t161",
+ "source": "RIG1_MDA5_complex",
+ "target": "MAVS",
+ "sign": true
+ },
+ {
+ "id": "t162",
+ "source": "Nsp15",
+ "target": "IFIH1",
+ "sign": true
+ },
+ {
+ "id": "t163",
+ "source": "Azithromycin_drug",
+ "target": "IFIH1",
+ "sign": true
+ },
+ {
+ "id": "t164",
+ "source": "Azithromycin_drug",
+ "target": "DDX58_ubiquitinated",
+ "sign": true
+ },
+ {
+ "id": "t165",
+ "source": "RNF135",
+ "target": "DDX58_ubiquitinated",
+ "sign": true
+ },
+ {
+ "id": "t166",
+ "source": "Nsp5",
+ "target": "DDX58_ubiquitinated",
+ "sign": true
+ },
+ {
+ "id": "t167",
+ "source": "N",
+ "target": "DDX58_ubiquitinated",
+ "sign": true
+ },
+ {
+ "id": "t168",
+ "source": "TRIM25",
+ "target": "DDX58_ubiquitinated",
+ "sign": true
+ },
+ {
+ "id": "t169",
+ "source": "OAS3_rna",
+ "target": "OAS3_cell",
+ "sign": true
+ },
+ {
+ "id": "t170",
+ "source": "OAS2_rna",
+ "target": "OAS2_cell",
+ "sign": true
+ },
+ {
+ "id": "t171",
+ "source": "OAS1_rna",
+ "target": "OAS1_cell",
+ "sign": true
+ },
+ {
+ "id": "t172",
+ "source": "pp1ab",
+ "target": "STING1_ubiquitinated",
+ "sign": true
+ },
+ {
+ "id": "t173",
+ "source": "MAVS",
+ "target": "STING1_ubiquitinated",
+ "sign": true
+ },
+ {
+ "id": "t174",
+ "source": "IFNA1_extracellular space",
+ "target": "Viral dsRNA_rna_cell",
+ "sign": true
+ },
+ {
+ "id": "t175",
+ "source": "Viral replication_phenotype",
+ "target": "Viral dsRNA_rna_cell",
+ "sign": true
+ },
+ {
+ "id": "t176",
+ "source": "IFNB1_extracellular space",
+ "target": "Viral dsRNA_rna_cell",
+ "sign": true
+ },
+ {
+ "id": "t177",
+ "source": "NLRP3_inflammasome_complex",
+ "target": "Proinflammatory cytokine expression_Inflammation_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t178",
+ "source": "p50_p65_complex_nucleus",
+ "target": "Proinflammatory cytokine expression_Inflammation_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t179",
+ "source": "Orf9b",
+ "target": "ITCH",
+ "sign": true
+ },
+ {
+ "id": "t180",
+ "source": "TRAF3_TANK_TBK1_IKKepsilon_complex",
+ "target": "IRF7_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t181",
+ "source": "IFNA1_extracellular space",
+ "target": "type I IFN response_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t182",
+ "source": "IFNB1_extracellular space",
+ "target": "type I IFN response_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t183",
+ "source": "IkB_p50_p65_complex_cell",
+ "target": "IkB_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t184",
+ "source": "TLR4_TRIF_TRAM_complex",
+ "target": "NAP1",
+ "sign": true
+ },
+ {
+ "id": "t185",
+ "source": "ISRE_complex",
+ "target": "ISG15_rna",
+ "sign": true
+ },
+ {
+ "id": "t186",
+ "source": "ISG15_rna",
+ "target": "ISG15",
+ "sign": true
+ }
+ ],
+ "parameters": []
+ },
+ "semantics": {
+ "ode": {
+ "rates": [],
+ "observables": [],
+ "time": {
+ "id": "t"
+ }
+ }
+ },
+ "metadata": {
+ "annotations": {}
+ }
+}
\ No newline at end of file
diff --git a/scripts/covid19_diseasemaps/regnet_amr_sbml/JNK_pathway.json b/scripts/covid19_diseasemaps/regnet_amr_sbml/JNK_pathway.json
new file mode 100644
index 000000000..a4e95e32d
--- /dev/null
+++ b/scripts/covid19_diseasemaps/regnet_amr_sbml/JNK_pathway.json
@@ -0,0 +1,307 @@
+{
+ "header": {
+ "name": "Model",
+ "schema": "https://raw.githubusercontent.com/DARPA-ASKEM/Model-Representations/regnet_v0.2/regnet/regnet_schema.json",
+ "schema_name": "regnet",
+ "description": "Model",
+ "model_version": "0.1"
+ },
+ "model": {
+ "vertices": [
+ {
+ "id": "JNK_complex_cell",
+ "name": "JNK_complex_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MAP2K4_phosphorylated",
+ "name": "MAP2K4_phosphorylated",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MAP2K7_phosphorylated",
+ "name": "MAP2K7_phosphorylated",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "7a",
+ "name": "7a",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "3a",
+ "name": "3a",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "S",
+ "name": "S",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SARS-CoV-1 proteins_complex",
+ "name": "SARS-CoV-1 proteins_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MLK1/2/3_complex",
+ "name": "MLK1/2/3_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "3b",
+ "name": "3b",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "AP-1_complex",
+ "name": "AP-1_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MEKK1/4_complex",
+ "name": "MEKK1/4_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "BCL2_phosphorylated",
+ "name": "BCL2_phosphorylated",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Innate Immunity_phenotype",
+ "name": "Innate Immunity_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "GO:0045087"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Autophagy_phenotype",
+ "name": "Autophagy_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "GO:0006914"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ATF2_phosphorylated",
+ "name": "ATF2_phosphorylated",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TP53_phosphorylated",
+ "name": "TP53_phosphorylated",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TP53 signalling_phenotype",
+ "name": "TP53 signalling_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "GO:0072331"
+ }
+ },
+ "initial": 3.0
+ }
+ ],
+ "edges": [
+ {
+ "id": "t1",
+ "source": "MAP2K7_phosphorylated",
+ "target": "JNK_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t2",
+ "source": "S",
+ "target": "JNK_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t3",
+ "source": "7a",
+ "target": "JNK_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t4",
+ "source": "MAP2K4_phosphorylated",
+ "target": "JNK_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t5",
+ "source": "3a",
+ "target": "JNK_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t6",
+ "source": "SARS-CoV-1 proteins_complex",
+ "target": "MLK1/2/3_complex",
+ "sign": true
+ },
+ {
+ "id": "t7",
+ "source": "3b",
+ "target": "AP-1_complex",
+ "sign": true
+ },
+ {
+ "id": "t8",
+ "source": "JNK_complex_cell",
+ "target": "AP-1_complex",
+ "sign": true
+ },
+ {
+ "id": "t9",
+ "source": "SARS-CoV-1 proteins_complex",
+ "target": "MEKK1/4_complex",
+ "sign": true
+ },
+ {
+ "id": "t10",
+ "source": "SARS-CoV-1 proteins_complex",
+ "target": "MAP2K4_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t11",
+ "source": "MEKK1/4_complex",
+ "target": "MAP2K4_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t12",
+ "source": "SARS-CoV-1 proteins_complex",
+ "target": "MAP2K7_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t13",
+ "source": "MLK1/2/3_complex",
+ "target": "MAP2K7_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t14",
+ "source": "JNK_complex_cell",
+ "target": "BCL2_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t15",
+ "source": "AP-1_complex",
+ "target": "Innate Immunity_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t16",
+ "source": "BCL2_phosphorylated",
+ "target": "BCL2_phosphorylated",
+ "sign": false
+ },
+ {
+ "id": "t17",
+ "source": "BCL2_phosphorylated",
+ "target": "Autophagy_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t18",
+ "source": "JNK_complex_cell",
+ "target": "ATF2_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t19",
+ "source": "JNK_complex_cell",
+ "target": "TP53_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t20",
+ "source": "TP53_phosphorylated",
+ "target": "TP53 signalling_phenotype",
+ "sign": true
+ }
+ ],
+ "parameters": []
+ },
+ "semantics": {
+ "ode": {
+ "rates": [],
+ "observables": [],
+ "time": {
+ "id": "t"
+ }
+ }
+ },
+ "metadata": {
+ "annotations": {}
+ }
+}
\ No newline at end of file
diff --git a/scripts/covid19_diseasemaps/regnet_amr_sbml/Kynurenine_pathway.json b/scripts/covid19_diseasemaps/regnet_amr_sbml/Kynurenine_pathway.json
new file mode 100644
index 000000000..635343c4f
--- /dev/null
+++ b/scripts/covid19_diseasemaps/regnet_amr_sbml/Kynurenine_pathway.json
@@ -0,0 +1,3469 @@
+{
+ "header": {
+ "name": "Model",
+ "schema": "https://raw.githubusercontent.com/DARPA-ASKEM/Model-Representations/regnet_v0.2/regnet/regnet_schema.json",
+ "schema_name": "regnet",
+ "description": "Model",
+ "model_version": "0.1"
+ },
+ "model": {
+ "vertices": [
+ {
+ "id": "L-Kynurenine_simple_molecule",
+ "name": "L-Kynurenine_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:16946"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "AHR",
+ "name": "AHR",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P35869"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "AHR/L-KYN_complex",
+ "name": "AHR/L-KYN_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CO_simple_molecule",
+ "name": "CO_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:17245"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Heme_simple_molecule",
+ "name": "Heme_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:30413"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "apo-IDO1",
+ "name": "apo-IDO1",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P14902"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IDO1_complex",
+ "name": "IDO1_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P14902"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "L-Tryptophan_simple_molecule_human host",
+ "name": "L-Tryptophan_simple_molecule_human host",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:57912"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SLC36A4",
+ "name": "SLC36A4",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:Q6YBV0"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "L-Tryptophan_simple_molecule_cell",
+ "name": "L-Tryptophan_simple_molecule_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:57912"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IDO1_rna",
+ "name": "IDO1_rna",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "ncbigene:3620",
+ "property1": "ncbigene:3620"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NADPH_simple_molecule_cell",
+ "name": "NADPH_simple_molecule_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:16474"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "H+_ion_cell",
+ "name": "H+_ion_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:15378"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "O2_simple_molecule",
+ "name": "O2_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:15379"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "KMO",
+ "name": "KMO",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:O15229"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "AP-DOBu_simple_molecule",
+ "name": "AP-DOBu_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:17442"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ACS_simple_molecule",
+ "name": "ACS_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:29044"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "QUIN_simple_molecule",
+ "name": "QUIN_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:16675"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PRPP_simple_molecule",
+ "name": "PRPP_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:17111"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "QPRT",
+ "name": "QPRT",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:Q15274"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "HMOX1_cell",
+ "name": "HMOX1_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "H2O_simple_molecule_cell",
+ "name": "H2O_simple_molecule_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:15377"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IDO2",
+ "name": "IDO2",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:Q6ZQW0"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Epacadostat_drug",
+ "name": "Epacadostat_drug",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NFK_simple_molecule",
+ "name": "NFK_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:18377"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PYR_simple_molecule",
+ "name": "PYR_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:15361"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PXLP-KYAT1_complex",
+ "name": "PXLP-KYAT1_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:18405",
+ "property1": "uniprot:Q16773"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "I3PROPA",
+ "name": "I3PROPA",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:43580"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "L-Phe_simple_molecule",
+ "name": "L-Phe_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:58095"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "I3LACT",
+ "name": "I3LACT",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:55528"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "AFMID",
+ "name": "AFMID",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:Q63HM1"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "HCOOH_simple_molecule",
+ "name": "HCOOH_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:30751"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NAD+_simple_molecule_cell",
+ "name": "NAD+_simple_molecule_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:57540"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ATP_simple_molecule_cell",
+ "name": "ATP_simple_molecule_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:30616"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NADK:Zn2+ tetramer_complex",
+ "name": "NADK:Zn2+ tetramer_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:29105",
+ "property1": "uniprot:O95544"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "L-Arginine_simple_molecule",
+ "name": "L-Arginine_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:16467"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "iNOS",
+ "name": "iNOS",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P35228"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NADP+_simple_molecule_cell",
+ "name": "NADP+_simple_molecule_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:18009"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "2AMA_simple_molecule",
+ "name": "2AMA_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:15745"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NAR_simple_molecule",
+ "name": "NAR_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:58527"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NMRK1",
+ "name": "NMRK1",
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+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NMRK2",
+ "name": "NMRK2",
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+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NR_simple_molecule",
+ "name": "NR_simple_molecule",
+ "grounding": {
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+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "KYNA_simple_molecule",
+ "name": "KYNA_simple_molecule",
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+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CCBL2",
+ "name": "CCBL2",
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+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "3HKYN_simple_molecule",
+ "name": "3HKYN_simple_molecule",
+ "grounding": {
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+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "KYNU",
+ "name": "KYNU",
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+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "L-Ala_simple_molecule",
+ "name": "L-Ala_simple_molecule",
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+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "3HAA_simple_molecule",
+ "name": "3HAA_simple_molecule",
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+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Regulatory T-cell generation_phenotype",
+ "name": "Regulatory T-cell generation_phenotype",
+ "grounding": {
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+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "HAAO",
+ "name": "HAAO",
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+ }
+ },
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+ },
+ {
+ "id": "ACMSD",
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+ }
+ },
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+ },
+ {
+ "id": "CO2_simple_molecule",
+ "name": "CO2_simple_molecule",
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+ }
+ },
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+ },
+ {
+ "id": "NADH_simple_molecule_cell",
+ "name": "NADH_simple_molecule_cell",
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+ }
+ },
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+ },
+ {
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+ }
+ },
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+ },
+ {
+ "id": "L-Gln_simple_molecule",
+ "name": "L-Gln_simple_molecule",
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+ }
+ },
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+ },
+ {
+ "id": "NADSYN1 hexamer",
+ "name": "NADSYN1 hexamer",
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+ }
+ },
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+ },
+ {
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+ }
+ },
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+ },
+ {
+ "id": "NMNAT2:Mg2+_complex",
+ "name": "NMNAT2:Mg2+_complex",
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+ "property1": "uniprot:Q9BZQ4"
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+ },
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+ },
+ {
+ "id": "2AM_simple_molecule",
+ "name": "2AM_simple_molecule",
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+ }
+ },
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+ },
+ {
+ "id": "IFN-G",
+ "name": "IFN-G",
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+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nf-KB Complex_complex",
+ "name": "Nf-KB Complex_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P19838",
+ "property1": "uniprot:Q00653",
+ "property2": "uniprot:Q04206"
+ }
+ },
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+ },
+ {
+ "id": "iNOS_rna",
+ "name": "iNOS_rna",
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+ },
+ {
+ "id": "NO_simple_molecule",
+ "name": "NO_simple_molecule",
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+ },
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+ },
+ {
+ "id": "NAMN_simple_molecule_mitochondrial matrix",
+ "name": "NAMN_simple_molecule_mitochondrial matrix",
+ "grounding": {
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+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ATP_simple_molecule_mitochondrial matrix",
+ "name": "ATP_simple_molecule_mitochondrial matrix",
+ "grounding": {
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+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NMNAT3:Mg2+_complex",
+ "name": "NMNAT3:Mg2+_complex",
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+ "property1": "uniprot:Q96T66"
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+ },
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+ },
+ {
+ "id": "PPi (3-)_simple_molecule",
+ "name": "PPi (3-)_simple_molecule",
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+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NAAD_simple_molecule_mitochondrial matrix",
+ "name": "NAAD_simple_molecule_mitochondrial matrix",
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+ }
+ },
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+ },
+ {
+ "id": "S-NADPHX_simple_molecule",
+ "name": "S-NADPHX_simple_molecule",
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+ }
+ },
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+ {
+ "id": "CARKD",
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+ {
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+ "name": "NAD+_simple_molecule_mitochondrial matrix",
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+ {
+ "id": "NADK2",
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+ },
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+ {
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+ {
+ "id": "ADP_simple_molecule_mitochondrial matrix",
+ "name": "ADP_simple_molecule_mitochondrial matrix",
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+ },
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+ },
+ {
+ "id": "NADPH_simple_molecule_mitochondrial matrix",
+ "name": "NADPH_simple_molecule_mitochondrial matrix",
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+ }
+ },
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+ },
+ {
+ "id": "R-NADPHX_simple_molecule",
+ "name": "R-NADPHX_simple_molecule",
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+ }
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+ },
+ {
+ "id": "APOA1BP",
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+ },
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+ },
+ {
+ "id": "NADP+_simple_molecule_mitochondrial matrix",
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+ }
+ },
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+ },
+ {
+ "id": "Pi_simple_molecule",
+ "name": "Pi_simple_molecule",
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+ },
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+ },
+ {
+ "id": "SLC22A13",
+ "name": "SLC22A13",
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+ },
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+ },
+ {
+ "id": "NCA_simple_molecule",
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+ "property1": "CHEBI:32544"
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+ {
+ "id": "NAPRT1",
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+ {
+ "id": "Mg2+_ion",
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+ },
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+ },
+ {
+ "id": "NAM_simple_molecule_cell",
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+ {
+ "id": "NAMPT",
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+ },
+ {
+ "id": "PPi_simple_molecule",
+ "name": "PPi_simple_molecule",
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+ }
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+ },
+ {
+ "id": "NAMN_simple_molecule_cell",
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+ {
+ "id": "PPi(3-)_simple_molecule_cell",
+ "name": "PPi(3-)_simple_molecule_cell",
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+ },
+ {
+ "id": "L-Glu_simple_molecule",
+ "name": "L-Glu_simple_molecule",
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+ },
+ {
+ "id": "AMP_simple_molecule_cell",
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+ {
+ "id": "ADP_simple_molecule_cell",
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+ },
+ {
+ "id": "AdoMet_simple_molecule",
+ "name": "AdoMet_simple_molecule",
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+ }
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+ {
+ "id": "NNMT",
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+ },
+ {
+ "id": "MNA_simple_molecule",
+ "name": "MNA_simple_molecule",
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+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "(ADP-D-ribosyl)(n)-acceptor_simple_molecule",
+ "name": "(ADP-D-ribosyl)(n)-acceptor_simple_molecule",
+ "grounding": {
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+ "context": {
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+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PARPs",
+ "name": "PARPs",
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+ "property1": "uniprot:Q8IXQ6",
+ "property2": "uniprot:Q8N5Y8"
+ }
+ },
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+ },
+ {
+ "id": "AdoHcy_simple_molecule",
+ "name": "AdoHcy_simple_molecule",
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+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "(ADP-D-ribosyl)(n+1)-acceptor_simple_molecule",
+ "name": "(ADP-D-ribosyl)(n+1)-acceptor_simple_molecule",
+ "grounding": {
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+ "context": {
+ "property": "CHEBI:133203"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NAD+_simple_molecule_human host",
+ "name": "NAD+_simple_molecule_human host",
+ "grounding": {
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+ "context": {
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+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "H2O_simple_molecule_human host",
+ "name": "H2O_simple_molecule_human host",
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+ "context": {
+ "property": "CHEBI:15377"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "BST1",
+ "name": "BST1",
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+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CD38",
+ "name": "CD38",
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+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "H+_ion_human host",
+ "name": "H+_ion_human host",
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+ "context": {
+ "property": "CHEBI:15378"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NAM_simple_molecule_human host",
+ "name": "NAM_simple_molecule_human host",
+ "grounding": {
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+ "context": {
+ "property": "CHEBI:17154"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "dh-beta-NAD_simple_molecule",
+ "name": "dh-beta-NAD_simple_molecule",
+ "grounding": {
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+ "context": {
+ "property": "CHEBI:90171",
+ "property1": "CHEBI:90174"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "O2_ion",
+ "name": "O2_ion",
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+ "context": {
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+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "RNLS:FAD_complex",
+ "name": "RNLS:FAD_complex",
+ "grounding": {
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+ "context": {
+ "property": "CHEBI:16238",
+ "property1": "uniprot:Q5VYX0"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "H2O2_simple_molecule",
+ "name": "H2O2_simple_molecule",
+ "grounding": {
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+ "context": {
+ "property": "CHEBI:16240"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ADP-ribose_simple_molecule",
+ "name": "ADP-ribose_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:57967"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NT5E:Zn2+_complex",
+ "name": "NT5E:Zn2+_complex",
+ "grounding": {
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+ "context": {
+ "property": "CHEBI:29105",
+ "property1": "uniprot:P21589"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NMN_simple_molecule_human host",
+ "name": "NMN_simple_molecule_human host",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:14649"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Pi_ion",
+ "name": "Pi_ion",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:18367"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NRNAM_simple_molecule",
+ "name": "NRNAM_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:15927"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NADH_simple_molecule_peroxisome",
+ "name": "NADH_simple_molecule_peroxisome",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:57945"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "AMP_simple_molecule_peroxisome",
+ "name": "AMP_simple_molecule_peroxisome",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:16027"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "H2O_simple_molecule_peroxisome",
+ "name": "H2O_simple_molecule_peroxisome",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:15377"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NUDT12",
+ "name": "NUDT12",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:Q9BQG2"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NMNH_simple_molecule",
+ "name": "NMNH_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:74452"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "H+_ion_peroxisome",
+ "name": "H+_ion_peroxisome",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:15378"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NAMN_simple_molecule_nucleus",
+ "name": "NAMN_simple_molecule_nucleus",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:15763"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ATP_simple_molecule_nucleus",
+ "name": "ATP_simple_molecule_nucleus",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:30616"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NMNAT1:Zn2+_complex",
+ "name": "NMNAT1:Zn2+_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:29105",
+ "property1": "uniprot:Q9HAN9"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NAAD_simple_molecule_nucleus",
+ "name": "NAAD_simple_molecule_nucleus",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:18304"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PPi(3-)_simple_molecule_nucleus",
+ "name": "PPi(3-)_simple_molecule_nucleus",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:33019"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PGH2_simple_molecule",
+ "name": "PGH2_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:15554"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PTGIS",
+ "name": "PTGIS",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:Q16647"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PGI2_simple_molecule",
+ "name": "PGI2_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:15552"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PGG2_simple_molecule",
+ "name": "PGG2_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:27647"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "e-_ion",
+ "name": "e-_ion",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:10545"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "H+_ion_endoplasmic reticulum",
+ "name": "H+_ion_endoplasmic reticulum",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:15378"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PTGS2",
+ "name": "PTGS2",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P35354"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PTCS2:celecoxib_complex",
+ "name": "PTCS2:celecoxib_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:41423",
+ "property1": "uniprot:P35354"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "H2O_simple_molecule_endoplasmic reticulum",
+ "name": "H2O_simple_molecule_endoplasmic reticulum",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:15377"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "monocarboxylates transported by SLC5A8_simple_molecule_human host",
+ "name": "monocarboxylates transported by SLC5A8_simple_molecule_human host",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Na+_ion_human host",
+ "name": "Na+_ion_human host",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:29101"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SLC5A8",
+ "name": "SLC5A8",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:Q8N695"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "monocarboxylates transported by SLC5A8_simple_molecule_cell",
+ "name": "monocarboxylates transported by SLC5A8_simple_molecule_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Na+_ion_cell",
+ "name": "Na+_ion_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:29101"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "HMOX1_rna",
+ "name": "HMOX1_rna",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "ncbigene:3162",
+ "property1": "ncbigene:3162"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf3a",
+ "name": "Orf3a",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "ncbiprotein:BCD58754",
+ "property1": "uniprot:P0DTC3"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Fe2+_ion",
+ "name": "Fe2+_ion",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:29033"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Biliverdin_simple_molecule",
+ "name": "Biliverdin_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:17033"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CA_simple_molecule",
+ "name": "CA_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "T-cell apoptosis_phenotype",
+ "name": "T-cell apoptosis_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "GO:0070231"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Dendritic cell maturation_phenotype",
+ "name": "Dendritic cell maturation_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "GO:0097029"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Citrulline_simple_molecule",
+ "name": "Citrulline_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:16349"
+ }
+ },
+ "initial": 3.0
+ }
+ ],
+ "edges": [
+ {
+ "id": "t1",
+ "source": "L-Kynurenine_simple_molecule",
+ "target": "AHR/L-KYN_complex",
+ "sign": true
+ },
+ {
+ "id": "t2",
+ "source": "AHR",
+ "target": "AHR/L-KYN_complex",
+ "sign": true
+ },
+ {
+ "id": "t3",
+ "source": "CO_simple_molecule",
+ "target": "CO_simple_molecule",
+ "sign": false
+ },
+ {
+ "id": "t4",
+ "source": "Heme_simple_molecule",
+ "target": "IDO1_complex",
+ "sign": true
+ },
+ {
+ "id": "t5",
+ "source": "apo-IDO1",
+ "target": "IDO1_complex",
+ "sign": true
+ },
+ {
+ "id": "t6",
+ "source": "SLC36A4",
+ "target": "L-Tryptophan_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t7",
+ "source": "L-Tryptophan_simple_molecule_human host",
+ "target": "L-Tryptophan_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t8",
+ "source": "IDO1_rna",
+ "target": "apo-IDO1",
+ "sign": true
+ },
+ {
+ "id": "t9",
+ "source": "KMO",
+ "target": "H2O_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t10",
+ "source": "O2_simple_molecule",
+ "target": "H2O_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t11",
+ "source": "QUIN_simple_molecule",
+ "target": "H2O_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t12",
+ "source": "Heme_simple_molecule",
+ "target": "H2O_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t13",
+ "source": "L-Kynurenine_simple_molecule",
+ "target": "H2O_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t14",
+ "source": "ACS_simple_molecule",
+ "target": "H2O_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t15",
+ "source": "PRPP_simple_molecule",
+ "target": "H2O_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t16",
+ "source": "QPRT",
+ "target": "H2O_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t17",
+ "source": "NADPH_simple_molecule_cell",
+ "target": "H2O_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t18",
+ "source": "AP-DOBu_simple_molecule",
+ "target": "H2O_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t19",
+ "source": "H+_ion_cell",
+ "target": "H2O_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t20",
+ "source": "HMOX1_cell",
+ "target": "H2O_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t21",
+ "source": "O2_simple_molecule",
+ "target": "NFK_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t22",
+ "source": "IDO2",
+ "target": "NFK_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t23",
+ "source": "L-Tryptophan_simple_molecule_cell",
+ "target": "NFK_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t24",
+ "source": "Epacadostat_drug",
+ "target": "NFK_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t25",
+ "source": "IDO1_complex",
+ "target": "NFK_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t26",
+ "source": "PYR_simple_molecule",
+ "target": "AP-DOBu_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t27",
+ "source": "L-Kynurenine_simple_molecule",
+ "target": "AP-DOBu_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t28",
+ "source": "L-Phe_simple_molecule",
+ "target": "AP-DOBu_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t29",
+ "source": "I3PROPA",
+ "target": "AP-DOBu_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t30",
+ "source": "PXLP-KYAT1_complex",
+ "target": "AP-DOBu_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t31",
+ "source": "I3LACT",
+ "target": "AP-DOBu_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t32",
+ "source": "NFK_simple_molecule",
+ "target": "HCOOH_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t33",
+ "source": "AFMID",
+ "target": "HCOOH_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t34",
+ "source": "H2O_simple_molecule_cell",
+ "target": "HCOOH_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t35",
+ "source": "NFK_simple_molecule",
+ "target": "L-Kynurenine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t36",
+ "source": "AFMID",
+ "target": "L-Kynurenine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t37",
+ "source": "H2O_simple_molecule_cell",
+ "target": "L-Kynurenine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t38",
+ "source": "KMO",
+ "target": "NADP+_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t39",
+ "source": "O2_simple_molecule",
+ "target": "NADP+_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t40",
+ "source": "Heme_simple_molecule",
+ "target": "NADP+_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t41",
+ "source": "NADK:Zn2+ tetramer_complex",
+ "target": "NADP+_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t42",
+ "source": "NAD+_simple_molecule_cell",
+ "target": "NADP+_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t43",
+ "source": "L-Kynurenine_simple_molecule",
+ "target": "NADP+_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t44",
+ "source": "L-Arginine_simple_molecule",
+ "target": "NADP+_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t45",
+ "source": "iNOS",
+ "target": "NADP+_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t46",
+ "source": "NADPH_simple_molecule_cell",
+ "target": "NADP+_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t47",
+ "source": "ATP_simple_molecule_cell",
+ "target": "NADP+_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t48",
+ "source": "H+_ion_cell",
+ "target": "NADP+_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t49",
+ "source": "HMOX1_cell",
+ "target": "NADP+_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t50",
+ "source": "NMRK2",
+ "target": "H+_ion_cell",
+ "sign": true
+ },
+ {
+ "id": "t51",
+ "source": "O2_simple_molecule",
+ "target": "H+_ion_cell",
+ "sign": true
+ },
+ {
+ "id": "t52",
+ "source": "NAD+_simple_molecule_cell",
+ "target": "H+_ion_cell",
+ "sign": true
+ },
+ {
+ "id": "t53",
+ "source": "NMRK1",
+ "target": "H+_ion_cell",
+ "sign": true
+ },
+ {
+ "id": "t54",
+ "source": "L-Arginine_simple_molecule",
+ "target": "H+_ion_cell",
+ "sign": true
+ },
+ {
+ "id": "t55",
+ "source": "H2O_simple_molecule_cell",
+ "target": "H+_ion_cell",
+ "sign": true
+ },
+ {
+ "id": "t56",
+ "source": "NR_simple_molecule",
+ "target": "H+_ion_cell",
+ "sign": true
+ },
+ {
+ "id": "t57",
+ "source": "iNOS",
+ "target": "H+_ion_cell",
+ "sign": true
+ },
+ {
+ "id": "t58",
+ "source": "ATP_simple_molecule_cell",
+ "target": "H+_ion_cell",
+ "sign": true
+ },
+ {
+ "id": "t59",
+ "source": "NAR_simple_molecule",
+ "target": "H+_ion_cell",
+ "sign": true
+ },
+ {
+ "id": "t60",
+ "source": "NADPH_simple_molecule_cell",
+ "target": "H+_ion_cell",
+ "sign": true
+ },
+ {
+ "id": "t61",
+ "source": "2AMA_simple_molecule",
+ "target": "H+_ion_cell",
+ "sign": true
+ },
+ {
+ "id": "t62",
+ "source": "AP-DOBu_simple_molecule",
+ "target": "KYNA_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t63",
+ "source": "3HKYN_simple_molecule",
+ "target": "L-Ala_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t64",
+ "source": "PYR_simple_molecule",
+ "target": "L-Ala_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t65",
+ "source": "L-Kynurenine_simple_molecule",
+ "target": "L-Ala_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t66",
+ "source": "L-Phe_simple_molecule",
+ "target": "L-Ala_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t67",
+ "source": "H2O_simple_molecule_cell",
+ "target": "L-Ala_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t68",
+ "source": "I3PROPA",
+ "target": "L-Ala_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t69",
+ "source": "PXLP-KYAT1_complex",
+ "target": "L-Ala_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t70",
+ "source": "I3LACT",
+ "target": "L-Ala_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t71",
+ "source": "KYNU",
+ "target": "L-Ala_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t72",
+ "source": "CCBL2",
+ "target": "L-Ala_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t73",
+ "source": "3HKYN_simple_molecule",
+ "target": "3HAA_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t74",
+ "source": "H2O_simple_molecule_cell",
+ "target": "3HAA_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t75",
+ "source": "KYNU",
+ "target": "3HAA_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t76",
+ "source": "KMO",
+ "target": "3HKYN_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t77",
+ "source": "O2_simple_molecule",
+ "target": "3HKYN_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t78",
+ "source": "L-Kynurenine_simple_molecule",
+ "target": "3HKYN_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t79",
+ "source": "NADPH_simple_molecule_cell",
+ "target": "3HKYN_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t80",
+ "source": "H+_ion_cell",
+ "target": "3HKYN_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t81",
+ "source": "3HAA_simple_molecule",
+ "target": "Regulatory T-cell generation_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t82",
+ "source": "AHR/L-KYN_complex",
+ "target": "Regulatory T-cell generation_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t83",
+ "source": "3HAA_simple_molecule",
+ "target": "ACS_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t84",
+ "source": "O2_simple_molecule",
+ "target": "ACS_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t85",
+ "source": "HAAO",
+ "target": "ACS_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t86",
+ "source": "QUIN_simple_molecule",
+ "target": "CO2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t87",
+ "source": "ACS_simple_molecule",
+ "target": "CO2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t88",
+ "source": "PRPP_simple_molecule",
+ "target": "CO2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t89",
+ "source": "QPRT",
+ "target": "CO2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t90",
+ "source": "ACMSD",
+ "target": "CO2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t91",
+ "source": "H+_ion_cell",
+ "target": "CO2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t92",
+ "source": "ACS_simple_molecule",
+ "target": "QUIN_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t93",
+ "source": "NAD+_simple_molecule_cell",
+ "target": "NADH_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t94",
+ "source": "2AMA_simple_molecule",
+ "target": "NADH_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t95",
+ "source": "H2O_simple_molecule_cell",
+ "target": "NADH_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t96",
+ "source": "NAAD_simple_molecule_cell",
+ "target": "NAD+_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t97",
+ "source": "L-Gln_simple_molecule",
+ "target": "NAD+_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t98",
+ "source": "H2O_simple_molecule_cell",
+ "target": "NAD+_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t99",
+ "source": "NADSYN1 hexamer",
+ "target": "NAD+_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t100",
+ "source": "ATP_simple_molecule_cell",
+ "target": "NAD+_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t101",
+ "source": "NMN_simple_molecule_cell",
+ "target": "NAD+_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t102",
+ "source": "NMNAT2:Mg2+_complex",
+ "target": "NAD+_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t103",
+ "source": "ACMSD",
+ "target": "2AMA_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t104",
+ "source": "ACS_simple_molecule",
+ "target": "2AMA_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t105",
+ "source": "NAD+_simple_molecule_cell",
+ "target": "2AM_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t106",
+ "source": "2AMA_simple_molecule",
+ "target": "2AM_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t107",
+ "source": "H2O_simple_molecule_cell",
+ "target": "2AM_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t108",
+ "source": "CO_simple_molecule",
+ "target": "iNOS_rna",
+ "sign": true
+ },
+ {
+ "id": "t109",
+ "source": "Nf-KB Complex_complex",
+ "target": "iNOS_rna",
+ "sign": true
+ },
+ {
+ "id": "t110",
+ "source": "IFN-G",
+ "target": "iNOS_rna",
+ "sign": true
+ },
+ {
+ "id": "t111",
+ "source": "iNOS_rna",
+ "target": "iNOS",
+ "sign": true
+ },
+ {
+ "id": "t112",
+ "source": "O2_simple_molecule",
+ "target": "NO_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t113",
+ "source": "L-Arginine_simple_molecule",
+ "target": "NO_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t114",
+ "source": "NADPH_simple_molecule_cell",
+ "target": "NO_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t115",
+ "source": "iNOS",
+ "target": "NO_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t116",
+ "source": "NO_simple_molecule",
+ "target": "IDO1_rna",
+ "sign": true
+ },
+ {
+ "id": "t117",
+ "source": "IFN-G",
+ "target": "IDO1_rna",
+ "sign": true
+ },
+ {
+ "id": "t118",
+ "source": "NAMN_simple_molecule_mitochondrial matrix",
+ "target": "PPi (3-)_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t119",
+ "source": "ATP_simple_molecule_mitochondrial matrix",
+ "target": "PPi (3-)_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t120",
+ "source": "NMNAT3:Mg2+_complex",
+ "target": "PPi (3-)_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t121",
+ "source": "NAMN_simple_molecule_mitochondrial matrix",
+ "target": "NAAD_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t122",
+ "source": "ATP_simple_molecule_mitochondrial matrix",
+ "target": "NAAD_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t123",
+ "source": "NMNAT3:Mg2+_complex",
+ "target": "NAAD_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t124",
+ "source": "CARKD",
+ "target": "H+_ion_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t125",
+ "source": "NAD+_simple_molecule_mitochondrial matrix",
+ "target": "H+_ion_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t126",
+ "source": "ATP_simple_molecule_mitochondrial matrix",
+ "target": "H+_ion_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t127",
+ "source": "S-NADPHX_simple_molecule",
+ "target": "H+_ion_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t128",
+ "source": "NADK2",
+ "target": "H+_ion_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t129",
+ "source": "CARKD",
+ "target": "ADP_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t130",
+ "source": "NAD+_simple_molecule_mitochondrial matrix",
+ "target": "ADP_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t131",
+ "source": "ATP_simple_molecule_mitochondrial matrix",
+ "target": "ADP_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t132",
+ "source": "S-NADPHX_simple_molecule",
+ "target": "ADP_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t133",
+ "source": "NADK2",
+ "target": "ADP_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t134",
+ "source": "ATP_simple_molecule_mitochondrial matrix",
+ "target": "NADPH_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t135",
+ "source": "S-NADPHX_simple_molecule",
+ "target": "NADPH_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t136",
+ "source": "CARKD",
+ "target": "NADPH_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t137",
+ "source": "R-NADPHX_simple_molecule",
+ "target": "S-NADPHX_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t138",
+ "source": "APOA1BP",
+ "target": "S-NADPHX_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t139",
+ "source": "ATP_simple_molecule_mitochondrial matrix",
+ "target": "NADP+_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t140",
+ "source": "NAD+_simple_molecule_mitochondrial matrix",
+ "target": "NADP+_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t141",
+ "source": "NADK2",
+ "target": "NADP+_simple_molecule_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t142",
+ "source": "ATP_simple_molecule_mitochondrial matrix",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t143",
+ "source": "S-NADPHX_simple_molecule",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t144",
+ "source": "CARKD",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t145",
+ "source": "SLC22A13",
+ "target": "NCA_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t146",
+ "source": "Mg2+_ion",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t147",
+ "source": "NAAD_simple_molecule_cell",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t148",
+ "source": "L-Gln_simple_molecule",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t149",
+ "source": "H2O_simple_molecule_cell",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t150",
+ "source": "NAMPT",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t151",
+ "source": "PRPP_simple_molecule",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t152",
+ "source": "NCA_simple_molecule",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t153",
+ "source": "NAPRT1",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t154",
+ "source": "ATP_simple_molecule_cell",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t155",
+ "source": "NADSYN1 hexamer",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t156",
+ "source": "H+_ion_cell",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t157",
+ "source": "NAM_simple_molecule_cell",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t158",
+ "source": "NMRK2",
+ "target": "NAMN_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t159",
+ "source": "Mg2+_ion",
+ "target": "NAMN_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t160",
+ "source": "QUIN_simple_molecule",
+ "target": "NAMN_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t161",
+ "source": "NMRK1",
+ "target": "NAMN_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t162",
+ "source": "NAMPT",
+ "target": "NAMN_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t163",
+ "source": "PRPP_simple_molecule",
+ "target": "NAMN_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t164",
+ "source": "NCA_simple_molecule",
+ "target": "NAMN_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t165",
+ "source": "QPRT",
+ "target": "NAMN_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t166",
+ "source": "ATP_simple_molecule_cell",
+ "target": "NAMN_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t167",
+ "source": "NAR_simple_molecule",
+ "target": "NAMN_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t168",
+ "source": "NAPRT1",
+ "target": "NAMN_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t169",
+ "source": "H+_ion_cell",
+ "target": "NAMN_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t170",
+ "source": "NAM_simple_molecule_cell",
+ "target": "NAMN_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t171",
+ "source": "NMNAT2:Mg2+_complex",
+ "target": "NAAD_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t172",
+ "source": "NAMN_simple_molecule_cell",
+ "target": "NAAD_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t173",
+ "source": "NMN_simple_molecule_cell",
+ "target": "PPi(3-)_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t174",
+ "source": "NMNAT2:Mg2+_complex",
+ "target": "PPi(3-)_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t175",
+ "source": "NAMN_simple_molecule_cell",
+ "target": "PPi(3-)_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t176",
+ "source": "ATP_simple_molecule_cell",
+ "target": "PPi(3-)_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t177",
+ "source": "NAAD_simple_molecule_cell",
+ "target": "L-Glu_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t178",
+ "source": "L-Gln_simple_molecule",
+ "target": "L-Glu_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t179",
+ "source": "H2O_simple_molecule_cell",
+ "target": "L-Glu_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t180",
+ "source": "ATP_simple_molecule_cell",
+ "target": "L-Glu_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t181",
+ "source": "NADSYN1 hexamer",
+ "target": "L-Glu_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t182",
+ "source": "NAAD_simple_molecule_cell",
+ "target": "AMP_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t183",
+ "source": "L-Gln_simple_molecule",
+ "target": "AMP_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t184",
+ "source": "H2O_simple_molecule_cell",
+ "target": "AMP_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t185",
+ "source": "ATP_simple_molecule_cell",
+ "target": "AMP_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t186",
+ "source": "NADSYN1 hexamer",
+ "target": "AMP_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t187",
+ "source": "NMRK2",
+ "target": "ADP_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t188",
+ "source": "NADK:Zn2+ tetramer_complex",
+ "target": "ADP_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t189",
+ "source": "NAD+_simple_molecule_cell",
+ "target": "ADP_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t190",
+ "source": "NMRK1",
+ "target": "ADP_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t191",
+ "source": "NR_simple_molecule",
+ "target": "ADP_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t192",
+ "source": "ATP_simple_molecule_cell",
+ "target": "ADP_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t193",
+ "source": "NAR_simple_molecule",
+ "target": "ADP_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t194",
+ "source": "NNMT",
+ "target": "MNA_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t195",
+ "source": "AdoMet_simple_molecule",
+ "target": "MNA_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t196",
+ "source": "NAM_simple_molecule_cell",
+ "target": "MNA_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t197",
+ "source": "(ADP-D-ribosyl)(n)-acceptor_simple_molecule",
+ "target": "NAM_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t198",
+ "source": "NAD+_simple_molecule_cell",
+ "target": "NAM_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t199",
+ "source": "PARPs",
+ "target": "NAM_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t200",
+ "source": "NMRK2",
+ "target": "NMN_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t201",
+ "source": "NR_simple_molecule",
+ "target": "NMN_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t202",
+ "source": "ATP_simple_molecule_cell",
+ "target": "NMN_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t203",
+ "source": "NMRK1",
+ "target": "NMN_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t204",
+ "source": "NNMT",
+ "target": "AdoHcy_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t205",
+ "source": "AdoMet_simple_molecule",
+ "target": "AdoHcy_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t206",
+ "source": "NAM_simple_molecule_cell",
+ "target": "AdoHcy_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t207",
+ "source": "(ADP-D-ribosyl)(n)-acceptor_simple_molecule",
+ "target": "(ADP-D-ribosyl)(n+1)-acceptor_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t208",
+ "source": "NAD+_simple_molecule_cell",
+ "target": "(ADP-D-ribosyl)(n+1)-acceptor_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t209",
+ "source": "PARPs",
+ "target": "(ADP-D-ribosyl)(n+1)-acceptor_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t210",
+ "source": "NAD+_simple_molecule_human host",
+ "target": "H+_ion_human host",
+ "sign": true
+ },
+ {
+ "id": "t211",
+ "source": "H2O_simple_molecule_human host",
+ "target": "H+_ion_human host",
+ "sign": true
+ },
+ {
+ "id": "t212",
+ "source": "CD38",
+ "target": "H+_ion_human host",
+ "sign": true
+ },
+ {
+ "id": "t213",
+ "source": "BST1",
+ "target": "H+_ion_human host",
+ "sign": true
+ },
+ {
+ "id": "t214",
+ "source": "NAD+_simple_molecule_human host",
+ "target": "NAM_simple_molecule_human host",
+ "sign": true
+ },
+ {
+ "id": "t215",
+ "source": "H2O_simple_molecule_human host",
+ "target": "NAM_simple_molecule_human host",
+ "sign": true
+ },
+ {
+ "id": "t216",
+ "source": "CD38",
+ "target": "NAM_simple_molecule_human host",
+ "sign": true
+ },
+ {
+ "id": "t217",
+ "source": "BST1",
+ "target": "NAM_simple_molecule_human host",
+ "sign": true
+ },
+ {
+ "id": "t218",
+ "source": "RNLS:FAD_complex",
+ "target": "H2O2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t219",
+ "source": "dh-beta-NAD_simple_molecule",
+ "target": "H2O2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t220",
+ "source": "O2_ion",
+ "target": "H2O2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t221",
+ "source": "H+_ion_human host",
+ "target": "H2O2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t222",
+ "source": "RNLS:FAD_complex",
+ "target": "NAD+_simple_molecule_human host",
+ "sign": true
+ },
+ {
+ "id": "t223",
+ "source": "dh-beta-NAD_simple_molecule",
+ "target": "NAD+_simple_molecule_human host",
+ "sign": true
+ },
+ {
+ "id": "t224",
+ "source": "O2_ion",
+ "target": "NAD+_simple_molecule_human host",
+ "sign": true
+ },
+ {
+ "id": "t225",
+ "source": "H+_ion_human host",
+ "target": "NAD+_simple_molecule_human host",
+ "sign": true
+ },
+ {
+ "id": "t226",
+ "source": "NAD+_simple_molecule_human host",
+ "target": "ADP-ribose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t227",
+ "source": "H2O_simple_molecule_human host",
+ "target": "ADP-ribose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t228",
+ "source": "CD38",
+ "target": "ADP-ribose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t229",
+ "source": "BST1",
+ "target": "ADP-ribose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t230",
+ "source": "NAD+_simple_molecule_human host",
+ "target": "Pi_ion",
+ "sign": true
+ },
+ {
+ "id": "t231",
+ "source": "H2O_simple_molecule_human host",
+ "target": "Pi_ion",
+ "sign": true
+ },
+ {
+ "id": "t232",
+ "source": "NT5E:Zn2+_complex",
+ "target": "Pi_ion",
+ "sign": true
+ },
+ {
+ "id": "t233",
+ "source": "NMN_simple_molecule_human host",
+ "target": "Pi_ion",
+ "sign": true
+ },
+ {
+ "id": "t234",
+ "source": "NAD+_simple_molecule_human host",
+ "target": "NMN_simple_molecule_human host",
+ "sign": true
+ },
+ {
+ "id": "t235",
+ "source": "H2O_simple_molecule_human host",
+ "target": "NMN_simple_molecule_human host",
+ "sign": true
+ },
+ {
+ "id": "t236",
+ "source": "NT5E:Zn2+_complex",
+ "target": "NMN_simple_molecule_human host",
+ "sign": true
+ },
+ {
+ "id": "t237",
+ "source": "NT5E:Zn2+_complex",
+ "target": "NRNAM_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t238",
+ "source": "H2O_simple_molecule_human host",
+ "target": "NRNAM_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t239",
+ "source": "NMN_simple_molecule_human host",
+ "target": "NRNAM_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t240",
+ "source": "AMP_simple_molecule_peroxisome",
+ "target": "NMNH_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t241",
+ "source": "H2O_simple_molecule_peroxisome",
+ "target": "NMNH_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t242",
+ "source": "NADH_simple_molecule_peroxisome",
+ "target": "NMNH_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t243",
+ "source": "NUDT12",
+ "target": "NMNH_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t244",
+ "source": "AMP_simple_molecule_peroxisome",
+ "target": "H+_ion_peroxisome",
+ "sign": true
+ },
+ {
+ "id": "t245",
+ "source": "H2O_simple_molecule_peroxisome",
+ "target": "H+_ion_peroxisome",
+ "sign": true
+ },
+ {
+ "id": "t246",
+ "source": "NADH_simple_molecule_peroxisome",
+ "target": "H+_ion_peroxisome",
+ "sign": true
+ },
+ {
+ "id": "t247",
+ "source": "NUDT12",
+ "target": "H+_ion_peroxisome",
+ "sign": true
+ },
+ {
+ "id": "t248",
+ "source": "NMNAT1:Zn2+_complex",
+ "target": "NAAD_simple_molecule_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t249",
+ "source": "NAMN_simple_molecule_nucleus",
+ "target": "NAAD_simple_molecule_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t250",
+ "source": "ATP_simple_molecule_nucleus",
+ "target": "NAAD_simple_molecule_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t251",
+ "source": "NMNAT1:Zn2+_complex",
+ "target": "PPi(3-)_simple_molecule_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t252",
+ "source": "NAMN_simple_molecule_nucleus",
+ "target": "PPi(3-)_simple_molecule_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t253",
+ "source": "ATP_simple_molecule_nucleus",
+ "target": "PPi(3-)_simple_molecule_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t254",
+ "source": "PTGIS",
+ "target": "PGI2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t255",
+ "source": "PGH2_simple_molecule",
+ "target": "PGI2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t256",
+ "source": "PGG2_simple_molecule",
+ "target": "PGH2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t257",
+ "source": "e-_ion",
+ "target": "PGH2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t258",
+ "source": "MNA_simple_molecule",
+ "target": "PGH2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t259",
+ "source": "PTCS2:celecoxib_complex",
+ "target": "PGH2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t260",
+ "source": "H+_ion_endoplasmic reticulum",
+ "target": "PGH2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t261",
+ "source": "PTGS2",
+ "target": "PGH2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t262",
+ "source": "PGG2_simple_molecule",
+ "target": "H2O_simple_molecule_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t263",
+ "source": "e-_ion",
+ "target": "H2O_simple_molecule_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t264",
+ "source": "MNA_simple_molecule",
+ "target": "H2O_simple_molecule_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t265",
+ "source": "PTCS2:celecoxib_complex",
+ "target": "H2O_simple_molecule_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t266",
+ "source": "H+_ion_endoplasmic reticulum",
+ "target": "H2O_simple_molecule_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t267",
+ "source": "PTGS2",
+ "target": "H2O_simple_molecule_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t268",
+ "source": "monocarboxylates transported by SLC5A8_simple_molecule_human host",
+ "target": "monocarboxylates transported by SLC5A8_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t269",
+ "source": "Na+_ion_human host",
+ "target": "monocarboxylates transported by SLC5A8_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t270",
+ "source": "SLC5A8",
+ "target": "monocarboxylates transported by SLC5A8_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t271",
+ "source": "monocarboxylates transported by SLC5A8_simple_molecule_human host",
+ "target": "Na+_ion_cell",
+ "sign": true
+ },
+ {
+ "id": "t272",
+ "source": "Na+_ion_human host",
+ "target": "Na+_ion_cell",
+ "sign": true
+ },
+ {
+ "id": "t273",
+ "source": "SLC5A8",
+ "target": "Na+_ion_cell",
+ "sign": true
+ },
+ {
+ "id": "t274",
+ "source": "3HAA_simple_molecule",
+ "target": "HMOX1_rna",
+ "sign": true
+ },
+ {
+ "id": "t275",
+ "source": "NO_simple_molecule",
+ "target": "HMOX1_rna",
+ "sign": true
+ },
+ {
+ "id": "t276",
+ "source": "IFN-G",
+ "target": "HMOX1_rna",
+ "sign": true
+ },
+ {
+ "id": "t277",
+ "source": "HMOX1_rna",
+ "target": "HMOX1_cell",
+ "sign": true
+ },
+ {
+ "id": "t278",
+ "source": "Orf3a",
+ "target": "HMOX1_cell",
+ "sign": true
+ },
+ {
+ "id": "t279",
+ "source": "O2_simple_molecule",
+ "target": "Fe2+_ion",
+ "sign": true
+ },
+ {
+ "id": "t280",
+ "source": "Heme_simple_molecule",
+ "target": "Fe2+_ion",
+ "sign": true
+ },
+ {
+ "id": "t281",
+ "source": "HMOX1_cell",
+ "target": "Fe2+_ion",
+ "sign": true
+ },
+ {
+ "id": "t282",
+ "source": "NADPH_simple_molecule_cell",
+ "target": "Fe2+_ion",
+ "sign": true
+ },
+ {
+ "id": "t283",
+ "source": "O2_simple_molecule",
+ "target": "Biliverdin_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t284",
+ "source": "Heme_simple_molecule",
+ "target": "Biliverdin_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t285",
+ "source": "HMOX1_cell",
+ "target": "Biliverdin_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t286",
+ "source": "NADPH_simple_molecule_cell",
+ "target": "Biliverdin_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t287",
+ "source": "O2_simple_molecule",
+ "target": "CO_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t288",
+ "source": "Heme_simple_molecule",
+ "target": "CO_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t289",
+ "source": "HMOX1_cell",
+ "target": "CO_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t290",
+ "source": "NADPH_simple_molecule_cell",
+ "target": "CO_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t291",
+ "source": "L-Tryptophan_simple_molecule_human host",
+ "target": "L-Tryptophan_simple_molecule_human host",
+ "sign": false
+ },
+ {
+ "id": "t292",
+ "source": "3HAA_simple_molecule",
+ "target": "CA_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t293",
+ "source": "3HAA_simple_molecule",
+ "target": "3HAA_simple_molecule",
+ "sign": false
+ },
+ {
+ "id": "t294",
+ "source": "3HAA_simple_molecule",
+ "target": "T-cell apoptosis_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t295",
+ "source": "L-Kynurenine_simple_molecule",
+ "target": "T-cell apoptosis_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t296",
+ "source": "3HKYN_simple_molecule",
+ "target": "T-cell apoptosis_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t297",
+ "source": "CA_simple_molecule",
+ "target": "T-cell apoptosis_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t298",
+ "source": "3HKYN_simple_molecule",
+ "target": "Dendritic cell maturation_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t299",
+ "source": "3HAA_simple_molecule",
+ "target": "Dendritic cell maturation_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t300",
+ "source": "O2_simple_molecule",
+ "target": "Citrulline_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t301",
+ "source": "L-Arginine_simple_molecule",
+ "target": "Citrulline_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t302",
+ "source": "NADPH_simple_molecule_cell",
+ "target": "Citrulline_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t303",
+ "source": "iNOS",
+ "target": "Citrulline_simple_molecule",
+ "sign": true
+ }
+ ],
+ "parameters": []
+ },
+ "semantics": {
+ "ode": {
+ "rates": [],
+ "observables": [],
+ "time": {
+ "id": "t"
+ }
+ }
+ },
+ "metadata": {
+ "annotations": {}
+ }
+}
\ No newline at end of file
diff --git a/scripts/covid19_diseasemaps/regnet_amr_sbml/NLRP3_Activation.json b/scripts/covid19_diseasemaps/regnet_amr_sbml/NLRP3_Activation.json
new file mode 100644
index 000000000..94f06207d
--- /dev/null
+++ b/scripts/covid19_diseasemaps/regnet_amr_sbml/NLRP3_Activation.json
@@ -0,0 +1,1212 @@
+{
+ "header": {
+ "name": "Model",
+ "schema": "https://raw.githubusercontent.com/DARPA-ASKEM/Model-Representations/regnet_v0.2/regnet/regnet_schema.json",
+ "schema_name": "regnet",
+ "description": "Model",
+ "model_version": "0.1"
+ },
+ "model": {
+ "vertices": [
+ {
+ "id": "ASC:MAVS_complex",
+ "name": "ASC:MAVS_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:Q9ULZ3"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TRAF3",
+ "name": "TRAF3",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:Q13114"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ASC:MAVS:TRAF3_complex_cell",
+ "name": "ASC:MAVS:TRAF3_complex_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:Q13114",
+ "property1": "uniprot:Q9ULZ3"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NLRP3_cell",
+ "name": "NLRP3_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:Q96P20"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SUGT1:HSP90AB1_complex",
+ "name": "SUGT1:HSP90AB1_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P08238",
+ "property1": "uniprot:P08238",
+ "property2": "uniprot:Q9Y2Z0",
+ "property3": "uniprot:Q9Y2Z0"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NLRP3:SUGT1:HSP90_complex",
+ "name": "NLRP3:SUGT1:HSP90_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P08238",
+ "property1": "uniprot:Q96P20",
+ "property2": "uniprot:Q9Y2Z0"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CASP1_cell",
+ "name": "CASP1_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P29466"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NLRP3 oligomer:ASC_complex",
+ "name": "NLRP3 oligomer:ASC_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:Q96P20",
+ "property1": "uniprot:Q9ULZ3"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NLRP3 oligomer:ASC:proCaspase1_complex",
+ "name": "NLRP3 oligomer:ASC:proCaspase1_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P29466",
+ "property1": "uniprot:Q96P20",
+ "property2": "uniprot:Q9ULZ3"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CTSG",
+ "name": "CTSG",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P08311"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ASC_ubiquitinated",
+ "name": "ASC_ubiquitinated",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:Q9ULZ3"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CASP1(120-197):CASP1(317-404)_complex",
+ "name": "CASP1(120-197):CASP1(317-404)_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P29466",
+ "property1": "uniprot:P29466"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Caspase-1 Tetramer_complex",
+ "name": "Caspase-1 Tetramer_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P29466",
+ "property1": "uniprot:P29466"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TXNIP",
+ "name": "TXNIP",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:Q9H3M7"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TXNIP:NLRP3_complex",
+ "name": "TXNIP:NLRP3_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:Q96P20",
+ "property1": "uniprot:Q9H3M7"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CASP1_cell",
+ "name": "CASP1_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TRAF3:SARS Orf3a_complex_cell",
+ "name": "TRAF3:SARS Orf3a_complex_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "taxonomy:694009",
+ "property1": "taxonomy:694009",
+ "property2": "uniprot:P59632",
+ "property3": "uniprot:P59632",
+ "property4": "uniprot:Q13114",
+ "property5": "uniprot:Q13114"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IKBA_phosphorylated_phosphorylated",
+ "name": "IKBA_phosphorylated_phosphorylated",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nf-KB Complex_complex_cell",
+ "name": "Nf-KB Complex_complex_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P19838",
+ "property1": "uniprot:Q00653"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NF-KB COMPLEX:IKBA_complex",
+ "name": "NF-KB COMPLEX:IKBA_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P19838"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "p50",
+ "name": "p50",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P19838"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "p65",
+ "name": "p65",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:Q00653"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nf-KB Complex_complex_nucleus",
+ "name": "Nf-KB Complex_complex_nucleus",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P19838",
+ "property1": "uniprot:Q00653"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TXN_cell",
+ "name": "TXN_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P10599"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Thioredoxin:TXNIP_complex",
+ "name": "Thioredoxin:TXNIP_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P10599",
+ "property1": "uniprot:Q9H3M7"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ASC",
+ "name": "ASC",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:Q9ULZ3"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MAVS",
+ "name": "MAVS",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:Q7Z434"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf3a",
+ "name": "Orf3a",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "taxonomy:694009",
+ "property1": "uniprot:P59632"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "DAMPs_phenotype",
+ "name": "DAMPs_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "GO:0002221"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PAMPs_phenotype",
+ "name": "PAMPs_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "GO:0002221"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NLRP3 Elicitor Small Molecules_simple_molecule",
+ "name": "NLRP3 Elicitor Small Molecules_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:16336",
+ "property1": "CHEBI:30563",
+ "property2": "CHEBI:46661"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NLRP3 Elicitor Proteins",
+ "name": "NLRP3 Elicitor Proteins",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P05067",
+ "property1": "uniprot:P09616"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Reactive Oxygen Species_simple_molecule",
+ "name": "Reactive Oxygen Species_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:26523"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Ca2+_ion",
+ "name": "Ca2+_ion",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:29108",
+ "property1": "CHEBI:29108",
+ "property2": "CHEBI:29108"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CO_simple_molecule",
+ "name": "CO_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:17245"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "proIL-18_rna",
+ "name": "proIL-18_rna",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "ncbigene:3606",
+ "property1": "ncbigene:3606"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "proIL-18_cell",
+ "name": "proIL-18_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:Q14116"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "proIL-1B_rna",
+ "name": "proIL-1B_rna",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "ncbigene:3553",
+ "property1": "ncbigene:3553"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "proIL-1B_cell",
+ "name": "proIL-1B_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P01584"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IL-18_cell",
+ "name": "IL-18_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:Q14116"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IL-1B_cell",
+ "name": "IL-1B_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P01584"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IL-18_default_compartment",
+ "name": "IL-18_default_compartment",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:Q14116"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IL-1B_default_compartment",
+ "name": "IL-1B_default_compartment",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P01584"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "p105_ubiquitinated",
+ "name": "p105_ubiquitinated",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P19838",
+ "property1": "uniprot:P19838"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "E_Golgi apparatus",
+ "name": "E_Golgi apparatus",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P59637"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "E_endoplasmic reticulum-Golgi intermediate compartment",
+ "name": "E_endoplasmic reticulum-Golgi intermediate compartment",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "taxonomy:694009",
+ "property1": "uniprot:P59637"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Heme_simple_molecule",
+ "name": "Heme_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:30413"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "O2_simple_molecule",
+ "name": "O2_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:15379"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NADPH_simple_molecule",
+ "name": "NADPH_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:16474"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "HMOX1",
+ "name": "HMOX1",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P09601"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NADP+_simple_molecule",
+ "name": "NADP+_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:18009"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Biliverdin_simple_molecule",
+ "name": "Biliverdin_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:17033"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "H2O_simple_molecule",
+ "name": "H2O_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:15377"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Fe2+_ion",
+ "name": "Fe2+_ion",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:29033"
+ }
+ },
+ "initial": 3.0
+ }
+ ],
+ "edges": [
+ {
+ "id": "t1",
+ "source": "TRAF3",
+ "target": "ASC:MAVS:TRAF3_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t2",
+ "source": "ASC:MAVS_complex",
+ "target": "ASC:MAVS:TRAF3_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t3",
+ "source": "NLRP3_cell",
+ "target": "NLRP3:SUGT1:HSP90_complex",
+ "sign": true
+ },
+ {
+ "id": "t4",
+ "source": "SUGT1:HSP90AB1_complex",
+ "target": "NLRP3:SUGT1:HSP90_complex",
+ "sign": true
+ },
+ {
+ "id": "t5",
+ "source": "NLRP3 oligomer:ASC_complex",
+ "target": "NLRP3 oligomer:ASC:proCaspase1_complex",
+ "sign": true
+ },
+ {
+ "id": "t6",
+ "source": "CASP1_cell",
+ "target": "NLRP3 oligomer:ASC:proCaspase1_complex",
+ "sign": true
+ },
+ {
+ "id": "t7",
+ "source": "NLRP3 oligomer:ASC:proCaspase1_complex",
+ "target": "NLRP3 oligomer:ASC_complex",
+ "sign": true
+ },
+ {
+ "id": "t8",
+ "source": "NLRP3_cell",
+ "target": "NLRP3 oligomer:ASC_complex",
+ "sign": true
+ },
+ {
+ "id": "t9",
+ "source": "CTSG",
+ "target": "NLRP3 oligomer:ASC_complex",
+ "sign": true
+ },
+ {
+ "id": "t10",
+ "source": "ASC_ubiquitinated",
+ "target": "NLRP3 oligomer:ASC_complex",
+ "sign": true
+ },
+ {
+ "id": "t11",
+ "source": "CASP1(120-197):CASP1(317-404)_complex",
+ "target": "Caspase-1 Tetramer_complex",
+ "sign": true
+ },
+ {
+ "id": "t12",
+ "source": "NLRP3_cell",
+ "target": "TXNIP:NLRP3_complex",
+ "sign": true
+ },
+ {
+ "id": "t13",
+ "source": "TXNIP",
+ "target": "TXNIP:NLRP3_complex",
+ "sign": true
+ },
+ {
+ "id": "t14",
+ "source": "CASP1_cell",
+ "target": "CASP1(120-197):CASP1(317-404)_complex",
+ "sign": true
+ },
+ {
+ "id": "t15",
+ "source": "TRAF3:SARS Orf3a_complex_cell",
+ "target": "ASC:MAVS:TRAF3_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t16",
+ "source": "Nf-KB Complex_complex_cell",
+ "target": "NF-KB COMPLEX:IKBA_complex",
+ "sign": true
+ },
+ {
+ "id": "t17",
+ "source": "IKBA_phosphorylated_phosphorylated",
+ "target": "NF-KB COMPLEX:IKBA_complex",
+ "sign": true
+ },
+ {
+ "id": "t18",
+ "source": "p65",
+ "target": "Nf-KB Complex_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t19",
+ "source": "p50",
+ "target": "Nf-KB Complex_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t20",
+ "source": "Nf-KB Complex_complex_cell",
+ "target": "Nf-KB Complex_complex_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t21",
+ "source": "NF-KB COMPLEX:IKBA_complex",
+ "target": "Nf-KB Complex_complex_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t22",
+ "source": "TXNIP",
+ "target": "Thioredoxin:TXNIP_complex",
+ "sign": true
+ },
+ {
+ "id": "t23",
+ "source": "TXN_cell",
+ "target": "Thioredoxin:TXNIP_complex",
+ "sign": true
+ },
+ {
+ "id": "t24",
+ "source": "ASC",
+ "target": "ASC:MAVS_complex",
+ "sign": true
+ },
+ {
+ "id": "t25",
+ "source": "MAVS",
+ "target": "ASC:MAVS_complex",
+ "sign": true
+ },
+ {
+ "id": "t26",
+ "source": "TRAF3",
+ "target": "TRAF3:SARS Orf3a_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t27",
+ "source": "Orf3a",
+ "target": "TRAF3:SARS Orf3a_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t28",
+ "source": "NLRP3 Elicitor Proteins",
+ "target": "SUGT1:HSP90AB1_complex",
+ "sign": true
+ },
+ {
+ "id": "t29",
+ "source": "DAMPs_phenotype",
+ "target": "SUGT1:HSP90AB1_complex",
+ "sign": true
+ },
+ {
+ "id": "t30",
+ "source": "PAMPs_phenotype",
+ "target": "SUGT1:HSP90AB1_complex",
+ "sign": true
+ },
+ {
+ "id": "t31",
+ "source": "Reactive Oxygen Species_simple_molecule",
+ "target": "SUGT1:HSP90AB1_complex",
+ "sign": true
+ },
+ {
+ "id": "t32",
+ "source": "NLRP3 Elicitor Small Molecules_simple_molecule",
+ "target": "SUGT1:HSP90AB1_complex",
+ "sign": true
+ },
+ {
+ "id": "t33",
+ "source": "TXNIP:NLRP3_complex",
+ "target": "SUGT1:HSP90AB1_complex",
+ "sign": true
+ },
+ {
+ "id": "t34",
+ "source": "Ca2+_ion",
+ "target": "SUGT1:HSP90AB1_complex",
+ "sign": true
+ },
+ {
+ "id": "t35",
+ "source": "NLRP3:SUGT1:HSP90_complex",
+ "target": "SUGT1:HSP90AB1_complex",
+ "sign": true
+ },
+ {
+ "id": "t36",
+ "source": "CO_simple_molecule",
+ "target": "CO_simple_molecule",
+ "sign": false
+ },
+ {
+ "id": "t37",
+ "source": "Thioredoxin:TXNIP_complex",
+ "target": "TXNIP",
+ "sign": true
+ },
+ {
+ "id": "t38",
+ "source": "proIL-18_rna",
+ "target": "proIL-18_cell",
+ "sign": true
+ },
+ {
+ "id": "t39",
+ "source": "proIL-1B_rna",
+ "target": "proIL-1B_cell",
+ "sign": true
+ },
+ {
+ "id": "t40",
+ "source": "proIL-18_cell",
+ "target": "IL-18_cell",
+ "sign": true
+ },
+ {
+ "id": "t41",
+ "source": "Caspase-1 Tetramer_complex",
+ "target": "IL-18_cell",
+ "sign": true
+ },
+ {
+ "id": "t42",
+ "source": "Caspase-1 Tetramer_complex",
+ "target": "IL-1B_cell",
+ "sign": true
+ },
+ {
+ "id": "t43",
+ "source": "proIL-1B_cell",
+ "target": "IL-1B_cell",
+ "sign": true
+ },
+ {
+ "id": "t44",
+ "source": "Caspase-1 Tetramer_complex",
+ "target": "proIL-18_cell",
+ "sign": true
+ },
+ {
+ "id": "t45",
+ "source": "IL-18_cell",
+ "target": "IL-18_default_compartment",
+ "sign": true
+ },
+ {
+ "id": "t46",
+ "source": "IL-1B_cell",
+ "target": "IL-1B_default_compartment",
+ "sign": true
+ },
+ {
+ "id": "t47",
+ "source": "p105_ubiquitinated",
+ "target": "p50",
+ "sign": true
+ },
+ {
+ "id": "t48",
+ "source": "TRAF3:SARS Orf3a_complex_cell",
+ "target": "p105_ubiquitinated",
+ "sign": true
+ },
+ {
+ "id": "t49",
+ "source": "Nf-KB Complex_complex_nucleus",
+ "target": "proIL-18_rna",
+ "sign": true
+ },
+ {
+ "id": "t50",
+ "source": "Nf-KB Complex_complex_nucleus",
+ "target": "proIL-1B_rna",
+ "sign": true
+ },
+ {
+ "id": "t51",
+ "source": "ASC:MAVS:TRAF3_complex_cell",
+ "target": "TRAF3",
+ "sign": true
+ },
+ {
+ "id": "t52",
+ "source": "NLRP3 Elicitor Proteins",
+ "target": "NLRP3_cell",
+ "sign": true
+ },
+ {
+ "id": "t53",
+ "source": "DAMPs_phenotype",
+ "target": "NLRP3_cell",
+ "sign": true
+ },
+ {
+ "id": "t54",
+ "source": "PAMPs_phenotype",
+ "target": "NLRP3_cell",
+ "sign": true
+ },
+ {
+ "id": "t55",
+ "source": "Reactive Oxygen Species_simple_molecule",
+ "target": "NLRP3_cell",
+ "sign": true
+ },
+ {
+ "id": "t56",
+ "source": "NLRP3 Elicitor Small Molecules_simple_molecule",
+ "target": "NLRP3_cell",
+ "sign": true
+ },
+ {
+ "id": "t57",
+ "source": "TXNIP:NLRP3_complex",
+ "target": "NLRP3_cell",
+ "sign": true
+ },
+ {
+ "id": "t58",
+ "source": "Ca2+_ion",
+ "target": "NLRP3_cell",
+ "sign": true
+ },
+ {
+ "id": "t59",
+ "source": "NLRP3:SUGT1:HSP90_complex",
+ "target": "NLRP3_cell",
+ "sign": true
+ },
+ {
+ "id": "t60",
+ "source": "ASC:MAVS:TRAF3_complex_cell",
+ "target": "MAVS",
+ "sign": true
+ },
+ {
+ "id": "t61",
+ "source": "ASC:MAVS:TRAF3_complex_cell",
+ "target": "ASC_ubiquitinated",
+ "sign": true
+ },
+ {
+ "id": "t62",
+ "source": "E_Golgi apparatus",
+ "target": "Ca2+_ion",
+ "sign": true
+ },
+ {
+ "id": "t63",
+ "source": "E_endoplasmic reticulum-Golgi intermediate compartment",
+ "target": "Ca2+_ion",
+ "sign": true
+ },
+ {
+ "id": "t64",
+ "source": "NADPH_simple_molecule",
+ "target": "NADP+_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t65",
+ "source": "O2_simple_molecule",
+ "target": "NADP+_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t66",
+ "source": "Heme_simple_molecule",
+ "target": "NADP+_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t67",
+ "source": "HMOX1",
+ "target": "NADP+_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t68",
+ "source": "NADPH_simple_molecule",
+ "target": "Biliverdin_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t69",
+ "source": "O2_simple_molecule",
+ "target": "Biliverdin_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t70",
+ "source": "Heme_simple_molecule",
+ "target": "Biliverdin_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t71",
+ "source": "HMOX1",
+ "target": "Biliverdin_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t72",
+ "source": "NADPH_simple_molecule",
+ "target": "H2O_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t73",
+ "source": "O2_simple_molecule",
+ "target": "H2O_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t74",
+ "source": "Heme_simple_molecule",
+ "target": "H2O_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t75",
+ "source": "HMOX1",
+ "target": "H2O_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t76",
+ "source": "NADPH_simple_molecule",
+ "target": "CO_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t77",
+ "source": "O2_simple_molecule",
+ "target": "CO_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t78",
+ "source": "Heme_simple_molecule",
+ "target": "CO_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t79",
+ "source": "HMOX1",
+ "target": "CO_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t80",
+ "source": "NADPH_simple_molecule",
+ "target": "Fe2+_ion",
+ "sign": true
+ },
+ {
+ "id": "t81",
+ "source": "O2_simple_molecule",
+ "target": "Fe2+_ion",
+ "sign": true
+ },
+ {
+ "id": "t82",
+ "source": "Heme_simple_molecule",
+ "target": "Fe2+_ion",
+ "sign": true
+ },
+ {
+ "id": "t83",
+ "source": "HMOX1",
+ "target": "Fe2+_ion",
+ "sign": true
+ },
+ {
+ "id": "t84",
+ "source": "CTSG",
+ "target": "CASP1_cell",
+ "sign": true
+ },
+ {
+ "id": "t85",
+ "source": "NLRP3 oligomer:ASC:proCaspase1_complex",
+ "target": "CASP1_cell",
+ "sign": true
+ },
+ {
+ "id": "t86",
+ "source": "CTSG",
+ "target": "CASP1_cell",
+ "sign": true
+ },
+ {
+ "id": "t87",
+ "source": "NLRP3 oligomer:ASC:proCaspase1_complex",
+ "target": "CASP1_cell",
+ "sign": true
+ },
+ {
+ "id": "t88",
+ "source": "CTSG",
+ "target": "CASP1_cell",
+ "sign": true
+ },
+ {
+ "id": "t89",
+ "source": "NLRP3 oligomer:ASC:proCaspase1_complex",
+ "target": "CASP1_cell",
+ "sign": true
+ },
+ {
+ "id": "t90",
+ "source": "CTSG",
+ "target": "CASP1_cell",
+ "sign": true
+ },
+ {
+ "id": "t91",
+ "source": "NLRP3 oligomer:ASC:proCaspase1_complex",
+ "target": "CASP1_cell",
+ "sign": true
+ },
+ {
+ "id": "t92",
+ "source": "Caspase-1 Tetramer_complex",
+ "target": "proIL-1B_cell",
+ "sign": true
+ },
+ {
+ "id": "t93",
+ "source": "Thioredoxin:TXNIP_complex",
+ "target": "TXN_cell",
+ "sign": true
+ },
+ {
+ "id": "t94",
+ "source": "Reactive Oxygen Species_simple_molecule",
+ "target": "TXN_cell",
+ "sign": true
+ }
+ ],
+ "parameters": []
+ },
+ "semantics": {
+ "ode": {
+ "rates": [],
+ "observables": [],
+ "time": {
+ "id": "t"
+ }
+ }
+ },
+ "metadata": {
+ "annotations": {}
+ }
+}
\ No newline at end of file
diff --git a/scripts/covid19_diseasemaps/regnet_amr_sbml/Nsp14.json b/scripts/covid19_diseasemaps/regnet_amr_sbml/Nsp14.json
new file mode 100644
index 000000000..08b98449b
--- /dev/null
+++ b/scripts/covid19_diseasemaps/regnet_amr_sbml/Nsp14.json
@@ -0,0 +1,5153 @@
+{
+ "header": {
+ "name": "Model",
+ "schema": "https://raw.githubusercontent.com/DARPA-ASKEM/Model-Representations/regnet_v0.2/regnet/regnet_schema.json",
+ "schema_name": "regnet",
+ "description": "Model",
+ "model_version": "0.1"
+ },
+ "model": {
+ "vertices": [
+ {
+ "id": "SIRT5",
+ "name": "SIRT5",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "17694089"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp14_mitochondrion",
+ "name": "Nsp14_mitochondrion",
+ "grounding": {
+ "identifiers": {
+ "doi": "10.1101/2020.03.22.002386"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SIRT5:Nsp14_complex",
+ "name": "SIRT5:Nsp14_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "GLA",
+ "name": "GLA",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp14_cell",
+ "name": "Nsp14_cell",
+ "grounding": {
+ "identifiers": {
+ "doi": "10.1101/2020.03.22.002386"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "GLA:Nsp14_complex",
+ "name": "GLA:Nsp14_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IMPDH2",
+ "name": "IMPDH2",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IMPDH2:Nsp14_complex",
+ "name": "IMPDH2:Nsp14_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Lactose_simple_molecule",
+ "name": "Lactose_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:17716",
+ "property1": "pubchem.compound:440995"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "H2O_simple_molecule_cell",
+ "name": "H2O_simple_molecule_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:15377",
+ "property1": "pubchem.compound:962"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "GLB1",
+ "name": "GLB1",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "LCT",
+ "name": "LCT",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Galacitol_simple_molecule",
+ "name": "Galacitol_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:16813",
+ "property1": "pubchem.compound:11850"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NADP_simple_molecule",
+ "name": "NADP_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:18009",
+ "property1": "pubchem.compound:5886"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "AKR1B1",
+ "name": "AKR1B1",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Melibiose_simple_molecule",
+ "name": "Melibiose_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:28053",
+ "property1": "pubchem.compound:440658"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Raffinose_simple_molecule",
+ "name": "Raffinose_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:16634",
+ "property1": "pubchem.compound:439242"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Stachyose_simple_molecule",
+ "name": "Stachyose_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:17164",
+ "property1": "pubchem.compound:439531"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Migalastat_drug",
+ "name": "Migalastat_drug",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "10866822"
+ },
+ "context": {
+ "property": "CHEBI:135923",
+ "property1": "pubchem.compound:176077"
+ }
+ },
+ "initial": 3.0
+ },
+ {
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+ "name": "lactose synthetase_complex",
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+ "property2": "pubchem.substance:3635"
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+ "sign": true
+ },
+ {
+ "id": "t41",
+ "source": "5-phospho-_alpha_-D-ribose 1-diphosphate_simple_molecule",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t42",
+ "source": "NADK",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t43",
+ "source": "L-Glutamine_simple_molecule",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t44",
+ "source": "GMP_simple_molecule",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t45",
+ "source": "AK8",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t46",
+ "source": "Adenosine_simple_molecule",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t47",
+ "source": "NAPRT1",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t48",
+ "source": "dGDP_simple_molecule",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t49",
+ "source": "NME5",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t50",
+ "source": "Nicotinate_simple_molecule",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t51",
+ "source": "PAICS",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t52",
+ "source": "NME3",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t53",
+ "source": "NADSYN1",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t54",
+ "source": "Nucleoside diphosphate kinase_complex_cell",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t55",
+ "source": "ATP_simple_molecule",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t56",
+ "source": "dAMP_simple_molecule",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t57",
+ "source": "NME6",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t58",
+ "source": "5-phosphoribosyl-N-formylglycinamide_simple_molecule",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t59",
+ "source": "PFAS",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t60",
+ "source": "GDP_simple_molecule",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t61",
+ "source": "DCK",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t62",
+ "source": "dADP_simple_molecule",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t63",
+ "source": "Deoxyguanosine_simple_molecule",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t64",
+ "source": "NAD_simple_molecule",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t65",
+ "source": "AK5",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t66",
+ "source": "N-Ribosyl-nicotinamide_simple_molecule",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t67",
+ "source": "GART",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t68",
+ "source": "H2O_simple_molecule_cell",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t69",
+ "source": "AK1",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t70",
+ "source": "GALE",
+ "target": "UDP-_alpha_-D-Galactose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t71",
+ "source": "UDP-_alpha_-D-Glucose_simple_molecule",
+ "target": "UDP-_alpha_-D-Galactose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t72",
+ "source": "GALT",
+ "target": "UDP-_alpha_-D-Galactose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t73",
+ "source": "_alpha_-D-Galactose-1P_simple_molecule",
+ "target": "UDP-_alpha_-D-Galactose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t74",
+ "source": "UDP-_alpha_-D-Glucose_simple_molecule",
+ "target": "_alpha_-D-Glucose-1-P_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t75",
+ "source": "GALT",
+ "target": "_alpha_-D-Glucose-1-P_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t76",
+ "source": "PPi_simple_molecule",
+ "target": "_alpha_-D-Glucose-1-P_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t77",
+ "source": "UGP2",
+ "target": "_alpha_-D-Glucose-1-P_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t78",
+ "source": "_alpha_-D-Galactose-1P_simple_molecule",
+ "target": "_alpha_-D-Glucose-1-P_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t79",
+ "source": "UDP-_alpha_-D-Glucose_simple_molecule",
+ "target": "UTP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t80",
+ "source": "UGP2",
+ "target": "UTP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t81",
+ "source": "PPi_simple_molecule",
+ "target": "UTP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t82",
+ "source": "HPRT1",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t83",
+ "source": "ITPA",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t84",
+ "source": "APRT",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t85",
+ "source": "NMNAT1",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t86",
+ "source": "GMPS",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t87",
+ "source": "Hypoxanthine_simple_molecule",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t88",
+ "source": "QPRT",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t89",
+ "source": "PPAT",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t90",
+ "source": "Nicotinate_simple_molecule",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t91",
+ "source": "dGTP_simple_molecule",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t92",
+ "source": "ATP_simple_molecule",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t93",
+ "source": "NAMPT",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t94",
+ "source": "NMNAT3",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t95",
+ "source": "Quinolinate_simple_molecule",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t96",
+ "source": "Guanine_simple_molecule",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t97",
+ "source": "Nicotinate D-ribonucleotide_simple_molecule",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t98",
+ "source": "H_simple_molecule",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t99",
+ "source": "Nicotinamide_simple_molecule",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t100",
+ "source": "XMP_simple_molecule",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t101",
+ "source": "Nicotinamide D-ribonucleotide_simple_molecule",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t102",
+ "source": "5-phospho-_alpha_-D-ribose 1-diphosphate_simple_molecule",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t103",
+ "source": "ENPP3",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t104",
+ "source": "Adenine_simple_molecule",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t105",
+ "source": "L-Glutamine_simple_molecule",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t106",
+ "source": "ENPP1",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t107",
+ "source": "NAPRT1",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t108",
+ "source": "H2O_simple_molecule_cell",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t109",
+ "source": "NMNAT2",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t110",
+ "source": "_alpha_-D-Glucose_simple_molecule",
+ "target": "Lactose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t111",
+ "source": "lactose synthetase_complex",
+ "target": "Lactose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t112",
+ "source": "UDP-_alpha_-D-Galactose_simple_molecule",
+ "target": "Lactose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t113",
+ "source": "GLA",
+ "target": "_alpha_-D-Glucose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t114",
+ "source": "Lactose_simple_molecule",
+ "target": "_alpha_-D-Glucose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t115",
+ "source": "GLA:Nsp14_complex",
+ "target": "_alpha_-D-Glucose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t116",
+ "source": "GLB1",
+ "target": "_alpha_-D-Glucose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t117",
+ "source": "LCT",
+ "target": "_alpha_-D-Glucose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t118",
+ "source": "Melibiose_simple_molecule",
+ "target": "_alpha_-D-Glucose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t119",
+ "source": "Migalastat_drug",
+ "target": "_alpha_-D-Glucose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t120",
+ "source": "H2O_simple_molecule_cell",
+ "target": "_alpha_-D-Glucose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t121",
+ "source": "_alpha_-D-Glucose_simple_molecule",
+ "target": "UDP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t122",
+ "source": "lactose synthetase_complex",
+ "target": "UDP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t123",
+ "source": "UDP-_alpha_-D-Galactose_simple_molecule",
+ "target": "UDP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t124",
+ "source": "GDP_simple_molecule",
+ "target": "H2O_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t125",
+ "source": "1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide_simple_molecule",
+ "target": "H2O_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t126",
+ "source": "ADP_simple_molecule",
+ "target": "H2O_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t127",
+ "source": "ribonucleoside reductase_complex_cell",
+ "target": "H2O_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t128",
+ "source": "ATIC",
+ "target": "H2O_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t129",
+ "source": "Thioredoxin_simple_molecule",
+ "target": "H2O_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t130",
+ "source": "NADPH_simple_molecule",
+ "target": "NADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t131",
+ "source": "NADK",
+ "target": "NADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t132",
+ "source": "NAD_simple_molecule",
+ "target": "NADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t133",
+ "source": "NNT",
+ "target": "NADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t134",
+ "source": "ATP_simple_molecule",
+ "target": "NADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t135",
+ "source": "IMP_simple_molecule",
+ "target": "NADPH_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t136",
+ "source": "NADP_simple_molecule",
+ "target": "NADPH_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t137",
+ "source": "Ammonium_simple_molecule",
+ "target": "NADPH_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t138",
+ "source": "GMPR",
+ "target": "NADPH_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t139",
+ "source": "AKR1B1",
+ "target": "NADPH_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t140",
+ "source": "GMPR2",
+ "target": "NADPH_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t141",
+ "source": "Galacitol_simple_molecule",
+ "target": "NADPH_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t142",
+ "source": "5-phospho-beta-D-ribosylglycinamide_simple_molecule",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t143",
+ "source": "2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine_simple_molecule",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t144",
+ "source": "ENTPD5",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t145",
+ "source": "1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate_simple_molecule",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t146",
+ "source": "IMP_simple_molecule",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t147",
+ "source": "GMPS",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t148",
+ "source": "Hypoxanthine_simple_molecule",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t149",
+ "source": "NRK1",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t150",
+ "source": "ADK",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t151",
+ "source": "Deoxyadenosine_simple_molecule",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t152",
+ "source": "Ammonium_simple_molecule",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t153",
+ "source": "IMPDH2:Nsp14_complex",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t154",
+ "source": "Ribavirin_drug",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t155",
+ "source": "CANT1",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t156",
+ "source": "5-phospho-beta-D-ribosylamine_simple_molecule",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t157",
+ "source": "Mycophenolic acid_drug",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t158",
+ "source": "GMPR2",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t159",
+ "source": "ENTPD2",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t160",
+ "source": "Merimepodib_drug",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t161",
+ "source": "Deamino-NAD_simple_molecule",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t162",
+ "source": "CD38",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t163",
+ "source": "L-Aspartate_simple_molecule",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t164",
+ "source": "XMP_simple_molecule",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t165",
+ "source": "Glycine_simple_molecule",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t166",
+ "source": "ENPP3",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t167",
+ "source": "NADK",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t168",
+ "source": "L-Glutamine_simple_molecule",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t169",
+ "source": "IMPDH2",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t170",
+ "source": "GTP_simple_molecule",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t171",
+ "source": "ENPP1",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t172",
+ "source": "Adenosine_simple_molecule",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t173",
+ "source": "AKR1B1",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t174",
+ "source": "Aminoimidazole ribotide_simple_molecule",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t175",
+ "source": "CO2_simple_molecule",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t176",
+ "source": "ITPA",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t177",
+ "source": "NTPCR",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t178",
+ "source": "NADP_simple_molecule",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t179",
+ "source": "IMPDH1",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t180",
+ "source": "PAICS",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t181",
+ "source": "NADSYN1",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t182",
+ "source": "dGTP_simple_molecule",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t183",
+ "source": "ATP_simple_molecule",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t184",
+ "source": "Galacitol_simple_molecule",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t185",
+ "source": "XDH",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t186",
+ "source": "5-phosphoribosyl-N-formylglycinamide_simple_molecule",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t187",
+ "source": "PFAS",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t188",
+ "source": "ENTPD4",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t189",
+ "source": "GDP_simple_molecule",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t190",
+ "source": "DCK",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t191",
+ "source": "ENTPD6",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t192",
+ "source": "Deoxyguanosine_simple_molecule",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t193",
+ "source": "NAD_simple_molecule",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t194",
+ "source": "GMPR",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t195",
+ "source": "N-Ribosyl-nicotinamide_simple_molecule",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t196",
+ "source": "10-Formyltetrahydrofolate_simple_molecule",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t197",
+ "source": "GART",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t198",
+ "source": "H2O_simple_molecule_cell",
+ "target": "H_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t199",
+ "source": "Stachyose_simple_molecule",
+ "target": "Raffinose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t200",
+ "source": "GLA",
+ "target": "Raffinose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t201",
+ "source": "Migalastat_drug",
+ "target": "Raffinose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t202",
+ "source": "GLA:Nsp14_complex",
+ "target": "Raffinose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t203",
+ "source": "H2O_simple_molecule_cell",
+ "target": "Raffinose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t204",
+ "source": "Raffinose_simple_molecule",
+ "target": "Sucrose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t205",
+ "source": "GLA",
+ "target": "Sucrose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t206",
+ "source": "GLA:Nsp14_complex",
+ "target": "Sucrose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t207",
+ "source": "Migalastat_drug",
+ "target": "Sucrose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t208",
+ "source": "H2O_simple_molecule_cell",
+ "target": "Sucrose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t209",
+ "source": "CD38",
+ "target": "Nicotinamide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t210",
+ "source": "H2O_simple_molecule_mitochondrion",
+ "target": "Nicotinamide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t211",
+ "source": "NADP_simple_molecule",
+ "target": "Nicotinamide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t212",
+ "source": "SIRT5:Nsp14_complex",
+ "target": "Nicotinamide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t213",
+ "source": "Pi_simple_molecule",
+ "target": "Nicotinamide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t214",
+ "source": "NAD_simple_molecule",
+ "target": "Nicotinamide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t215",
+ "source": "Histone N6-acetyl-L-lysine_simple_molecule",
+ "target": "Nicotinamide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t216",
+ "source": "SIRT5",
+ "target": "Nicotinamide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t217",
+ "source": "Nicotinate_simple_molecule",
+ "target": "Nicotinamide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t218",
+ "source": "N-Ribosyl-nicotinamide_simple_molecule",
+ "target": "Nicotinamide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t219",
+ "source": "H2O_simple_molecule_cell",
+ "target": "Nicotinamide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t220",
+ "source": "PNP",
+ "target": "Nicotinamide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t221",
+ "source": "Nicotinamide D-ribonucleotide_simple_molecule",
+ "target": "N-Ribosyl-nicotinamide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t222",
+ "source": "H2O_simple_molecule_cell",
+ "target": "N-Ribosyl-nicotinamide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t223",
+ "source": "NT5E",
+ "target": "N-Ribosyl-nicotinamide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t224",
+ "source": "Nicotinamide_simple_molecule",
+ "target": "Nicotinamide D-ribonucleotide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t225",
+ "source": "ENPP3",
+ "target": "Nicotinamide D-ribonucleotide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t226",
+ "source": "5-phospho-_alpha_-D-ribose 1-diphosphate_simple_molecule",
+ "target": "Nicotinamide D-ribonucleotide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t227",
+ "source": "NRK1",
+ "target": "Nicotinamide D-ribonucleotide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t228",
+ "source": "NAD_simple_molecule",
+ "target": "Nicotinamide D-ribonucleotide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t229",
+ "source": "ENPP1",
+ "target": "Nicotinamide D-ribonucleotide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t230",
+ "source": "N-Ribosyl-nicotinamide_simple_molecule",
+ "target": "Nicotinamide D-ribonucleotide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t231",
+ "source": "ATP_simple_molecule",
+ "target": "Nicotinamide D-ribonucleotide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t232",
+ "source": "NAMPT",
+ "target": "Nicotinamide D-ribonucleotide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t233",
+ "source": "H2O_simple_molecule_cell",
+ "target": "Nicotinamide D-ribonucleotide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t234",
+ "source": "Deamino-NAD_simple_molecule",
+ "target": "NAD_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t235",
+ "source": "H_simple_molecule",
+ "target": "NAD_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t236",
+ "source": "NMNAT1",
+ "target": "NAD_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t237",
+ "source": "Nicotinamide D-ribonucleotide_simple_molecule",
+ "target": "NAD_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t238",
+ "source": "NMNAT3",
+ "target": "NAD_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t239",
+ "source": "L-Glutamine_simple_molecule",
+ "target": "NAD_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t240",
+ "source": "NADSYN1",
+ "target": "NAD_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t241",
+ "source": "ATP_simple_molecule",
+ "target": "NAD_simple_molecule",
+ "sign": true
+ },
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+ "id": "t242",
+ "source": "H2O_simple_molecule_cell",
+ "target": "NAD_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t243",
+ "source": "NMNAT2",
+ "target": "NAD_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t244",
+ "source": "Nicotinate D-ribonucleotide_simple_molecule",
+ "target": "Deamino-NAD_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t245",
+ "source": "H_simple_molecule",
+ "target": "Deamino-NAD_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t246",
+ "source": "NMNAT1",
+ "target": "Deamino-NAD_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t247",
+ "source": "ATP_simple_molecule",
+ "target": "Deamino-NAD_simple_molecule",
+ "sign": true
+ },
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+ "id": "t248",
+ "source": "NMNAT3",
+ "target": "Deamino-NAD_simple_molecule",
+ "sign": true
+ },
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+ "id": "t249",
+ "source": "NMNAT2",
+ "target": "Deamino-NAD_simple_molecule",
+ "sign": true
+ },
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+ "id": "t250",
+ "source": "H_simple_molecule",
+ "target": "Nicotinate D-ribonucleotide_simple_molecule",
+ "sign": true
+ },
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+ "id": "t251",
+ "source": "5-phospho-_alpha_-D-ribose 1-diphosphate_simple_molecule",
+ "target": "Nicotinate D-ribonucleotide_simple_molecule",
+ "sign": true
+ },
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+ "id": "t252",
+ "source": "QPRT",
+ "target": "Nicotinate D-ribonucleotide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t253",
+ "source": "Nicotinate_simple_molecule",
+ "target": "Nicotinate D-ribonucleotide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t254",
+ "source": "NAPRT1",
+ "target": "Nicotinate D-ribonucleotide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t255",
+ "source": "ATP_simple_molecule",
+ "target": "Nicotinate D-ribonucleotide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t256",
+ "source": "H2O_simple_molecule_cell",
+ "target": "Nicotinate D-ribonucleotide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t257",
+ "source": "Quinolinate_simple_molecule",
+ "target": "Nicotinate D-ribonucleotide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t258",
+ "source": "Merimepodib_drug",
+ "target": "NADH_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t259",
+ "source": "NADPH_simple_molecule",
+ "target": "NADH_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t260",
+ "source": "IMP_simple_molecule",
+ "target": "NADH_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t261",
+ "source": "Hypoxanthine_simple_molecule",
+ "target": "NADH_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t262",
+ "source": "NAD_simple_molecule",
+ "target": "NADH_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t263",
+ "source": "IMPDH2",
+ "target": "NADH_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t264",
+ "source": "IMPDH1",
+ "target": "NADH_simple_molecule",
+ "sign": true
+ },
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+ "id": "t265",
+ "source": "IMPDH2:Nsp14_complex",
+ "target": "NADH_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t266",
+ "source": "NNT",
+ "target": "NADH_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t267",
+ "source": "Ribavirin_drug",
+ "target": "NADH_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t268",
+ "source": "Mycophenolic acid_drug",
+ "target": "NADH_simple_molecule",
+ "sign": true
+ },
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+ "id": "t269",
+ "source": "XDH",
+ "target": "NADH_simple_molecule",
+ "sign": true
+ },
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+ "id": "t270",
+ "source": "H2O_simple_molecule_cell",
+ "target": "NADH_simple_molecule",
+ "sign": true
+ },
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+ "id": "t271",
+ "source": "PFAS",
+ "target": "L-Glutamate_simple_molecule",
+ "sign": true
+ },
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+ "id": "t272",
+ "source": "Deamino-NAD_simple_molecule",
+ "target": "L-Glutamate_simple_molecule",
+ "sign": true
+ },
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+ "id": "t273",
+ "source": "XMP_simple_molecule",
+ "target": "L-Glutamate_simple_molecule",
+ "sign": true
+ },
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+ "id": "t274",
+ "source": "GMPS",
+ "target": "L-Glutamate_simple_molecule",
+ "sign": true
+ },
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+ "id": "t275",
+ "source": "5-phospho-_alpha_-D-ribose 1-diphosphate_simple_molecule",
+ "target": "L-Glutamate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t276",
+ "source": "L-Glutamine_simple_molecule",
+ "target": "L-Glutamate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t277",
+ "source": "PPAT",
+ "target": "L-Glutamate_simple_molecule",
+ "sign": true
+ },
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+ "id": "t278",
+ "source": "NADSYN1",
+ "target": "L-Glutamate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t279",
+ "source": "ATP_simple_molecule",
+ "target": "L-Glutamate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t280",
+ "source": "H2O_simple_molecule_cell",
+ "target": "L-Glutamate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t281",
+ "source": "5-phosphoribosyl-N-formylglycinamide_simple_molecule",
+ "target": "L-Glutamate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t282",
+ "source": "APRT",
+ "target": "AMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t283",
+ "source": "PRPS1L1",
+ "target": "AMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t284",
+ "source": "GMPS",
+ "target": "AMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t285",
+ "source": "ADK",
+ "target": "AMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t286",
+ "source": "D-Ribose 5P_simple_molecule",
+ "target": "AMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t287",
+ "source": "ATP_simple_molecule",
+ "target": "AMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t288",
+ "source": "XMP_simple_molecule",
+ "target": "AMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t289",
+ "source": "ENPP3",
+ "target": "AMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t290",
+ "source": "5-phospho-_alpha_-D-ribose 1-diphosphate_simple_molecule",
+ "target": "AMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t291",
+ "source": "Adenine_simple_molecule",
+ "target": "AMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t292",
+ "source": "NAD_simple_molecule",
+ "target": "AMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t293",
+ "source": "L-Glutamine_simple_molecule",
+ "target": "AMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t294",
+ "source": "ENPP1",
+ "target": "AMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t295",
+ "source": "Adenosine_simple_molecule",
+ "target": "AMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t296",
+ "source": "PRPS1",
+ "target": "AMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t297",
+ "source": "PRPS2",
+ "target": "AMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t298",
+ "source": "H2O_simple_molecule_cell",
+ "target": "AMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t299",
+ "source": "2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine_simple_molecule",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t300",
+ "source": "ENTPD5",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t301",
+ "source": "1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate_simple_molecule",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t302",
+ "source": "IMP_simple_molecule",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t303",
+ "source": "Hypoxanthine_simple_molecule",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t304",
+ "source": "NT5E",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t305",
+ "source": "CANT1",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t306",
+ "source": "5-phospho-beta-D-ribosylamine_simple_molecule",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t307",
+ "source": "ENTPD2",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t308",
+ "source": "L-Aspartate_simple_molecule",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t309",
+ "source": "2-deoxy-_alpha_-D-ribose 1-phosphate_simple_molecule",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t310",
+ "source": "XMP_simple_molecule",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t311",
+ "source": "AMP_simple_molecule",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t312",
+ "source": "Glycine_simple_molecule",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t313",
+ "source": "Nicotinamide D-ribonucleotide_simple_molecule",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t314",
+ "source": "5-phospho-_alpha_-D-ribose 1-diphosphate_simple_molecule",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t315",
+ "source": "L-Glutamine_simple_molecule",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t316",
+ "source": "GMP_simple_molecule",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t317",
+ "source": "GTP_simple_molecule",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t318",
+ "source": "NAPRT1",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t319",
+ "source": "NTPCR",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t320",
+ "source": "Nicotinate_simple_molecule",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t321",
+ "source": "PAICS",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t322",
+ "source": "ATP_simple_molecule",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t323",
+ "source": "5-phosphoribosyl-N-formylglycinamide_simple_molecule",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t324",
+ "source": "PNP",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t325",
+ "source": "PFAS",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t326",
+ "source": "ENTPD4",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t327",
+ "source": "GDP_simple_molecule",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t328",
+ "source": "ENTPD6",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t329",
+ "source": "GART",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t330",
+ "source": "H2O_simple_molecule_cell",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t331",
+ "source": "NADP_simple_molecule",
+ "target": "nicotinate-adenine dinucleotide phosphate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t332",
+ "source": "CD38",
+ "target": "nicotinate-adenine dinucleotide phosphate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t333",
+ "source": "Nicotinate_simple_molecule",
+ "target": "nicotinate-adenine dinucleotide phosphate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t334",
+ "source": "PRPS1L1",
+ "target": "5-phospho-_alpha_-D-ribose 1-diphosphate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t335",
+ "source": "D-Ribose 5P_simple_molecule",
+ "target": "5-phospho-_alpha_-D-ribose 1-diphosphate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t336",
+ "source": "PRPS1",
+ "target": "5-phospho-_alpha_-D-ribose 1-diphosphate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t337",
+ "source": "ATP_simple_molecule",
+ "target": "5-phospho-_alpha_-D-ribose 1-diphosphate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t338",
+ "source": "PRPS2",
+ "target": "5-phospho-_alpha_-D-ribose 1-diphosphate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t339",
+ "source": "Xanthosine_simple_molecule",
+ "target": "_alpha_-D-Ribose 1-phosphate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t340",
+ "source": "Guanosine_simple_molecule",
+ "target": "_alpha_-D-Ribose 1-phosphate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t341",
+ "source": "Pi_simple_molecule",
+ "target": "_alpha_-D-Ribose 1-phosphate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t342",
+ "source": "Inosine_simple_molecule",
+ "target": "_alpha_-D-Ribose 1-phosphate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t343",
+ "source": "N-Ribosyl-nicotinamide_simple_molecule",
+ "target": "_alpha_-D-Ribose 1-phosphate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t344",
+ "source": "Adenosine_simple_molecule",
+ "target": "_alpha_-D-Ribose 1-phosphate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t345",
+ "source": "PNP",
+ "target": "_alpha_-D-Ribose 1-phosphate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t346",
+ "source": "H2O_simple_molecule_mitochondrion",
+ "target": "Histone-L-lysine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t347",
+ "source": "SIRT5:Nsp14_complex",
+ "target": "Histone-L-lysine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t348",
+ "source": "Histone N6-acetyl-L-lysine_simple_molecule",
+ "target": "Histone-L-lysine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t349",
+ "source": "NAD_simple_molecule",
+ "target": "Histone-L-lysine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t350",
+ "source": "SIRT5",
+ "target": "Histone-L-lysine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t351",
+ "source": "H2O_simple_molecule_mitochondrion",
+ "target": "O-Acetyl-ADP-ribose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t352",
+ "source": "SIRT5:Nsp14_complex",
+ "target": "O-Acetyl-ADP-ribose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t353",
+ "source": "Histone N6-acetyl-L-lysine_simple_molecule",
+ "target": "O-Acetyl-ADP-ribose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t354",
+ "source": "NAD_simple_molecule",
+ "target": "O-Acetyl-ADP-ribose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t355",
+ "source": "SIRT5",
+ "target": "O-Acetyl-ADP-ribose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t356",
+ "source": "CD38",
+ "target": "ADP-D-ribose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t357",
+ "source": "H2O_simple_molecule_cell",
+ "target": "ADP-D-ribose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t358",
+ "source": "NAD_simple_molecule",
+ "target": "ADP-D-ribose_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t359",
+ "source": "5-phospho-_alpha_-D-ribose 1-diphosphate_simple_molecule",
+ "target": "CO2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t360",
+ "source": "H_simple_molecule",
+ "target": "CO2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t361",
+ "source": "Quinolinate_simple_molecule",
+ "target": "CO2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t362",
+ "source": "QPRT",
+ "target": "CO2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t363",
+ "source": "_alpha_D-Ribose 1P_simple_molecule",
+ "target": "D-Ribose 5P_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t364",
+ "source": "PGM2",
+ "target": "D-Ribose 5P_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t365",
+ "source": "5-phospho-_alpha_-D-ribose 1-diphosphate_simple_molecule",
+ "target": "5-phospho-beta-D-ribosylamine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t366",
+ "source": "H2O_simple_molecule_cell",
+ "target": "5-phospho-beta-D-ribosylamine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t367",
+ "source": "PPAT",
+ "target": "5-phospho-beta-D-ribosylamine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t368",
+ "source": "L-Glutamine_simple_molecule",
+ "target": "5-phospho-beta-D-ribosylamine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t369",
+ "source": "Glycine_simple_molecule",
+ "target": "5-phospho-beta-D-ribosylglycinamide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t370",
+ "source": "ATP_simple_molecule",
+ "target": "5-phospho-beta-D-ribosylglycinamide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t371",
+ "source": "GART",
+ "target": "5-phospho-beta-D-ribosylglycinamide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t372",
+ "source": "5-phospho-beta-D-ribosylamine_simple_molecule",
+ "target": "5-phospho-beta-D-ribosylglycinamide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t373",
+ "source": "GART",
+ "target": "5-phosphoribosyl-N-formylglycinamide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t374",
+ "source": "5-phospho-beta-D-ribosylglycinamide_simple_molecule",
+ "target": "5-phosphoribosyl-N-formylglycinamide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t375",
+ "source": "10-Formyltetrahydrofolate_simple_molecule",
+ "target": "5-phosphoribosyl-N-formylglycinamide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t376",
+ "source": "5-phospho-beta-D-ribosylglycinamide_simple_molecule",
+ "target": "Tetrahydrofolate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t377",
+ "source": "GART",
+ "target": "Tetrahydrofolate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t378",
+ "source": "10-Formyltetrahydrofolate_simple_molecule",
+ "target": "Tetrahydrofolate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t379",
+ "source": "ATIC",
+ "target": "Tetrahydrofolate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t380",
+ "source": "1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide_simple_molecule",
+ "target": "Tetrahydrofolate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t381",
+ "source": "PFAS",
+ "target": "2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t382",
+ "source": "L-Glutamine_simple_molecule",
+ "target": "2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t383",
+ "source": "ATP_simple_molecule",
+ "target": "2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t384",
+ "source": "H2O_simple_molecule_cell",
+ "target": "2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t385",
+ "source": "5-phosphoribosyl-N-formylglycinamide_simple_molecule",
+ "target": "2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t386",
+ "source": "ATP_simple_molecule",
+ "target": "Aminoimidazole ribotide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t387",
+ "source": "GART",
+ "target": "Aminoimidazole ribotide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t388",
+ "source": "2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine_simple_molecule",
+ "target": "Aminoimidazole ribotide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t389",
+ "source": "Aminoimidazole ribotide_simple_molecule",
+ "target": "1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t390",
+ "source": "CO2_simple_molecule",
+ "target": "1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t391",
+ "source": "PAICS",
+ "target": "1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t392",
+ "source": "ATP_simple_molecule",
+ "target": "1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t393",
+ "source": "L-Aspartate_simple_molecule",
+ "target": "1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t394",
+ "source": "PAICS",
+ "target": "1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t395",
+ "source": "1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate_simple_molecule",
+ "target": "1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t396",
+ "source": "1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole_simple_molecule",
+ "target": "1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t397",
+ "source": "ADSL",
+ "target": "1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t398",
+ "source": "1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole_simple_molecule",
+ "target": "Fumarate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t399",
+ "source": "ADSL",
+ "target": "Fumarate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t400",
+ "source": "ATIC",
+ "target": "1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t401",
+ "source": "1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide_simple_molecule",
+ "target": "1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t402",
+ "source": "10-Formyltetrahydrofolate_simple_molecule",
+ "target": "1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t403",
+ "source": "HPRT1",
+ "target": "IMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t404",
+ "source": "H_simple_molecule",
+ "target": "IMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t405",
+ "source": "AMP_simple_molecule",
+ "target": "IMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t406",
+ "source": "1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide_simple_molecule",
+ "target": "IMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t407",
+ "source": "Hypoxanthine_simple_molecule",
+ "target": "IMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t408",
+ "source": "AMPD1",
+ "target": "IMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t409",
+ "source": "5-phospho-_alpha_-D-ribose 1-diphosphate_simple_molecule",
+ "target": "IMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t410",
+ "source": "AMPD3",
+ "target": "IMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t411",
+ "source": "ATIC",
+ "target": "IMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t412",
+ "source": "H2O_simple_molecule_cell",
+ "target": "IMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t413",
+ "source": "AMDP2",
+ "target": "IMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t414",
+ "source": "Merimepodib_drug",
+ "target": "XMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t415",
+ "source": "IMP_simple_molecule",
+ "target": "XMP_simple_molecule",
+ "sign": true
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+ "id": "t416",
+ "source": "NAD_simple_molecule",
+ "target": "XMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t417",
+ "source": "IMPDH2",
+ "target": "XMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t418",
+ "source": "IMPDH1",
+ "target": "XMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t419",
+ "source": "IMPDH2:Nsp14_complex",
+ "target": "XMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t420",
+ "source": "Ribavirin_drug",
+ "target": "XMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t421",
+ "source": "Mycophenolic acid_drug",
+ "target": "XMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t422",
+ "source": "H2O_simple_molecule_cell",
+ "target": "XMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t423",
+ "source": "HPRT1",
+ "target": "GMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t424",
+ "source": "ENTPD5",
+ "target": "GMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t425",
+ "source": "IMP_simple_molecule",
+ "target": "GMP_simple_molecule",
+ "sign": true
+ },
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+ "id": "t426",
+ "source": "GMPS",
+ "target": "GMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t427",
+ "source": "NADP_simple_molecule",
+ "target": "GMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t428",
+ "source": "Ammonium_simple_molecule",
+ "target": "GMP_simple_molecule",
+ "sign": true
+ },
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+ "id": "t429",
+ "source": "CANT1",
+ "target": "GMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t430",
+ "source": "GMPR2",
+ "target": "GMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t431",
+ "source": "ATP_simple_molecule",
+ "target": "GMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t432",
+ "source": "Guanine_simple_molecule",
+ "target": "GMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t433",
+ "source": "ENTPD2",
+ "target": "GMP_simple_molecule",
+ "sign": true
+ },
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+ "id": "t434",
+ "source": "ENTPD4",
+ "target": "GMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t435",
+ "source": "GDP_simple_molecule",
+ "target": "GMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t436",
+ "source": "XMP_simple_molecule",
+ "target": "GMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t437",
+ "source": "ENTPD6",
+ "target": "GMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t438",
+ "source": "5-phospho-_alpha_-D-ribose 1-diphosphate_simple_molecule",
+ "target": "GMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t439",
+ "source": "L-Glutamine_simple_molecule",
+ "target": "GMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t440",
+ "source": "GTP_simple_molecule",
+ "target": "GMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t441",
+ "source": "GMPR",
+ "target": "GMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t442",
+ "source": "H2O_simple_molecule_cell",
+ "target": "GMP_simple_molecule",
+ "sign": true
+ },
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+ "id": "t443",
+ "source": "ENTPD2",
+ "target": "GDP_simple_molecule",
+ "sign": true
+ },
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+ "id": "t444",
+ "source": "NTPCR",
+ "target": "GDP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t445",
+ "source": "GTP_simple_molecule",
+ "target": "GDP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t446",
+ "source": "GMP_simple_molecule",
+ "target": "GDP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t447",
+ "source": "ATP_simple_molecule",
+ "target": "GDP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t448",
+ "source": "GUK1",
+ "target": "GDP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t449",
+ "source": "H2O_simple_molecule_cell",
+ "target": "GDP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t450",
+ "source": "GDP_simple_molecule",
+ "target": "GTP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t451",
+ "source": "NME5",
+ "target": "GTP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t452",
+ "source": "NME7",
+ "target": "GTP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t453",
+ "source": "NME3",
+ "target": "GTP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t454",
+ "source": "Nucleoside diphosphate kinase_complex_cell",
+ "target": "GTP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t455",
+ "source": "ATP_simple_molecule",
+ "target": "GTP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t456",
+ "source": "NME6",
+ "target": "GTP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t457",
+ "source": "GDP_simple_molecule",
+ "target": "dGDP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t458",
+ "source": "ribonucleoside reductase_complex_cell",
+ "target": "dGDP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t459",
+ "source": "ATP_simple_molecule",
+ "target": "dGDP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t460",
+ "source": "Thioredoxin_simple_molecule",
+ "target": "dGDP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t461",
+ "source": "GUK1",
+ "target": "dGDP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t462",
+ "source": "dGMP_simple_molecule",
+ "target": "dGDP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t463",
+ "source": "GDP_simple_molecule",
+ "target": "Thioredoxin disulfide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t464",
+ "source": "ADP_simple_molecule",
+ "target": "Thioredoxin disulfide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t465",
+ "source": "Thioredoxin_simple_molecule",
+ "target": "Thioredoxin disulfide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t466",
+ "source": "ribonucleoside reductase_complex_cell",
+ "target": "Thioredoxin disulfide_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t467",
+ "source": "NME5",
+ "target": "dGTP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t468",
+ "source": "NME7",
+ "target": "dGTP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t469",
+ "source": "NME3",
+ "target": "dGTP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t470",
+ "source": "Nucleoside diphosphate kinase_complex_cell",
+ "target": "dGTP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t471",
+ "source": "ATP_simple_molecule",
+ "target": "dGTP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t472",
+ "source": "dGDP_simple_molecule",
+ "target": "dGTP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t473",
+ "source": "NME6",
+ "target": "dGTP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t474",
+ "source": "DCK",
+ "target": "dGMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t475",
+ "source": "ITPA",
+ "target": "dGMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t476",
+ "source": "ENPP3",
+ "target": "dGMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t477",
+ "source": "Deoxyguanosine_simple_molecule",
+ "target": "dGMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t478",
+ "source": "ENPP1",
+ "target": "dGMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t479",
+ "source": "dGTP_simple_molecule",
+ "target": "dGMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t480",
+ "source": "ATP_simple_molecule",
+ "target": "dGMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t481",
+ "source": "H2O_simple_molecule_cell",
+ "target": "dGMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t482",
+ "source": "Guanosine_simple_molecule",
+ "target": "Guanine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t483",
+ "source": "Deoxyguanosine_simple_molecule",
+ "target": "Guanine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t484",
+ "source": "Pi_simple_molecule",
+ "target": "Guanine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t485",
+ "source": "PNP",
+ "target": "Guanine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t486",
+ "source": "GMP_simple_molecule",
+ "target": "Guanosine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t487",
+ "source": "H2O_simple_molecule_cell",
+ "target": "Guanosine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t488",
+ "source": "NT5E",
+ "target": "Guanosine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t489",
+ "source": "Deoxyguanosine_simple_molecule",
+ "target": "2-deoxy-_alpha_-D-ribose 1-phosphate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t490",
+ "source": "Pi_simple_molecule",
+ "target": "2-deoxy-_alpha_-D-ribose 1-phosphate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t491",
+ "source": "PNP",
+ "target": "2-deoxy-_alpha_-D-ribose 1-phosphate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t492",
+ "source": "Guanine_simple_molecule",
+ "target": "Ammonium_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t493",
+ "source": "GDA",
+ "target": "Ammonium_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t494",
+ "source": "H_simple_molecule",
+ "target": "Ammonium_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t495",
+ "source": "AMP_simple_molecule",
+ "target": "Ammonium_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t496",
+ "source": "H2O_simple_molecule_cell",
+ "target": "Ammonium_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t497",
+ "source": "AMPD1",
+ "target": "Ammonium_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t498",
+ "source": "Deoxyadenosine_simple_molecule",
+ "target": "Ammonium_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t499",
+ "source": "Adenosine_simple_molecule",
+ "target": "Ammonium_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t500",
+ "source": "AMPD3",
+ "target": "Ammonium_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t501",
+ "source": "AMDP2",
+ "target": "Ammonium_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t502",
+ "source": "ADA",
+ "target": "Ammonium_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t503",
+ "source": "XMP_simple_molecule",
+ "target": "Xanthosine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t504",
+ "source": "H2O_simple_molecule_cell",
+ "target": "Xanthosine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t505",
+ "source": "NT5E",
+ "target": "Xanthosine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t506",
+ "source": "Xanthosine_simple_molecule",
+ "target": "Xanthine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t507",
+ "source": "Guanine_simple_molecule",
+ "target": "Xanthine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t508",
+ "source": "GDA",
+ "target": "Xanthine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t509",
+ "source": "H_simple_molecule",
+ "target": "Xanthine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t510",
+ "source": "Hypoxanthine_simple_molecule",
+ "target": "Xanthine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t511",
+ "source": "Pi_simple_molecule",
+ "target": "Xanthine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t512",
+ "source": "NAD_simple_molecule",
+ "target": "Xanthine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t513",
+ "source": "XDH",
+ "target": "Xanthine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t514",
+ "source": "H2O_simple_molecule_cell",
+ "target": "Xanthine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t515",
+ "source": "PNP",
+ "target": "Xanthine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t516",
+ "source": "H_simple_molecule",
+ "target": "Inosine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t517",
+ "source": "IMP_simple_molecule",
+ "target": "Inosine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t518",
+ "source": "NT5E",
+ "target": "Inosine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t519",
+ "source": "Adenosine_simple_molecule",
+ "target": "Inosine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t520",
+ "source": "H2O_simple_molecule_cell",
+ "target": "Inosine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t521",
+ "source": "ADA",
+ "target": "Inosine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t522",
+ "source": "Inosine_simple_molecule",
+ "target": "Hypoxanthine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t523",
+ "source": "Pi_simple_molecule",
+ "target": "Hypoxanthine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t524",
+ "source": "PNP",
+ "target": "Hypoxanthine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t525",
+ "source": "AMP_simple_molecule",
+ "target": "Adenosine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t526",
+ "source": "H2O_simple_molecule_cell",
+ "target": "Adenosine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t527",
+ "source": "NT5E",
+ "target": "Adenosine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t528",
+ "source": "Adenosine_simple_molecule",
+ "target": "Adenine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t529",
+ "source": "Pi_simple_molecule",
+ "target": "Adenine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t530",
+ "source": "PNP",
+ "target": "Adenine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t531",
+ "source": "2-deoxy-_alpha_-D-ribose 1-phosphate_simple_molecule",
+ "target": "Deoxyinosine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t532",
+ "source": "H_simple_molecule",
+ "target": "Deoxyinosine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t533",
+ "source": "Hypoxanthine_simple_molecule",
+ "target": "Deoxyinosine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t534",
+ "source": "Deoxyadenosine_simple_molecule",
+ "target": "Deoxyinosine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t535",
+ "source": "H2O_simple_molecule_cell",
+ "target": "Deoxyinosine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t536",
+ "source": "ADA",
+ "target": "Deoxyinosine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t537",
+ "source": "PNP",
+ "target": "Deoxyinosine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t538",
+ "source": "ATP_simple_molecule",
+ "target": "dAMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t539",
+ "source": "DCK",
+ "target": "dAMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t540",
+ "source": "Deoxyadenosine_simple_molecule",
+ "target": "dAMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t541",
+ "source": "dAMP_simple_molecule",
+ "target": "dADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t542",
+ "source": "AK5",
+ "target": "dADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t543",
+ "source": "ADP_simple_molecule",
+ "target": "dADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t544",
+ "source": "ribonucleoside reductase_complex_cell",
+ "target": "dADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t545",
+ "source": "ATP_simple_molecule",
+ "target": "dADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t546",
+ "source": "Thioredoxin_simple_molecule",
+ "target": "dADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t547",
+ "source": "NME5",
+ "target": "dATP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t548",
+ "source": "dADP_simple_molecule",
+ "target": "dATP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t549",
+ "source": "NME7",
+ "target": "dATP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t550",
+ "source": "NME3",
+ "target": "dATP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t551",
+ "source": "Nucleoside diphosphate kinase_complex_cell",
+ "target": "dATP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t552",
+ "source": "ATP_simple_molecule",
+ "target": "dATP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t553",
+ "source": "NME6",
+ "target": "dATP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t554",
+ "source": "IMPDH2",
+ "target": "Guanine nucleotide synthesis_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t555",
+ "source": "SIRT5",
+ "target": "Urea cycle_phenotype",
+ "sign": true
+ }
+ ],
+ "parameters": []
+ },
+ "semantics": {
+ "ode": {
+ "rates": [],
+ "observables": [],
+ "time": {
+ "id": "t"
+ }
+ }
+ },
+ "metadata": {
+ "annotations": {}
+ }
+}
\ No newline at end of file
diff --git a/scripts/covid19_diseasemaps/regnet_amr_sbml/Nsp4_Nsp6.json b/scripts/covid19_diseasemaps/regnet_amr_sbml/Nsp4_Nsp6.json
new file mode 100644
index 000000000..a3c212243
--- /dev/null
+++ b/scripts/covid19_diseasemaps/regnet_amr_sbml/Nsp4_Nsp6.json
@@ -0,0 +1,1094 @@
+{
+ "header": {
+ "name": "Model",
+ "schema": "https://raw.githubusercontent.com/DARPA-ASKEM/Model-Representations/regnet_v0.2/regnet/regnet_schema.json",
+ "schema_name": "regnet",
+ "description": "Model",
+ "model_version": "0.1"
+ },
+ "model": {
+ "vertices": [
+ {
+ "id": "Nsp3",
+ "name": "Nsp3",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {
+ "property": "taxonomy:2697049"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp6",
+ "name": "Nsp6",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {
+ "property": "taxonomy:2697049"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp4_cell",
+ "name": "Nsp4_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "ncbiprotein:BCD58761",
+ "property1": "taxonomy:2697049"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp3:Nsp4:Nsp6_complex",
+ "name": "Nsp3:Nsp4:Nsp6_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "29128390"
+ },
+ "context": {
+ "property": "taxonomy:694009"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ALG11_endoplasmic reticulum",
+ "name": "ALG11_endoplasmic reticulum",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "20080937"
+ },
+ "context": {
+ "property": "uniprot:Q2TAA5"
+ }
+ },
+ "initial": 3.0,
+ "sign": true
+ },
+ {
+ "id": "Nsp4_ALG11_complex_endoplasmic reticulum",
+ "name": "Nsp4_ALG11_complex_endoplasmic reticulum",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "20080937"
+ },
+ "context": {}
+ },
+ "initial": 3.0,
+ "sign": true
+ },
+ {
+ "id": "Nsp4:IDE_complex_cell",
+ "name": "Nsp4:IDE_complex_cell",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp4_IDE_complex",
+ "name": "Nsp4_IDE_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "DNAJC11",
+ "name": "DNAJC11",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "25997101"
+ },
+ "context": {
+ "property": "uniprot:Q9NVH1"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp4:DNAJC11_complex",
+ "name": "Nsp4:DNAJC11_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "25997101"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "F-ATPase_complex_mitochondrial matrix",
+ "name": "F-ATPase_complex_mitochondrial matrix",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:O75964"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "F-ATPase:Nsp6_complex",
+ "name": "F-ATPase:Nsp6_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp4:NUP210_complex_endoplasmic reticulum",
+ "name": "Nsp4:NUP210_complex_endoplasmic reticulum",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp4:NUP210_complex_nucleus",
+ "name": "Nsp4:NUP210_complex_nucleus",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "14517331"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NUP210_endoplasmic reticulum",
+ "name": "NUP210_endoplasmic reticulum",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "Q8TEM1"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Several drugs_drug",
+ "name": "Several drugs_drug",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SIGMAR1_endoplasmic reticulum",
+ "name": "SIGMAR1_endoplasmic reticulum",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "10406945"
+ },
+ "context": {
+ "property": "uniprot:Q99720"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SIGMAR1:Drugs_complex",
+ "name": "SIGMAR1:Drugs_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp6:SIGMAR1_complex_endoplasmic reticulum",
+ "name": "Nsp6:SIGMAR1_complex_endoplasmic reticulum",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp6:SIGMAR1_complex_nucleus",
+ "name": "Nsp6:SIGMAR1_complex_nucleus",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "V-ATPase:Nsp6_complex_endoplasmic reticulum",
+ "name": "V-ATPase:Nsp6_complex_endoplasmic reticulum",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "V-ATPase:Nsp6_complex_endosome",
+ "name": "V-ATPase:Nsp6_complex_endosome",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "Q15904"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp4_mitochondrion",
+ "name": "Nsp4_mitochondrion",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "ncbiprotein:BCD58761",
+ "property1": "taxonomy:2697049"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TIM complex_complex",
+ "name": "TIM complex_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TIM complex:Nsp4_complex",
+ "name": "TIM complex:Nsp4_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "V-ATPase_complex_endoplasmic reticulum",
+ "name": "V-ATPase_complex_endoplasmic reticulum",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ATP5MG",
+ "name": "ATP5MG",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:O75964"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "V-type_space_proton_space_ATPase_complex",
+ "name": "V-type_space_proton_space_ATPase_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "GO:0046611"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ATP6AP1",
+ "name": "ATP6AP1",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "27231034"
+ },
+ "context": {
+ "property": "uniprot:Q15904"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Selinexor_drug",
+ "name": "Selinexor_drug",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NUP210:Selinexor_complex",
+ "name": "NUP210:Selinexor_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ATP13A3",
+ "name": "ATP13A3",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:Q9H7F0"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "P-ATPase_complex_cell",
+ "name": "P-ATPase_complex_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "P-ATPase:Nsp6_complex",
+ "name": "P-ATPase:Nsp6_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp4:IDE_complex_cell",
+ "name": "Nsp4:IDE_complex_cell",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "10116"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SLC6A15",
+ "name": "SLC6A15",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {
+ "property": "uniprot:Q8IY34"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SLC6A15:Nsp6_complex",
+ "name": "SLC6A15:Nsp6_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf9c",
+ "name": "Orf9c",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "taxonomy:2697049"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SLC6A15:Orf9c_complex",
+ "name": "SLC6A15:Orf9c_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "M",
+ "name": "M",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "taxonomy:2697049"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SLC6A15:M_complex",
+ "name": "SLC6A15:M_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Loratadine_drug",
+ "name": "Loratadine_drug",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "123134323"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SLC6A15:Loratadine_complex",
+ "name": "SLC6A15:Loratadine_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "V-ATPase_complex_endosome",
+ "name": "V-ATPase_complex_endosome",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Bafilomycin A1_drug",
+ "name": "Bafilomycin A1_drug",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ATP6AP1:Bafilomycin A1_complex",
+ "name": "ATP6AP1:Bafilomycin A1_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IDE_cell",
+ "name": "IDE_cell",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {
+ "property": "uniprot:P14735"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp6:SIGMAR1_complex_cell",
+ "name": "Nsp6:SIGMAR1_complex_cell",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "10406945"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp4 (-)_rna",
+ "name": "Nsp4 (-)_rna",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp4 (+)_rna",
+ "name": "Nsp4 (+)_rna",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp6 (-)_rna",
+ "name": "Nsp6 (-)_rna",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp6 (+)_rna",
+ "name": "Nsp6 (+)_rna",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IDE_human host",
+ "name": "IDE_human host",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp3 (-)_rna",
+ "name": "Nsp3 (-)_rna",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp3 (+)_rna",
+ "name": "Nsp3 (+)_rna",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Plasma membrane organization_phenotype",
+ "name": "Plasma membrane organization_phenotype",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "23943763"
+ },
+ "context": {
+ "property": "GO:0007009",
+ "property1": "taxonomy:694009"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TOM complex_complex",
+ "name": "TOM complex_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NUP210_nucleus",
+ "name": "NUP210_nucleus",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "Q8TEM1"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IDE_cell",
+ "name": "IDE_cell",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "10116"
+ },
+ "context": {
+ "property": "uniprot:P14735"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SIGMAR1_nucleus",
+ "name": "SIGMAR1_nucleus",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "10406945"
+ },
+ "context": {
+ "property": "uniprot:Q99720"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SIGMAR1_cell",
+ "name": "SIGMAR1_cell",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "10406945"
+ },
+ "context": {
+ "property": "uniprot:Q99720"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "H+_ion",
+ "name": "H+_ion",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:15378",
+ "property1": "CHEBI:15378"
+ }
+ },
+ "initial": 3.0
+ }
+ ],
+ "edges": [
+ {
+ "id": "t1",
+ "source": "Nsp3",
+ "target": "Nsp3:Nsp4:Nsp6_complex",
+ "sign": true
+ },
+ {
+ "id": "t2",
+ "source": "Nsp4_cell",
+ "target": "Nsp3:Nsp4:Nsp6_complex",
+ "sign": true
+ },
+ {
+ "id": "t3",
+ "source": "Nsp6",
+ "target": "Nsp3:Nsp4:Nsp6_complex",
+ "sign": true
+ },
+ {
+ "id": "t4",
+ "source": "ALG11_endoplasmic reticulum",
+ "target": "Nsp4_ALG11_complex_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t5",
+ "source": "Nsp4_cell",
+ "target": "Nsp4_ALG11_complex_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t6",
+ "source": "Nsp4:IDE_complex_cell",
+ "target": "Nsp4_IDE_complex",
+ "sign": true
+ },
+ {
+ "id": "t7",
+ "source": "Nsp4_cell",
+ "target": "Nsp4:DNAJC11_complex",
+ "sign": true
+ },
+ {
+ "id": "t8",
+ "source": "DNAJC11",
+ "target": "Nsp4:DNAJC11_complex",
+ "sign": true
+ },
+ {
+ "id": "t9",
+ "source": "Nsp6",
+ "target": "F-ATPase:Nsp6_complex",
+ "sign": true
+ },
+ {
+ "id": "t10",
+ "source": "F-ATPase_complex_mitochondrial matrix",
+ "target": "F-ATPase:Nsp6_complex",
+ "sign": true
+ },
+ {
+ "id": "t11",
+ "source": "Nsp4:NUP210_complex_endoplasmic reticulum",
+ "target": "Nsp4:NUP210_complex_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t12",
+ "source": "NUP210_endoplasmic reticulum",
+ "target": "Nsp4:NUP210_complex_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t13",
+ "source": "Nsp4_cell",
+ "target": "Nsp4:NUP210_complex_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t14",
+ "source": "Several drugs_drug",
+ "target": "SIGMAR1:Drugs_complex",
+ "sign": true
+ },
+ {
+ "id": "t15",
+ "source": "SIGMAR1_endoplasmic reticulum",
+ "target": "SIGMAR1:Drugs_complex",
+ "sign": true
+ },
+ {
+ "id": "t16",
+ "source": "Nsp6:SIGMAR1_complex_endoplasmic reticulum",
+ "target": "Nsp6:SIGMAR1_complex_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t17",
+ "source": "V-ATPase:Nsp6_complex_endoplasmic reticulum",
+ "target": "V-ATPase:Nsp6_complex_endosome",
+ "sign": true
+ },
+ {
+ "id": "t18",
+ "source": "Nsp4_mitochondrion",
+ "target": "TIM complex:Nsp4_complex",
+ "sign": true
+ },
+ {
+ "id": "t19",
+ "source": "TIM complex_complex",
+ "target": "TIM complex:Nsp4_complex",
+ "sign": true
+ },
+ {
+ "id": "t20",
+ "source": "Nsp6",
+ "target": "V-ATPase:Nsp6_complex_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t21",
+ "source": "V-ATPase_complex_endoplasmic reticulum",
+ "target": "V-ATPase:Nsp6_complex_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t22",
+ "source": "ATP5MG",
+ "target": "F-ATPase_complex_mitochondrial matrix",
+ "sign": true
+ },
+ {
+ "id": "t23",
+ "source": "V-type_space_proton_space_ATPase_complex",
+ "target": "V-ATPase_complex_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t24",
+ "source": "ATP6AP1",
+ "target": "V-ATPase_complex_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t25",
+ "source": "NUP210_endoplasmic reticulum",
+ "target": "NUP210:Selinexor_complex",
+ "sign": true
+ },
+ {
+ "id": "t26",
+ "source": "Selinexor_drug",
+ "target": "NUP210:Selinexor_complex",
+ "sign": true
+ },
+ {
+ "id": "t27",
+ "source": "ATP13A3",
+ "target": "P-ATPase_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t28",
+ "source": "Nsp6",
+ "target": "P-ATPase:Nsp6_complex",
+ "sign": true
+ },
+ {
+ "id": "t29",
+ "source": "P-ATPase_complex_cell",
+ "target": "P-ATPase:Nsp6_complex",
+ "sign": true
+ },
+ {
+ "id": "t30",
+ "source": "Nsp4:IDE_complex_cell",
+ "target": "Nsp4:IDE_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t31",
+ "source": "SLC6A15",
+ "target": "SLC6A15:Nsp6_complex",
+ "sign": true
+ },
+ {
+ "id": "t32",
+ "source": "Nsp6",
+ "target": "SLC6A15:Nsp6_complex",
+ "sign": true
+ },
+ {
+ "id": "t33",
+ "source": "SLC6A15",
+ "target": "SLC6A15:Orf9c_complex",
+ "sign": true
+ },
+ {
+ "id": "t34",
+ "source": "Orf9c",
+ "target": "SLC6A15:Orf9c_complex",
+ "sign": true
+ },
+ {
+ "id": "t35",
+ "source": "SLC6A15",
+ "target": "SLC6A15:M_complex",
+ "sign": true
+ },
+ {
+ "id": "t36",
+ "source": "M",
+ "target": "SLC6A15:M_complex",
+ "sign": true
+ },
+ {
+ "id": "t37",
+ "source": "SLC6A15",
+ "target": "SLC6A15:Loratadine_complex",
+ "sign": true
+ },
+ {
+ "id": "t38",
+ "source": "Loratadine_drug",
+ "target": "SLC6A15:Loratadine_complex",
+ "sign": true
+ },
+ {
+ "id": "t39",
+ "source": "V-ATPase_complex_endoplasmic reticulum",
+ "target": "V-ATPase_complex_endosome",
+ "sign": true
+ },
+ {
+ "id": "t40",
+ "source": "Bafilomycin A1_drug",
+ "target": "ATP6AP1:Bafilomycin A1_complex",
+ "sign": true
+ },
+ {
+ "id": "t41",
+ "source": "ATP6AP1",
+ "target": "ATP6AP1:Bafilomycin A1_complex",
+ "sign": true
+ },
+ {
+ "id": "t42",
+ "source": "Nsp6",
+ "target": "Nsp6:SIGMAR1_complex_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t43",
+ "source": "SIGMAR1_endoplasmic reticulum",
+ "target": "Nsp6:SIGMAR1_complex_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t44",
+ "source": "Nsp4_cell",
+ "target": "Nsp4:IDE_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t45",
+ "source": "IDE_cell",
+ "target": "Nsp4:IDE_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t46",
+ "source": "Nsp6:SIGMAR1_complex_endoplasmic reticulum",
+ "target": "Nsp6:SIGMAR1_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t47",
+ "source": "Nsp4 (-)_rna",
+ "target": "Nsp4 (+)_rna",
+ "sign": true
+ },
+ {
+ "id": "t48",
+ "source": "Nsp4 (+)_rna",
+ "target": "Nsp4_cell",
+ "sign": true
+ },
+ {
+ "id": "t49",
+ "source": "Nsp6 (-)_rna",
+ "target": "Nsp6 (+)_rna",
+ "sign": true
+ },
+ {
+ "id": "t50",
+ "source": "Nsp6 (+)_rna",
+ "target": "Nsp6",
+ "sign": true
+ },
+ {
+ "id": "t51",
+ "source": "IDE_cell",
+ "target": "IDE_human host",
+ "sign": true
+ },
+ {
+ "id": "t52",
+ "source": "Nsp3 (-)_rna",
+ "target": "Nsp3 (+)_rna",
+ "sign": true
+ },
+ {
+ "id": "t53",
+ "source": "Nsp3 (+)_rna",
+ "target": "Nsp3",
+ "sign": true
+ },
+ {
+ "id": "t54",
+ "source": "Nsp3:Nsp4:Nsp6_complex",
+ "target": "Plasma membrane organization_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t55",
+ "source": "Nsp4_cell",
+ "target": "Nsp4_mitochondrion",
+ "sign": true
+ },
+ {
+ "id": "t56",
+ "source": "TOM complex_complex",
+ "target": "Nsp4_mitochondrion",
+ "sign": true
+ },
+ {
+ "id": "t57",
+ "source": "Nsp6 (+)_rna",
+ "target": "Nsp6 (-)_rna",
+ "sign": true
+ },
+ {
+ "id": "t58",
+ "source": "Nsp3 (+)_rna",
+ "target": "Nsp3 (-)_rna",
+ "sign": true
+ },
+ {
+ "id": "t59",
+ "source": "Nsp4 (+)_rna",
+ "target": "Nsp4 (-)_rna",
+ "sign": true
+ },
+ {
+ "id": "t60",
+ "source": "NUP210_endoplasmic reticulum",
+ "target": "NUP210_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t61",
+ "source": "IDE_cell",
+ "target": "IDE_cell",
+ "sign": true
+ },
+ {
+ "id": "t62",
+ "source": "SIGMAR1_endoplasmic reticulum",
+ "target": "SIGMAR1_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t63",
+ "source": "SIGMAR1_endoplasmic reticulum",
+ "target": "SIGMAR1_cell",
+ "sign": true
+ },
+ {
+ "id": "t64",
+ "source": "V-type_space_proton_space_ATPase_complex",
+ "target": "H+_ion",
+ "sign": true
+ }
+ ],
+ "parameters": []
+ },
+ "semantics": {
+ "ode": {
+ "rates": [],
+ "observables": [],
+ "time": {
+ "id": "t"
+ }
+ }
+ },
+ "metadata": {
+ "annotations": {}
+ }
+}
\ No newline at end of file
diff --git a/scripts/covid19_diseasemaps/regnet_amr_sbml/Nsp9_protein.json b/scripts/covid19_diseasemaps/regnet_amr_sbml/Nsp9_protein.json
new file mode 100644
index 000000000..b59365516
--- /dev/null
+++ b/scripts/covid19_diseasemaps/regnet_amr_sbml/Nsp9_protein.json
@@ -0,0 +1,4070 @@
+{
+ "header": {
+ "name": "Model",
+ "schema": "https://raw.githubusercontent.com/DARPA-ASKEM/Model-Representations/regnet_v0.2/regnet/regnet_schema.json",
+ "schema_name": "regnet",
+ "description": "Model",
+ "model_version": "0.1"
+ },
+ "model": {
+ "vertices": [
+ {
+ "id": "Nsp9_cell",
+ "name": "Nsp9_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "ncbiprotein:YP_009725305"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Fibrillin_complex_human host",
+ "name": "Fibrillin_complex_human host",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "8702639"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "FBLN5",
+ "name": "FBLN5",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PLG",
+ "name": "PLG",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Fibrillincomp_complex",
+ "name": "Fibrillincomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nuclear Pore_complex",
+ "name": "Nuclear Pore_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32296183"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nuclear Pore comp_complex",
+ "name": "Nuclear Pore comp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MIB1",
+ "name": "MIB1",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "24185901"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "DLL1",
+ "name": "DLL1",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MIBcomp_complex",
+ "name": "MIBcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "21985982"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Vpr",
+ "name": "Vpr",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "COPS_complex_nucleus",
+ "name": "COPS_complex_nucleus",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "16045761"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "COPS_complex_nucleus",
+ "name": "COPS_complex_nucleus",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "22190034"
+ },
+ "context": {}
+ },
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+ },
+ {
+ "id": "SCARB1",
+ "name": "SCARB1",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Phosphatidyl serine_simple_molecule",
+ "name": "Phosphatidyl serine_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "lipidcomp_complex",
+ "name": "lipidcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "16530182"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MAT1A",
+ "name": "MAT1A",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "S-Adenosylmethionine_drug",
+ "name": "S-Adenosylmethionine_drug",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SAdComp_complex",
+ "name": "SAdComp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "11301045"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "nup2_complex",
+ "name": "nup2_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "9049309"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "nup1_complex",
+ "name": "nup1_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "12196509"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "EXOSC2",
+ "name": "EXOSC2",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp8",
+ "name": "Nsp8",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "ncbiprotein:YP_009725304"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "EXOSC3",
+ "name": "EXOSC3",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "EXOSC5",
+ "name": "EXOSC5",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "EXOSC8",
+ "name": "EXOSC8",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "EXOCcomp_complex",
+ "name": "EXOCcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "28514442"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp9_nucleus",
+ "name": "Nsp9_nucleus",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "ncbiprotein:YP_009725305"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "GTF2F2",
+ "name": "GTF2F2",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "10428810"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "gtf2f2comp_complex",
+ "name": "gtf2f2comp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "EDN1-homo_complex_human host",
+ "name": "EDN1-homo_complex_human host",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "17678888"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "EDNRA",
+ "name": "EDNRA",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "EDN1-homo_complex_cell",
+ "name": "EDN1-homo_complex_cell",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "7509919"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "mibcomp_complex",
+ "name": "mibcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "EDN1-homo_complex_nucleus",
+ "name": "EDN1-homo_complex_nucleus",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "28514442"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ZNF503",
+ "name": "ZNF503",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "znfcomp_complex",
+ "name": "znfcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp7",
+ "name": "Nsp7",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp12",
+ "name": "Nsp12",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp7812_complex_cell",
+ "name": "Nsp7812_complex_cell",
+ "grounding": {
+ "identifiers": {
+ "doi": "10.1101/2020.03.16.993386"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "RdRpassembled_rna",
+ "name": "RdRpassembled_rna",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "remdesivir _drug",
+ "name": "remdesivir _drug",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "favipiravir_drug",
+ "name": "favipiravir_drug",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32620147"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp7812_complex_cell",
+ "name": "Nsp7812_complex_cell",
+ "grounding": {
+ "identifiers": {
+ "doi": "10.1126/science.abc1560"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NUP54",
+ "name": "NUP54",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NUP58",
+ "name": "NUP58",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NUP62",
+ "name": "NUP62",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NUP214",
+ "name": "NUP214",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NUP88",
+ "name": "NUP88",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "30543681"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "BAG6",
+ "name": "BAG6",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "EDN1-homo_complex_nucleus",
+ "name": "EDN1-homo_complex_nucleus",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "16169070"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NEK9",
+ "name": "NEK9",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NEK7",
+ "name": "NEK7",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NEK6",
+ "name": "NEK6",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NEKs_complex",
+ "name": "NEKs_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "28514442"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "GTF2B",
+ "name": "GTF2B",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "POLR2A",
+ "name": "POLR2A",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "POLR2B",
+ "name": "POLR2B",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "POLR2E",
+ "name": "POLR2E",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "POLR2G",
+ "name": "POLR2G",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "gtfrnapoly_complex",
+ "name": "gtfrnapoly_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "26344197"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "EDN1-homo_complex_nucleus",
+ "name": "EDN1-homo_complex_nucleus",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "16713569"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "EDN1-homo_complex_endoplasmic reticulum",
+ "name": "EDN1-homo_complex_endoplasmic reticulum",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "16713569"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "EDN1",
+ "name": "EDN1",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "EIF4H",
+ "name": "EIF4H",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "10585411"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "eifcomp_complex",
+ "name": "eifcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "COPS2",
+ "name": "COPS2",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "COPS4",
+ "name": "COPS4",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "COPS5",
+ "name": "COPS5",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "COPS6",
+ "name": "COPS6",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "COPS7A",
+ "name": "COPS7A",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "COPS8",
+ "name": "COPS8",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "UBQLN4",
+ "name": "UBQLN4",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TAT",
+ "name": "TAT",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TAT-HIV_complex",
+ "name": "TAT-HIV_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "8934526"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "DCAF7",
+ "name": "DCAF7",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "16887337"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "dcafcomp_complex",
+ "name": "dcafcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SPART",
+ "name": "SPART",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "AIFM1",
+ "name": "AIFM1",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SPARTcomp_complex",
+ "name": "SPARTcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "19765186"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp10_cell",
+ "name": "Nsp10_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp16",
+ "name": "Nsp16",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NEMF",
+ "name": "NEMF",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp14_cell",
+ "name": "Nsp14_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "pathogen_complex",
+ "name": "pathogen_complex",
+ "grounding": {
+ "identifiers": {
+ "doi": "10.1101/2020.03.31.019216"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CA12",
+ "name": "CA12",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Hydrochlorothiazide_drug",
+ "name": "Hydrochlorothiazide_drug",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "HCTcomp_complex",
+ "name": "HCTcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "19119014"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "FOCAD",
+ "name": "FOCAD",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "FOCADcomp_complex",
+ "name": "FOCADcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "doi": "10.1101/2020.06.17.156455"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "spartcomp_complex",
+ "name": "spartcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "homodimer_complex",
+ "name": "homodimer_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "19153232"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ssRNAoligo_rna",
+ "name": "ssRNAoligo_rna",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "19153232"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "RNArecognition_complex",
+ "name": "RNArecognition_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "19153232"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MAT2B",
+ "name": "MAT2B",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "10644686"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "mat2bcomp_complex",
+ "name": "mat2bcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MAT2A",
+ "name": "MAT2A",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SAdComp2_complex",
+ "name": "SAdComp2_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "11596649"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PTGS2",
+ "name": "PTGS2",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Rofecoxib_drug",
+ "name": "Rofecoxib_drug",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PTGScomp_complex",
+ "name": "PTGScomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "20724158"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "RHOA",
+ "name": "RHOA",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "RHOA7comp_complex",
+ "name": "RHOA7comp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MAT_complex",
+ "name": "MAT_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "12671891"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PCSK1",
+ "name": "PCSK1",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NEC1_complex",
+ "name": "NEC1_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "25544563"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Flavin adenine dinucleotide_drug",
+ "name": "Flavin adenine dinucleotide_drug",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "AIFMFlaComp_complex",
+ "name": "AIFMFlaComp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "10592235"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Sitaxentan_drug",
+ "name": "Sitaxentan_drug",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "EDNRASitaComp_complex",
+ "name": "EDNRASitaComp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "17472992"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Ambrisentan_drug",
+ "name": "Ambrisentan_drug",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "EDNRAmbComp_complex",
+ "name": "EDNRAmbComp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "20811346"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Acetylsalicylic acid_drug",
+ "name": "Acetylsalicylic acid_drug",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "EDNRAcetComp_complex",
+ "name": "EDNRAcetComp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "10727528"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Macitentan_drug",
+ "name": "Macitentan_drug",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "EDNRMacComp_complex",
+ "name": "EDNRMacComp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "22458347"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SEPSECS",
+ "name": "SEPSECS",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Pyridoxal phosphate_simple_molecule",
+ "name": "Pyridoxal phosphate_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SPcomp_complex",
+ "name": "SPcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "17194211"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MYCBP2",
+ "name": "MYCBP2",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MYCBPcomp_complex",
+ "name": "MYCBPcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SBNO1",
+ "name": "SBNO1",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SBNOcomp_complex",
+ "name": "SBNOcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "BCKDK",
+ "name": "BCKDK",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "s389_complex",
+ "name": "s389_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ADP_simple_molecule",
+ "name": "ADP_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ADPcomp_complex",
+ "name": "ADPcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "17016423"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "dcafznf_complex",
+ "name": "dcafznf_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "27705803"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "RBM41",
+ "name": "RBM41",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "RBMcomp_complex",
+ "name": "RBMcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ZNF318",
+ "name": "ZNF318",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ZNFcomp_complex",
+ "name": "ZNFcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "LARP4B ",
+ "name": "LARP4B ",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "LARPcomp_complex",
+ "name": "LARPcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SRP54",
+ "name": "SRP54",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SRP19",
+ "name": "SRP19",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SRP54comp_complex",
+ "name": "SRP54comp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ZC3H7A ",
+ "name": "ZC3H7A ",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ZC3H7Acomp_complex",
+ "name": "ZC3H7Acomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Insulin",
+ "name": "Insulin",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NECINsComp_complex",
+ "name": "NECINsComp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "17016423"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SCARB1_complex",
+ "name": "SCARB1_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CA12comp_complex",
+ "name": "CA12comp_complex",
+ "grounding": {
+ "identifiers": {
+ "doi": "10.1101/2020.06.17.156455"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Zonisamide_drug",
+ "name": "Zonisamide_drug",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ZonisamideComp_complex",
+ "name": "ZonisamideComp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "19703035"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Ellagic Acid_drug",
+ "name": "Ellagic Acid_drug",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "EAcomp_complex",
+ "name": "EAcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "20185318"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Hydroflumethiazide_drug",
+ "name": "Hydroflumethiazide_drug",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "HFTcomp_complex",
+ "name": "HFTcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "19119014"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Benzthiazide_drug",
+ "name": "Benzthiazide_drug",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "BZcomp_complex",
+ "name": "BZcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "19119014"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "AP2A2",
+ "name": "AP2A2",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "AP2A2comp_complex",
+ "name": "AP2A2comp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ELN",
+ "name": "ELN",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Fibrillin_complex_human host",
+ "name": "Fibrillin_complex_human host",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "10544250"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "RofecoxibComp_complex",
+ "name": "RofecoxibComp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "16679386"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NspComp_complex",
+ "name": "NspComp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32296183"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ENV",
+ "name": "ENV",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NECENVComp_complex",
+ "name": "NECENVComp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "8940009"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CYB5R3",
+ "name": "CYB5R3",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NADH_simple_molecule",
+ "name": "NADH_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NADHcomp_complex",
+ "name": "NADHcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "17341833"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CYB5R3comp_complex",
+ "name": "CYB5R3comp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "FAD_simple_molecule",
+ "name": "FAD_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "FADcomp_complex",
+ "name": "FADcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "17016423"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "COMT",
+ "name": "COMT",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "COMT_complex",
+ "name": "COMT_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "RALA",
+ "name": "RALA",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "GDP_simple_molecule",
+ "name": "GDP_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "GDPcomp_complex",
+ "name": "GDPcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "10592235"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "RALAcomp_complex",
+ "name": "RALAcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Tolcapone_drug",
+ "name": "Tolcapone_drug",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TCcomp_complex",
+ "name": "TCcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "20502133"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Entacapone_drug",
+ "name": "Entacapone_drug",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NCcomp_complex",
+ "name": "NCcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "12876237"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "3,5-Dinitrocatechol_drug",
+ "name": "3,5-Dinitrocatechol_drug",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "DCcomp_complex",
+ "name": "DCcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "17016423"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Ademetionine_drug",
+ "name": "Ademetionine_drug",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ACcomp_complex",
+ "name": "ACcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "20196537"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "(3,4-DIHYDROXY-2-NITROPHENYL)(PHENYL)METHANONE_drug",
+ "name": "(3,4-DIHYDROXY-2-NITROPHENYL)(PHENYL)METHANONE_drug",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "DNCcomp_complex",
+ "name": "DNCcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "10592235"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "2-Methoxyestradiol_drug",
+ "name": "2-Methoxyestradiol_drug",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MCcomp_complex",
+ "name": "MCcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "1170911"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "RAB7A",
+ "name": "RAB7A",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "RAB7comp_complex",
+ "name": "RAB7comp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "RGcomp_complex_cell",
+ "name": "RGcomp_complex_cell",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "10592235"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SIRT5",
+ "name": "SIRT5",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Suramin_drug",
+ "name": "Suramin_drug",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SScomp_complex",
+ "name": "SScomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "17355872"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "RGcomp_complex_cell",
+ "name": "RGcomp_complex_cell",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "17016423"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "nek9comp_complex",
+ "name": "nek9comp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MPHOSPH10",
+ "name": "MPHOSPH10",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MPHOSPHcomp_complex",
+ "name": "MPHOSPHcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ACSL3",
+ "name": "ACSL3",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ACSLcomp_complex",
+ "name": "ACSLcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IMPDH2",
+ "name": "IMPDH2",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Mercaptopurine_drug",
+ "name": "Mercaptopurine_drug",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IMercomp_complex",
+ "name": "IMercomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "18506437"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MRPS5",
+ "name": "MRPS5",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MRPS2",
+ "name": "MRPS2",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MRPScomp_complex",
+ "name": "MRPScomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Ribavirin_drug",
+ "name": "Ribavirin_drug",
+ "grounding": {
+ "identifiers": {
+ "doi": "10.1016/S0140-6736(20)31042-4"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IRcomp_complex",
+ "name": "IRcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "17139284"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "LOXL1",
+ "name": "LOXL1",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "LOXcomp_complex",
+ "name": "LOXcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "14745449"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SEPSECScomp_complex",
+ "name": "SEPSECScomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NOL10",
+ "name": "NOL10",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NOL10comp_complex",
+ "name": "NOL10comp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SRP72",
+ "name": "SRP72",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SRP72comp_complex",
+ "name": "SRP72comp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NARS2",
+ "name": "NARS2",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "L-Asparagine_simple_molecule",
+ "name": "L-Asparagine_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NLcomp_complex",
+ "name": "NLcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "16753178"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SIRT5comp_complex",
+ "name": "SIRT5comp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "AATF",
+ "name": "AATF",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "AATFcomp_complex",
+ "name": "AATFcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp14_nucleus",
+ "name": "Nsp14_nucleus",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "INPDH2comp_complex",
+ "name": "INPDH2comp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "DDX10",
+ "name": "DDX10",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "DDX10comp_complex",
+ "name": "DDX10comp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TCF12",
+ "name": "TCF12",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TCFcomp_complex",
+ "name": "TCFcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp10_nucleus",
+ "name": "Nsp10_nucleus",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ERGIC1",
+ "name": "ERGIC1",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ERGIC1comp_complex",
+ "name": "ERGIC1comp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "GFER",
+ "name": "GFER",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "GFERcomp_complex",
+ "name": "GFERcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "FGCOMP_complex",
+ "name": "FGCOMP_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "10592235"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "AP2M1",
+ "name": "AP2M1",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "AP2M1comp_complex",
+ "name": "AP2M1comp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Mycophenolic acid_drug",
+ "name": "Mycophenolic acid_drug",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "17496727"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IMcomp_complex",
+ "name": "IMcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "17496727"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NGDN",
+ "name": "NGDN",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NGDNcomp_complex",
+ "name": "NGDNcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CCDC86",
+ "name": "CCDC86",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CCDCcomp_complex",
+ "name": "CCDCcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32353859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MEPCE",
+ "name": "MEPCE",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "LARP7",
+ "name": "LARP7",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MEPCEcomp_complex",
+ "name": "MEPCEcomp_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "29845934"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NARS2comp_complex",
+ "name": "NARS2comp_complex",
+ "grounding": {
+ "identifiers": {
+ "doi": "10.1101/2020.03.31.019216"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ZNF250",
+ "name": "ZNF250",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ZNF250comp_complex",
+ "name": "ZNF250comp_complex",
+ "grounding": {
+ "identifiers": {
+ "doi": "10.1101/2020.06.17.156455"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PEG10",
+ "name": "PEG10",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PEG10comp_complex",
+ "name": "PEG10comp_complex",
+ "grounding": {
+ "identifiers": {
+ "doi": "10.1101/2020.06.17.156455"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "EDN1_rna",
+ "name": "EDN1_rna",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "ncbigene:1906"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "virus_replication_phenotype",
+ "name": "virus_replication_phenotype",
+ "grounding": {
+ "identifiers": {
+ "doi": "10.1126/science.abc1560"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Neutrophil_activation_phenotype",
+ "name": "Neutrophil_activation_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Mycophenolate mofetil_drug",
+ "name": "Mycophenolate mofetil_drug",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PLAT",
+ "name": "PLAT",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nafamostat_drug",
+ "name": "Nafamostat_drug",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32620147"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ }
+ ],
+ "edges": [
+ {
+ "id": "t1",
+ "source": "Fibrillin_complex_human host",
+ "target": "Fibrillincomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t2",
+ "source": "Nsp9_cell",
+ "target": "Fibrillincomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t3",
+ "source": "PLG",
+ "target": "Fibrillincomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t4",
+ "source": "FBLN5",
+ "target": "Fibrillincomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t5",
+ "source": "Nsp9_cell",
+ "target": "Nuclear Pore comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t6",
+ "source": "Nuclear Pore_complex",
+ "target": "Nuclear Pore comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t7",
+ "source": "DLL1",
+ "target": "MIBcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t8",
+ "source": "MIB1",
+ "target": "MIBcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t9",
+ "source": "COPS_complex_nucleus",
+ "target": "COPS_complex_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t10",
+ "source": "Vpr",
+ "target": "COPS_complex_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t11",
+ "source": "SCARB1",
+ "target": "lipidcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t12",
+ "source": "Phosphatidyl serine_simple_molecule",
+ "target": "lipidcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t13",
+ "source": "MAT1A",
+ "target": "SAdComp_complex",
+ "sign": true
+ },
+ {
+ "id": "t14",
+ "source": "S-Adenosylmethionine_drug",
+ "target": "SAdComp_complex",
+ "sign": true
+ },
+ {
+ "id": "t15",
+ "source": "nup2_complex",
+ "target": "Nuclear Pore_complex",
+ "sign": true
+ },
+ {
+ "id": "t16",
+ "source": "nup1_complex",
+ "target": "Nuclear Pore_complex",
+ "sign": true
+ },
+ {
+ "id": "t17",
+ "source": "EXOSC5",
+ "target": "EXOCcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t18",
+ "source": "EXOSC8",
+ "target": "EXOCcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t19",
+ "source": "EXOSC3",
+ "target": "EXOCcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t20",
+ "source": "Nsp8",
+ "target": "EXOCcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t21",
+ "source": "EXOSC2",
+ "target": "EXOCcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t22",
+ "source": "GTF2F2",
+ "target": "gtf2f2comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t23",
+ "source": "Nsp9_nucleus",
+ "target": "gtf2f2comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t24",
+ "source": "EDN1-homo_complex_human host",
+ "target": "EDN1-homo_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t25",
+ "source": "EDNRA",
+ "target": "EDN1-homo_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t26",
+ "source": "Nsp9_cell",
+ "target": "mibcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t27",
+ "source": "MIB1",
+ "target": "mibcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t28",
+ "source": "EDN1-homo_complex_nucleus",
+ "target": "EDN1-homo_complex_human host",
+ "sign": true
+ },
+ {
+ "id": "t29",
+ "source": "ZNF503",
+ "target": "znfcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t30",
+ "source": "Nsp9_nucleus",
+ "target": "znfcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t31",
+ "source": "Nsp7",
+ "target": "Nsp7812_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t32",
+ "source": "Nsp12",
+ "target": "Nsp7812_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t33",
+ "source": "Nsp8",
+ "target": "Nsp7812_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t34",
+ "source": "remdesivir _drug",
+ "target": "Nsp7812_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t35",
+ "source": "favipiravir_drug",
+ "target": "Nsp7812_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t36",
+ "source": "Nsp7812_complex_cell",
+ "target": "Nsp7812_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t37",
+ "source": "RdRpassembled_rna",
+ "target": "Nsp7812_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t38",
+ "source": "NUP62",
+ "target": "nup1_complex",
+ "sign": true
+ },
+ {
+ "id": "t39",
+ "source": "NUP54",
+ "target": "nup1_complex",
+ "sign": true
+ },
+ {
+ "id": "t40",
+ "source": "NUP58",
+ "target": "nup1_complex",
+ "sign": true
+ },
+ {
+ "id": "t41",
+ "source": "NUP88",
+ "target": "nup2_complex",
+ "sign": true
+ },
+ {
+ "id": "t42",
+ "source": "NUP214",
+ "target": "nup2_complex",
+ "sign": true
+ },
+ {
+ "id": "t43",
+ "source": "BAG6",
+ "target": "EDN1-homo_complex_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t44",
+ "source": "EDN1-homo_complex_nucleus",
+ "target": "EDN1-homo_complex_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t45",
+ "source": "NEK6",
+ "target": "NEKs_complex",
+ "sign": true
+ },
+ {
+ "id": "t46",
+ "source": "NEK9",
+ "target": "NEKs_complex",
+ "sign": true
+ },
+ {
+ "id": "t47",
+ "source": "NEK7",
+ "target": "NEKs_complex",
+ "sign": true
+ },
+ {
+ "id": "t48",
+ "source": "POLR2A",
+ "target": "gtfrnapoly_complex",
+ "sign": true
+ },
+ {
+ "id": "t49",
+ "source": "POLR2G",
+ "target": "gtfrnapoly_complex",
+ "sign": true
+ },
+ {
+ "id": "t50",
+ "source": "GTF2F2",
+ "target": "gtfrnapoly_complex",
+ "sign": true
+ },
+ {
+ "id": "t51",
+ "source": "POLR2E",
+ "target": "gtfrnapoly_complex",
+ "sign": true
+ },
+ {
+ "id": "t52",
+ "source": "POLR2B",
+ "target": "gtfrnapoly_complex",
+ "sign": true
+ },
+ {
+ "id": "t53",
+ "source": "GTF2B",
+ "target": "gtfrnapoly_complex",
+ "sign": true
+ },
+ {
+ "id": "t54",
+ "source": "EDN1-homo_complex_nucleus",
+ "target": "EDN1-homo_complex_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t55",
+ "source": "EDN1",
+ "target": "EDN1-homo_complex_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t56",
+ "source": "EIF4H",
+ "target": "eifcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t57",
+ "source": "Nsp9_nucleus",
+ "target": "eifcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t58",
+ "source": "COPS6",
+ "target": "COPS_complex_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t59",
+ "source": "COPS2",
+ "target": "COPS_complex_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t60",
+ "source": "COPS4",
+ "target": "COPS_complex_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t61",
+ "source": "COPS5",
+ "target": "COPS_complex_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t62",
+ "source": "COPS7A",
+ "target": "COPS_complex_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t63",
+ "source": "COPS8",
+ "target": "COPS_complex_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t64",
+ "source": "EDN1-homo_complex_nucleus",
+ "target": "EDN1-homo_complex_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t65",
+ "source": "COPS6",
+ "target": "EDN1-homo_complex_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t66",
+ "source": "EDN1-homo_complex_nucleus",
+ "target": "EDN1-homo_complex_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t67",
+ "source": "UBQLN4",
+ "target": "EDN1-homo_complex_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t68",
+ "source": "EDN1-homo_complex_nucleus",
+ "target": "EDN1-homo_complex_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t69",
+ "source": "GTF2F2",
+ "target": "TAT-HIV_complex",
+ "sign": true
+ },
+ {
+ "id": "t70",
+ "source": "TAT",
+ "target": "TAT-HIV_complex",
+ "sign": true
+ },
+ {
+ "id": "t71",
+ "source": "DCAF7",
+ "target": "dcafcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t72",
+ "source": "Nsp9_nucleus",
+ "target": "dcafcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t73",
+ "source": "SPART",
+ "target": "SPARTcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t74",
+ "source": "AIFM1",
+ "target": "SPARTcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t75",
+ "source": "Nsp16",
+ "target": "pathogen_complex",
+ "sign": true
+ },
+ {
+ "id": "t76",
+ "source": "Nsp14_cell",
+ "target": "pathogen_complex",
+ "sign": true
+ },
+ {
+ "id": "t77",
+ "source": "Nsp9_cell",
+ "target": "pathogen_complex",
+ "sign": true
+ },
+ {
+ "id": "t78",
+ "source": "Nsp10_cell",
+ "target": "pathogen_complex",
+ "sign": true
+ },
+ {
+ "id": "t79",
+ "source": "NEMF",
+ "target": "pathogen_complex",
+ "sign": true
+ },
+ {
+ "id": "t80",
+ "source": "Hydrochlorothiazide_drug",
+ "target": "HCTcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t81",
+ "source": "CA12",
+ "target": "HCTcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t82",
+ "source": "Nsp7",
+ "target": "FOCADcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t83",
+ "source": "Nsp8",
+ "target": "FOCADcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t84",
+ "source": "FOCAD",
+ "target": "FOCADcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t85",
+ "source": "Nsp9_cell",
+ "target": "spartcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t86",
+ "source": "SPART",
+ "target": "spartcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t87",
+ "source": "ssRNAoligo_rna",
+ "target": "RNArecognition_complex",
+ "sign": true
+ },
+ {
+ "id": "t88",
+ "source": "homodimer_complex",
+ "target": "RNArecognition_complex",
+ "sign": true
+ },
+ {
+ "id": "t89",
+ "source": "Nsp9_cell",
+ "target": "mat2bcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t90",
+ "source": "MAT2B",
+ "target": "mat2bcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t91",
+ "source": "S-Adenosylmethionine_drug",
+ "target": "SAdComp2_complex",
+ "sign": true
+ },
+ {
+ "id": "t92",
+ "source": "MAT2A",
+ "target": "SAdComp2_complex",
+ "sign": true
+ },
+ {
+ "id": "t93",
+ "source": "PTGS2",
+ "target": "PTGScomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t94",
+ "source": "Rofecoxib_drug",
+ "target": "PTGScomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t95",
+ "source": "RHOA",
+ "target": "RHOA7comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t96",
+ "source": "Nsp7",
+ "target": "RHOA7comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t97",
+ "source": "MAT1A",
+ "target": "MAT_complex",
+ "sign": true
+ },
+ {
+ "id": "t98",
+ "source": "MAT2B",
+ "target": "MAT_complex",
+ "sign": true
+ },
+ {
+ "id": "t99",
+ "source": "MAT2A",
+ "target": "MAT_complex",
+ "sign": true
+ },
+ {
+ "id": "t100",
+ "source": "PCSK1",
+ "target": "NEC1_complex",
+ "sign": true
+ },
+ {
+ "id": "t101",
+ "source": "MAT2B",
+ "target": "NEC1_complex",
+ "sign": true
+ },
+ {
+ "id": "t102",
+ "source": "AIFM1",
+ "target": "AIFMFlaComp_complex",
+ "sign": true
+ },
+ {
+ "id": "t103",
+ "source": "Flavin adenine dinucleotide_drug",
+ "target": "AIFMFlaComp_complex",
+ "sign": true
+ },
+ {
+ "id": "t104",
+ "source": "EDNRA",
+ "target": "EDNRASitaComp_complex",
+ "sign": true
+ },
+ {
+ "id": "t105",
+ "source": "Sitaxentan_drug",
+ "target": "EDNRASitaComp_complex",
+ "sign": true
+ },
+ {
+ "id": "t106",
+ "source": "Ambrisentan_drug",
+ "target": "EDNRAmbComp_complex",
+ "sign": true
+ },
+ {
+ "id": "t107",
+ "source": "EDNRA",
+ "target": "EDNRAmbComp_complex",
+ "sign": true
+ },
+ {
+ "id": "t108",
+ "source": "Acetylsalicylic acid_drug",
+ "target": "EDNRAcetComp_complex",
+ "sign": true
+ },
+ {
+ "id": "t109",
+ "source": "EDNRA",
+ "target": "EDNRAcetComp_complex",
+ "sign": true
+ },
+ {
+ "id": "t110",
+ "source": "EDNRA",
+ "target": "EDNRMacComp_complex",
+ "sign": true
+ },
+ {
+ "id": "t111",
+ "source": "Macitentan_drug",
+ "target": "EDNRMacComp_complex",
+ "sign": true
+ },
+ {
+ "id": "t112",
+ "source": "SEPSECS",
+ "target": "SPcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t113",
+ "source": "Pyridoxal phosphate_simple_molecule",
+ "target": "SPcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t114",
+ "source": "Nsp12",
+ "target": "MYCBPcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t115",
+ "source": "MYCBP2",
+ "target": "MYCBPcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t116",
+ "source": "Nsp12",
+ "target": "SBNOcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t117",
+ "source": "SBNO1",
+ "target": "SBNOcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t118",
+ "source": "BCKDK",
+ "target": "s389_complex",
+ "sign": true
+ },
+ {
+ "id": "t119",
+ "source": "Nsp12",
+ "target": "s389_complex",
+ "sign": true
+ },
+ {
+ "id": "t120",
+ "source": "BCKDK",
+ "target": "ADPcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t121",
+ "source": "ADP_simple_molecule",
+ "target": "ADPcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t122",
+ "source": "ZNF503",
+ "target": "dcafznf_complex",
+ "sign": true
+ },
+ {
+ "id": "t123",
+ "source": "DCAF7",
+ "target": "dcafznf_complex",
+ "sign": true
+ },
+ {
+ "id": "t124",
+ "source": "RBM41",
+ "target": "RBMcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t125",
+ "source": "Nsp12",
+ "target": "RBMcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t126",
+ "source": "Nsp12",
+ "target": "ZNFcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t127",
+ "source": "ZNF318",
+ "target": "ZNFcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t128",
+ "source": "LARP4B ",
+ "target": "LARPcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t129",
+ "source": "Nsp12",
+ "target": "LARPcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t130",
+ "source": "Nsp8",
+ "target": "SRP54comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t131",
+ "source": "SRP54",
+ "target": "SRP54comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t132",
+ "source": "SRP19",
+ "target": "SRP54comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t133",
+ "source": "Nsp12",
+ "target": "ZC3H7Acomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t134",
+ "source": "ZC3H7A ",
+ "target": "ZC3H7Acomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t135",
+ "source": "PCSK1",
+ "target": "NECINsComp_complex",
+ "sign": true
+ },
+ {
+ "id": "t136",
+ "source": "Insulin",
+ "target": "NECINsComp_complex",
+ "sign": true
+ },
+ {
+ "id": "t137",
+ "source": "SCARB1",
+ "target": "SCARB1_complex",
+ "sign": true
+ },
+ {
+ "id": "t138",
+ "source": "Nsp7",
+ "target": "SCARB1_complex",
+ "sign": true
+ },
+ {
+ "id": "t139",
+ "source": "Nsp7",
+ "target": "CA12comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t140",
+ "source": "CA12",
+ "target": "CA12comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t141",
+ "source": "Zonisamide_drug",
+ "target": "ZonisamideComp_complex",
+ "sign": true
+ },
+ {
+ "id": "t142",
+ "source": "CA12",
+ "target": "ZonisamideComp_complex",
+ "sign": true
+ },
+ {
+ "id": "t143",
+ "source": "CA12",
+ "target": "EAcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t144",
+ "source": "Ellagic Acid_drug",
+ "target": "EAcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t145",
+ "source": "Hydroflumethiazide_drug",
+ "target": "HFTcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t146",
+ "source": "CA12",
+ "target": "HFTcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t147",
+ "source": "Benzthiazide_drug",
+ "target": "BZcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t148",
+ "source": "CA12",
+ "target": "BZcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t149",
+ "source": "Nsp10_cell",
+ "target": "AP2A2comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t150",
+ "source": "AP2A2",
+ "target": "AP2A2comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t151",
+ "source": "PLG",
+ "target": "Fibrillin_complex_human host",
+ "sign": true
+ },
+ {
+ "id": "t152",
+ "source": "ELN",
+ "target": "Fibrillin_complex_human host",
+ "sign": true
+ },
+ {
+ "id": "t153",
+ "source": "Fibrillin_complex_human host",
+ "target": "Fibrillin_complex_human host",
+ "sign": true
+ },
+ {
+ "id": "t154",
+ "source": "Rofecoxib_drug",
+ "target": "RofecoxibComp_complex",
+ "sign": true
+ },
+ {
+ "id": "t155",
+ "source": "ELN",
+ "target": "RofecoxibComp_complex",
+ "sign": true
+ },
+ {
+ "id": "t156",
+ "source": "Nsp9_cell",
+ "target": "NspComp_complex",
+ "sign": true
+ },
+ {
+ "id": "t157",
+ "source": "Nsp8",
+ "target": "NspComp_complex",
+ "sign": true
+ },
+ {
+ "id": "t158",
+ "source": "PCSK1",
+ "target": "NECENVComp_complex",
+ "sign": true
+ },
+ {
+ "id": "t159",
+ "source": "ENV",
+ "target": "NECENVComp_complex",
+ "sign": true
+ },
+ {
+ "id": "t160",
+ "source": "CYB5R3",
+ "target": "NADHcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t161",
+ "source": "NADH_simple_molecule",
+ "target": "NADHcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t162",
+ "source": "CYB5R3",
+ "target": "CYB5R3comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t163",
+ "source": "Nsp7",
+ "target": "CYB5R3comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t164",
+ "source": "CYB5R3",
+ "target": "FADcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t165",
+ "source": "FAD_simple_molecule",
+ "target": "FADcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t166",
+ "source": "Nsp7",
+ "target": "COMT_complex",
+ "sign": true
+ },
+ {
+ "id": "t167",
+ "source": "COMT",
+ "target": "COMT_complex",
+ "sign": true
+ },
+ {
+ "id": "t168",
+ "source": "RALA",
+ "target": "GDPcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t169",
+ "source": "GDP_simple_molecule",
+ "target": "GDPcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t170",
+ "source": "RALA",
+ "target": "RALAcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t171",
+ "source": "Nsp7",
+ "target": "RALAcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t172",
+ "source": "Tolcapone_drug",
+ "target": "TCcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t173",
+ "source": "COMT",
+ "target": "TCcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t174",
+ "source": "COMT",
+ "target": "NCcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t175",
+ "source": "Entacapone_drug",
+ "target": "NCcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t176",
+ "source": "COMT",
+ "target": "DCcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t177",
+ "source": "3,5-Dinitrocatechol_drug",
+ "target": "DCcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t178",
+ "source": "COMT",
+ "target": "ACcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t179",
+ "source": "Ademetionine_drug",
+ "target": "ACcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t180",
+ "source": "COMT",
+ "target": "DNCcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t181",
+ "source": "(3,4-DIHYDROXY-2-NITROPHENYL)(PHENYL)METHANONE_drug",
+ "target": "DNCcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t182",
+ "source": "2-Methoxyestradiol_drug",
+ "target": "MCcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t183",
+ "source": "COMT",
+ "target": "MCcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t184",
+ "source": "RAB7A",
+ "target": "RAB7comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t185",
+ "source": "Nsp7",
+ "target": "RAB7comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t186",
+ "source": "RAB7A",
+ "target": "RGcomp_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t187",
+ "source": "GDP_simple_molecule",
+ "target": "RGcomp_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t188",
+ "source": "SIRT5",
+ "target": "SScomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t189",
+ "source": "Suramin_drug",
+ "target": "SScomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t190",
+ "source": "RHOA",
+ "target": "RGcomp_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t191",
+ "source": "GDP_simple_molecule",
+ "target": "RGcomp_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t192",
+ "source": "NEK9",
+ "target": "nek9comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t193",
+ "source": "Nsp9_nucleus",
+ "target": "nek9comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t194",
+ "source": "MPHOSPH10",
+ "target": "MPHOSPHcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t195",
+ "source": "Nsp8",
+ "target": "MPHOSPHcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t196",
+ "source": "ACSL3",
+ "target": "ACSLcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t197",
+ "source": "Nsp7",
+ "target": "ACSLcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t198",
+ "source": "Mercaptopurine_drug",
+ "target": "IMercomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t199",
+ "source": "IMPDH2",
+ "target": "IMercomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t200",
+ "source": "Nsp8",
+ "target": "MRPScomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t201",
+ "source": "MRPS2",
+ "target": "MRPScomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t202",
+ "source": "MRPS5",
+ "target": "MRPScomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t203",
+ "source": "Ribavirin_drug",
+ "target": "IRcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t204",
+ "source": "IMPDH2",
+ "target": "IRcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t205",
+ "source": "FBLN5",
+ "target": "LOXcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t206",
+ "source": "PLG",
+ "target": "LOXcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t207",
+ "source": "LOXL1",
+ "target": "LOXcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t208",
+ "source": "SEPSECS",
+ "target": "SEPSECScomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t209",
+ "source": "Nsp8",
+ "target": "SEPSECScomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t210",
+ "source": "Nsp8",
+ "target": "NOL10comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t211",
+ "source": "NOL10",
+ "target": "NOL10comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t212",
+ "source": "Nsp7",
+ "target": "SRP72comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t213",
+ "source": "SRP72",
+ "target": "SRP72comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t214",
+ "source": "L-Asparagine_simple_molecule",
+ "target": "NLcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t215",
+ "source": "NARS2",
+ "target": "NLcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t216",
+ "source": "SIRT5",
+ "target": "SIRT5comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t217",
+ "source": "Nsp14_cell",
+ "target": "SIRT5comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t218",
+ "source": "AATF",
+ "target": "AATFcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t219",
+ "source": "Nsp8",
+ "target": "AATFcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t220",
+ "source": "Nsp14_nucleus",
+ "target": "INPDH2comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t221",
+ "source": "IMPDH2",
+ "target": "INPDH2comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t222",
+ "source": "Nsp8",
+ "target": "DDX10comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t223",
+ "source": "DDX10",
+ "target": "DDX10comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t224",
+ "source": "Nsp12",
+ "target": "TCFcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t225",
+ "source": "TCF12",
+ "target": "TCFcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t226",
+ "source": "ERGIC1",
+ "target": "ERGIC1comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t227",
+ "source": "Nsp10_nucleus",
+ "target": "ERGIC1comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t228",
+ "source": "GFER",
+ "target": "GFERcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t229",
+ "source": "Nsp10_cell",
+ "target": "GFERcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t230",
+ "source": "FAD_simple_molecule",
+ "target": "FGCOMP_complex",
+ "sign": true
+ },
+ {
+ "id": "t231",
+ "source": "GFER",
+ "target": "FGCOMP_complex",
+ "sign": true
+ },
+ {
+ "id": "t232",
+ "source": "AP2M1",
+ "target": "AP2M1comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t233",
+ "source": "Nsp10_cell",
+ "target": "AP2M1comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t234",
+ "source": "Mycophenolic acid_drug",
+ "target": "IMcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t235",
+ "source": "IMPDH2",
+ "target": "IMcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t236",
+ "source": "NGDN",
+ "target": "NGDNcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t237",
+ "source": "Nsp8",
+ "target": "NGDNcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t238",
+ "source": "Nsp8",
+ "target": "CCDCcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t239",
+ "source": "CCDC86",
+ "target": "CCDCcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t240",
+ "source": "Nsp8",
+ "target": "MEPCEcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t241",
+ "source": "LARP7",
+ "target": "MEPCEcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t242",
+ "source": "MEPCE",
+ "target": "MEPCEcomp_complex",
+ "sign": true
+ },
+ {
+ "id": "t243",
+ "source": "Nsp9_cell",
+ "target": "homodimer_complex",
+ "sign": true
+ },
+ {
+ "id": "t244",
+ "source": "Nsp8",
+ "target": "NARS2comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t245",
+ "source": "NARS2",
+ "target": "NARS2comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t246",
+ "source": "Nsp14_nucleus",
+ "target": "ZNF250comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t247",
+ "source": "ZNF250",
+ "target": "ZNF250comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t248",
+ "source": "PEG10",
+ "target": "PEG10comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t249",
+ "source": "Nsp14_cell",
+ "target": "PEG10comp_complex",
+ "sign": true
+ },
+ {
+ "id": "t250",
+ "source": "EDN1_rna",
+ "target": "EDN1",
+ "sign": true
+ },
+ {
+ "id": "t251",
+ "source": "DCAF7",
+ "target": "EDN1_rna",
+ "sign": true
+ },
+ {
+ "id": "t252",
+ "source": "Nsp7812_complex_cell",
+ "target": "virus_replication_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t253",
+ "source": "pathogen_complex",
+ "target": "Neutrophil_activation_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t254",
+ "source": "Mycophenolate mofetil_drug",
+ "target": "Mycophenolic acid_drug",
+ "sign": true
+ },
+ {
+ "id": "t255",
+ "source": "Nafamostat_drug",
+ "target": "PLG",
+ "sign": true
+ },
+ {
+ "id": "t256",
+ "source": "PLAT",
+ "target": "PLG",
+ "sign": true
+ }
+ ],
+ "parameters": []
+ },
+ "semantics": {
+ "ode": {
+ "rates": [],
+ "observables": [],
+ "time": {
+ "id": "t"
+ }
+ }
+ },
+ "metadata": {
+ "annotations": {}
+ }
+}
\ No newline at end of file
diff --git a/scripts/covid19_diseasemaps/regnet_amr_sbml/Orf10_Cul2_pathway.json b/scripts/covid19_diseasemaps/regnet_amr_sbml/Orf10_Cul2_pathway.json
new file mode 100644
index 000000000..071d3ab6b
--- /dev/null
+++ b/scripts/covid19_diseasemaps/regnet_amr_sbml/Orf10_Cul2_pathway.json
@@ -0,0 +1,1242 @@
+{
+ "header": {
+ "name": "Model",
+ "schema": "https://raw.githubusercontent.com/DARPA-ASKEM/Model-Representations/regnet_v0.2/regnet/regnet_schema.json",
+ "schema_name": "regnet",
+ "description": "Model",
+ "model_version": "0.1"
+ },
+ "model": {
+ "vertices": [
+ {
+ "id": "Cul2 ubiquitin ligase:substrate_complex_cell",
+ "name": "Cul2 ubiquitin ligase:substrate_complex_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Cul2 ubiquitin ligase:Orf10_complex",
+ "name": "Cul2 ubiquitin ligase:Orf10_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Cul2 ubiquitin ligase:N8_complex",
+ "name": "Cul2 ubiquitin ligase:N8_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CSN5_complex",
+ "name": "CSN5_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Zyg11B:EloBC_complex",
+ "name": "Zyg11B:EloBC_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Rbx1:Cul2_complex",
+ "name": "Rbx1:Cul2_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Cul2 ubiquitin ligase_complex",
+ "name": "Cul2 ubiquitin ligase_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ELOB:ELOC_complex",
+ "name": "ELOB:ELOC_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ZYG11B",
+ "name": "ZYG11B",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:25820"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Cul2 ubiquitin ligase:Orf10:substrate_complex",
+ "name": "Cul2 ubiquitin ligase:Orf10:substrate_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Cul2 ubiquitin ligase:N8:Orf10_complex",
+ "name": "Cul2 ubiquitin ligase:N8:Orf10_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf10",
+ "name": "Orf10",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "ncbiprotein:BCD58762"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ubit_traget",
+ "name": "ubit_traget",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ELOB",
+ "name": "ELOB",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:11619"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ELOC",
+ "name": "ELOC",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:11617"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NAE_complex",
+ "name": "NAE_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Pevonedistat_drug",
+ "name": "Pevonedistat_drug",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "145535"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NAE:Pevonedistat_complex",
+ "name": "NAE:Pevonedistat_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NEDD8",
+ "name": "NEDD8",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:7732"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NAE:NEDD8_complex",
+ "name": "NAE:NEDD8_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "RBX1",
+ "name": "RBX1",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:9928"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CUL2",
+ "name": "CUL2",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:2552"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Cul2 ubiquitin ligase:N8:Orf10:E2-Ub:substrate_complex",
+ "name": "Cul2 ubiquitin ligase:N8:Orf10:E2-Ub:substrate_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Cul2 ubiquitin ligase:N8:Orf10:E2:substrate-Ub_complex",
+ "name": "Cul2 ubiquitin ligase:N8:Orf10:E2:substrate-Ub_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Cul2 ubiquitin ligase:N8:E2:substrate_complex",
+ "name": "Cul2 ubiquitin ligase:N8:E2:substrate_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Cul2 ubiquitin ligase:N8:E2-Ub:substrate_complex",
+ "name": "Cul2 ubiquitin ligase:N8:E2-Ub:substrate_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "UBE2M:NEDD8_complex",
+ "name": "UBE2M:NEDD8_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Cul2 ubiquitin ligase:N8:E2:substrate-Ub_complex",
+ "name": "Cul2 ubiquitin ligase:N8:E2:substrate-Ub_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "E2_ubiquitinated",
+ "name": "E2_ubiquitinated",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:UBE2"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Cul2 ubiquitin ligase:N8:substrate-Ub_complex",
+ "name": "Cul2 ubiquitin ligase:N8:substrate-Ub_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "E2",
+ "name": "E2",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:UBE2"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Cul2 ubiquitin ligase:N8:Orf10:substrate-Ub_complex",
+ "name": "Cul2 ubiquitin ligase:N8:Orf10:substrate-Ub_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Cul2 ubiquitin ligase:N8:Orf10:substrate_complex",
+ "name": "Cul2 ubiquitin ligase:N8:Orf10:substrate_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Cul2 ubiquitin ligase:N8:Orf10:0E2:substrate_complex",
+ "name": "Cul2 ubiquitin ligase:N8:Orf10:0E2:substrate_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "UBE2M",
+ "name": "UBE2M",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:12491"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NAE1",
+ "name": "NAE1",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:621"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "UBA3",
+ "name": "UBA3",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:12470"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ELOB_rna",
+ "name": "ELOB_rna",
+ "grounding": {
+ "identifiers": {
+ "HGNC": "11619"
+ },
+ "context": {
+ "property": "HGNC:11619"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ELOC_rna",
+ "name": "ELOC_rna",
+ "grounding": {
+ "identifiers": {
+ "HGNC": "11617"
+ },
+ "context": {
+ "property": "HGNC:11617"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ZYG11B_rna",
+ "name": "ZYG11B_rna",
+ "grounding": {
+ "identifiers": {
+ "HGNC": "25820"
+ },
+ "context": {
+ "property": "HGNC:25820"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "RBX1_rna",
+ "name": "RBX1_rna",
+ "grounding": {
+ "identifiers": {
+ "HGNC": "9928"
+ },
+ "context": {
+ "property": "HGNC:9928"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CUL2_rna",
+ "name": "CUL2_rna",
+ "grounding": {
+ "identifiers": {
+ "HGNC": "2552"
+ },
+ "context": {
+ "property": "HGNC:2552"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "E1_ubiquitinated",
+ "name": "E1_ubiquitinated",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:UBA"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "E1_rna",
+ "name": "E1_rna",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "UBA"
+ },
+ "context": {
+ "property": "hgnc:UBA"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "E1",
+ "name": "E1",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:UBA"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "E2_rna",
+ "name": "E2_rna",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "UBE2"
+ },
+ "context": {
+ "property": "hgnc:UBE2"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "DUB_rna",
+ "name": "DUB_rna",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "DUB"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "DUB",
+ "name": "DUB",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:DUB"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Ub_simple_molecule",
+ "name": "Ub_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ATP_simple_molecule",
+ "name": "ATP_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "AMP_simple_molecule",
+ "name": "AMP_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PPi_simple_molecule",
+ "name": "PPi_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf10 (+)ss sgmRNA_rna",
+ "name": "Orf10 (+)ss sgmRNA_rna",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "ncbiprotein:BCD58762"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "UBE2M_rna",
+ "name": "UBE2M_rna",
+ "grounding": {
+ "identifiers": {
+ "HGNC": "12491"
+ },
+ "context": {
+ "property": "HGNC:12491"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ubit_traget_ubiquitinated",
+ "name": "ubit_traget_ubiquitinated",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NEDD8_rna",
+ "name": "NEDD8_rna",
+ "grounding": {
+ "identifiers": {
+ "HGNC": "7732"
+ },
+ "context": {
+ "property": "HGNC:7732"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NAE1_rna",
+ "name": "NAE1_rna",
+ "grounding": {
+ "identifiers": {
+ "HGNC": "621"
+ },
+ "context": {
+ "property": "HGNC:621"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "UBA3_rna",
+ "name": "UBA3_rna",
+ "grounding": {
+ "identifiers": {
+ "HGNC": "12470"
+ },
+ "context": {
+ "property": "HGNC:12470"
+ }
+ },
+ "initial": 3.0
+ }
+ ],
+ "edges": [
+ {
+ "id": "t1",
+ "source": "Cul2 ubiquitin ligase:Orf10_complex",
+ "target": "Cul2 ubiquitin ligase_complex",
+ "sign": true
+ },
+ {
+ "id": "t2",
+ "source": "Zyg11B:EloBC_complex",
+ "target": "Cul2 ubiquitin ligase_complex",
+ "sign": true
+ },
+ {
+ "id": "t3",
+ "source": "Cul2 ubiquitin ligase:N8_complex",
+ "target": "Cul2 ubiquitin ligase_complex",
+ "sign": true
+ },
+ {
+ "id": "t4",
+ "source": "Rbx1:Cul2_complex",
+ "target": "Cul2 ubiquitin ligase_complex",
+ "sign": true
+ },
+ {
+ "id": "t5",
+ "source": "Cul2 ubiquitin ligase:substrate_complex_cell",
+ "target": "Cul2 ubiquitin ligase_complex",
+ "sign": true
+ },
+ {
+ "id": "t6",
+ "source": "CSN5_complex",
+ "target": "Cul2 ubiquitin ligase_complex",
+ "sign": true
+ },
+ {
+ "id": "t7",
+ "source": "ELOB:ELOC_complex",
+ "target": "Zyg11B:EloBC_complex",
+ "sign": true
+ },
+ {
+ "id": "t8",
+ "source": "Cul2 ubiquitin ligase_complex",
+ "target": "Zyg11B:EloBC_complex",
+ "sign": true
+ },
+ {
+ "id": "t9",
+ "source": "ZYG11B",
+ "target": "Zyg11B:EloBC_complex",
+ "sign": true
+ },
+ {
+ "id": "t10",
+ "source": "Orf10",
+ "target": "Cul2 ubiquitin ligase:Orf10_complex",
+ "sign": true
+ },
+ {
+ "id": "t11",
+ "source": "Cul2 ubiquitin ligase:Orf10:substrate_complex",
+ "target": "Cul2 ubiquitin ligase:Orf10_complex",
+ "sign": true
+ },
+ {
+ "id": "t12",
+ "source": "Cul2 ubiquitin ligase_complex",
+ "target": "Cul2 ubiquitin ligase:Orf10_complex",
+ "sign": true
+ },
+ {
+ "id": "t13",
+ "source": "Cul2 ubiquitin ligase:N8:Orf10_complex",
+ "target": "Cul2 ubiquitin ligase:Orf10_complex",
+ "sign": true
+ },
+ {
+ "id": "t14",
+ "source": "CSN5_complex",
+ "target": "Cul2 ubiquitin ligase:Orf10_complex",
+ "sign": true
+ },
+ {
+ "id": "t15",
+ "source": "Cul2 ubiquitin ligase_complex",
+ "target": "Cul2 ubiquitin ligase:substrate_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t16",
+ "source": "ubit_traget",
+ "target": "Cul2 ubiquitin ligase:substrate_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t17",
+ "source": "ELOB",
+ "target": "ELOB:ELOC_complex",
+ "sign": true
+ },
+ {
+ "id": "t18",
+ "source": "Zyg11B:EloBC_complex",
+ "target": "ELOB:ELOC_complex",
+ "sign": true
+ },
+ {
+ "id": "t19",
+ "source": "ELOC",
+ "target": "ELOB:ELOC_complex",
+ "sign": true
+ },
+ {
+ "id": "t20",
+ "source": "NAE_complex",
+ "target": "NAE:Pevonedistat_complex",
+ "sign": true
+ },
+ {
+ "id": "t21",
+ "source": "Pevonedistat_drug",
+ "target": "NAE:Pevonedistat_complex",
+ "sign": true
+ },
+ {
+ "id": "t22",
+ "source": "NAE_complex",
+ "target": "NAE:NEDD8_complex",
+ "sign": true
+ },
+ {
+ "id": "t23",
+ "source": "NEDD8",
+ "target": "NAE:NEDD8_complex",
+ "sign": true
+ },
+ {
+ "id": "t24",
+ "source": "Cul2 ubiquitin ligase_complex",
+ "target": "Rbx1:Cul2_complex",
+ "sign": true
+ },
+ {
+ "id": "t25",
+ "source": "RBX1",
+ "target": "Rbx1:Cul2_complex",
+ "sign": true
+ },
+ {
+ "id": "t26",
+ "source": "CUL2",
+ "target": "Rbx1:Cul2_complex",
+ "sign": true
+ },
+ {
+ "id": "t27",
+ "source": "ubit_traget",
+ "target": "Cul2 ubiquitin ligase:Orf10:substrate_complex",
+ "sign": true
+ },
+ {
+ "id": "t28",
+ "source": "Cul2 ubiquitin ligase:Orf10_complex",
+ "target": "Cul2 ubiquitin ligase:Orf10:substrate_complex",
+ "sign": true
+ },
+ {
+ "id": "t29",
+ "source": "Cul2 ubiquitin ligase:N8:Orf10:E2-Ub:substrate_complex",
+ "target": "Cul2 ubiquitin ligase:N8:Orf10:E2:substrate-Ub_complex",
+ "sign": true
+ },
+ {
+ "id": "t30",
+ "source": "UBE2M:NEDD8_complex",
+ "target": "Cul2 ubiquitin ligase:substrate_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t31",
+ "source": "Cul2 ubiquitin ligase:N8:E2-Ub:substrate_complex",
+ "target": "Cul2 ubiquitin ligase:substrate_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t32",
+ "source": "Cul2 ubiquitin ligase:N8:E2:substrate_complex",
+ "target": "Cul2 ubiquitin ligase:substrate_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t33",
+ "source": "Cul2 ubiquitin ligase:N8:E2-Ub:substrate_complex",
+ "target": "Cul2 ubiquitin ligase:N8:E2:substrate-Ub_complex",
+ "sign": true
+ },
+ {
+ "id": "t34",
+ "source": "E2_ubiquitinated",
+ "target": "Cul2 ubiquitin ligase:N8:E2-Ub:substrate_complex",
+ "sign": true
+ },
+ {
+ "id": "t35",
+ "source": "Cul2 ubiquitin ligase:substrate_complex_cell",
+ "target": "Cul2 ubiquitin ligase:N8:E2-Ub:substrate_complex",
+ "sign": true
+ },
+ {
+ "id": "t36",
+ "source": "Cul2 ubiquitin ligase:N8:E2:substrate-Ub_complex",
+ "target": "Cul2 ubiquitin ligase:N8:substrate-Ub_complex",
+ "sign": true
+ },
+ {
+ "id": "t37",
+ "source": "Cul2 ubiquitin ligase:N8:substrate-Ub_complex",
+ "target": "Cul2 ubiquitin ligase:N8_complex",
+ "sign": true
+ },
+ {
+ "id": "t38",
+ "source": "E2",
+ "target": "Cul2 ubiquitin ligase:N8:E2:substrate_complex",
+ "sign": true
+ },
+ {
+ "id": "t39",
+ "source": "Cul2 ubiquitin ligase:substrate_complex_cell",
+ "target": "Cul2 ubiquitin ligase:N8:E2:substrate_complex",
+ "sign": true
+ },
+ {
+ "id": "t40",
+ "source": "Cul2 ubiquitin ligase:N8:Orf10:substrate-Ub_complex",
+ "target": "Cul2 ubiquitin ligase:N8:Orf10_complex",
+ "sign": true
+ },
+ {
+ "id": "t41",
+ "source": "E2_ubiquitinated",
+ "target": "Cul2 ubiquitin ligase:N8:Orf10:E2-Ub:substrate_complex",
+ "sign": true
+ },
+ {
+ "id": "t42",
+ "source": "Cul2 ubiquitin ligase:N8:Orf10:substrate_complex",
+ "target": "Cul2 ubiquitin ligase:N8:Orf10:E2-Ub:substrate_complex",
+ "sign": true
+ },
+ {
+ "id": "t43",
+ "source": "Cul2 ubiquitin ligase:Orf10:substrate_complex",
+ "target": "Cul2 ubiquitin ligase:N8:Orf10:substrate_complex",
+ "sign": true
+ },
+ {
+ "id": "t44",
+ "source": "Cul2 ubiquitin ligase:N8:Orf10:E2-Ub:substrate_complex",
+ "target": "Cul2 ubiquitin ligase:N8:Orf10:substrate_complex",
+ "sign": true
+ },
+ {
+ "id": "t45",
+ "source": "UBE2M:NEDD8_complex",
+ "target": "Cul2 ubiquitin ligase:N8:Orf10:substrate_complex",
+ "sign": true
+ },
+ {
+ "id": "t46",
+ "source": "Cul2 ubiquitin ligase:N8:Orf10:0E2:substrate_complex",
+ "target": "Cul2 ubiquitin ligase:N8:Orf10:substrate_complex",
+ "sign": true
+ },
+ {
+ "id": "t47",
+ "source": "Cul2 ubiquitin ligase:N8:Orf10:substrate_complex",
+ "target": "Cul2 ubiquitin ligase:N8:Orf10:0E2:substrate_complex",
+ "sign": true
+ },
+ {
+ "id": "t48",
+ "source": "E2",
+ "target": "Cul2 ubiquitin ligase:N8:Orf10:0E2:substrate_complex",
+ "sign": true
+ },
+ {
+ "id": "t49",
+ "source": "NAE:NEDD8_complex",
+ "target": "UBE2M:NEDD8_complex",
+ "sign": true
+ },
+ {
+ "id": "t50",
+ "source": "UBE2M",
+ "target": "UBE2M:NEDD8_complex",
+ "sign": true
+ },
+ {
+ "id": "t51",
+ "source": "NAE:Pevonedistat_complex",
+ "target": "NAE_complex",
+ "sign": true
+ },
+ {
+ "id": "t52",
+ "source": "UBA3",
+ "target": "NAE_complex",
+ "sign": true
+ },
+ {
+ "id": "t53",
+ "source": "NAE1",
+ "target": "NAE_complex",
+ "sign": true
+ },
+ {
+ "id": "t54",
+ "source": "ELOB_rna",
+ "target": "ELOB",
+ "sign": true
+ },
+ {
+ "id": "t55",
+ "source": "ELOB:ELOC_complex",
+ "target": "ELOB",
+ "sign": true
+ },
+ {
+ "id": "t56",
+ "source": "ELOB:ELOC_complex",
+ "target": "ELOC",
+ "sign": true
+ },
+ {
+ "id": "t57",
+ "source": "ELOC_rna",
+ "target": "ELOC",
+ "sign": true
+ },
+ {
+ "id": "t58",
+ "source": "ZYG11B_rna",
+ "target": "ZYG11B",
+ "sign": true
+ },
+ {
+ "id": "t59",
+ "source": "Zyg11B:EloBC_complex",
+ "target": "ZYG11B",
+ "sign": true
+ },
+ {
+ "id": "t60",
+ "source": "RBX1_rna",
+ "target": "RBX1",
+ "sign": true
+ },
+ {
+ "id": "t61",
+ "source": "Rbx1:Cul2_complex",
+ "target": "RBX1",
+ "sign": true
+ },
+ {
+ "id": "t62",
+ "source": "CUL2_rna",
+ "target": "CUL2",
+ "sign": true
+ },
+ {
+ "id": "t63",
+ "source": "Rbx1:Cul2_complex",
+ "target": "CUL2",
+ "sign": true
+ },
+ {
+ "id": "t64",
+ "source": "E1_rna",
+ "target": "E1",
+ "sign": true
+ },
+ {
+ "id": "t65",
+ "source": "E2",
+ "target": "E1",
+ "sign": true
+ },
+ {
+ "id": "t66",
+ "source": "E1_ubiquitinated",
+ "target": "E1",
+ "sign": true
+ },
+ {
+ "id": "t67",
+ "source": "Cul2 ubiquitin ligase:N8:Orf10:0E2:substrate_complex",
+ "target": "E2",
+ "sign": true
+ },
+ {
+ "id": "t68",
+ "source": "Cul2 ubiquitin ligase:N8:E2:substrate-Ub_complex",
+ "target": "E2",
+ "sign": true
+ },
+ {
+ "id": "t69",
+ "source": "Cul2 ubiquitin ligase:N8:E2:substrate_complex",
+ "target": "E2",
+ "sign": true
+ },
+ {
+ "id": "t70",
+ "source": "E2_rna",
+ "target": "E2",
+ "sign": true
+ },
+ {
+ "id": "t71",
+ "source": "DUB_rna",
+ "target": "DUB",
+ "sign": true
+ },
+ {
+ "id": "t72",
+ "source": "Ub_simple_molecule",
+ "target": "E1_ubiquitinated",
+ "sign": true
+ },
+ {
+ "id": "t73",
+ "source": "ATP_simple_molecule",
+ "target": "E1_ubiquitinated",
+ "sign": true
+ },
+ {
+ "id": "t74",
+ "source": "E1",
+ "target": "E1_ubiquitinated",
+ "sign": true
+ },
+ {
+ "id": "t75",
+ "source": "Cul2 ubiquitin ligase:N8:Orf10:E2-Ub:substrate_complex",
+ "target": "E2_ubiquitinated",
+ "sign": true
+ },
+ {
+ "id": "t76",
+ "source": "Cul2 ubiquitin ligase:N8:E2-Ub:substrate_complex",
+ "target": "E2_ubiquitinated",
+ "sign": true
+ },
+ {
+ "id": "t77",
+ "source": "E2",
+ "target": "E2_ubiquitinated",
+ "sign": true
+ },
+ {
+ "id": "t78",
+ "source": "E1_ubiquitinated",
+ "target": "E2_ubiquitinated",
+ "sign": true
+ },
+ {
+ "id": "t79",
+ "source": "Ub_simple_molecule",
+ "target": "AMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t80",
+ "source": "ATP_simple_molecule",
+ "target": "AMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t81",
+ "source": "E1",
+ "target": "AMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t82",
+ "source": "Ub_simple_molecule",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t83",
+ "source": "ATP_simple_molecule",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t84",
+ "source": "E1",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t85",
+ "source": "NAE:Pevonedistat_complex",
+ "target": "Pevonedistat_drug",
+ "sign": true
+ },
+ {
+ "id": "t86",
+ "source": "Cul2 ubiquitin ligase:Orf10_complex",
+ "target": "Orf10",
+ "sign": true
+ },
+ {
+ "id": "t87",
+ "source": "Orf10 (+)ss sgmRNA_rna",
+ "target": "Orf10",
+ "sign": true
+ },
+ {
+ "id": "t88",
+ "source": "Cul2 ubiquitin ligase:Orf10:substrate_complex",
+ "target": "UBE2M",
+ "sign": true
+ },
+ {
+ "id": "t89",
+ "source": "UBE2M_rna",
+ "target": "UBE2M",
+ "sign": true
+ },
+ {
+ "id": "t90",
+ "source": "UBE2M:NEDD8_complex",
+ "target": "UBE2M",
+ "sign": true
+ },
+ {
+ "id": "t91",
+ "source": "Cul2 ubiquitin ligase:substrate_complex_cell",
+ "target": "UBE2M",
+ "sign": true
+ },
+ {
+ "id": "t92",
+ "source": "DUB",
+ "target": "ubit_traget",
+ "sign": true
+ },
+ {
+ "id": "t93",
+ "source": "Cul2 ubiquitin ligase:Orf10:substrate_complex",
+ "target": "ubit_traget",
+ "sign": true
+ },
+ {
+ "id": "t94",
+ "source": "ubit_traget_ubiquitinated",
+ "target": "ubit_traget",
+ "sign": true
+ },
+ {
+ "id": "t95",
+ "source": "Cul2 ubiquitin ligase:substrate_complex_cell",
+ "target": "ubit_traget",
+ "sign": true
+ },
+ {
+ "id": "t96",
+ "source": "NEDD8_rna",
+ "target": "NEDD8",
+ "sign": true
+ },
+ {
+ "id": "t97",
+ "source": "Cul2 ubiquitin ligase:N8:Orf10:substrate-Ub_complex",
+ "target": "ubit_traget_ubiquitinated",
+ "sign": true
+ },
+ {
+ "id": "t98",
+ "source": "Cul2 ubiquitin ligase:N8:substrate-Ub_complex",
+ "target": "ubit_traget_ubiquitinated",
+ "sign": true
+ },
+ {
+ "id": "t99",
+ "source": "NAE1_rna",
+ "target": "NAE1",
+ "sign": true
+ },
+ {
+ "id": "t100",
+ "source": "NAE_complex",
+ "target": "NAE1",
+ "sign": true
+ },
+ {
+ "id": "t101",
+ "source": "NAE_complex",
+ "target": "UBA3",
+ "sign": true
+ },
+ {
+ "id": "t102",
+ "source": "UBA3_rna",
+ "target": "UBA3",
+ "sign": true
+ }
+ ],
+ "parameters": []
+ },
+ "semantics": {
+ "ode": {
+ "rates": [],
+ "observables": [],
+ "time": {
+ "id": "t"
+ }
+ }
+ },
+ "metadata": {
+ "annotations": {}
+ }
+}
\ No newline at end of file
diff --git a/scripts/covid19_diseasemaps/regnet_amr_sbml/Orf3a.json b/scripts/covid19_diseasemaps/regnet_amr_sbml/Orf3a.json
new file mode 100644
index 000000000..fc3e64ea6
--- /dev/null
+++ b/scripts/covid19_diseasemaps/regnet_amr_sbml/Orf3a.json
@@ -0,0 +1,755 @@
+{
+ "header": {
+ "name": "Model",
+ "schema": "https://raw.githubusercontent.com/DARPA-ASKEM/Model-Representations/regnet_v0.2/regnet/regnet_schema.json",
+ "schema_name": "regnet",
+ "description": "Model",
+ "model_version": "0.1"
+ },
+ "model": {
+ "vertices": [
+ {
+ "id": "Orf3a",
+ "name": "Orf3a",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Hops Complex_complex",
+ "name": "Hops Complex_complex",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "J9TC74"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "LPS/TNF \u03b1/IL-1_complex",
+ "name": "LPS/TNF \u03b1/IL-1_complex",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "11916"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IKBKG/IKBKB/CHUK_complex",
+ "name": "IKBKG/IKBKB/CHUK_complex",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "1974"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TLR4",
+ "name": "TLR4",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IRF6",
+ "name": "IRF6",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MYD88",
+ "name": "MYD88",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "7562"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "LPS/TLR4/MYD88_complex",
+ "name": "LPS/TLR4/MYD88_complex",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "11850"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "E",
+ "name": "E",
+ "grounding": {
+ "identifiers": {
+ "ncbiprotein": "1796318600"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TRAF3",
+ "name": "TRAF3",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "12033"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "P65/P015_complex",
+ "name": "P65/P015_complex",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "7794"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TRAF6",
+ "name": "TRAF6",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "12036"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TRIM30a/TRIM38_complex",
+ "name": "TRIM30a/TRIM38_complex",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "10059"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TAB2/TAB3/TAK1_complex",
+ "name": "TAB2/TAB3/TAK1_complex",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "17075"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ssRNA_rna",
+ "name": "ssRNA_rna",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TLR7/8/9_complex",
+ "name": "TLR7/8/9_complex",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "15631"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TRIM14/TRIM23_complex",
+ "name": "TRIM14/TRIM23_complex",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "16283"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TRIM22",
+ "name": "TRIM22",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "16379"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TRIM29",
+ "name": "TRIM29",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "17274"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TRIM27/TRIM21_complex",
+ "name": "TRIM27/TRIM21_complex",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "11312"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NEMO/IKKA/IKKB_complex",
+ "name": "NEMO/IKKA/IKKB_complex",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "1974"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NFKB1",
+ "name": "NFKB1",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "7794"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NFKBIA_phosphorylated_ubiquitinated_ubiquitinated_ubiquitinated",
+ "name": "NFKBIA_phosphorylated_ubiquitinated_ubiquitinated_ubiquitinated",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "7797"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CACTIN",
+ "name": "CACTIN",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "29938"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NFKB1:NFKNIA_complex",
+ "name": "NFKB1:NFKNIA_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TRIM59",
+ "name": "TRIM59",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "22588174"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ORF8b",
+ "name": "ORF8b",
+ "grounding": {
+ "identifiers": {
+ "ncbiprotein": "BCD58760"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NLRP3",
+ "name": "NLRP3",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "16400"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PYCARD_ubiquitinated_ubiquitinated_ubiquitinated",
+ "name": "PYCARD_ubiquitinated_ubiquitinated_ubiquitinated",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32172672"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TICAM1",
+ "name": "TICAM1",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "18348"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CASP1",
+ "name": "CASP1",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "1499"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TRIM23",
+ "name": "TRIM23",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "660"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TRIM38",
+ "name": "TRIM38",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "10059"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TLR3",
+ "name": "TLR3",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "11849"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "BTRC",
+ "name": "BTRC",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "1144"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TRIM9",
+ "name": "TRIM9",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "16288"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TRIM39",
+ "name": "TRIM39",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "10065"
+ },
+ "context": {}
+ },
+ "initial": 3.0,
+ "sign": true
+ },
+ {
+ "id": "S",
+ "name": "S",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P0DTC2"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SERPINF2",
+ "name": "SERPINF2",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "9075"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IFNB1",
+ "name": "IFNB1",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "5434"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IL1b",
+ "name": "IL1b",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "5992"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "double-stranded RNA_rna",
+ "name": "double-stranded RNA_rna",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ }
+ ],
+ "edges": [
+ {
+ "id": "t1",
+ "source": "Orf3a",
+ "target": "Hops Complex_complex",
+ "sign": true
+ },
+ {
+ "id": "t2",
+ "source": "LPS/TNF \u03b1/IL-1_complex",
+ "target": "IKBKG/IKBKB/CHUK_complex",
+ "sign": true
+ },
+ {
+ "id": "t3",
+ "source": "TLR4",
+ "target": "LPS/TLR4/MYD88_complex",
+ "sign": true
+ },
+ {
+ "id": "t4",
+ "source": "IRF6",
+ "target": "LPS/TLR4/MYD88_complex",
+ "sign": true
+ },
+ {
+ "id": "t5",
+ "source": "MYD88",
+ "target": "LPS/TLR4/MYD88_complex",
+ "sign": true
+ },
+ {
+ "id": "t6",
+ "source": "TRAF3",
+ "target": "P65/P015_complex",
+ "sign": true
+ },
+ {
+ "id": "t7",
+ "source": "E",
+ "target": "P65/P015_complex",
+ "sign": true
+ },
+ {
+ "id": "t8",
+ "source": "Orf3a",
+ "target": "P65/P015_complex",
+ "sign": true
+ },
+ {
+ "id": "t9",
+ "source": "IKBKG/IKBKB/CHUK_complex",
+ "target": "P65/P015_complex",
+ "sign": true
+ },
+ {
+ "id": "t10",
+ "source": "TRAF6",
+ "target": "TAB2/TAB3/TAK1_complex",
+ "sign": true
+ },
+ {
+ "id": "t11",
+ "source": "TRIM30a/TRIM38_complex",
+ "target": "TAB2/TAB3/TAK1_complex",
+ "sign": true
+ },
+ {
+ "id": "t12",
+ "source": "ssRNA_rna",
+ "target": "TLR7/8/9_complex",
+ "sign": true
+ },
+ {
+ "id": "t13",
+ "source": "TRIM22",
+ "target": "NEMO/IKKA/IKKB_complex",
+ "sign": true
+ },
+ {
+ "id": "t14",
+ "source": "TRIM27/TRIM21_complex",
+ "target": "NEMO/IKKA/IKKB_complex",
+ "sign": true
+ },
+ {
+ "id": "t15",
+ "source": "TAB2/TAB3/TAK1_complex",
+ "target": "NEMO/IKKA/IKKB_complex",
+ "sign": true
+ },
+ {
+ "id": "t16",
+ "source": "TRIM14/TRIM23_complex",
+ "target": "NEMO/IKKA/IKKB_complex",
+ "sign": true
+ },
+ {
+ "id": "t17",
+ "source": "TRIM29",
+ "target": "NEMO/IKKA/IKKB_complex",
+ "sign": true
+ },
+ {
+ "id": "t18",
+ "source": "NFKBIA_phosphorylated_ubiquitinated_ubiquitinated_ubiquitinated",
+ "target": "NFKB1:NFKNIA_complex",
+ "sign": true
+ },
+ {
+ "id": "t19",
+ "source": "NFKB1",
+ "target": "NFKB1:NFKNIA_complex",
+ "sign": true
+ },
+ {
+ "id": "t20",
+ "source": "CACTIN",
+ "target": "NFKB1:NFKNIA_complex",
+ "sign": true
+ },
+ {
+ "id": "t21",
+ "source": "Orf3a",
+ "target": "TRIM59",
+ "sign": true
+ },
+ {
+ "id": "t22",
+ "source": "ORF8b",
+ "target": "NLRP3",
+ "sign": true
+ },
+ {
+ "id": "t23",
+ "source": "TRAF3",
+ "target": "PYCARD_ubiquitinated_ubiquitinated_ubiquitinated",
+ "sign": true
+ },
+ {
+ "id": "t24",
+ "source": "Orf3a",
+ "target": "PYCARD_ubiquitinated_ubiquitinated_ubiquitinated",
+ "sign": true
+ },
+ {
+ "id": "t25",
+ "source": "TICAM1",
+ "target": "TRAF3",
+ "sign": true
+ },
+ {
+ "id": "t26",
+ "source": "NLRP3",
+ "target": "CASP1",
+ "sign": true
+ },
+ {
+ "id": "t27",
+ "source": "PYCARD_ubiquitinated_ubiquitinated_ubiquitinated",
+ "target": "CASP1",
+ "sign": true
+ },
+ {
+ "id": "t28",
+ "source": "TRIM23",
+ "target": "TRAF6",
+ "sign": true
+ },
+ {
+ "id": "t29",
+ "source": "LPS/TLR4/MYD88_complex",
+ "target": "TRAF6",
+ "sign": true
+ },
+ {
+ "id": "t30",
+ "source": "TRIM38",
+ "target": "TRAF6",
+ "sign": true
+ },
+ {
+ "id": "t31",
+ "source": "MYD88",
+ "target": "TRAF6",
+ "sign": true
+ },
+ {
+ "id": "t32",
+ "source": "TLR3",
+ "target": "TICAM1",
+ "sign": true
+ },
+ {
+ "id": "t33",
+ "source": "TRIM38",
+ "target": "TICAM1",
+ "sign": true
+ },
+ {
+ "id": "t34",
+ "source": "TLR7/8/9_complex",
+ "target": "MYD88",
+ "sign": true
+ },
+ {
+ "id": "t35",
+ "source": "TRIM59",
+ "target": "MYD88",
+ "sign": true
+ },
+ {
+ "id": "t36",
+ "source": "NEMO/IKKA/IKKB_complex",
+ "target": "NFKBIA_phosphorylated_ubiquitinated_ubiquitinated_ubiquitinated",
+ "sign": true
+ },
+ {
+ "id": "t37",
+ "source": "BTRC",
+ "target": "NFKBIA_phosphorylated_ubiquitinated_ubiquitinated_ubiquitinated",
+ "sign": true
+ },
+ {
+ "id": "t38",
+ "source": "TRIM9",
+ "target": "BTRC",
+ "sign": true
+ },
+ {
+ "id": "t39",
+ "source": "TRIM39",
+ "target": "CACTIN",
+ "sign": true
+ },
+ {
+ "id": "t40",
+ "source": "Orf3a",
+ "target": "S",
+ "sign": true
+ },
+ {
+ "id": "t41",
+ "source": "TAB2/TAB3/TAK1_complex",
+ "target": "SERPINF2",
+ "sign": true
+ },
+ {
+ "id": "t42",
+ "source": "SERPINF2",
+ "target": "IFNB1",
+ "sign": true
+ },
+ {
+ "id": "t43",
+ "source": "CASP1",
+ "target": "IL1b",
+ "sign": true
+ },
+ {
+ "id": "t44",
+ "source": "P65/P015_complex",
+ "target": "IL1b",
+ "sign": true
+ },
+ {
+ "id": "t45",
+ "source": "E",
+ "target": "IL1b",
+ "sign": true
+ },
+ {
+ "id": "t46",
+ "source": "double-stranded RNA_rna",
+ "target": "TLR3",
+ "sign": true
+ }
+ ],
+ "parameters": []
+ },
+ "semantics": {
+ "ode": {
+ "rates": [],
+ "observables": [],
+ "time": {
+ "id": "t"
+ }
+ }
+ },
+ "metadata": {
+ "annotations": {}
+ }
+}
\ No newline at end of file
diff --git a/scripts/covid19_diseasemaps/regnet_amr_sbml/PAMP_signaling.json b/scripts/covid19_diseasemaps/regnet_amr_sbml/PAMP_signaling.json
new file mode 100644
index 000000000..4ddf4dfcb
--- /dev/null
+++ b/scripts/covid19_diseasemaps/regnet_amr_sbml/PAMP_signaling.json
@@ -0,0 +1,1404 @@
+{
+ "header": {
+ "name": "Model",
+ "schema": "https://raw.githubusercontent.com/DARPA-ASKEM/Model-Representations/regnet_v0.2/regnet/regnet_schema.json",
+ "schema_name": "regnet",
+ "description": "Model",
+ "model_version": "0.1"
+ },
+ "model": {
+ "vertices": [
+ {
+ "id": "MYD88",
+ "name": "MYD88",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "19366914"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IRAK1",
+ "name": "IRAK1",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "6112"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IRAK4",
+ "name": "IRAK4",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "17967"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TRAF6",
+ "name": "TRAF6",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "12036"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MYD88:IRAK:TRAF_complex",
+ "name": "MYD88:IRAK:TRAF_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TRAF2",
+ "name": "TRAF2",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "12032"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TRAF5",
+ "name": "TRAF5",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "12035"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MAVS",
+ "name": "MAVS",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "29233"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MAVS:TRAF_complex",
+ "name": "MAVS:TRAF_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TRADD",
+ "name": "TRADD",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "12030"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MAVS:TRADD_complex",
+ "name": "MAVS:TRADD_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TICAM1_cell",
+ "name": "TICAM1_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TICAM1_cell",
+ "name": "TICAM1_cell",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "18348"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TICAM1:TRAF3:TRAF6_complex",
+ "name": "TICAM1:TRAF3:TRAF6_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IKBKG",
+ "name": "IKBKG",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CHUK",
+ "name": "CHUK",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IKBKB",
+ "name": "IKBKB",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IKK Complex_complex_cell",
+ "name": "IKK Complex_complex_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NFKBIA",
+ "name": "NFKBIA",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "7797"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "RELA",
+ "name": "RELA",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NFKB1",
+ "name": "NFKB1",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NFKB:NFKBIA_complex_cell",
+ "name": "NFKB:NFKBIA_complex_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp3",
+ "name": "Nsp3",
+ "grounding": {
+ "identifiers": {
+ "ncbiprotein": "1802476807"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "M",
+ "name": "M",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TANK:TRAF3:IKBKE_complex_cell",
+ "name": "TANK:TRAF3:IKBKE_complex_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "RIPK1:FADD_complex",
+ "name": "RIPK1:FADD_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "dsRNA_rna_endosome",
+ "name": "dsRNA_rna_endosome",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TLR3:dsRNA_complex",
+ "name": "TLR3:dsRNA_complex",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "11849"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TRAF3",
+ "name": "TRAF3",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TANK",
+ "name": "TANK",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IKBKE_cell",
+ "name": "IKBKE_cell",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "14552"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TLR7",
+ "name": "TLR7",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "15631"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ssRNA_rna",
+ "name": "ssRNA_rna",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TLR7:ssRNA_complex",
+ "name": "TLR7:ssRNA_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TLR8",
+ "name": "TLR8",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "15632"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TLR8:ssRNA_complex",
+ "name": "TLR8:ssRNA_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "dsRNA_rna_cell",
+ "name": "dsRNA_rna_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "DDX58",
+ "name": "DDX58",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "19102"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "DDX58:dsRNA_complex",
+ "name": "DDX58:dsRNA_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IFIH1",
+ "name": "IFIH1",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "18873"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp15",
+ "name": "Nsp15",
+ "grounding": {
+ "identifiers": {
+ "ncbiprotein": "1802476818"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IFIH1:dsRNA_complex",
+ "name": "IFIH1:dsRNA_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MAP2K7_phosphorylated",
+ "name": "MAP2K7_phosphorylated",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "6847"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MAP2K4_phosphorylated",
+ "name": "MAP2K4_phosphorylated",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "6844"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "JNK_complex",
+ "name": "JNK_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "N",
+ "name": "N",
+ "grounding": {
+ "identifiers": {
+ "ncbiprotein": "1798174255"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NFKB_complex",
+ "name": "NFKB_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "EIF2AK2",
+ "name": "EIF2AK2",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "9437"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "EIF2AK2:dsRNA_complex",
+ "name": "EIF2AK2:dsRNA_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TRAF6_ubiquitinated",
+ "name": "TRAF6_ubiquitinated",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "12036"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CASP8",
+ "name": "CASP8",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "1509"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CASP10",
+ "name": "CASP10",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "1500"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MAPK14_phosphorylated",
+ "name": "MAPK14_phosphorylated",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "6876"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "AP1_complex",
+ "name": "AP1_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TBK1_cell",
+ "name": "TBK1_cell",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "11584"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TBK1_cell",
+ "name": "TBK1_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IKBKE_cell",
+ "name": "IKBKE_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IRF3",
+ "name": "IRF3",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "6118"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf3b",
+ "name": "Orf3b",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P59633"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf8",
+ "name": "Orf8",
+ "grounding": {
+ "identifiers": {
+ "ncbiprotein": "1796318604"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IRF3_phosphorylated_cell",
+ "name": "IRF3_phosphorylated_cell",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "6118"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "RNF135",
+ "name": "RNF135",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "21158"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TRIM25",
+ "name": "TRIM25",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "12932"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "DDX58_ubiquitinated",
+ "name": "DDX58_ubiquitinated",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "19102"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IRF3_phosphorylated_nucleus",
+ "name": "IRF3_phosphorylated_nucleus",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "6118"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IRF7_phosphorylated",
+ "name": "IRF7_phosphorylated",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "6122"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "UBE2N",
+ "name": "UBE2N",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "12492"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MAP3K7",
+ "name": "MAP3K7",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "6859"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MAP2K6_phosphorylated",
+ "name": "MAP2K6_phosphorylated",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "6846"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MAP2K3_phosphorylated",
+ "name": "MAP2K3_phosphorylated",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "6843"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf9",
+ "name": "Orf9",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P59636"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ITCH",
+ "name": "ITCH",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "13890"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NFKBIA_phosphorylated",
+ "name": "NFKBIA_phosphorylated",
+ "grounding": {
+ "identifiers": {
+ "hgnc": "7797"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "transcription of proinflammatory proteins_phenotype",
+ "name": "transcription of proinflammatory proteins_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ }
+ ],
+ "edges": [
+ {
+ "id": "t1",
+ "source": "MYD88",
+ "target": "MYD88:IRAK:TRAF_complex",
+ "sign": true
+ },
+ {
+ "id": "t2",
+ "source": "IRAK1",
+ "target": "MYD88:IRAK:TRAF_complex",
+ "sign": true
+ },
+ {
+ "id": "t3",
+ "source": "IRAK4",
+ "target": "MYD88:IRAK:TRAF_complex",
+ "sign": true
+ },
+ {
+ "id": "t4",
+ "source": "TRAF6",
+ "target": "MYD88:IRAK:TRAF_complex",
+ "sign": true
+ },
+ {
+ "id": "t5",
+ "source": "TRAF5",
+ "target": "MAVS:TRAF_complex",
+ "sign": true
+ },
+ {
+ "id": "t6",
+ "source": "TRAF6",
+ "target": "MAVS:TRAF_complex",
+ "sign": true
+ },
+ {
+ "id": "t7",
+ "source": "TRAF2",
+ "target": "MAVS:TRAF_complex",
+ "sign": true
+ },
+ {
+ "id": "t8",
+ "source": "MAVS",
+ "target": "MAVS:TRAF_complex",
+ "sign": true
+ },
+ {
+ "id": "t9",
+ "source": "MAVS",
+ "target": "MAVS:TRADD_complex",
+ "sign": true
+ },
+ {
+ "id": "t10",
+ "source": "TRADD",
+ "target": "MAVS:TRADD_complex",
+ "sign": true
+ },
+ {
+ "id": "t11",
+ "source": "TICAM1_cell",
+ "target": "TICAM1:TRAF3:TRAF6_complex",
+ "sign": true
+ },
+ {
+ "id": "t12",
+ "source": "TRAF6",
+ "target": "TICAM1:TRAF3:TRAF6_complex",
+ "sign": true
+ },
+ {
+ "id": "t13",
+ "source": "TICAM1_cell",
+ "target": "TICAM1:TRAF3:TRAF6_complex",
+ "sign": true
+ },
+ {
+ "id": "t14",
+ "source": "IKBKB",
+ "target": "IKK Complex_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t15",
+ "source": "CHUK",
+ "target": "IKK Complex_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t16",
+ "source": "IKBKG",
+ "target": "IKK Complex_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t17",
+ "source": "NFKB1",
+ "target": "NFKB:NFKBIA_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t18",
+ "source": "NFKBIA",
+ "target": "NFKB:NFKBIA_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t19",
+ "source": "RELA",
+ "target": "NFKB:NFKBIA_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t20",
+ "source": "MAVS:TRADD_complex",
+ "target": "TANK:TRAF3:IKBKE_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t21",
+ "source": "Nsp3",
+ "target": "TANK:TRAF3:IKBKE_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t22",
+ "source": "M",
+ "target": "TANK:TRAF3:IKBKE_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t23",
+ "source": "M",
+ "target": "TANK:TRAF3:IKBKE_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t24",
+ "source": "TICAM1:TRAF3:TRAF6_complex",
+ "target": "TANK:TRAF3:IKBKE_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t25",
+ "source": "MAVS:TRADD_complex",
+ "target": "RIPK1:FADD_complex",
+ "sign": true
+ },
+ {
+ "id": "t26",
+ "source": "dsRNA_rna_endosome",
+ "target": "TLR3:dsRNA_complex",
+ "sign": true
+ },
+ {
+ "id": "t27",
+ "source": "TRAF3",
+ "target": "TANK:TRAF3:IKBKE_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t28",
+ "source": "TANK",
+ "target": "TANK:TRAF3:IKBKE_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t29",
+ "source": "IKBKE_cell",
+ "target": "TANK:TRAF3:IKBKE_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t30",
+ "source": "TLR7",
+ "target": "TLR7:ssRNA_complex",
+ "sign": true
+ },
+ {
+ "id": "t31",
+ "source": "ssRNA_rna",
+ "target": "TLR7:ssRNA_complex",
+ "sign": true
+ },
+ {
+ "id": "t32",
+ "source": "ssRNA_rna",
+ "target": "TLR8:ssRNA_complex",
+ "sign": true
+ },
+ {
+ "id": "t33",
+ "source": "TLR8",
+ "target": "TLR8:ssRNA_complex",
+ "sign": true
+ },
+ {
+ "id": "t34",
+ "source": "Nsp3",
+ "target": "DDX58:dsRNA_complex",
+ "sign": true
+ },
+ {
+ "id": "t35",
+ "source": "dsRNA_rna_cell",
+ "target": "DDX58:dsRNA_complex",
+ "sign": true
+ },
+ {
+ "id": "t36",
+ "source": "DDX58",
+ "target": "DDX58:dsRNA_complex",
+ "sign": true
+ },
+ {
+ "id": "t37",
+ "source": "M",
+ "target": "DDX58:dsRNA_complex",
+ "sign": true
+ },
+ {
+ "id": "t38",
+ "source": "M",
+ "target": "IFIH1:dsRNA_complex",
+ "sign": true
+ },
+ {
+ "id": "t39",
+ "source": "Nsp3",
+ "target": "IFIH1:dsRNA_complex",
+ "sign": true
+ },
+ {
+ "id": "t40",
+ "source": "IFIH1",
+ "target": "IFIH1:dsRNA_complex",
+ "sign": true
+ },
+ {
+ "id": "t41",
+ "source": "dsRNA_rna_cell",
+ "target": "IFIH1:dsRNA_complex",
+ "sign": true
+ },
+ {
+ "id": "t42",
+ "source": "Nsp15",
+ "target": "IFIH1:dsRNA_complex",
+ "sign": true
+ },
+ {
+ "id": "t43",
+ "source": "MAP2K7_phosphorylated",
+ "target": "JNK_complex",
+ "sign": true
+ },
+ {
+ "id": "t44",
+ "source": "MAP2K4_phosphorylated",
+ "target": "JNK_complex",
+ "sign": true
+ },
+ {
+ "id": "t45",
+ "source": "NFKB:NFKBIA_complex_cell",
+ "target": "NFKB_complex",
+ "sign": true
+ },
+ {
+ "id": "t46",
+ "source": "N",
+ "target": "NFKB_complex",
+ "sign": true
+ },
+ {
+ "id": "t47",
+ "source": "EIF2AK2",
+ "target": "EIF2AK2:dsRNA_complex",
+ "sign": true
+ },
+ {
+ "id": "t48",
+ "source": "dsRNA_rna_cell",
+ "target": "EIF2AK2:dsRNA_complex",
+ "sign": true
+ },
+ {
+ "id": "t49",
+ "source": "Nsp15",
+ "target": "EIF2AK2:dsRNA_complex",
+ "sign": true
+ },
+ {
+ "id": "t50",
+ "source": "IKK Complex_complex_cell",
+ "target": "NFKB:NFKBIA_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t51",
+ "source": "TRAF6_ubiquitinated",
+ "target": "IKK Complex_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t52",
+ "source": "CASP10",
+ "target": "IKK Complex_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t53",
+ "source": "CASP8",
+ "target": "IKK Complex_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t54",
+ "source": "M",
+ "target": "IKK Complex_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t55",
+ "source": "MAPK14_phosphorylated",
+ "target": "AP1_complex",
+ "sign": true
+ },
+ {
+ "id": "t56",
+ "source": "JNK_complex",
+ "target": "AP1_complex",
+ "sign": true
+ },
+ {
+ "id": "t57",
+ "source": "TLR7:ssRNA_complex",
+ "target": "MYD88",
+ "sign": true
+ },
+ {
+ "id": "t58",
+ "source": "TLR8:ssRNA_complex",
+ "target": "MYD88",
+ "sign": true
+ },
+ {
+ "id": "t59",
+ "source": "TICAM1_cell",
+ "target": "TICAM1_cell",
+ "sign": true
+ },
+ {
+ "id": "t60",
+ "source": "TLR3:dsRNA_complex",
+ "target": "TICAM1_cell",
+ "sign": true
+ },
+ {
+ "id": "t61",
+ "source": "TANK:TRAF3:IKBKE_complex_cell",
+ "target": "TBK1_cell",
+ "sign": true
+ },
+ {
+ "id": "t62",
+ "source": "TBK1_cell",
+ "target": "TBK1_cell",
+ "sign": true
+ },
+ {
+ "id": "t63",
+ "source": "TANK:TRAF3:IKBKE_complex_cell",
+ "target": "IKBKE_cell",
+ "sign": true
+ },
+ {
+ "id": "t64",
+ "source": "Nsp3",
+ "target": "IKBKE_cell",
+ "sign": true
+ },
+ {
+ "id": "t65",
+ "source": "IKBKE_cell",
+ "target": "IKBKE_cell",
+ "sign": true
+ },
+ {
+ "id": "t66",
+ "source": "Orf3b",
+ "target": "IRF3_phosphorylated_cell",
+ "sign": true
+ },
+ {
+ "id": "t67",
+ "source": "Nsp3",
+ "target": "IRF3_phosphorylated_cell",
+ "sign": true
+ },
+ {
+ "id": "t68",
+ "source": "Orf8",
+ "target": "IRF3_phosphorylated_cell",
+ "sign": true
+ },
+ {
+ "id": "t69",
+ "source": "IRF3",
+ "target": "IRF3_phosphorylated_cell",
+ "sign": true
+ },
+ {
+ "id": "t70",
+ "source": "TBK1_cell",
+ "target": "IRF3_phosphorylated_cell",
+ "sign": true
+ },
+ {
+ "id": "t71",
+ "source": "TRIM25",
+ "target": "DDX58_ubiquitinated",
+ "sign": true
+ },
+ {
+ "id": "t72",
+ "source": "RNF135",
+ "target": "DDX58_ubiquitinated",
+ "sign": true
+ },
+ {
+ "id": "t73",
+ "source": "N",
+ "target": "DDX58_ubiquitinated",
+ "sign": true
+ },
+ {
+ "id": "t74",
+ "source": "DDX58:dsRNA_complex",
+ "target": "DDX58_ubiquitinated",
+ "sign": true
+ },
+ {
+ "id": "t75",
+ "source": "DDX58_ubiquitinated",
+ "target": "MAVS",
+ "sign": true
+ },
+ {
+ "id": "t76",
+ "source": "IFIH1:dsRNA_complex",
+ "target": "MAVS",
+ "sign": true
+ },
+ {
+ "id": "t77",
+ "source": "TRAF6_ubiquitinated",
+ "target": "TRAF6",
+ "sign": true
+ },
+ {
+ "id": "t78",
+ "source": "Nsp3",
+ "target": "TRAF6",
+ "sign": true
+ },
+ {
+ "id": "t79",
+ "source": "IRF3_phosphorylated_cell",
+ "target": "IRF3_phosphorylated_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t80",
+ "source": "IKBKE_cell",
+ "target": "IRF7_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t81",
+ "source": "MYD88:IRAK:TRAF_complex",
+ "target": "IRF7_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t82",
+ "source": "IRF3_phosphorylated_cell",
+ "target": "IRF3_phosphorylated_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t83",
+ "source": "MAVS:TRAF_complex",
+ "target": "TRAF6_ubiquitinated",
+ "sign": true
+ },
+ {
+ "id": "t84",
+ "source": "MYD88:IRAK:TRAF_complex",
+ "target": "TRAF6_ubiquitinated",
+ "sign": true
+ },
+ {
+ "id": "t85",
+ "source": "TRAF6",
+ "target": "TRAF6_ubiquitinated",
+ "sign": true
+ },
+ {
+ "id": "t86",
+ "source": "UBE2N",
+ "target": "TRAF6_ubiquitinated",
+ "sign": true
+ },
+ {
+ "id": "t87",
+ "source": "TRAF6_ubiquitinated",
+ "target": "MAP3K7",
+ "sign": true
+ },
+ {
+ "id": "t88",
+ "source": "TICAM1:TRAF3:TRAF6_complex",
+ "target": "MAP3K7",
+ "sign": true
+ },
+ {
+ "id": "t89",
+ "source": "MAP2K3_phosphorylated",
+ "target": "MAPK14_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t90",
+ "source": "MAP2K6_phosphorylated",
+ "target": "MAPK14_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t91",
+ "source": "RIPK1:FADD_complex",
+ "target": "CASP10",
+ "sign": true
+ },
+ {
+ "id": "t92",
+ "source": "RIPK1:FADD_complex",
+ "target": "CASP8",
+ "sign": true
+ },
+ {
+ "id": "t93",
+ "source": "Orf9",
+ "target": "ITCH",
+ "sign": true
+ },
+ {
+ "id": "t94",
+ "source": "EIF2AK2:dsRNA_complex",
+ "target": "MAP2K6_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t95",
+ "source": "MAP3K7",
+ "target": "MAP2K6_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t96",
+ "source": "MAP3K7",
+ "target": "MAP2K3_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t97",
+ "source": "MAP3K7",
+ "target": "MAP2K4_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t98",
+ "source": "MAP3K7",
+ "target": "MAP2K7_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t99",
+ "source": "NFKB:NFKBIA_complex_cell",
+ "target": "NFKBIA_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t100",
+ "source": "N",
+ "target": "NFKBIA_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t101",
+ "source": "NFKB_complex",
+ "target": "transcription of proinflammatory proteins_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t102",
+ "source": "AP1_complex",
+ "target": "transcription of proinflammatory proteins_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t103",
+ "source": "IRF3_phosphorylated_nucleus",
+ "target": "transcription of proinflammatory proteins_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t104",
+ "source": "IRF7_phosphorylated",
+ "target": "transcription of proinflammatory proteins_phenotype",
+ "sign": true
+ }
+ ],
+ "parameters": []
+ },
+ "semantics": {
+ "ode": {
+ "rates": [],
+ "observables": [],
+ "time": {
+ "id": "t"
+ }
+ }
+ },
+ "metadata": {
+ "annotations": {}
+ }
+}
\ No newline at end of file
diff --git a/scripts/covid19_diseasemaps/regnet_amr_sbml/Pyrimidine_deprivation.json b/scripts/covid19_diseasemaps/regnet_amr_sbml/Pyrimidine_deprivation.json
new file mode 100644
index 000000000..6cade6b34
--- /dev/null
+++ b/scripts/covid19_diseasemaps/regnet_amr_sbml/Pyrimidine_deprivation.json
@@ -0,0 +1,1796 @@
+{
+ "header": {
+ "name": "Model",
+ "schema": "https://raw.githubusercontent.com/DARPA-ASKEM/Model-Representations/regnet_v0.2/regnet/regnet_schema.json",
+ "schema_name": "regnet",
+ "description": "Model",
+ "model_version": "0.1"
+ },
+ "model": {
+ "vertices": [
+ {
+ "id": "NF-kB_complex",
+ "name": "NF-kB_complex",
+ "grounding": {
+ "identifiers": {
+ "GO": "0071159"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IRF3_phosphorylated",
+ "name": "IRF3_phosphorylated",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "Q14653"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IFNB1_space_expression_space_complex_complex",
+ "name": "IFNB1_space_expression_space_complex_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "cGAMP:STING_complex_endoplasmic reticulum",
+ "name": "cGAMP:STING_complex_endoplasmic reticulum",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "cGAMP:STING_complex_Golgi apparatus",
+ "name": "cGAMP:STING_complex_Golgi apparatus",
+ "grounding": {
+ "identifiers": {
+ "GO": "1990231"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "cGAMP_simple_molecule",
+ "name": "cGAMP_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "STING_endoplasmic reticulum",
+ "name": "STING_endoplasmic reticulum",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "cGAMP-STING_complex_COPII-coated vesicle",
+ "name": "cGAMP-STING_complex_COPII-coated vesicle",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "cGAMP-STING_complex_endoplasmic reticulum-Golgi intermediate compartment",
+ "name": "cGAMP-STING_complex_endoplasmic reticulum-Golgi intermediate compartment",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "LC3",
+ "name": "LC3",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "WIPI2",
+ "name": "WIPI2",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "Q9Y4P8"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "cGAMP:STING:LC3_complex",
+ "name": "cGAMP:STING:LC3_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "dsDNA_simple_molecule",
+ "name": "dsDNA_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "cGAS",
+ "name": "cGAS",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "Q8N884"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "cGAS:dsDNA_complex",
+ "name": "cGAS:dsDNA_complex",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "Q8N884"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MRE11",
+ "name": "MRE11",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P49959"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MRE11:dsDNA_complex",
+ "name": "MRE11:dsDNA_complex",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P49959"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TBK1",
+ "name": "TBK1",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "Q9UHD2"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "STING_Golgi apparatus",
+ "name": "STING_Golgi apparatus",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "STING:TBK1_complex_Golgi apparatus",
+ "name": "STING:TBK1_complex_Golgi apparatus",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "30842653"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SAR1A",
+ "name": "SAR1A",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "Q9NR31"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "STING:TBK1_complex_endolysosome",
+ "name": "STING:TBK1_complex_endolysosome",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "Q9UHD2"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MRE11:RAD50:DNA_complex_pulmonary endothelial cell",
+ "name": "MRE11:RAD50:DNA_complex_pulmonary endothelial cell",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P49959"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MRE11:RAD50:DNA_complex_endoplasmic reticulum",
+ "name": "MRE11:RAD50:DNA_complex_endoplasmic reticulum",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P49959"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "RAD50",
+ "name": "RAD50",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "Q92878"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "N-carbamoyl-L-aspartate_simple_molecule",
+ "name": "N-carbamoyl-L-aspartate_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "32814"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "H+simple_molecule",
+ "name": "H+simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CAD",
+ "name": "CAD",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P27708"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "H2O_simple_molecule",
+ "name": "H2O_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "15377"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "uridine_simple_molecule",
+ "name": "uridine_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "16704"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "UCK2",
+ "name": "UCK2",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "orotidine_space_5'-monophosphate_simple_molecule",
+ "name": "orotidine_space_5'-monophosphate_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "UMPS",
+ "name": "UMPS",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P11172"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "UMP_simple_molecule",
+ "name": "UMP_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "57865"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ATP_simple_molecule",
+ "name": "ATP_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "15422"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "GTP_simple_molecule",
+ "name": "GTP_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "15996"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "RTC and transcription pw_phenotype",
+ "name": "RTC and transcription pw_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "RNA_space_biosynthesis_phenotype",
+ "name": "RNA_space_biosynthesis_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CDP_simple_molecule",
+ "name": "CDP_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "17239"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ribonucleoside-diphosphate reductase_complex",
+ "name": "ribonucleoside-diphosphate reductase_complex",
+ "grounding": {
+ "identifiers": {
+ "GO": "0005971"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "dCDP_simple_molecule",
+ "name": "dCDP_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "28846"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CMPK",
+ "name": "CMPK",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "UDP_simple_molecule",
+ "name": "UDP_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "17659"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "dUMP_simple_molecule",
+ "name": "dUMP_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "17622"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TYMS",
+ "name": "TYMS",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "dTMP_simple_molecule",
+ "name": "dTMP_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "17013"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IFNA1_rna",
+ "name": "IFNA1_rna",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P01562"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IFNA1_pulmonary endothelial cell",
+ "name": "IFNA1_pulmonary endothelial cell",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P01562"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "L-Gln_simple_molecule",
+ "name": "L-Gln_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "HCO3-simple_molecule",
+ "name": "HCO3-simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CAP_simple_molecule",
+ "name": "CAP_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "L-Asp_simple_molecule",
+ "name": "L-Asp_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Pi_simple_molecule",
+ "name": "Pi_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "(S)-dihydroorotate_simple_molecule",
+ "name": "(S)-dihydroorotate_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "30864"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ADP_simple_molecule",
+ "name": "ADP_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "16761"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "dUTP_simple_molecule",
+ "name": "dUTP_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "17625"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "DUT",
+ "name": "DUT",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "dCMP_simple_molecule",
+ "name": "dCMP_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "DCTD",
+ "name": "DCTD",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "cytidine_simple_molecule",
+ "name": "cytidine_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "17562"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CMP_simple_molecule",
+ "name": "CMP_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "17361"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IFNB1_pulmonary endothelial cell",
+ "name": "IFNB1_pulmonary endothelial cell",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P01574"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IFNB1_human host",
+ "name": "IFNB1_human host",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P01574"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "dTTP_simple_molecule",
+ "name": "dTTP_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "18077"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "DNA_space_biosynthesis_phenotype",
+ "name": "DNA_space_biosynthesis_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "virus_space_replication_phenotype",
+ "name": "virus_space_replication_phenotype",
+ "grounding": {
+ "identifiers": {
+ "GO": "0019079"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "DNA_gene",
+ "name": "DNA_gene",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "dTYMK",
+ "name": "dTYMK",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "dTDP_simple_molecule",
+ "name": "dTDP_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "18075"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "DNA damage_phenotype",
+ "name": "DNA damage_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NME1",
+ "name": "NME1",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "UTP_simple_molecule",
+ "name": "UTP_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "15713"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "orotate_simple_molecule",
+ "name": "orotate_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "30839"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PRPP_simple_molecule",
+ "name": "PRPP_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "17111"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PPi_simple_molecule",
+ "name": "PPi_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "L-Glu_simple_molecule",
+ "name": "L-Glu_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "16015"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CDA",
+ "name": "CDA",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P32320"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IFNB1_rna",
+ "name": "IFNB1_rna",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P01574"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IFNA1_human host",
+ "name": "IFNA1_human host",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P01562"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "dCTP_simple_molecule",
+ "name": "dCTP_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "16311"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "DCTPP1",
+ "name": "DCTPP1",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CoQ_simple_molecule",
+ "name": "CoQ_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "16389"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "dihydroorotate_space_dehydrogenase_space_holoenzyme_simple_molecule",
+ "name": "dihydroorotate_space_dehydrogenase_space_holoenzyme_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "P1788_simple_molecule",
+ "name": "P1788_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "31740051"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Teriflunomide_drug",
+ "name": "Teriflunomide_drug",
+ "grounding": {
+ "identifiers": {
+ "drugbank": "DB08880"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "QH2_simple_molecule",
+ "name": "QH2_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "17976"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "dUDP_simple_molecule",
+ "name": "dUDP_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "28850"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CO2_simple_molecule",
+ "name": "CO2_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "16526"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CTPS1",
+ "name": "CTPS1",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CTP_simple_molecule",
+ "name": "CTP_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "17677"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "HCoVs Type I Ifn signalling(WP4868)_phenotype",
+ "name": "HCoVs Type I Ifn signalling(WP4868)_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Interferon 1 pathway_phenotype",
+ "name": "Interferon 1 pathway_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "HCoVs autophagy (WP4863)_phenotype",
+ "name": "HCoVs autophagy (WP4863)_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "HCoVs IFN induction WP4880_phenotype",
+ "name": "HCoVs IFN induction WP4880_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ }
+ ],
+ "edges": [
+ {
+ "id": "t1",
+ "source": "IRF3_phosphorylated",
+ "target": "IFNB1_space_expression_space_complex_complex",
+ "sign": true
+ },
+ {
+ "id": "t2",
+ "source": "NF-kB_complex",
+ "target": "IFNB1_space_expression_space_complex_complex",
+ "sign": true
+ },
+ {
+ "id": "t3",
+ "source": "cGAMP:STING_complex_endoplasmic reticulum",
+ "target": "cGAMP:STING_complex_Golgi apparatus",
+ "sign": true
+ },
+ {
+ "id": "t4",
+ "source": "cGAMP_simple_molecule",
+ "target": "cGAMP:STING_complex_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t5",
+ "source": "STING_endoplasmic reticulum",
+ "target": "cGAMP:STING_complex_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t6",
+ "source": "cGAMP-STING_complex_COPII-coated vesicle",
+ "target": "cGAMP-STING_complex_endoplasmic reticulum-Golgi intermediate compartment",
+ "sign": true
+ },
+ {
+ "id": "t7",
+ "source": "LC3",
+ "target": "cGAMP:STING:LC3_complex",
+ "sign": true
+ },
+ {
+ "id": "t8",
+ "source": "cGAMP-STING_complex_endoplasmic reticulum-Golgi intermediate compartment",
+ "target": "cGAMP:STING:LC3_complex",
+ "sign": true
+ },
+ {
+ "id": "t9",
+ "source": "WIPI2",
+ "target": "cGAMP:STING:LC3_complex",
+ "sign": true
+ },
+ {
+ "id": "t10",
+ "source": "dsDNA_simple_molecule",
+ "target": "cGAS:dsDNA_complex",
+ "sign": true
+ },
+ {
+ "id": "t11",
+ "source": "cGAS",
+ "target": "cGAS:dsDNA_complex",
+ "sign": true
+ },
+ {
+ "id": "t12",
+ "source": "dsDNA_simple_molecule",
+ "target": "MRE11:dsDNA_complex",
+ "sign": true
+ },
+ {
+ "id": "t13",
+ "source": "MRE11",
+ "target": "MRE11:dsDNA_complex",
+ "sign": true
+ },
+ {
+ "id": "t14",
+ "source": "TBK1",
+ "target": "STING:TBK1_complex_Golgi apparatus",
+ "sign": true
+ },
+ {
+ "id": "t15",
+ "source": "STING_Golgi apparatus",
+ "target": "STING:TBK1_complex_Golgi apparatus",
+ "sign": true
+ },
+ {
+ "id": "t16",
+ "source": "cGAMP:STING_complex_Golgi apparatus",
+ "target": "STING:TBK1_complex_Golgi apparatus",
+ "sign": true
+ },
+ {
+ "id": "t17",
+ "source": "cGAMP:STING_complex_endoplasmic reticulum",
+ "target": "cGAMP-STING_complex_COPII-coated vesicle",
+ "sign": true
+ },
+ {
+ "id": "t18",
+ "source": "SAR1A",
+ "target": "cGAMP-STING_complex_COPII-coated vesicle",
+ "sign": true
+ },
+ {
+ "id": "t19",
+ "source": "STING:TBK1_complex_Golgi apparatus",
+ "target": "STING:TBK1_complex_endolysosome",
+ "sign": true
+ },
+ {
+ "id": "t20",
+ "source": "MRE11:RAD50:DNA_complex_pulmonary endothelial cell",
+ "target": "MRE11:RAD50:DNA_complex_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t21",
+ "source": "RAD50",
+ "target": "MRE11:RAD50:DNA_complex_pulmonary endothelial cell",
+ "sign": true
+ },
+ {
+ "id": "t22",
+ "source": "MRE11:dsDNA_complex",
+ "target": "MRE11:RAD50:DNA_complex_pulmonary endothelial cell",
+ "sign": true
+ },
+ {
+ "id": "t23",
+ "source": "N-carbamoyl-L-aspartate_simple_molecule",
+ "target": "H2O_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t24",
+ "source": "CAD",
+ "target": "H2O_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t25",
+ "source": "H+simple_molecule",
+ "target": "H2O_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t26",
+ "source": "orotidine_space_5'-monophosphate_simple_molecule",
+ "target": "UMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t27",
+ "source": "UCK2",
+ "target": "UMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t28",
+ "source": "UMPS",
+ "target": "UMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t29",
+ "source": "uridine_simple_molecule",
+ "target": "UMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t30",
+ "source": "GTP_simple_molecule",
+ "target": "cGAMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t31",
+ "source": "ATP_simple_molecule",
+ "target": "cGAMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t32",
+ "source": "cGAS:dsDNA_complex",
+ "target": "cGAMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t33",
+ "source": "RTC and transcription pw_phenotype",
+ "target": "RNA_space_biosynthesis_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t34",
+ "source": "ribonucleoside-diphosphate reductase_complex",
+ "target": "dCDP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t35",
+ "source": "CDP_simple_molecule",
+ "target": "dCDP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t36",
+ "source": "CMPK",
+ "target": "UDP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t37",
+ "source": "UMP_simple_molecule",
+ "target": "UDP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t38",
+ "source": "dUMP_simple_molecule",
+ "target": "dTMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t39",
+ "source": "TYMS",
+ "target": "dTMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t40",
+ "source": "IFNA1_rna",
+ "target": "IFNA1_pulmonary endothelial cell",
+ "sign": true
+ },
+ {
+ "id": "t41",
+ "source": "L-Asp_simple_molecule",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t42",
+ "source": "CAD",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t43",
+ "source": "L-Gln_simple_molecule",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t44",
+ "source": "H2O_simple_molecule",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t45",
+ "source": "ATP_simple_molecule",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t46",
+ "source": "HCO3-simple_molecule",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t47",
+ "source": "CAP_simple_molecule",
+ "target": "Pi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t48",
+ "source": "N-carbamoyl-L-aspartate_simple_molecule",
+ "target": "(S)-dihydroorotate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t49",
+ "source": "CAD",
+ "target": "(S)-dihydroorotate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t50",
+ "source": "H+simple_molecule",
+ "target": "(S)-dihydroorotate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t51",
+ "source": "CAD",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t52",
+ "source": "L-Gln_simple_molecule",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t53",
+ "source": "H2O_simple_molecule",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t54",
+ "source": "ATP_simple_molecule",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t55",
+ "source": "HCO3-simple_molecule",
+ "target": "ADP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t56",
+ "source": "DCTD",
+ "target": "dUMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t57",
+ "source": "dUTP_simple_molecule",
+ "target": "dUMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t58",
+ "source": "DUT",
+ "target": "dUMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t59",
+ "source": "dCMP_simple_molecule",
+ "target": "dUMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t60",
+ "source": "L-Asp_simple_molecule",
+ "target": "N-carbamoyl-L-aspartate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t61",
+ "source": "CAD",
+ "target": "N-carbamoyl-L-aspartate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t62",
+ "source": "CAP_simple_molecule",
+ "target": "N-carbamoyl-L-aspartate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t63",
+ "source": "cytidine_simple_molecule",
+ "target": "CMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t64",
+ "source": "UCK2",
+ "target": "CMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t65",
+ "source": "CMP_simple_molecule",
+ "target": "CDP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t66",
+ "source": "CMPK",
+ "target": "CDP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t67",
+ "source": "IFNB1_pulmonary endothelial cell",
+ "target": "IFNB1_human host",
+ "sign": true
+ },
+ {
+ "id": "t68",
+ "source": "dsDNA_simple_molecule",
+ "target": "DNA_gene",
+ "sign": true
+ },
+ {
+ "id": "t69",
+ "source": "DNA_space_biosynthesis_phenotype",
+ "target": "DNA_gene",
+ "sign": true
+ },
+ {
+ "id": "t70",
+ "source": "virus_space_replication_phenotype",
+ "target": "DNA_gene",
+ "sign": true
+ },
+ {
+ "id": "t71",
+ "source": "dTTP_simple_molecule",
+ "target": "DNA_gene",
+ "sign": true
+ },
+ {
+ "id": "t72",
+ "source": "dTMP_simple_molecule",
+ "target": "dTDP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t73",
+ "source": "dTYMK",
+ "target": "dTDP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t74",
+ "source": "DNA damage_phenotype",
+ "target": "dsDNA_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t75",
+ "source": "IFNB1_space_expression_space_complex_complex",
+ "target": "IFNA1_rna",
+ "sign": true
+ },
+ {
+ "id": "t76",
+ "source": "UDP_simple_molecule",
+ "target": "UTP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t77",
+ "source": "NME1",
+ "target": "UTP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t78",
+ "source": "dTDP_simple_molecule",
+ "target": "dTTP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t79",
+ "source": "orotate_simple_molecule",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t80",
+ "source": "PRPP_simple_molecule",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t81",
+ "source": "UMPS",
+ "target": "PPi_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t82",
+ "source": "CAD",
+ "target": "L-Glu_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t83",
+ "source": "L-Gln_simple_molecule",
+ "target": "L-Glu_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t84",
+ "source": "H2O_simple_molecule",
+ "target": "L-Glu_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t85",
+ "source": "ATP_simple_molecule",
+ "target": "L-Glu_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t86",
+ "source": "HCO3-simple_molecule",
+ "target": "L-Glu_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t87",
+ "source": "cytidine_simple_molecule",
+ "target": "uridine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t88",
+ "source": "CDA",
+ "target": "uridine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t89",
+ "source": "IFNB1_rna",
+ "target": "IFNB1_pulmonary endothelial cell",
+ "sign": true
+ },
+ {
+ "id": "t90",
+ "source": "IFNA1_pulmonary endothelial cell",
+ "target": "IFNA1_human host",
+ "sign": true
+ },
+ {
+ "id": "t91",
+ "source": "CAD",
+ "target": "CAP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t92",
+ "source": "L-Gln_simple_molecule",
+ "target": "CAP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t93",
+ "source": "H2O_simple_molecule",
+ "target": "CAP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t94",
+ "source": "ATP_simple_molecule",
+ "target": "CAP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t95",
+ "source": "HCO3-simple_molecule",
+ "target": "CAP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t96",
+ "source": "dCTP_simple_molecule",
+ "target": "dCMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t97",
+ "source": "DCTPP1",
+ "target": "dCMP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t98",
+ "source": "STING_endoplasmic reticulum",
+ "target": "STING_Golgi apparatus",
+ "sign": true
+ },
+ {
+ "id": "t99",
+ "source": "MRE11:RAD50:DNA_complex_endoplasmic reticulum",
+ "target": "STING_Golgi apparatus",
+ "sign": true
+ },
+ {
+ "id": "t100",
+ "source": "dCDP_simple_molecule",
+ "target": "dCTP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t101",
+ "source": "NME1",
+ "target": "dCTP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t102",
+ "source": "STING:TBK1_complex_endolysosome",
+ "target": "IRF3_phosphorylated",
+ "sign": true
+ },
+ {
+ "id": "t103",
+ "source": "dihydroorotate_space_dehydrogenase_space_holoenzyme_simple_molecule",
+ "target": "QH2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t104",
+ "source": "Teriflunomide_drug",
+ "target": "QH2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t105",
+ "source": "CoQ_simple_molecule",
+ "target": "QH2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t106",
+ "source": "P1788_simple_molecule",
+ "target": "QH2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t107",
+ "source": "(S)-dihydroorotate_simple_molecule",
+ "target": "QH2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t108",
+ "source": "orotate_simple_molecule",
+ "target": "orotidine_space_5'-monophosphate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t109",
+ "source": "PRPP_simple_molecule",
+ "target": "orotidine_space_5'-monophosphate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t110",
+ "source": "UMPS",
+ "target": "orotidine_space_5'-monophosphate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t111",
+ "source": "dUDP_simple_molecule",
+ "target": "dUTP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t112",
+ "source": "NME1",
+ "target": "dUTP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t113",
+ "source": "dihydroorotate_space_dehydrogenase_space_holoenzyme_simple_molecule",
+ "target": "orotate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t114",
+ "source": "Teriflunomide_drug",
+ "target": "orotate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t115",
+ "source": "CoQ_simple_molecule",
+ "target": "orotate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t116",
+ "source": "P1788_simple_molecule",
+ "target": "orotate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t117",
+ "source": "(S)-dihydroorotate_simple_molecule",
+ "target": "orotate_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t118",
+ "source": "orotidine_space_5'-monophosphate_simple_molecule",
+ "target": "CO2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t119",
+ "source": "UMPS",
+ "target": "CO2_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t120",
+ "source": "UTP_simple_molecule",
+ "target": "CTP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t121",
+ "source": "NME1",
+ "target": "CTP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t122",
+ "source": "CDP_simple_molecule",
+ "target": "CTP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t123",
+ "source": "CTPS1",
+ "target": "CTP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t124",
+ "source": "ribonucleoside-diphosphate reductase_complex",
+ "target": "dUDP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t125",
+ "source": "UDP_simple_molecule",
+ "target": "dUDP_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t126",
+ "source": "IFNB1_space_expression_space_complex_complex",
+ "target": "IFNB1_rna",
+ "sign": true
+ },
+ {
+ "id": "t127",
+ "source": "CTP_simple_molecule",
+ "target": "RTC and transcription pw_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t128",
+ "source": "Teriflunomide_drug",
+ "target": "DNA damage_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t129",
+ "source": "IFNA1_human host",
+ "target": "HCoVs Type I Ifn signalling(WP4868)_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t130",
+ "source": "IFNB1_human host",
+ "target": "HCoVs Type I Ifn signalling(WP4868)_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t131",
+ "source": "IFNA1_human host",
+ "target": "Interferon 1 pathway_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t132",
+ "source": "IFNB1_human host",
+ "target": "Interferon 1 pathway_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t133",
+ "source": "cGAMP:STING:LC3_complex",
+ "target": "HCoVs autophagy (WP4863)_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t134",
+ "source": "IFNA1_human host",
+ "target": "HCoVs IFN induction WP4880_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t135",
+ "source": "IFNB1_human host",
+ "target": "HCoVs IFN induction WP4880_phenotype",
+ "sign": true
+ }
+ ],
+ "parameters": []
+ },
+ "semantics": {
+ "ode": {
+ "rates": [],
+ "observables": [],
+ "time": {
+ "id": "t"
+ }
+ }
+ },
+ "metadata": {
+ "annotations": {}
+ }
+}
\ No newline at end of file
diff --git a/scripts/covid19_diseasemaps/regnet_amr_sbml/RTC-and-transcription.json b/scripts/covid19_diseasemaps/regnet_amr_sbml/RTC-and-transcription.json
new file mode 100644
index 000000000..8b70c26f0
--- /dev/null
+++ b/scripts/covid19_diseasemaps/regnet_amr_sbml/RTC-and-transcription.json
@@ -0,0 +1,560 @@
+{
+ "header": {
+ "name": "Model",
+ "schema": "https://raw.githubusercontent.com/DARPA-ASKEM/Model-Representations/regnet_v0.2/regnet/regnet_schema.json",
+ "schema_name": "regnet",
+ "description": "Model",
+ "model_version": "0.1"
+ },
+ "model": {
+ "vertices": [
+ {
+ "id": "Replication_space_transcription_space_complex_space__complex_double membrane vesicle viral factory",
+ "name": "Replication_space_transcription_space_complex_space__complex_double membrane vesicle viral factory",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0,
+ "sign": true
+ },
+ {
+ "id": "CoV_space_poly-br_merase_space_complex_complex_cell",
+ "name": "CoV_space_poly-br_merase_space_complex_complex_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "nsp9_cell",
+ "name": "nsp9_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "complex_complex_cell",
+ "name": "complex_complex_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "(+)gRNA_space_(including_space_ORF1a_space_ORF1b)_gene_cell",
+ "name": "(+)gRNA_space_(including_space_ORF1a_space_ORF1b)_gene_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "nsp8_space_(I)",
+ "name": "nsp8_space_(I)",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "nsp8_space_(II)",
+ "name": "nsp8_space_(II)",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "nsp7",
+ "name": "nsp7",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "nsp14",
+ "name": "nsp14",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "nsp10",
+ "name": "nsp10",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "nsp12",
+ "name": "nsp12",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CoV_space_poly-br_merase_space_complex_complex_double membrane vesicle viral factory",
+ "name": "CoV_space_poly-br_merase_space_complex_complex_double membrane vesicle viral factory",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "complex_complex_double membrane vesicle viral factory",
+ "name": "complex_complex_double membrane vesicle viral factory",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "pp1a_cell",
+ "name": "pp1a_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "nsp2",
+ "name": "nsp2",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "nsp5",
+ "name": "nsp5",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "pp1ab_cell",
+ "name": "pp1ab_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "nsp3",
+ "name": "nsp3",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "nsp4",
+ "name": "nsp4",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "nsp15",
+ "name": "nsp15",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "nsp16",
+ "name": "nsp16",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "(+)gRNA_space_(including_space_ORF1a_space_ORF1b)_gene_double membrane vesicle viral factory",
+ "name": "(+)gRNA_space_(including_space_ORF1a_space_ORF1b)_gene_double membrane vesicle viral factory",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "pp1a_double membrane vesicle viral factory",
+ "name": "pp1a_double membrane vesicle viral factory",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "nsp1",
+ "name": "nsp1",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "(+)sgRNA_space_(2-9)_gene",
+ "name": "(+)sgRNA_space_(2-9)_gene",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "nsp9_double membrane vesicle viral factory",
+ "name": "nsp9_double membrane vesicle viral factory",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "nsp13",
+ "name": "nsp13",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "(-)gRNA_space_(including_space_ORF1a_space_ORF1b)_gene",
+ "name": "(-)gRNA_space_(including_space_ORF1a_space_ORF1b)_gene",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "pp1ab_double membrane vesicle viral factory",
+ "name": "pp1ab_double membrane vesicle viral factory",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "nsp11",
+ "name": "nsp11",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "viral_space_accessory",
+ "name": "viral_space_accessory",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "nsp6",
+ "name": "nsp6",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "structural_space_proteins",
+ "name": "structural_space_proteins",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ }
+ ],
+ "edges": [
+ {
+ "id": "t1",
+ "source": "nsp9_cell",
+ "target": "Replication_space_transcription_space_complex_space__complex_double membrane vesicle viral factory",
+ "sign": true
+ },
+ {
+ "id": "t2",
+ "source": "CoV_space_poly-br_merase_space_complex_complex_cell",
+ "target": "Replication_space_transcription_space_complex_space__complex_double membrane vesicle viral factory",
+ "sign": true
+ },
+ {
+ "id": "t3",
+ "source": "complex_complex_cell",
+ "target": "Replication_space_transcription_space_complex_space__complex_double membrane vesicle viral factory",
+ "sign": true
+ },
+ {
+ "id": "t4",
+ "source": "(+)gRNA_space_(including_space_ORF1a_space_ORF1b)_gene_cell",
+ "target": "Replication_space_transcription_space_complex_space__complex_double membrane vesicle viral factory",
+ "sign": true
+ },
+ {
+ "id": "t5",
+ "source": "nsp8_space_(I)",
+ "target": "complex_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t6",
+ "source": "nsp7",
+ "target": "complex_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t7",
+ "source": "nsp8_space_(II)",
+ "target": "complex_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t8",
+ "source": "nsp10",
+ "target": "CoV_space_poly-br_merase_space_complex_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t9",
+ "source": "nsp14",
+ "target": "CoV_space_poly-br_merase_space_complex_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t10",
+ "source": "nsp12",
+ "target": "CoV_space_poly-br_merase_space_complex_complex_cell",
+ "sign": true
+ },
+ {
+ "id": "t11",
+ "source": "Replication_space_transcription_space_complex_space__complex_double membrane vesicle viral factory",
+ "target": "CoV_space_poly-br_merase_space_complex_complex_double membrane vesicle viral factory",
+ "sign": true
+ },
+ {
+ "id": "t12",
+ "source": "Replication_space_transcription_space_complex_space__complex_double membrane vesicle viral factory",
+ "target": "complex_complex_double membrane vesicle viral factory",
+ "sign": true
+ },
+ {
+ "id": "t13",
+ "source": "pp1a_cell",
+ "target": "nsp2",
+ "sign": true
+ },
+ {
+ "id": "t14",
+ "source": "pp1a_cell",
+ "target": "nsp5",
+ "sign": true
+ },
+ {
+ "id": "t15",
+ "source": "pp1ab_cell",
+ "target": "nsp14",
+ "sign": true
+ },
+ {
+ "id": "t16",
+ "source": "pp1a_cell",
+ "target": "nsp3",
+ "sign": true
+ },
+ {
+ "id": "t17",
+ "source": "pp1a_cell",
+ "target": "nsp4",
+ "sign": true
+ },
+ {
+ "id": "t18",
+ "source": "pp1ab_cell",
+ "target": "nsp15",
+ "sign": true
+ },
+ {
+ "id": "t19",
+ "source": "(+)gRNA_space_(including_space_ORF1a_space_ORF1b)_gene_cell",
+ "target": "pp1ab_cell",
+ "sign": true
+ },
+ {
+ "id": "t20",
+ "source": "pp1a_cell",
+ "target": "nsp9_cell",
+ "sign": true
+ },
+ {
+ "id": "t21",
+ "source": "pp1ab_cell",
+ "target": "nsp16",
+ "sign": true
+ },
+ {
+ "id": "t22",
+ "source": "Replication_space_transcription_space_complex_space__complex_double membrane vesicle viral factory",
+ "target": "(+)gRNA_space_(including_space_ORF1a_space_ORF1b)_gene_double membrane vesicle viral factory",
+ "sign": true
+ },
+ {
+ "id": "t23",
+ "source": "(+)gRNA_space_(including_space_ORF1a_space_ORF1b)_gene_double membrane vesicle viral factory",
+ "target": "pp1a_double membrane vesicle viral factory",
+ "sign": true
+ },
+ {
+ "id": "t24",
+ "source": "pp1a_cell",
+ "target": "nsp8_space_(I)",
+ "sign": true
+ },
+ {
+ "id": "t25",
+ "source": "pp1a_cell",
+ "target": "nsp1",
+ "sign": true
+ },
+ {
+ "id": "t26",
+ "source": "Replication_space_transcription_space_complex_space__complex_double membrane vesicle viral factory",
+ "target": "(+)sgRNA_space_(2-9)_gene",
+ "sign": true
+ },
+ {
+ "id": "t27",
+ "source": "Replication_space_transcription_space_complex_space__complex_double membrane vesicle viral factory",
+ "target": "nsp9_double membrane vesicle viral factory",
+ "sign": true
+ },
+ {
+ "id": "t28",
+ "source": "pp1a_cell",
+ "target": "nsp7",
+ "sign": true
+ },
+ {
+ "id": "t29",
+ "source": "pp1ab_cell",
+ "target": "nsp12",
+ "sign": true
+ },
+ {
+ "id": "t30",
+ "source": "pp1ab_cell",
+ "target": "nsp13",
+ "sign": true
+ },
+ {
+ "id": "t31",
+ "source": "(+)gRNA_space_(including_space_ORF1a_space_ORF1b)_gene_cell",
+ "target": "pp1a_cell",
+ "sign": true
+ },
+ {
+ "id": "t32",
+ "source": "Replication_space_transcription_space_complex_space__complex_double membrane vesicle viral factory",
+ "target": "(-)gRNA_space_(including_space_ORF1a_space_ORF1b)_gene",
+ "sign": true
+ },
+ {
+ "id": "t33",
+ "source": "(+)gRNA_space_(including_space_ORF1a_space_ORF1b)_gene_double membrane vesicle viral factory",
+ "target": "pp1ab_double membrane vesicle viral factory",
+ "sign": true
+ },
+ {
+ "id": "t34",
+ "source": "pp1a_cell",
+ "target": "nsp10",
+ "sign": true
+ },
+ {
+ "id": "t35",
+ "source": "pp1a_cell",
+ "target": "nsp11",
+ "sign": true
+ },
+ {
+ "id": "t36",
+ "source": "pp1a_cell",
+ "target": "nsp8_space_(II)",
+ "sign": true
+ },
+ {
+ "id": "t37",
+ "source": "(+)sgRNA_space_(2-9)_gene",
+ "target": "viral_space_accessory",
+ "sign": true
+ },
+ {
+ "id": "t38",
+ "source": "pp1a_cell",
+ "target": "nsp6",
+ "sign": true
+ },
+ {
+ "id": "t39",
+ "source": "(+)sgRNA_space_(2-9)_gene",
+ "target": "structural_space_proteins",
+ "sign": true
+ }
+ ],
+ "parameters": []
+ },
+ "semantics": {
+ "ode": {
+ "rates": [],
+ "observables": [],
+ "time": {
+ "id": "t"
+ }
+ }
+ },
+ "metadata": {
+ "annotations": {}
+ }
+}
\ No newline at end of file
diff --git a/scripts/covid19_diseasemaps/regnet_amr_sbml/Renin_angiotensin.json b/scripts/covid19_diseasemaps/regnet_amr_sbml/Renin_angiotensin.json
new file mode 100644
index 000000000..41846515a
--- /dev/null
+++ b/scripts/covid19_diseasemaps/regnet_amr_sbml/Renin_angiotensin.json
@@ -0,0 +1,1637 @@
+{
+ "header": {
+ "name": "Model",
+ "schema": "https://raw.githubusercontent.com/DARPA-ASKEM/Model-Representations/regnet_v0.2/regnet/regnet_schema.json",
+ "schema_name": "regnet",
+ "description": "Model",
+ "model_version": "0.1"
+ },
+ "model": {
+ "vertices": [
+ {
+ "id": "AGTR1_cell",
+ "name": "AGTR1_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:336"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ACE2_cell",
+ "name": "ACE2_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:13557"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "angiotensin II_simple_molecule_cell",
+ "name": "angiotensin II_simple_molecule_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:48432"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ACE2:AGTR1_complex",
+ "name": "ACE2:AGTR1_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "25225202"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "S",
+ "name": "S",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "uniprot:P0DTC2",
+ "property1": "uniprot:P59594"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TMPRSS2",
+ "name": "TMPRSS2",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:11876",
+ "property1": "HGNC:11876"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Camostat mesilate_drug",
+ "name": "Camostat mesilate_drug",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "135632"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ACE2-Spike complex_complex",
+ "name": "ACE2-Spike complex_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "32275855"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "AGTR1_cell_active",
+ "name": "AGTR1_cell_active",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:336",
+ "property1": "HGNC:336"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MAS1_cell",
+ "name": "MAS1_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:6899"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MAS1:AGTR1_complex",
+ "name": "MAS1:AGTR1_complex",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "15809376"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "AGT",
+ "name": "AGT",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:333",
+ "property1": "HGNC:333"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "REN",
+ "name": "REN",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:9958",
+ "property1": "HGNC:9958",
+ "property2": "HGNC:9958"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "angiotensin 1-12_simple_molecule",
+ "name": "angiotensin 1-12_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "27465904"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ACE_cell",
+ "name": "ACE_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:2707"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CTSD",
+ "name": "CTSD",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:2529"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CTSG",
+ "name": "CTSG",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:2532"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "angiotensin I_simple_molecule",
+ "name": "angiotensin I_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:2718"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "angiotensin 1-9_simple_molecule",
+ "name": "angiotensin 1-9_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:80128"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CMA1",
+ "name": "CMA1",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:2097"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "KLK1",
+ "name": "KLK1",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:6357"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ACE_cell_active",
+ "name": "ACE_cell_active",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:2707"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MME_cell",
+ "name": "MME_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:7154"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PRCP",
+ "name": "PRCP",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:9344"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "THOP1",
+ "name": "THOP1",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:11793"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PREP",
+ "name": "PREP",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:9358"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "angiotensin 1-7_simple_molecule_cell",
+ "name": "angiotensin 1-7_simple_molecule_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:55438"
+ }
+ },
+ "initial": 3.0
+ },
+ {
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+ "name": "AGTR2_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:338"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CGP42112A_drug",
+ "name": "CGP42112A_drug",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
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+ "name": "angiotensin A_simple_molecule",
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+ "context": {
+ "property": "kegg.compound:C20970",
+ "property1": "pubchem.compound:91691124"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "AGTR2_cell_active",
+ "name": "AGTR2_cell_active",
+ "grounding": {
+ "identifiers": {
+ "HGNC": "338"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "angiotensin 1-5_simple_molecule",
+ "name": "angiotensin 1-5_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:80129"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "AR234960_drug",
+ "name": "AR234960_drug",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MAS1_cell_active",
+ "name": "MAS1_cell_active",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:6899"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "estradiol_simple_molecule",
+ "name": "estradiol_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:16469"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Calcitriol_simple_molecule",
+ "name": "Calcitriol_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:17823"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ACE2_gene",
+ "name": "ACE2_gene",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:13557"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "aging_phenotype",
+ "name": "aging_phenotype",
+ "grounding": {
+ "identifiers": {
+ "GO": "0007568"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SARS-CoV-2 infection_phenotype",
+ "name": "SARS-CoV-2 infection_phenotype",
+ "grounding": {
+ "identifiers": {
+ "mesh": "C000657245"
+ },
+ "context": {
+ "property": "taxonomy:2697049"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "hypertension_phenotype",
+ "name": "hypertension_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "mesh:D006973"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": " Diabetes mellitus, type II_phenotype",
+ "name": " Diabetes mellitus, type II_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "mesh:D003924"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ethynylestradiol_simple_molecule",
+ "name": "ethynylestradiol_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:4903"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "androgen_simple_molecule",
+ "name": "androgen_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:50113"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "alamandine_simple_molecule",
+ "name": "alamandine_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "pubchem.compound": "44192273"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MRGPRD_cell",
+ "name": "MRGPRD_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:29626"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MRGPRD_cell_active",
+ "name": "MRGPRD_cell_active",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:29626"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "LNPEP_cell_active",
+ "name": "LNPEP_cell_active",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:6656"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "vasoconstriction_phenotype",
+ "name": "vasoconstriction_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "inflammatory response_phenotype",
+ "name": "inflammatory response_phenotype",
+ "grounding": {
+ "identifiers": {
+ "GO": "0006954"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ENPEP_cell_active",
+ "name": "ENPEP_cell_active",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:3355"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "angiotensin III_simple_molecule",
+ "name": "angiotensin III_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "CHEBI": "89666"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ANPEP ",
+ "name": "ANPEP ",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:500"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "angiotensin IV_simple_molecule",
+ "name": "angiotensin IV_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:80127"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ENPEP_cell",
+ "name": "ENPEP_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:3355"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "QGC001_drug",
+ "name": "QGC001_drug",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "sex, male_phenotype",
+ "name": "sex, male_phenotype",
+ "grounding": {
+ "identifiers": {
+ "mesh": "D008297"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ADAM17",
+ "name": "ADAM17",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:195"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ACE2, soluble",
+ "name": "ACE2, soluble",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "hgnc:ACE2"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "aldosterone_simple_molecule",
+ "name": "aldosterone_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:27584"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "angiotensin II_simple_molecule_human host",
+ "name": "angiotensin II_simple_molecule_human host",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:48432"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "angiotensin 1-7_simple_molecule_human host",
+ "name": "angiotensin 1-7_simple_molecule_human host",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:55438"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ACE2_cell_active",
+ "name": "ACE2_cell_active",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:13557"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ABO blood group system_phenotype",
+ "name": "ABO blood group system_phenotype",
+ "grounding": {
+ "identifiers": {
+ "mesh": "D000017"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Lisinopril_drug",
+ "name": "Lisinopril_drug",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Losartan_drug",
+ "name": "Losartan_drug",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "angiotensin 1-4_simple_molecule",
+ "name": "angiotensin 1-4_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "22490446"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "LNPEP_cell",
+ "name": "LNPEP_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "HGNC:6656"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "angiotensin 3-7_simple_molecule",
+ "name": "angiotensin 3-7_simple_molecule",
+ "grounding": {
+ "identifiers": {
+ "pubmed": "30934934"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "oxidative stress_phenotype",
+ "name": "oxidative stress_phenotype",
+ "grounding": {
+ "identifiers": {
+ "GO": "0006979"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "viral replication cycle_phenotype",
+ "name": "viral replication cycle_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "fibrosis_phenotype",
+ "name": "fibrosis_phenotype",
+ "grounding": {
+ "identifiers": {
+ "mesh": "D005355"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "thrombosis_phenotype",
+ "name": "thrombosis_phenotype",
+ "grounding": {
+ "identifiers": {
+ "mesh": "D013927"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MME_cell_active",
+ "name": "MME_cell_active",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "cognition_phenotype",
+ "name": "cognition_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "mesh:D003071"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "pulmonary edema_phenotype",
+ "name": "pulmonary edema_phenotype",
+ "grounding": {
+ "identifiers": {
+ "mesh": "D011654"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "platelet aggregation_phenotype",
+ "name": "platelet aggregation_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "GO:0070527"
+ }
+ },
+ "initial": 3.0
+ }
+ ],
+ "edges": [
+ {
+ "id": "t1",
+ "source": "angiotensin II_simple_molecule_cell",
+ "target": "ACE2:AGTR1_complex",
+ "sign": true
+ },
+ {
+ "id": "t2",
+ "source": "ACE2_cell",
+ "target": "ACE2:AGTR1_complex",
+ "sign": true
+ },
+ {
+ "id": "t3",
+ "source": "AGTR1_cell",
+ "target": "ACE2:AGTR1_complex",
+ "sign": true
+ },
+ {
+ "id": "t4",
+ "source": "ACE2_cell",
+ "target": "ACE2-Spike complex_complex",
+ "sign": true
+ },
+ {
+ "id": "t5",
+ "source": "TMPRSS2",
+ "target": "ACE2-Spike complex_complex",
+ "sign": true
+ },
+ {
+ "id": "t6",
+ "source": "Camostat mesilate_drug",
+ "target": "ACE2-Spike complex_complex",
+ "sign": true
+ },
+ {
+ "id": "t7",
+ "source": "S",
+ "target": "ACE2-Spike complex_complex",
+ "sign": true
+ },
+ {
+ "id": "t8",
+ "source": "MAS1_cell",
+ "target": "MAS1:AGTR1_complex",
+ "sign": true
+ },
+ {
+ "id": "t9",
+ "source": "AGTR1_cell_active",
+ "target": "MAS1:AGTR1_complex",
+ "sign": true
+ },
+ {
+ "id": "t10",
+ "source": "AGT",
+ "target": "angiotensin I_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t11",
+ "source": "ACE_cell",
+ "target": "angiotensin I_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t12",
+ "source": "REN",
+ "target": "angiotensin I_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t13",
+ "source": "CTSG",
+ "target": "angiotensin I_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t14",
+ "source": "CTSD",
+ "target": "angiotensin I_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t15",
+ "source": "angiotensin 1-12_simple_molecule",
+ "target": "angiotensin I_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t16",
+ "source": "angiotensin I_simple_molecule",
+ "target": "angiotensin 1-9_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t17",
+ "source": "ACE2_cell",
+ "target": "angiotensin 1-9_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t18",
+ "source": "ACE_cell",
+ "target": "angiotensin II_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t19",
+ "source": "CMA1",
+ "target": "angiotensin II_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t20",
+ "source": "KLK1",
+ "target": "angiotensin II_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t21",
+ "source": "angiotensin 1-12_simple_molecule",
+ "target": "angiotensin II_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t22",
+ "source": "angiotensin I_simple_molecule",
+ "target": "angiotensin II_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t23",
+ "source": "S",
+ "target": "angiotensin II_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t24",
+ "source": "angiotensin 1-9_simple_molecule",
+ "target": "angiotensin 1-7_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t25",
+ "source": "PREP",
+ "target": "angiotensin 1-7_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t26",
+ "source": "THOP1",
+ "target": "angiotensin 1-7_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t27",
+ "source": "ACE_cell_active",
+ "target": "angiotensin 1-7_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t28",
+ "source": "ACE2_cell",
+ "target": "angiotensin 1-7_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t29",
+ "source": "angiotensin I_simple_molecule",
+ "target": "angiotensin 1-7_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t30",
+ "source": "angiotensin II_simple_molecule_cell",
+ "target": "angiotensin 1-7_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t31",
+ "source": "PRCP",
+ "target": "angiotensin 1-7_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t32",
+ "source": "MME_cell",
+ "target": "angiotensin 1-7_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t33",
+ "source": "angiotensin 1-12_simple_molecule",
+ "target": "angiotensin 1-7_simple_molecule_cell",
+ "sign": true
+ },
+ {
+ "id": "t34",
+ "source": "angiotensin 1-9_simple_molecule",
+ "target": "AGTR2_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t35",
+ "source": "angiotensin A_simple_molecule",
+ "target": "AGTR2_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t36",
+ "source": "angiotensin 1-7_simple_molecule_cell",
+ "target": "AGTR2_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t37",
+ "source": "AGTR2_cell",
+ "target": "AGTR2_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t38",
+ "source": "angiotensin II_simple_molecule_cell",
+ "target": "AGTR2_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t39",
+ "source": "CGP42112A_drug",
+ "target": "AGTR2_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t40",
+ "source": "angiotensin 1-5_simple_molecule",
+ "target": "MAS1_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t41",
+ "source": "angiotensin 1-7_simple_molecule_cell",
+ "target": "MAS1_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t42",
+ "source": "MAS1_cell",
+ "target": "MAS1_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t43",
+ "source": "AR234960_drug",
+ "target": "MAS1_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t44",
+ "source": "estradiol_simple_molecule",
+ "target": "ACE_cell",
+ "sign": true
+ },
+ {
+ "id": "t45",
+ "source": "Calcitriol_simple_molecule",
+ "target": "ACE_cell",
+ "sign": true
+ },
+ {
+ "id": "t46",
+ "source": "hypertension_phenotype",
+ "target": "ACE2_cell",
+ "sign": true
+ },
+ {
+ "id": "t47",
+ "source": "aging_phenotype",
+ "target": "ACE2_cell",
+ "sign": true
+ },
+ {
+ "id": "t48",
+ "source": "Calcitriol_simple_molecule",
+ "target": "ACE2_cell",
+ "sign": true
+ },
+ {
+ "id": "t49",
+ "source": "SARS-CoV-2 infection_phenotype",
+ "target": "ACE2_cell",
+ "sign": true
+ },
+ {
+ "id": "t50",
+ "source": "estradiol_simple_molecule",
+ "target": "ACE2_cell",
+ "sign": true
+ },
+ {
+ "id": "t51",
+ "source": "ACE2_gene",
+ "target": "ACE2_cell",
+ "sign": true
+ },
+ {
+ "id": "t52",
+ "source": " Diabetes mellitus, type II_phenotype",
+ "target": "ACE2_cell",
+ "sign": true
+ },
+ {
+ "id": "t53",
+ "source": "S",
+ "target": "ACE2_cell",
+ "sign": true
+ },
+ {
+ "id": "t54",
+ "source": "ACE_cell_active",
+ "target": "angiotensin 1-5_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t55",
+ "source": "angiotensin 1-7_simple_molecule_cell",
+ "target": "angiotensin 1-5_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t56",
+ "source": "ethynylestradiol_simple_molecule",
+ "target": "AGT",
+ "sign": true
+ },
+ {
+ "id": "t57",
+ "source": "androgen_simple_molecule",
+ "target": "TMPRSS2",
+ "sign": true
+ },
+ {
+ "id": "t58",
+ "source": "angiotensin 1-7_simple_molecule_cell",
+ "target": "alamandine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t59",
+ "source": "ACE2_cell",
+ "target": "alamandine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t60",
+ "source": "angiotensin A_simple_molecule",
+ "target": "alamandine_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t61",
+ "source": "alamandine_simple_molecule",
+ "target": "MRGPRD_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t62",
+ "source": "angiotensin 1-7_simple_molecule_cell",
+ "target": "MRGPRD_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t63",
+ "source": "MRGPRD_cell",
+ "target": "MRGPRD_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t64",
+ "source": "angiotensin II_simple_molecule_cell",
+ "target": "angiotensin A_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t65",
+ "source": "MAS1_cell_active",
+ "target": "vasoconstriction_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t66",
+ "source": "LNPEP_cell_active",
+ "target": "vasoconstriction_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t67",
+ "source": "MRGPRD_cell_active",
+ "target": "vasoconstriction_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t68",
+ "source": "AGTR1_cell_active",
+ "target": "vasoconstriction_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t69",
+ "source": "AGTR2_cell_active",
+ "target": "vasoconstriction_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t70",
+ "source": "MAS1_cell_active",
+ "target": "inflammatory response_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t71",
+ "source": "MRGPRD_cell_active",
+ "target": "inflammatory response_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t72",
+ "source": "AGTR1_cell_active",
+ "target": "inflammatory response_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t73",
+ "source": "LNPEP_cell_active",
+ "target": "inflammatory response_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t74",
+ "source": "ENPEP_cell_active",
+ "target": "angiotensin III_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t75",
+ "source": "angiotensin II_simple_molecule_cell",
+ "target": "angiotensin III_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t76",
+ "source": "ANPEP ",
+ "target": "angiotensin IV_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t77",
+ "source": "angiotensin III_simple_molecule",
+ "target": "angiotensin IV_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t78",
+ "source": "ENPEP_cell",
+ "target": "ENPEP_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t79",
+ "source": "sex, male_phenotype",
+ "target": "ENPEP_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t80",
+ "source": "QGC001_drug",
+ "target": "ENPEP_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t81",
+ "source": "Calcitriol_simple_molecule",
+ "target": "Calcitriol_simple_molecule",
+ "sign": false
+ },
+ {
+ "id": "t82",
+ "source": "ADAM17",
+ "target": "ACE2, soluble",
+ "sign": true
+ },
+ {
+ "id": "t83",
+ "source": "AGTR1_cell_active",
+ "target": "ACE2, soluble",
+ "sign": true
+ },
+ {
+ "id": "t84",
+ "source": "ACE2_cell",
+ "target": "ACE2, soluble",
+ "sign": true
+ },
+ {
+ "id": "t85",
+ "source": "aldosterone_simple_molecule",
+ "target": "aldosterone_simple_molecule",
+ "sign": false
+ },
+ {
+ "id": "t86",
+ "source": "SARS-CoV-2 infection_phenotype",
+ "target": "angiotensin II_simple_molecule_human host",
+ "sign": true
+ },
+ {
+ "id": "t87",
+ "source": "angiotensin II_simple_molecule_human host",
+ "target": "angiotensin 1-7_simple_molecule_human host",
+ "sign": true
+ },
+ {
+ "id": "t88",
+ "source": "ACE2, soluble",
+ "target": "angiotensin 1-7_simple_molecule_human host",
+ "sign": true
+ },
+ {
+ "id": "t89",
+ "source": "aging_phenotype",
+ "target": "ACE2_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t90",
+ "source": "sex, male_phenotype",
+ "target": "ACE2_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t91",
+ "source": "ACE2_cell",
+ "target": "ACE2_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t92",
+ "source": "hypertension_phenotype",
+ "target": "ACE2_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t93",
+ "source": "aldosterone_simple_molecule",
+ "target": "ACE_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t94",
+ "source": "hypertension_phenotype",
+ "target": "ACE_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t95",
+ "source": "aging_phenotype",
+ "target": "ACE_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t96",
+ "source": "ACE_cell",
+ "target": "ACE_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t97",
+ "source": "ABO blood group system_phenotype",
+ "target": "ACE_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t98",
+ "source": "Lisinopril_drug",
+ "target": "ACE_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t99",
+ "source": "sex, male_phenotype",
+ "target": "ACE_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t100",
+ "source": "angiotensin IV_simple_molecule",
+ "target": "AGTR1_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t101",
+ "source": "Losartan_drug",
+ "target": "AGTR1_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t102",
+ "source": "angiotensin A_simple_molecule",
+ "target": "AGTR1_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t103",
+ "source": "angiotensin 1-7_simple_molecule_cell",
+ "target": "AGTR1_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t104",
+ "source": "angiotensin II_simple_molecule_cell",
+ "target": "AGTR1_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t105",
+ "source": "MAS1:AGTR1_complex",
+ "target": "AGTR1_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t106",
+ "source": "AGTR1_cell",
+ "target": "AGTR1_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t107",
+ "source": "MME_cell",
+ "target": "angiotensin 1-4_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t108",
+ "source": "angiotensin 1-12_simple_molecule",
+ "target": "angiotensin 1-4_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t109",
+ "source": "angiotensin 3-7_simple_molecule",
+ "target": "LNPEP_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t110",
+ "source": "angiotensin IV_simple_molecule",
+ "target": "LNPEP_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t111",
+ "source": "LNPEP_cell",
+ "target": "LNPEP_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t112",
+ "source": "MAS1_cell_active",
+ "target": "oxidative stress_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t113",
+ "source": "AGTR1_cell_active",
+ "target": "oxidative stress_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t114",
+ "source": "angiotensin IV_simple_molecule",
+ "target": "angiotensin 3-7_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t115",
+ "source": "angiotensin 1-7_simple_molecule_cell",
+ "target": "angiotensin 3-7_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t116",
+ "source": "angiotensin II_simple_molecule_cell",
+ "target": "angiotensin 3-7_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t117",
+ "source": "ACE2-Spike complex_complex",
+ "target": "viral replication cycle_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t118",
+ "source": "MAS1_cell_active",
+ "target": "fibrosis_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t119",
+ "source": "AGTR2_cell_active",
+ "target": "fibrosis_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t120",
+ "source": "AGTR1_cell_active",
+ "target": "fibrosis_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t121",
+ "source": "MAS1_cell_active",
+ "target": "thrombosis_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t122",
+ "source": "AGTR1_cell_active",
+ "target": "thrombosis_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t123",
+ "source": "LNPEP_cell_active",
+ "target": "LNPEP_cell_active",
+ "sign": false
+ },
+ {
+ "id": "t124",
+ "source": "MME_cell",
+ "target": "MME_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t125",
+ "source": "sex, male_phenotype",
+ "target": "MME_cell_active",
+ "sign": true
+ },
+ {
+ "id": "t126",
+ "source": "AGTR1_cell_active",
+ "target": "aldosterone_simple_molecule",
+ "sign": true
+ },
+ {
+ "id": "t127",
+ "source": "AGTR1_cell_active",
+ "target": "cognition_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t128",
+ "source": "LNPEP_cell_active",
+ "target": "cognition_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t129",
+ "source": "AGTR1_cell_active",
+ "target": "pulmonary edema_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t130",
+ "source": "AGTR1_cell_active",
+ "target": "platelet aggregation_phenotype",
+ "sign": true
+ }
+ ],
+ "parameters": []
+ },
+ "semantics": {
+ "ode": {
+ "rates": [],
+ "observables": [],
+ "time": {
+ "id": "t"
+ }
+ }
+ },
+ "metadata": {
+ "annotations": {}
+ }
+}
\ No newline at end of file
diff --git a/scripts/covid19_diseasemaps/regnet_amr_sbml/TGFB_pathway.json b/scripts/covid19_diseasemaps/regnet_amr_sbml/TGFB_pathway.json
new file mode 100644
index 000000000..a35415b89
--- /dev/null
+++ b/scripts/covid19_diseasemaps/regnet_amr_sbml/TGFB_pathway.json
@@ -0,0 +1,361 @@
+{
+ "header": {
+ "name": "Model",
+ "schema": "https://raw.githubusercontent.com/DARPA-ASKEM/Model-Representations/regnet_v0.2/regnet/regnet_schema.json",
+ "schema_name": "regnet",
+ "description": "Model",
+ "model_version": "0.1"
+ },
+ "model": {
+ "vertices": [
+ {
+ "id": "BMPR1/2/ACTR2_complex",
+ "name": "BMPR1/2/ACTR2_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf3a",
+ "name": "Orf3a",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp7b_cell",
+ "name": "Nsp7b_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "E",
+ "name": "E",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "BAMBI",
+ "name": "BAMBI",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "MAPK3",
+ "name": "MAPK3",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SMAD1/5/8_complex",
+ "name": "SMAD1/5/8_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "TGFB/TGFBR_complex",
+ "name": "TGFB/TGFBR_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ACVR1",
+ "name": "ACVR1",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ACVR1B",
+ "name": "ACVR1B",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp7b_default_compartment",
+ "name": "Nsp7b_default_compartment",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "E3 ubiquitin ligase complex_complex",
+ "name": "E3 ubiquitin ligase complex_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SMAD2/3_complex",
+ "name": "SMAD2/3_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf8",
+ "name": "Orf8",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "LTBP1",
+ "name": "LTBP1",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf7a",
+ "name": "Orf7a",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "PP2A_complex",
+ "name": "PP2A_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp7",
+ "name": "Nsp7",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "RHOA",
+ "name": "RHOA",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "RPS6KB1_empty",
+ "name": "RPS6KB1_empty",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Modulation of cell cycle_phenotype",
+ "name": "Modulation of cell cycle_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ }
+ ],
+ "edges": [
+ {
+ "id": "t1",
+ "source": "MAPK3",
+ "target": "SMAD1/5/8_complex",
+ "sign": true
+ },
+ {
+ "id": "t2",
+ "source": "E",
+ "target": "SMAD1/5/8_complex",
+ "sign": true
+ },
+ {
+ "id": "t3",
+ "source": "Orf3a",
+ "target": "SMAD1/5/8_complex",
+ "sign": true
+ },
+ {
+ "id": "t4",
+ "source": "BAMBI",
+ "target": "SMAD1/5/8_complex",
+ "sign": true
+ },
+ {
+ "id": "t5",
+ "source": "BMPR1/2/ACTR2_complex",
+ "target": "SMAD1/5/8_complex",
+ "sign": true
+ },
+ {
+ "id": "t6",
+ "source": "Nsp7b_cell",
+ "target": "SMAD1/5/8_complex",
+ "sign": true
+ },
+ {
+ "id": "t7",
+ "source": "ACVR1B",
+ "target": "SMAD2/3_complex",
+ "sign": true
+ },
+ {
+ "id": "t8",
+ "source": "TGFB/TGFBR_complex",
+ "target": "SMAD2/3_complex",
+ "sign": true
+ },
+ {
+ "id": "t9",
+ "source": "MAPK3",
+ "target": "SMAD2/3_complex",
+ "sign": true
+ },
+ {
+ "id": "t10",
+ "source": "ACVR1",
+ "target": "SMAD2/3_complex",
+ "sign": true
+ },
+ {
+ "id": "t11",
+ "source": "E3 ubiquitin ligase complex_complex",
+ "target": "SMAD2/3_complex",
+ "sign": true
+ },
+ {
+ "id": "t12",
+ "source": "BAMBI",
+ "target": "SMAD2/3_complex",
+ "sign": true
+ },
+ {
+ "id": "t13",
+ "source": "Orf3a",
+ "target": "SMAD2/3_complex",
+ "sign": true
+ },
+ {
+ "id": "t14",
+ "source": "Nsp7b_default_compartment",
+ "target": "SMAD2/3_complex",
+ "sign": true
+ },
+ {
+ "id": "t15",
+ "source": "Orf8",
+ "target": "TGFB/TGFBR_complex",
+ "sign": true
+ },
+ {
+ "id": "t16",
+ "source": "BAMBI",
+ "target": "TGFB/TGFBR_complex",
+ "sign": true
+ },
+ {
+ "id": "t17",
+ "source": "LTBP1",
+ "target": "TGFB/TGFBR_complex",
+ "sign": true
+ },
+ {
+ "id": "t18",
+ "source": "Orf7a",
+ "target": "PP2A_complex",
+ "sign": true
+ },
+ {
+ "id": "t19",
+ "source": "TGFB/TGFBR_complex",
+ "target": "PP2A_complex",
+ "sign": true
+ },
+ {
+ "id": "t20",
+ "source": "Nsp7",
+ "target": "RHOA",
+ "sign": true
+ },
+ {
+ "id": "t21",
+ "source": "TGFB/TGFBR_complex",
+ "target": "RHOA",
+ "sign": true
+ },
+ {
+ "id": "t22",
+ "source": "PP2A_complex",
+ "target": "RPS6KB1_empty",
+ "sign": true
+ },
+ {
+ "id": "t23",
+ "source": "SMAD2/3_complex",
+ "target": "Modulation of cell cycle_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t24",
+ "source": "SMAD1/5/8_complex",
+ "target": "Modulation of cell cycle_phenotype",
+ "sign": true
+ }
+ ],
+ "parameters": []
+ },
+ "semantics": {
+ "ode": {
+ "rates": [],
+ "observables": [],
+ "time": {
+ "id": "t"
+ }
+ }
+ },
+ "metadata": {
+ "annotations": {}
+ }
+}
\ No newline at end of file
diff --git a/scripts/covid19_diseasemaps/regnet_amr_sbml/Virus_replication_cycle.json b/scripts/covid19_diseasemaps/regnet_amr_sbml/Virus_replication_cycle.json
new file mode 100644
index 000000000..d976ee828
--- /dev/null
+++ b/scripts/covid19_diseasemaps/regnet_amr_sbml/Virus_replication_cycle.json
@@ -0,0 +1,3907 @@
+{
+ "header": {
+ "name": "Model",
+ "schema": "https://raw.githubusercontent.com/DARPA-ASKEM/Model-Representations/regnet_v0.2/regnet/regnet_schema.json",
+ "schema_name": "regnet",
+ "description": "Model",
+ "model_version": "0.1"
+ },
+ "model": {
+ "vertices": [
+ {
+ "id": "Nsp16",
+ "name": "Nsp16",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp15",
+ "name": "Nsp15",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp14",
+ "name": "Nsp14",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp13",
+ "name": "Nsp13",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp12",
+ "name": "Nsp12",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp9",
+ "name": "Nsp9",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp8",
+ "name": "Nsp8",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp6_endoplasmic reticulum",
+ "name": "Nsp6_endoplasmic reticulum",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp3",
+ "name": "Nsp3",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "Nsp3"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp4_endoplasmic reticulum",
+ "name": "Nsp4_endoplasmic reticulum",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp7",
+ "name": "Nsp7",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp10",
+ "name": "Nsp10",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp2",
+ "name": "Nsp2",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "name": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ACE2_epithelial_space_cell",
+ "name": "ACE2_epithelial_space_cell",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "Q9BYF1"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "S_SARS-CoV-2_space_virion",
+ "name": "S_SARS-CoV-2_space_virion",
+ "grounding": {
+ "identifiers": {
+ "ncbigene": "43740568"
+ },
+ "context": {
+ "property": "uniprot:P0DTC2"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Heparan_space_sulfate_simple_molecule",
+ "name": "Heparan_space_sulfate_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:28815"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ACE2:SPIKE_space_complex_complex_epithelial_space_cell",
+ "name": "ACE2:SPIKE_space_complex_complex_epithelial_space_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nucleocapsid_complex_SARS-CoV-2_space_virion",
+ "name": "Nucleocapsid_complex_SARS-CoV-2_space_virion",
+ "grounding": {
+ "identifiers": {
+ "ncbigene": "43740575"
+ },
+ "context": {
+ "property": "GO:0019013",
+ "property1": "refseq:NC_045512",
+ "property2": "uniprot:P0DTC9"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf7a_SARS-CoV-2_space_virion",
+ "name": "Orf7a_SARS-CoV-2_space_virion",
+ "grounding": {
+ "identifiers": {
+ "ncbigene": "43740573"
+ },
+ "context": {
+ "property": "uniprot:P0DTC7"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "E_SARS-CoV-2_space_virion",
+ "name": "E_SARS-CoV-2_space_virion",
+ "grounding": {
+ "identifiers": {
+ "ncbigene": "43740570"
+ },
+ "context": {
+ "property": "uniprot:P0DTC4"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "M_SARS-CoV-2_space_virion",
+ "name": "M_SARS-CoV-2_space_virion",
+ "grounding": {
+ "identifiers": {
+ "ncbigene": "43740571"
+ },
+ "context": {
+ "property": "uniprot:P0DTC5"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "S2_epithelial_space_cell",
+ "name": "S2_epithelial_space_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "interpro:IPR002552"
+ }
+ },
+ "initial": 3.0,
+ "sign": true
+ },
+ {
+ "id": "cholesterol_simple_molecule",
+ "name": "cholesterol_simple_molecule",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:16113"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "S1:NRP1_space_complex_complex",
+ "name": "S1:NRP1_space_complex_complex",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "O14786"
+ },
+ "context": {
+ "property": "interpro:IPR002551"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nucleocapsid_complex_SARS-CoV-2_space_virion",
+ "name": "Nucleocapsid_complex_SARS-CoV-2_space_virion",
+ "grounding": {
+ "identifiers": {
+ "ncbigene": "43740575"
+ },
+ "context": {
+ "property": "GO:0019013",
+ "property1": "GO:0019013",
+ "property2": "refseq:NC_045512",
+ "property3": "refseq:NC_045512",
+ "property4": "uniprot:P0DTC9",
+ "property5": "uniprot:P0DTC9"
+ }
+ },
+ "initial": 3.0,
+ "sign": true
+ },
+ {
+ "id": "S2_SARS-CoV-2_space_virion",
+ "name": "S2_SARS-CoV-2_space_virion",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "interpro:IPR002552"
+ }
+ },
+ "initial": 3.0,
+ "sign": true
+ },
+ {
+ "id": "Nucleocapsid_complex_epithelial_space_cell",
+ "name": "Nucleocapsid_complex_epithelial_space_cell",
+ "grounding": {
+ "identifiers": {
+ "ncbigene": "43740575"
+ },
+ "context": {
+ "property": "GO:0019013",
+ "property1": "refseq:NC_045512",
+ "property2": "uniprot:P0DTC9"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ACE2:SPIKE_space_complex_complex_epithelial_space_cell",
+ "name": "ACE2:SPIKE_space_complex_complex_epithelial_space_cell",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "Q9BYF1"
+ },
+ "context": {
+ "property": "uniprot:P0DTC2"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "S1_default_compartment",
+ "name": "S1_default_compartment",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "interpro:IPR002551"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NRP1",
+ "name": "NRP1",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "O14786"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "N_epithelial_space_cell",
+ "name": "N_epithelial_space_cell",
+ "grounding": {
+ "identifiers": {
+ "ncbigene": "43740575"
+ },
+ "context": {
+ "property": "uniprot:P0DTC9"
+ }
+ },
+ "initial": 3.0,
+ "sign": true
+ },
+ {
+ "id": "Replication_space_transcription_space_complex:N_space_oligomer_complex",
+ "name": "Replication_space_transcription_space_complex:N_space_oligomer_complex",
+ "grounding": {
+ "identifiers": {
+ "ncbigene": "43740575"
+ },
+ "context": {
+ "property": "uniprot:P0DTC9"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nucleocapsid_complex_endoplasmic_space_reticulum-Golgi_space_intermediate_space_compartment",
+ "name": "Nucleocapsid_complex_endoplasmic_space_reticulum-Golgi_space_intermediate_space_compartment",
+ "grounding": {
+ "identifiers": {
+ "ncbigene": "43740575"
+ },
+ "context": {
+ "property": "GO:0019013",
+ "property1": "refseq:NC_045512",
+ "property2": "uniprot:P0DTC9"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "(+)ss gRNA_rna_epithelial_space_cell",
+ "name": "(+)ss gRNA_rna_epithelial_space_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "refseq:NC_045512"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp4:IDE_complex_epithelial_space_cell",
+ "name": "Nsp4:IDE_complex_epithelial_space_cell",
+ "grounding": {
+ "identifiers": {
+ "refseq": "NM_004969"
+ },
+ "context": {
+ "property": "ncbiprotein:BCD58761",
+ "property1": "taxonomy:2697049",
+ "property2": "uniprot:P14735"
+ }
+ },
+ "initial": 3.0,
+ "sign": true
+ },
+ {
+ "id": "Nsp4_IDE_complex",
+ "name": "Nsp4_IDE_complex",
+ "grounding": {
+ "identifiers": {
+ "refseq": "NM_004969"
+ },
+ "context": {
+ "property": "ncbiprotein:BCD58761",
+ "property1": "taxonomy:2697049",
+ "property2": "uniprot:P14735"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp4_epithelial_space_cell",
+ "name": "Nsp4_epithelial_space_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IDE_epithelial_space_cell",
+ "name": "IDE_epithelial_space_cell",
+ "grounding": {
+ "identifiers": {
+ "taxonomy": "10116"
+ },
+ "context": {
+ "property": "uniprot:P14735"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SARS-CoV2 candidate drugs_complex",
+ "name": "SARS-CoV2 candidate drugs_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SIGMAR1_endoplasmic reticulum",
+ "name": "SIGMAR1_endoplasmic reticulum",
+ "grounding": {
+ "identifiers": {
+ "refseq": "NM_005866"
+ },
+ "context": {
+ "property": "uniprot:Q99720"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SIGMAR1: drug complex_complex",
+ "name": "SIGMAR1: drug complex_complex",
+ "grounding": {
+ "identifiers": {
+ "refseq": "NM_005866"
+ },
+ "context": {
+ "property": "uniprot:Q99720"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NUP210_endoplasmic reticulum",
+ "name": "NUP210_endoplasmic reticulum",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "Q8TEM1"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp4:NUP210_complex_endoplasmic reticulum",
+ "name": "Nsp4:NUP210_complex_endoplasmic reticulum",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "Q8TEM1"
+ },
+ "context": {
+ "property": "ncbiprotein:BCD58761",
+ "property1": "taxonomy:2697049"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp6_epithelial_space_cell",
+ "name": "Nsp6_epithelial_space_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "V-ATPase_complex_endoplasmic reticulum",
+ "name": "V-ATPase_complex_endoplasmic reticulum",
+ "grounding": {
+ "identifiers": {
+ "refseq": "NM_001183"
+ },
+ "context": {
+ "property": "uniprot:Q15904"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "V-ATPase:Nsp6_complex_endoplasmic reticulum",
+ "name": "V-ATPase:Nsp6_complex_endoplasmic reticulum",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "Q15904"
+ },
+ "context": {
+ "property": "taxonomy:2697049",
+ "property1": "uniprot:Q15904"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "V-type_space_proton_space_ATPase_complex",
+ "name": "V-type_space_proton_space_ATPase_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "GO:0046611"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ATP6AP1",
+ "name": "ATP6AP1",
+ "grounding": {
+ "identifiers": {
+ "refseq": "NM_001183"
+ },
+ "context": {
+ "property": "uniprot:Q15904"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp6:SIGMAR1_complex_endoplasmic reticulum",
+ "name": "Nsp6:SIGMAR1_complex_endoplasmic reticulum",
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+ "id": "Orf7a_space_(-)ss_space_sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "name": "Orf7a_space_(-)ss_space_sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "M_endoplasmic_space_reticulum-Golgi_space_intermediate_space_compartment",
+ "name": "M_endoplasmic_space_reticulum-Golgi_space_intermediate_space_compartment",
+ "grounding": {
+ "identifiers": {
+ "ncbigene": "43740571"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "N (+)ss sgmRNA_rna_epithelial_space_cell",
+ "name": "N (+)ss sgmRNA_rna_epithelial_space_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "S_space_ds_space_sgmRNA_rna",
+ "name": "S_space_ds_space_sgmRNA_rna",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "S_space_(-)ss_space_sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "name": "S_space_(-)ss_space_sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "S_space_(-)ss_space_sgmRNA_rna_epithelial_space_cell",
+ "name": "S_space_(-)ss_space_sgmRNA_rna_epithelial_space_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf7a_endoplasmic_space_reticulum-Golgi_space_intermediate_space_compartment",
+ "name": "Orf7a_endoplasmic_space_reticulum-Golgi_space_intermediate_space_compartment",
+ "grounding": {
+ "identifiers": {
+ "ncbigene": "43740573"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf14 (+)ss sgmRNA_rna_epithelial_space_cell",
+ "name": "Orf14 (+)ss sgmRNA_rna_epithelial_space_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ACE2_default_compartment",
+ "name": "ACE2_default_compartment",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "Q9BYF1"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "S (+)ss sgmRNA_rna_epithelial_space_cell",
+ "name": "S (+)ss sgmRNA_rna_epithelial_space_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "E_endosome",
+ "name": "E_endosome",
+ "grounding": {
+ "identifiers": {
+ "ncbigene": "43740570"
+ },
+ "context": {
+ "property": "uniprot:P0DTC4"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "ACE2:SPIKE_space_complex_complex_SARS-CoV-2_space_virion",
+ "name": "ACE2:SPIKE_space_complex_complex_SARS-CoV-2_space_virion",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "Q9BYF1"
+ },
+ "context": {
+ "property": "uniprot:P0DTC2"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CTSB",
+ "name": "CTSB",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P07858"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "CTSL",
+ "name": "CTSL",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "P07711"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "M_endosome",
+ "name": "M_endosome",
+ "grounding": {
+ "identifiers": {
+ "ncbigene": "43740571"
+ },
+ "context": {
+ "property": "uniprot:P0DTC5"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf7b_space_(-)ss_space_sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "name": "Orf7b_space_(-)ss_space_sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf14_space_(-)ss_space_sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "name": "Orf14_space_(-)ss_space_sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf8_rough_space_endoplasmic_space_reticulum",
+ "name": "Orf8_rough_space_endoplasmic_space_reticulum",
+ "grounding": {
+ "identifiers": {
+ "ncbigene": "43740577"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf8_endoplasmic_space_reticulum-Golgi_space_intermediate_space_compartment",
+ "name": "Orf8_endoplasmic_space_reticulum-Golgi_space_intermediate_space_compartment",
+ "grounding": {
+ "identifiers": {
+ "ncbigene": "43740577"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf9b_space_(-)ss_space_sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "name": "Orf9b_space_(-)ss_space_sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "M_epithelial_space_cell",
+ "name": "M_epithelial_space_cell",
+ "grounding": {
+ "identifiers": {
+ "ncbigene": "43740571"
+ },
+ "context": {
+ "property": "uniprot:P0DTC5"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf7b (+)ss sgmRNA_rna_epithelial_space_cell",
+ "name": "Orf7b (+)ss sgmRNA_rna_epithelial_space_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf7a_space_(-)ss_space_sgmRNA_rna_epithelial_space_cell",
+ "name": "Orf7a_space_(-)ss_space_sgmRNA_rna_epithelial_space_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Nsp11",
+ "name": "Nsp11",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "E_epithelial_space_cell",
+ "name": "E_epithelial_space_cell",
+ "grounding": {
+ "identifiers": {
+ "ncbigene": "43740570"
+ },
+ "context": {
+ "property": "uniprot:P0DTC4"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "S1_endosome",
+ "name": "S1_endosome",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "interpro:IPR002551"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf6_endoplasmic_space_reticulum-Golgi_space_intermediate_space_compartment",
+ "name": "Orf6_endoplasmic_space_reticulum-Golgi_space_intermediate_space_compartment",
+ "grounding": {
+ "identifiers": {
+ "ncbigene": "43740572"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf3a_space_ds_space_sgmRNA_rna",
+ "name": "Orf3a_space_ds_space_sgmRNA_rna",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf3a_space_(-)ss_space_sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "name": "Orf3a_space_(-)ss_space_sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "M (+)ss sgmRNA_rna_epithelial_space_cell",
+ "name": "M (+)ss sgmRNA_rna_epithelial_space_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "M_rough_space_endoplasmic_space_reticulum",
+ "name": "M_rough_space_endoplasmic_space_reticulum",
+ "grounding": {
+ "identifiers": {
+ "ncbigene": "43740571"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf3a_endoplasmic_space_reticulum-Golgi_space_intermediate_space_compartment",
+ "name": "Orf3a_endoplasmic_space_reticulum-Golgi_space_intermediate_space_compartment",
+ "grounding": {
+ "identifiers": {
+ "ncbigene": "43740569"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf8 (+)ss sgmRNA_rna_epithelial_space_cell",
+ "name": "Orf8 (+)ss sgmRNA_rna_epithelial_space_cell",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IDE_default_compartment",
+ "name": "IDE_default_compartment",
+ "grounding": {
+ "identifiers": {
+ "refseq": "NM_004969"
+ },
+ "context": {
+ "property": "uniprot:P14735"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "IDE_epithelial_space_cell",
+ "name": "IDE_epithelial_space_cell",
+ "grounding": {
+ "identifiers": {
+ "refseq": "NM_004969"
+ },
+ "context": {
+ "property": "uniprot:P14735"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "H+_ion",
+ "name": "H+_ion",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "CHEBI:15378",
+ "property1": "CHEBI:15378"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SIGMAR1_epithelial_space_cell",
+ "name": "SIGMAR1_epithelial_space_cell",
+ "grounding": {
+ "identifiers": {
+ "refseq": "NM_005866"
+ },
+ "context": {
+ "property": "uniprot:Q99720"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "NUP210_nucleus",
+ "name": "NUP210_nucleus",
+ "grounding": {
+ "identifiers": {
+ "uniprot": "Q8TEM1"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "SIGMAR1_nucleus",
+ "name": "SIGMAR1_nucleus",
+ "grounding": {
+ "identifiers": {
+ "refseq": "NM_005866"
+ },
+ "context": {
+ "property": "uniprot:Q99720"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "double membrane vesicle viral factory assembly_phenotype",
+ "name": "double membrane vesicle viral factory assembly_phenotype",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "GO:0140526"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "(+)ss gRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "name": "(+)ss gRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "grounding": {
+ "identifiers": {},
+ "context": {
+ "property": "refseq:NC_045512"
+ }
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "N (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "name": "N (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "M (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "name": "M (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "S (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "name": "S (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "E (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "name": "E (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf6 (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "name": "Orf6 (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf7a (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "name": "Orf7a (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf3a (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "name": "Orf3a (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf8 (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "name": "Orf8 (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "DMV molecular pore_complex",
+ "name": "DMV molecular pore_complex",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf9b (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "name": "Orf9b (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf14 (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "name": "Orf14 (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf7b (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "name": "Orf7b (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "grounding": {
+ "identifiers": {},
+ "context": {}
+ },
+ "initial": 3.0
+ },
+ {
+ "id": "Orf3a_lysosome",
+ "name": "Orf3a_lysosome",
+ "grounding": {
+ "identifiers": {
+ "ncbigene": "43740569"
+ },
+ "context": {}
+ },
+ "initial": 3.0
+ }
+ ],
+ "edges": [
+ {
+ "id": "t1",
+ "source": "Nsp16",
+ "target": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t2",
+ "source": "Nsp9",
+ "target": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t3",
+ "source": "Nsp12",
+ "target": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t4",
+ "source": "Nsp3",
+ "target": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t5",
+ "source": "Nsp7",
+ "target": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t6",
+ "source": "Nsp14",
+ "target": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t7",
+ "source": "Nsp6_endoplasmic reticulum",
+ "target": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t8",
+ "source": "Nsp10",
+ "target": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t9",
+ "source": "Nsp8",
+ "target": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t10",
+ "source": "Nsp2",
+ "target": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t11",
+ "source": "Nsp4_endoplasmic reticulum",
+ "target": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t12",
+ "source": "Nsp15",
+ "target": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t13",
+ "source": "Nsp13",
+ "target": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t14",
+ "source": "ACE2_epithelial_space_cell",
+ "target": "ACE2:SPIKE_space_complex_complex_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t15",
+ "source": "S_SARS-CoV-2_space_virion",
+ "target": "ACE2:SPIKE_space_complex_complex_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t16",
+ "source": "Heparan_space_sulfate_simple_molecule",
+ "target": "ACE2:SPIKE_space_complex_complex_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t17",
+ "source": "Orf7a_SARS-CoV-2_space_virion",
+ "target": "Nucleocapsid_complex_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t18",
+ "source": "E_SARS-CoV-2_space_virion",
+ "target": "Nucleocapsid_complex_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t19",
+ "source": "Nucleocapsid_complex_SARS-CoV-2_space_virion",
+ "target": "Nucleocapsid_complex_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t20",
+ "source": "S2_SARS-CoV-2_space_virion",
+ "target": "Nucleocapsid_complex_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t21",
+ "source": "Nucleocapsid_complex_SARS-CoV-2_space_virion",
+ "target": "Nucleocapsid_complex_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t22",
+ "source": "M_SARS-CoV-2_space_virion",
+ "target": "Nucleocapsid_complex_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t23",
+ "source": "cholesterol_simple_molecule",
+ "target": "Nucleocapsid_complex_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t24",
+ "source": "S2_epithelial_space_cell",
+ "target": "Nucleocapsid_complex_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t25",
+ "source": "S1:NRP1_space_complex_complex",
+ "target": "Nucleocapsid_complex_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t26",
+ "source": "ACE2:SPIKE_space_complex_complex_epithelial_space_cell",
+ "target": "Nucleocapsid_complex_SARS-CoV-2_space_virion",
+ "sign": true
+ },
+ {
+ "id": "t27",
+ "source": "NRP1",
+ "target": "S1:NRP1_space_complex_complex",
+ "sign": true
+ },
+ {
+ "id": "t28",
+ "source": "S1_default_compartment",
+ "target": "S1:NRP1_space_complex_complex",
+ "sign": true
+ },
+ {
+ "id": "t29",
+ "source": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "Replication_space_transcription_space_complex:N_space_oligomer_complex",
+ "sign": true
+ },
+ {
+ "id": "t30",
+ "source": "N_epithelial_space_cell",
+ "target": "Replication_space_transcription_space_complex:N_space_oligomer_complex",
+ "sign": true
+ },
+ {
+ "id": "t31",
+ "source": "ACE2_epithelial_space_cell",
+ "target": "ACE2:SPIKE_space_complex_complex_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t32",
+ "source": "S_SARS-CoV-2_space_virion",
+ "target": "ACE2:SPIKE_space_complex_complex_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t33",
+ "source": "Heparan_space_sulfate_simple_molecule",
+ "target": "ACE2:SPIKE_space_complex_complex_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t34",
+ "source": "Nucleocapsid_complex_endoplasmic_space_reticulum-Golgi_space_intermediate_space_compartment",
+ "target": "Nucleocapsid_complex_SARS-CoV-2_space_virion",
+ "sign": true
+ },
+ {
+ "id": "t35",
+ "source": "Replication_space_transcription_space_complex:N_space_oligomer_complex",
+ "target": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t36",
+ "source": "(+)ss gRNA_rna_epithelial_space_cell",
+ "target": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t37",
+ "source": "Replication_space_transcription_space_complex:N_space_oligomer_complex",
+ "target": "Nucleocapsid_complex_endoplasmic_space_reticulum-Golgi_space_intermediate_space_compartment",
+ "sign": true
+ },
+ {
+ "id": "t38",
+ "source": "(+)ss gRNA_rna_epithelial_space_cell",
+ "target": "Nucleocapsid_complex_endoplasmic_space_reticulum-Golgi_space_intermediate_space_compartment",
+ "sign": true
+ },
+ {
+ "id": "t39",
+ "source": "Nsp4:IDE_complex_epithelial_space_cell",
+ "target": "Nsp4_IDE_complex",
+ "sign": true
+ },
+ {
+ "id": "t40",
+ "source": "Nsp4_epithelial_space_cell",
+ "target": "Nsp4:IDE_complex_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t41",
+ "source": "IDE_epithelial_space_cell",
+ "target": "Nsp4:IDE_complex_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t42",
+ "source": "SARS-CoV2 candidate drugs_complex",
+ "target": "SIGMAR1: drug complex_complex",
+ "sign": true
+ },
+ {
+ "id": "t43",
+ "source": "SIGMAR1_endoplasmic reticulum",
+ "target": "SIGMAR1: drug complex_complex",
+ "sign": true
+ },
+ {
+ "id": "t44",
+ "source": "Nsp4_epithelial_space_cell",
+ "target": "Nsp4:NUP210_complex_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t45",
+ "source": "NUP210_endoplasmic reticulum",
+ "target": "Nsp4:NUP210_complex_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t46",
+ "source": "Nsp6_epithelial_space_cell",
+ "target": "V-ATPase:Nsp6_complex_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t47",
+ "source": "V-ATPase_complex_endoplasmic reticulum",
+ "target": "V-ATPase:Nsp6_complex_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t48",
+ "source": "V-type_space_proton_space_ATPase_complex",
+ "target": "V-ATPase_complex_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t49",
+ "source": "ATP6AP1",
+ "target": "V-ATPase_complex_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t50",
+ "source": "Nsp6:SIGMAR1_complex_endoplasmic reticulum",
+ "target": "Nsp6:SIGMAR1_complex_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t51",
+ "source": "Nsp4:NUP210_complex_endoplasmic reticulum",
+ "target": "Nsp4:NUP210_complex_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t52",
+ "source": "V-ATPase:Nsp6_complex_endoplasmic reticulum",
+ "target": "V-ATPase:Nsp6_complex_endosome",
+ "sign": true
+ },
+ {
+ "id": "t53",
+ "source": "V-ATPase_complex_endoplasmic reticulum",
+ "target": "V-ATPase_complex_endosome",
+ "sign": true
+ },
+ {
+ "id": "t54",
+ "source": "Nsp6:SIGMAR1_complex_endoplasmic reticulum",
+ "target": "Nsp6:SIGMAR1_complex_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t55",
+ "source": "NUP210_endoplasmic reticulum",
+ "target": "NUP210:Selinexor_complex",
+ "sign": true
+ },
+ {
+ "id": "t56",
+ "source": "Selinexor_drug",
+ "target": "NUP210:Selinexor_complex",
+ "sign": true
+ },
+ {
+ "id": "t57",
+ "source": "SIGMAR1_endoplasmic reticulum",
+ "target": "Nsp6:SIGMAR1_complex_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t58",
+ "source": "Nsp6_epithelial_space_cell",
+ "target": "Nsp6:SIGMAR1_complex_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t59",
+ "source": "bafilomycin_space_A1_drug",
+ "target": "ATP6AP1:Bafilomycin_space_A1_complex",
+ "sign": true
+ },
+ {
+ "id": "t60",
+ "source": "ATP6AP1",
+ "target": "ATP6AP1:Bafilomycin_space_A1_complex",
+ "sign": true
+ },
+ {
+ "id": "t61",
+ "source": "Nsp4_epithelial_space_cell",
+ "target": "Nsp4_ALG11_complex_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t62",
+ "source": "ALG11_endoplasmic reticulum",
+ "target": "Nsp4_ALG11_complex_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t63",
+ "source": "RAB7A",
+ "target": "Nucleocapsid_complex_SARS-CoV-2_space_virion",
+ "sign": true
+ },
+ {
+ "id": "t64",
+ "source": "ARL8B",
+ "target": "Nucleocapsid_complex_SARS-CoV-2_space_virion",
+ "sign": true
+ },
+ {
+ "id": "t65",
+ "source": "Ca+2_simple_molecule",
+ "target": "Nucleocapsid_complex_SARS-CoV-2_space_virion",
+ "sign": true
+ },
+ {
+ "id": "t66",
+ "source": "RAB7A",
+ "target": "Nucleocapsid_complex_SARS-CoV-2_space_virion",
+ "sign": true
+ },
+ {
+ "id": "t67",
+ "source": "ARL8B",
+ "target": "Nucleocapsid_complex_SARS-CoV-2_space_virion",
+ "sign": true
+ },
+ {
+ "id": "t68",
+ "source": "Nucleocapsid_complex_SARS-CoV-2_space_virion",
+ "target": "Nucleocapsid_complex_SARS-CoV-2_space_virion",
+ "sign": true
+ },
+ {
+ "id": "t69",
+ "source": "ds_space_gRNA_rna",
+ "target": "(-)ss_space_gRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t70",
+ "source": "Nsp1",
+ "target": "Nsp1",
+ "sign": false
+ },
+ {
+ "id": "t71",
+ "source": "S_rough_space_endoplasmic_space_reticulum",
+ "target": "S_endoplasmic_space_reticulum-Golgi_space_intermediate_space_compartment",
+ "sign": true
+ },
+ {
+ "id": "t72",
+ "source": "(-)ss_space_gRNA_rna_epithelial_space_cell",
+ "target": "Orf9b_space_(-)ss_space_sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t73",
+ "source": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "Orf9b_space_(-)ss_space_sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t74",
+ "source": "E_space_ds_space_sgmRNA_rna",
+ "target": "E_space_(-)ss_space_sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t75",
+ "source": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "Orf9b_space_ds_space_sgmRNA_rna",
+ "sign": true
+ },
+ {
+ "id": "t76",
+ "source": "Orf9b_space_(-)ss_space_sgmRNA_rna_epithelial_space_cell",
+ "target": "Orf9b_space_ds_space_sgmRNA_rna",
+ "sign": true
+ },
+ {
+ "id": "t77",
+ "source": "M_space_ds_space_sgmRNA_rna",
+ "target": "M_space_(-)ss_space_sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t78",
+ "source": "Orf9b_rough_space_endoplasmic_space_reticulum",
+ "target": "Orf9b_endoplasmic_space_reticulum-Golgi_space_intermediate_space_compartment",
+ "sign": true
+ },
+ {
+ "id": "t79",
+ "source": "(-)ss_space_gRNA_rna_epithelial_space_cell",
+ "target": "Orf3a_space_(-)ss_space_sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t80",
+ "source": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "Orf3a_space_(-)ss_space_sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t81",
+ "source": "pp1ab_space_Nsp3-16_endoplasmic reticulum",
+ "target": "pp1ab_space_nsp6-16",
+ "sign": true
+ },
+ {
+ "id": "t82",
+ "source": "E (+)ss sgmRNA_rna_epithelial_space_cell",
+ "target": "E_rough_space_endoplasmic_space_reticulum",
+ "sign": true
+ },
+ {
+ "id": "t83",
+ "source": "Host_space_translation_space_complex_complex_rough_space_endoplasmic_space_reticulum",
+ "target": "E_rough_space_endoplasmic_space_reticulum",
+ "sign": true
+ },
+ {
+ "id": "t84",
+ "source": "Orf14_rough_space_endoplasmic_space_reticulum",
+ "target": "Orf14_endoplasmic_space_reticulum-Golgi_space_intermediate_space_compartment",
+ "sign": true
+ },
+ {
+ "id": "t85",
+ "source": "(-)ss_space_gRNA_rna_epithelial_space_cell",
+ "target": "M_space_(-)ss_space_sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t86",
+ "source": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "M_space_(-)ss_space_sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t87",
+ "source": "pp1ab_space_nsp6-16",
+ "target": "Nsp13",
+ "sign": true
+ },
+ {
+ "id": "t88",
+ "source": "Nsp5_epithelial_space_cell",
+ "target": "Nsp13",
+ "sign": true
+ },
+ {
+ "id": "t89",
+ "source": "(+)ss_space_gRNA_rna",
+ "target": "pp1a",
+ "sign": true
+ },
+ {
+ "id": "t90",
+ "source": "Host_space_translation_space_complex_complex_epithelial_space_cell",
+ "target": "pp1a",
+ "sign": true
+ },
+ {
+ "id": "t91",
+ "source": "pp1a",
+ "target": "Nsp1",
+ "sign": true
+ },
+ {
+ "id": "t92",
+ "source": "pp1ab",
+ "target": "Nsp1",
+ "sign": true
+ },
+ {
+ "id": "t93",
+ "source": "Orf14_space_(-)ss_space_sgmRNA_rna_epithelial_space_cell",
+ "target": "Orf14_space_ds_space_sgmRNA_rna",
+ "sign": true
+ },
+ {
+ "id": "t94",
+ "source": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "Orf14_space_ds_space_sgmRNA_rna",
+ "sign": true
+ },
+ {
+ "id": "t95",
+ "source": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "E_space_ds_space_sgmRNA_rna",
+ "sign": true
+ },
+ {
+ "id": "t96",
+ "source": "E_space_(-)ss_space_sgmRNA_rna_epithelial_space_cell",
+ "target": "E_space_ds_space_sgmRNA_rna",
+ "sign": true
+ },
+ {
+ "id": "t97",
+ "source": "(-)ss_space_gRNA_rna_epithelial_space_cell",
+ "target": "Orf7b_space_(-)ss_space_sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t98",
+ "source": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "Orf7b_space_(-)ss_space_sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t99",
+ "source": "Nsp15",
+ "target": "Nsp15",
+ "sign": false
+ },
+ {
+ "id": "t100",
+ "source": "pp1ab_space_Nsp3-16_endoplasmic reticulum",
+ "target": "Nsp5_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t101",
+ "source": "Nsp3-4",
+ "target": "Nsp3-4_glycosylated",
+ "sign": true
+ },
+ {
+ "id": "t102",
+ "source": "Nsp3-4_glycosylated",
+ "target": "Nsp3",
+ "sign": true
+ },
+ {
+ "id": "t103",
+ "source": "pp1ab_space_nsp6-16",
+ "target": "Nsp7",
+ "sign": true
+ },
+ {
+ "id": "t104",
+ "source": "Nsp5_endoplasmic reticulum",
+ "target": "Nsp7",
+ "sign": true
+ },
+ {
+ "id": "t105",
+ "source": "pp1a_space_Nsp6-11",
+ "target": "Nsp7",
+ "sign": true
+ },
+ {
+ "id": "t106",
+ "source": "Nsp5_epithelial_space_cell",
+ "target": "Nsp7",
+ "sign": true
+ },
+ {
+ "id": "t107",
+ "source": "pp1ab_space_nsp6-16",
+ "target": "Nsp16",
+ "sign": true
+ },
+ {
+ "id": "t108",
+ "source": "Nsp5_epithelial_space_cell",
+ "target": "Nsp16",
+ "sign": true
+ },
+ {
+ "id": "t109",
+ "source": "Orf8_space_ds_space_sgmRNA_rna",
+ "target": "Orf8_space_(-)ss_space_sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t110",
+ "source": "pp1ab_space_nsp6-16",
+ "target": "Nsp12",
+ "sign": true
+ },
+ {
+ "id": "t111",
+ "source": "Nsp5_epithelial_space_cell",
+ "target": "Nsp12",
+ "sign": true
+ },
+ {
+ "id": "t112",
+ "source": "pp1a",
+ "target": "Nsp2",
+ "sign": true
+ },
+ {
+ "id": "t113",
+ "source": "pp1ab",
+ "target": "Nsp2",
+ "sign": true
+ },
+ {
+ "id": "t114",
+ "source": "Nucleocapsid_complex_epithelial_space_cell",
+ "target": "(+)ss_space_gRNA_rna",
+ "sign": true
+ },
+ {
+ "id": "t115",
+ "source": "Orf6_space_ds_space_sgmRNA_rna",
+ "target": "Orf6_space_(-)ss_space_sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t116",
+ "source": "(-)ss_space_gRNA_rna_epithelial_space_cell",
+ "target": "ds_space_gRNA_rna",
+ "sign": true
+ },
+ {
+ "id": "t117",
+ "source": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "ds_space_gRNA_rna",
+ "sign": true
+ },
+ {
+ "id": "t118",
+ "source": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "M_space_ds_space_sgmRNA_rna",
+ "sign": true
+ },
+ {
+ "id": "t119",
+ "source": "M_space_(-)ss_space_sgmRNA_rna_epithelial_space_cell",
+ "target": "M_space_ds_space_sgmRNA_rna",
+ "sign": true
+ },
+ {
+ "id": "t120",
+ "source": "FURIN",
+ "target": "S2_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t121",
+ "source": "TMPRSS2",
+ "target": "S2_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t122",
+ "source": "ACE2:SPIKE_space_complex_complex_epithelial_space_cell",
+ "target": "S2_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t123",
+ "source": "Camostat_space_mesylate_drug",
+ "target": "S2_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t124",
+ "source": "pp1ab_space_nsp6-16",
+ "target": "Nsp14",
+ "sign": true
+ },
+ {
+ "id": "t125",
+ "source": "Nsp5_epithelial_space_cell",
+ "target": "Nsp14",
+ "sign": true
+ },
+ {
+ "id": "t126",
+ "source": "FURIN",
+ "target": "ACE2_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t127",
+ "source": "TMPRSS2",
+ "target": "ACE2_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t128",
+ "source": "ACE2:SPIKE_space_complex_complex_epithelial_space_cell",
+ "target": "ACE2_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t129",
+ "source": "Camostat_space_mesylate_drug",
+ "target": "ACE2_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t130",
+ "source": "pp1ab_space_nsp6-16",
+ "target": "Nsp10",
+ "sign": true
+ },
+ {
+ "id": "t131",
+ "source": "Nsp5_endoplasmic reticulum",
+ "target": "Nsp10",
+ "sign": true
+ },
+ {
+ "id": "t132",
+ "source": "pp1a_space_Nsp6-11",
+ "target": "Nsp10",
+ "sign": true
+ },
+ {
+ "id": "t133",
+ "source": "Nsp5_epithelial_space_cell",
+ "target": "Nsp10",
+ "sign": true
+ },
+ {
+ "id": "t134",
+ "source": "E_SARS-CoV-2_space_virion",
+ "target": "Orf7a_endosome",
+ "sign": true
+ },
+ {
+ "id": "t135",
+ "source": "Nucleocapsid_complex_SARS-CoV-2_space_virion",
+ "target": "Orf7a_endosome",
+ "sign": true
+ },
+ {
+ "id": "t136",
+ "source": "Orf7a_SARS-CoV-2_space_virion",
+ "target": "Orf7a_endosome",
+ "sign": true
+ },
+ {
+ "id": "t137",
+ "source": "S2_SARS-CoV-2_space_virion",
+ "target": "Orf7a_endosome",
+ "sign": true
+ },
+ {
+ "id": "t138",
+ "source": "M_SARS-CoV-2_space_virion",
+ "target": "Orf7a_endosome",
+ "sign": true
+ },
+ {
+ "id": "t139",
+ "source": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "Orf7b_space_ds_space_sgmRNA_rna",
+ "sign": true
+ },
+ {
+ "id": "t140",
+ "source": "Orf7b_space_(-)ss_space_sgmRNA_rna_epithelial_space_cell",
+ "target": "Orf7b_space_ds_space_sgmRNA_rna",
+ "sign": true
+ },
+ {
+ "id": "t141",
+ "source": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "N_space_ds_space_sgmRNA_rna",
+ "sign": true
+ },
+ {
+ "id": "t142",
+ "source": "N_space_space_(-)ss_space_sgmRNA_rna",
+ "target": "N_space_ds_space_sgmRNA_rna",
+ "sign": true
+ },
+ {
+ "id": "t143",
+ "source": "pp1ab_space_nsp6-16",
+ "target": "Nsp9",
+ "sign": true
+ },
+ {
+ "id": "t144",
+ "source": "Nsp5_epithelial_space_cell",
+ "target": "Nsp9",
+ "sign": true
+ },
+ {
+ "id": "t145",
+ "source": "pp1a_space_Nsp6-11",
+ "target": "Nsp9",
+ "sign": true
+ },
+ {
+ "id": "t146",
+ "source": "Nsp5_endoplasmic reticulum",
+ "target": "Nsp9",
+ "sign": true
+ },
+ {
+ "id": "t147",
+ "source": "(-)ss_space_gRNA_rna_epithelial_space_cell",
+ "target": "N_space_space_(-)ss_space_sgmRNA_rna",
+ "sign": true
+ },
+ {
+ "id": "t148",
+ "source": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "N_space_space_(-)ss_space_sgmRNA_rna",
+ "sign": true
+ },
+ {
+ "id": "t149",
+ "source": "E_rough_space_endoplasmic_space_reticulum",
+ "target": "E_endoplasmic_space_reticulum-Golgi_space_intermediate_space_compartment",
+ "sign": true
+ },
+ {
+ "id": "t150",
+ "source": "pp1ab_space_Nsp3-16_endoplasmic reticulum",
+ "target": "Nsp3-4",
+ "sign": true
+ },
+ {
+ "id": "t151",
+ "source": "pp1a_space_Nsp3-11_endoplasmic reticulum",
+ "target": "Nsp3-4",
+ "sign": true
+ },
+ {
+ "id": "t152",
+ "source": "Orf7b_rough_space_endoplasmic_space_reticulum",
+ "target": "Orf7b_endoplasmic_space_reticulum-Golgi_space_intermediate_space_compartment",
+ "sign": true
+ },
+ {
+ "id": "t153",
+ "source": "(+)ss_space_gRNA_rna",
+ "target": "pp1ab",
+ "sign": true
+ },
+ {
+ "id": "t154",
+ "source": "Host_space_translation_space_complex_complex_epithelial_space_cell",
+ "target": "pp1ab",
+ "sign": true
+ },
+ {
+ "id": "t155",
+ "source": "Host_space_translation_space_complex_complex_rough_space_endoplasmic_space_reticulum",
+ "target": "Orf3a_rough_space_endoplasmic_space_reticulum",
+ "sign": true
+ },
+ {
+ "id": "t156",
+ "source": "Orf3a (+)ss sgmRNA_rna_epithelial_space_cell",
+ "target": "Orf3a_rough_space_endoplasmic_space_reticulum",
+ "sign": true
+ },
+ {
+ "id": "t157",
+ "source": "Orf9b (+)ss sgmRNA_rna_epithelial_space_cell",
+ "target": "Orf9b_rough_space_endoplasmic_space_reticulum",
+ "sign": true
+ },
+ {
+ "id": "t158",
+ "source": "Host_space_translation_space_complex_complex_rough_space_endoplasmic_space_reticulum",
+ "target": "Orf9b_rough_space_endoplasmic_space_reticulum",
+ "sign": true
+ },
+ {
+ "id": "t159",
+ "source": "Orf7a_SARS-CoV-2_space_virion",
+ "target": "Orf7a_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t160",
+ "source": "E_SARS-CoV-2_space_virion",
+ "target": "Orf7a_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t161",
+ "source": "Nucleocapsid_complex_SARS-CoV-2_space_virion",
+ "target": "Orf7a_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t162",
+ "source": "M_SARS-CoV-2_space_virion",
+ "target": "Orf7a_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t163",
+ "source": "cholesterol_simple_molecule",
+ "target": "Orf7a_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t164",
+ "source": "S2_epithelial_space_cell",
+ "target": "Orf7a_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t165",
+ "source": "S1:NRP1_space_complex_complex",
+ "target": "Orf7a_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t166",
+ "source": "N_space_ds_space_sgmRNA_rna",
+ "target": "N_space_(-)ss_space_sgmRNA_rna",
+ "sign": true
+ },
+ {
+ "id": "t167",
+ "source": "Orf6 (+)ss sgmRNA_rna_epithelial_space_cell",
+ "target": "Orf6_rough_space_endoplasmic_space_reticulum",
+ "sign": true
+ },
+ {
+ "id": "t168",
+ "source": "Host_space_translation_space_complex_complex_rough_space_endoplasmic_space_reticulum",
+ "target": "Orf6_rough_space_endoplasmic_space_reticulum",
+ "sign": true
+ },
+ {
+ "id": "t169",
+ "source": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "Orf6_space_ds_space_sgmRNA_rna",
+ "sign": true
+ },
+ {
+ "id": "t170",
+ "source": "Orf6_space_(-)ss_space_sgmRNA_rna_epithelial_space_cell",
+ "target": "Orf6_space_ds_space_sgmRNA_rna",
+ "sign": true
+ },
+ {
+ "id": "t171",
+ "source": "Orf7a (+)ss sgmRNA_rna_epithelial_space_cell",
+ "target": "Orf7a_rough_space_endoplasmic_space_reticulum",
+ "sign": true
+ },
+ {
+ "id": "t172",
+ "source": "Host_space_translation_space_complex_complex_rough_space_endoplasmic_space_reticulum",
+ "target": "Orf7a_rough_space_endoplasmic_space_reticulum",
+ "sign": true
+ },
+ {
+ "id": "t173",
+ "source": "pp1ab_space_nsp6-16",
+ "target": "Nsp8",
+ "sign": true
+ },
+ {
+ "id": "t174",
+ "source": "Nsp5_epithelial_space_cell",
+ "target": "Nsp8",
+ "sign": true
+ },
+ {
+ "id": "t175",
+ "source": "pp1a_space_Nsp6-11",
+ "target": "Nsp8",
+ "sign": true
+ },
+ {
+ "id": "t176",
+ "source": "Nsp5_endoplasmic reticulum",
+ "target": "Nsp8",
+ "sign": true
+ },
+ {
+ "id": "t177",
+ "source": "pp1ab_space_nsp6-16",
+ "target": "Nsp6_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t178",
+ "source": "Nsp5_epithelial_space_cell",
+ "target": "Nsp6_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t179",
+ "source": "pp1a_space_Nsp6-11",
+ "target": "Nsp6_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t180",
+ "source": "Nsp5_endoplasmic reticulum",
+ "target": "Nsp6_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t181",
+ "source": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "Orf8_space_ds_space_sgmRNA_rna",
+ "sign": true
+ },
+ {
+ "id": "t182",
+ "source": "Orf8_space_(-)ss_space_sgmRNA_rna_epithelial_space_cell",
+ "target": "Orf8_space_ds_space_sgmRNA_rna",
+ "sign": true
+ },
+ {
+ "id": "t183",
+ "source": "Orf7a_space_ds_space_sgmRNA_rna",
+ "target": "Orf7a_space_(-)ss_space_sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t184",
+ "source": "M_endoplasmic_space_reticulum-Golgi_space_intermediate_space_compartment",
+ "target": "M_SARS-CoV-2_space_virion",
+ "sign": true
+ },
+ {
+ "id": "t185",
+ "source": "Host_space_translation_space_complex_complex_epithelial_space_cell",
+ "target": "N_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t186",
+ "source": "N (+)ss sgmRNA_rna_epithelial_space_cell",
+ "target": "N_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t187",
+ "source": "Nucleocapsid_complex_epithelial_space_cell",
+ "target": "N_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t188",
+ "source": "S_space_ds_space_sgmRNA_rna",
+ "target": "S_space_(-)ss_space_sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t189",
+ "source": "(-)ss_space_gRNA_rna_epithelial_space_cell",
+ "target": "S_space_(-)ss_space_sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t190",
+ "source": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "S_space_(-)ss_space_sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t191",
+ "source": "Orf7a_endoplasmic_space_reticulum-Golgi_space_intermediate_space_compartment",
+ "target": "Orf7a_SARS-CoV-2_space_virion",
+ "sign": true
+ },
+ {
+ "id": "t192",
+ "source": "Orf14 (+)ss sgmRNA_rna_epithelial_space_cell",
+ "target": "Orf14_rough_space_endoplasmic_space_reticulum",
+ "sign": true
+ },
+ {
+ "id": "t193",
+ "source": "Host_space_translation_space_complex_complex_rough_space_endoplasmic_space_reticulum",
+ "target": "Orf14_rough_space_endoplasmic_space_reticulum",
+ "sign": true
+ },
+ {
+ "id": "t194",
+ "source": "FURIN",
+ "target": "ACE2_default_compartment",
+ "sign": true
+ },
+ {
+ "id": "t195",
+ "source": "TMPRSS2",
+ "target": "ACE2_default_compartment",
+ "sign": true
+ },
+ {
+ "id": "t196",
+ "source": "ACE2:SPIKE_space_complex_complex_epithelial_space_cell",
+ "target": "ACE2_default_compartment",
+ "sign": true
+ },
+ {
+ "id": "t197",
+ "source": "Camostat_space_mesylate_drug",
+ "target": "ACE2_default_compartment",
+ "sign": true
+ },
+ {
+ "id": "t198",
+ "source": "(-)ss_space_gRNA_rna_epithelial_space_cell",
+ "target": "Orf8_space_(-)ss_space_sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t199",
+ "source": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "Orf8_space_(-)ss_space_sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t200",
+ "source": "S (+)ss sgmRNA_rna_epithelial_space_cell",
+ "target": "S_rough_space_endoplasmic_space_reticulum",
+ "sign": true
+ },
+ {
+ "id": "t201",
+ "source": "Host_space_translation_space_complex_complex_rough_space_endoplasmic_space_reticulum",
+ "target": "S_rough_space_endoplasmic_space_reticulum",
+ "sign": true
+ },
+ {
+ "id": "t202",
+ "source": "E_SARS-CoV-2_space_virion",
+ "target": "E_endosome",
+ "sign": true
+ },
+ {
+ "id": "t203",
+ "source": "Nucleocapsid_complex_SARS-CoV-2_space_virion",
+ "target": "E_endosome",
+ "sign": true
+ },
+ {
+ "id": "t204",
+ "source": "Orf7a_SARS-CoV-2_space_virion",
+ "target": "E_endosome",
+ "sign": true
+ },
+ {
+ "id": "t205",
+ "source": "S2_SARS-CoV-2_space_virion",
+ "target": "E_endosome",
+ "sign": true
+ },
+ {
+ "id": "t206",
+ "source": "M_SARS-CoV-2_space_virion",
+ "target": "E_endosome",
+ "sign": true
+ },
+ {
+ "id": "t207",
+ "source": "S_endoplasmic_space_reticulum-Golgi_space_intermediate_space_compartment",
+ "target": "S_SARS-CoV-2_space_virion",
+ "sign": true
+ },
+ {
+ "id": "t208",
+ "source": "(-)ss_space_gRNA_rna_epithelial_space_cell",
+ "target": "Orf6_space_(-)ss_space_sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t209",
+ "source": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "Orf6_space_(-)ss_space_sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t210",
+ "source": "ACE2:SPIKE_space_complex_complex_SARS-CoV-2_space_virion",
+ "target": "S2_SARS-CoV-2_space_virion",
+ "sign": true
+ },
+ {
+ "id": "t211",
+ "source": "CTSL",
+ "target": "S2_SARS-CoV-2_space_virion",
+ "sign": true
+ },
+ {
+ "id": "t212",
+ "source": "CTSB",
+ "target": "S2_SARS-CoV-2_space_virion",
+ "sign": true
+ },
+ {
+ "id": "t213",
+ "source": "E_SARS-CoV-2_space_virion",
+ "target": "M_endosome",
+ "sign": true
+ },
+ {
+ "id": "t214",
+ "source": "Nucleocapsid_complex_SARS-CoV-2_space_virion",
+ "target": "M_endosome",
+ "sign": true
+ },
+ {
+ "id": "t215",
+ "source": "Orf7a_SARS-CoV-2_space_virion",
+ "target": "M_endosome",
+ "sign": true
+ },
+ {
+ "id": "t216",
+ "source": "S2_SARS-CoV-2_space_virion",
+ "target": "M_endosome",
+ "sign": true
+ },
+ {
+ "id": "t217",
+ "source": "M_SARS-CoV-2_space_virion",
+ "target": "M_endosome",
+ "sign": true
+ },
+ {
+ "id": "t218",
+ "source": "Orf7b_space_ds_space_sgmRNA_rna",
+ "target": "Orf7b_space_(-)ss_space_sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t219",
+ "source": "Orf14_space_ds_space_sgmRNA_rna",
+ "target": "Orf14_space_(-)ss_space_sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t220",
+ "source": "pp1ab",
+ "target": "pp1ab_space_Nsp3-16_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t221",
+ "source": "pp1a_space_Nsp3-11_endoplasmic reticulum",
+ "target": "pp1a_space_Nsp6-11",
+ "sign": true
+ },
+ {
+ "id": "t222",
+ "source": "FURIN",
+ "target": "S1_default_compartment",
+ "sign": true
+ },
+ {
+ "id": "t223",
+ "source": "TMPRSS2",
+ "target": "S1_default_compartment",
+ "sign": true
+ },
+ {
+ "id": "t224",
+ "source": "ACE2:SPIKE_space_complex_complex_epithelial_space_cell",
+ "target": "S1_default_compartment",
+ "sign": true
+ },
+ {
+ "id": "t225",
+ "source": "Camostat_space_mesylate_drug",
+ "target": "S1_default_compartment",
+ "sign": true
+ },
+ {
+ "id": "t226",
+ "source": "(-)ss_space_gRNA_rna_epithelial_space_cell",
+ "target": "E_space_(-)ss_space_sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t227",
+ "source": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "E_space_(-)ss_space_sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t228",
+ "source": "(-)ss_space_gRNA_rna_epithelial_space_cell",
+ "target": "Orf14_space_(-)ss_space_sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t229",
+ "source": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "Orf14_space_(-)ss_space_sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t230",
+ "source": "Orf8_rough_space_endoplasmic_space_reticulum",
+ "target": "Orf8_endoplasmic_space_reticulum-Golgi_space_intermediate_space_compartment",
+ "sign": true
+ },
+ {
+ "id": "t231",
+ "source": "Orf9b_space_ds_space_sgmRNA_rna",
+ "target": "Orf9b_space_(-)ss_space_sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t232",
+ "source": "Orf7a_SARS-CoV-2_space_virion",
+ "target": "M_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t233",
+ "source": "E_SARS-CoV-2_space_virion",
+ "target": "M_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t234",
+ "source": "Nucleocapsid_complex_SARS-CoV-2_space_virion",
+ "target": "M_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t235",
+ "source": "M_SARS-CoV-2_space_virion",
+ "target": "M_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t236",
+ "source": "cholesterol_simple_molecule",
+ "target": "M_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t237",
+ "source": "S2_epithelial_space_cell",
+ "target": "M_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t238",
+ "source": "S1:NRP1_space_complex_complex",
+ "target": "M_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t239",
+ "source": "Orf7b (+)ss sgmRNA_rna_epithelial_space_cell",
+ "target": "Orf7b_rough_space_endoplasmic_space_reticulum",
+ "sign": true
+ },
+ {
+ "id": "t240",
+ "source": "Host_space_translation_space_complex_complex_rough_space_endoplasmic_space_reticulum",
+ "target": "Orf7b_rough_space_endoplasmic_space_reticulum",
+ "sign": true
+ },
+ {
+ "id": "t241",
+ "source": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "Orf7a_space_ds_space_sgmRNA_rna",
+ "sign": true
+ },
+ {
+ "id": "t242",
+ "source": "Orf7a_space_(-)ss_space_sgmRNA_rna_epithelial_space_cell",
+ "target": "Orf7a_space_ds_space_sgmRNA_rna",
+ "sign": true
+ },
+ {
+ "id": "t243",
+ "source": "Nsp5_endoplasmic reticulum",
+ "target": "Nsp11",
+ "sign": true
+ },
+ {
+ "id": "t244",
+ "source": "pp1a_space_Nsp6-11",
+ "target": "Nsp11",
+ "sign": true
+ },
+ {
+ "id": "t245",
+ "source": "Orf7a_SARS-CoV-2_space_virion",
+ "target": "E_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t246",
+ "source": "E_SARS-CoV-2_space_virion",
+ "target": "E_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t247",
+ "source": "Nucleocapsid_complex_SARS-CoV-2_space_virion",
+ "target": "E_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t248",
+ "source": "M_SARS-CoV-2_space_virion",
+ "target": "E_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t249",
+ "source": "cholesterol_simple_molecule",
+ "target": "E_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t250",
+ "source": "S2_epithelial_space_cell",
+ "target": "E_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t251",
+ "source": "S1:NRP1_space_complex_complex",
+ "target": "E_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t252",
+ "source": "E_endoplasmic_space_reticulum-Golgi_space_intermediate_space_compartment",
+ "target": "E_SARS-CoV-2_space_virion",
+ "sign": true
+ },
+ {
+ "id": "t253",
+ "source": "ACE2:SPIKE_space_complex_complex_SARS-CoV-2_space_virion",
+ "target": "S1_endosome",
+ "sign": true
+ },
+ {
+ "id": "t254",
+ "source": "CTSL",
+ "target": "S1_endosome",
+ "sign": true
+ },
+ {
+ "id": "t255",
+ "source": "CTSB",
+ "target": "S1_endosome",
+ "sign": true
+ },
+ {
+ "id": "t256",
+ "source": "Orf6_rough_space_endoplasmic_space_reticulum",
+ "target": "Orf6_endoplasmic_space_reticulum-Golgi_space_intermediate_space_compartment",
+ "sign": true
+ },
+ {
+ "id": "t257",
+ "source": "Orf3a_space_ds_space_sgmRNA_rna",
+ "target": "Orf3a_space_(-)ss_space_sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t258",
+ "source": "pp1a_space_Nsp3-11_endoplasmic reticulum",
+ "target": "Nsp5_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t259",
+ "source": "(-)ss_space_gRNA_rna_epithelial_space_cell",
+ "target": "Orf7a_space_(-)ss_space_sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t260",
+ "source": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "Orf7a_space_(-)ss_space_sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t261",
+ "source": "Orf7a_rough_space_endoplasmic_space_reticulum",
+ "target": "Orf7a_endoplasmic_space_reticulum-Golgi_space_intermediate_space_compartment",
+ "sign": true
+ },
+ {
+ "id": "t262",
+ "source": "M (+)ss sgmRNA_rna_epithelial_space_cell",
+ "target": "M_rough_space_endoplasmic_space_reticulum",
+ "sign": true
+ },
+ {
+ "id": "t263",
+ "source": "Host_space_translation_space_complex_complex_rough_space_endoplasmic_space_reticulum",
+ "target": "M_rough_space_endoplasmic_space_reticulum",
+ "sign": true
+ },
+ {
+ "id": "t264",
+ "source": "Orf3a_rough_space_endoplasmic_space_reticulum",
+ "target": "Orf3a_endoplasmic_space_reticulum-Golgi_space_intermediate_space_compartment",
+ "sign": true
+ },
+ {
+ "id": "t265",
+ "source": "Nsp3-4_glycosylated",
+ "target": "Nsp4_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t266",
+ "source": "pp1a",
+ "target": "pp1a_space_Nsp3-11_endoplasmic reticulum",
+ "sign": true
+ },
+ {
+ "id": "t267",
+ "source": "Orf8 (+)ss sgmRNA_rna_epithelial_space_cell",
+ "target": "Orf8_rough_space_endoplasmic_space_reticulum",
+ "sign": true
+ },
+ {
+ "id": "t268",
+ "source": "Host_space_translation_space_complex_complex_rough_space_endoplasmic_space_reticulum",
+ "target": "Orf8_rough_space_endoplasmic_space_reticulum",
+ "sign": true
+ },
+ {
+ "id": "t269",
+ "source": "(+)ss_space_gRNA_rna",
+ "target": "(-)ss_space_gRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t270",
+ "source": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "(-)ss_space_gRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t271",
+ "source": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "S_space_ds_space_sgmRNA_rna",
+ "sign": true
+ },
+ {
+ "id": "t272",
+ "source": "S_space_(-)ss_space_sgmRNA_rna_epithelial_space_cell",
+ "target": "S_space_ds_space_sgmRNA_rna",
+ "sign": true
+ },
+ {
+ "id": "t273",
+ "source": "pp1ab_space_nsp6-16",
+ "target": "Nsp15",
+ "sign": true
+ },
+ {
+ "id": "t274",
+ "source": "Nsp5_epithelial_space_cell",
+ "target": "Nsp15",
+ "sign": true
+ },
+ {
+ "id": "t275",
+ "source": "Replication_space_transcription_space_complex_complex_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "Orf3a_space_ds_space_sgmRNA_rna",
+ "sign": true
+ },
+ {
+ "id": "t276",
+ "source": "Orf3a_space_(-)ss_space_sgmRNA_rna_epithelial_space_cell",
+ "target": "Orf3a_space_ds_space_sgmRNA_rna",
+ "sign": true
+ },
+ {
+ "id": "t277",
+ "source": "M_rough_space_endoplasmic_space_reticulum",
+ "target": "M_endoplasmic_space_reticulum-Golgi_space_intermediate_space_compartment",
+ "sign": true
+ },
+ {
+ "id": "t278",
+ "source": "IDE_epithelial_space_cell",
+ "target": "IDE_default_compartment",
+ "sign": true
+ },
+ {
+ "id": "t279",
+ "source": "IDE_epithelial_space_cell",
+ "target": "IDE_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t280",
+ "source": "V-type_space_proton_space_ATPase_complex",
+ "target": "H+_ion",
+ "sign": true
+ },
+ {
+ "id": "t281",
+ "source": "SIGMAR1_endoplasmic reticulum",
+ "target": "SIGMAR1_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t282",
+ "source": "NUP210_endoplasmic reticulum",
+ "target": "NUP210_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t283",
+ "source": "SIGMAR1_endoplasmic reticulum",
+ "target": "SIGMAR1_nucleus",
+ "sign": true
+ },
+ {
+ "id": "t284",
+ "source": "Nsp6_endoplasmic reticulum",
+ "target": "double membrane vesicle viral factory assembly_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t285",
+ "source": "Nsp3",
+ "target": "double membrane vesicle viral factory assembly_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t286",
+ "source": "Nsp4_endoplasmic reticulum",
+ "target": "double membrane vesicle viral factory assembly_phenotype",
+ "sign": true
+ },
+ {
+ "id": "t287",
+ "source": "bafilomycin_space_A1_drug",
+ "target": "SARS-CoV2 candidate drugs_complex",
+ "sign": false
+ },
+ {
+ "id": "t288",
+ "source": "ds_space_gRNA_rna",
+ "target": "(+)ss gRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t289",
+ "source": "N_space_ds_space_sgmRNA_rna",
+ "target": "N (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t290",
+ "source": "M_space_ds_space_sgmRNA_rna",
+ "target": "M (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t291",
+ "source": "S_space_ds_space_sgmRNA_rna",
+ "target": "S (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t292",
+ "source": "E_space_ds_space_sgmRNA_rna",
+ "target": "E (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t293",
+ "source": "Orf6_space_ds_space_sgmRNA_rna",
+ "target": "Orf6 (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t294",
+ "source": "Orf7a_space_ds_space_sgmRNA_rna",
+ "target": "Orf7a (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t295",
+ "source": "Orf3a_space_ds_space_sgmRNA_rna",
+ "target": "Orf3a (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t296",
+ "source": "Orf8_space_ds_space_sgmRNA_rna",
+ "target": "Orf8 (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t297",
+ "source": "DMV molecular pore_complex",
+ "target": "Orf7a (+)ss sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t298",
+ "source": "Orf7a (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "Orf7a (+)ss sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t299",
+ "source": "DMV molecular pore_complex",
+ "target": "S (+)ss sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t300",
+ "source": "S (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "S (+)ss sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t301",
+ "source": "DMV molecular pore_complex",
+ "target": "Orf6 (+)ss sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t302",
+ "source": "Orf6 (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "Orf6 (+)ss sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t303",
+ "source": "DMV molecular pore_complex",
+ "target": "E (+)ss sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t304",
+ "source": "E (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "E (+)ss sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t305",
+ "source": "DMV molecular pore_complex",
+ "target": "Orf3a (+)ss sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t306",
+ "source": "Orf3a (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "Orf3a (+)ss sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t307",
+ "source": "DMV molecular pore_complex",
+ "target": "M (+)ss sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t308",
+ "source": "M (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "M (+)ss sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t309",
+ "source": "DMV molecular pore_complex",
+ "target": "Orf8 (+)ss sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t310",
+ "source": "Orf8 (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "Orf8 (+)ss sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t311",
+ "source": "DMV molecular pore_complex",
+ "target": "N (+)ss sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t312",
+ "source": "N (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "N (+)ss sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t313",
+ "source": "DMV molecular pore_complex",
+ "target": "(+)ss gRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t314",
+ "source": "(+)ss gRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "(+)ss gRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t315",
+ "source": "DMV molecular pore_complex",
+ "target": "Orf9b (+)ss sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t316",
+ "source": "Orf9b (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "Orf9b (+)ss sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t317",
+ "source": "DMV molecular pore_complex",
+ "target": "Orf14 (+)ss sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t318",
+ "source": "Orf14 (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "Orf14 (+)ss sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t319",
+ "source": "DMV molecular pore_complex",
+ "target": "Orf7b (+)ss sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t320",
+ "source": "Orf7b (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "target": "Orf7b (+)ss sgmRNA_rna_epithelial_space_cell",
+ "sign": true
+ },
+ {
+ "id": "t321",
+ "source": "Orf9b_space_ds_space_sgmRNA_rna",
+ "target": "Orf9b (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t322",
+ "source": "Orf14_space_ds_space_sgmRNA_rna",
+ "target": "Orf14 (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t323",
+ "source": "Orf7b_space_ds_space_sgmRNA_rna",
+ "target": "Orf7b (+)ss sgmRNA_rna_double_space_membrane_space_vesicle_space_viral_space_factory",
+ "sign": true
+ },
+ {
+ "id": "t324",
+ "source": "Orf3a_endoplasmic_space_reticulum-Golgi_space_intermediate_space_compartment",
+ "target": "Orf3a_lysosome",
+ "sign": true
+ }
+ ],
+ "parameters": []
+ },
+ "semantics": {
+ "ode": {
+ "rates": [],
+ "observables": [],
+ "time": {
+ "id": "t"
+ }
+ }
+ },
+ "metadata": {
+ "annotations": {}
+ }
+}
\ No newline at end of file
diff --git a/tests/test_sbml_qual.py b/tests/test_sbml_qual.py
new file mode 100644
index 000000000..8328b83b6
--- /dev/null
+++ b/tests/test_sbml_qual.py
@@ -0,0 +1,27 @@
+"""
+These tests are smoke tests to determine whether we can convert SBML Qual documents into MIRA
+template models. They do not test for correctness.
+"""
+import requests
+
+from mira.sources.sbml.qual_api import template_model_from_sbml_qual_string
+from mira.sources.biomodels import get_sbml_model
+
+models = ["Apoptosis"]
+BASE_URL = "https://git-r3lab.uni.lu/covid/models/-/raw/master/Executable%20Modules/SBML_qual_build/sbml"
+
+
+def test_qual_models_from_example_repo():
+ for model in models:
+ url = f"{BASE_URL}/{model}_stable.sbml"
+ xml_string = requests.get(url).text
+ tm = template_model_from_sbml_qual_string(xml_string)
+
+
+def test_qual_models_from_biomodels():
+ model_ids = ["BIOMD0000000562"]
+ # Full model list for reference
+ #model_ids = ["BIOMD0000000562", "BIOMD0000000592", "BIOMD0000000593"]
+ for model_id in model_ids:
+ model_text = get_sbml_model(model_id)
+ tm = template_model_from_sbml_qual_string(model_text)