Palladio is a supporting library and set of components. It's best-known use is in the Palladio app, which can be found at https://github.com/humanitiesplusdesign/palladio-app. In order to run Palladio locally, first make sure you have yarn installed and then use yarn to install the dependencies and build the assets:
git clone https://github.com/humanitiesplusdesign/palladio-app.git
cd palladio-app
yarn install
yarn build
Then simply run a local web server from this directory -- if you have python installed, you can just use:
python -m http.server
or on python 2.x:
python -m SimpleHTTPServer
The servable files in the assets/ folder are built by webpack. Running yarn develop will set webpack to automatically detect changes in the src/ directory and update the compiled Palladio files as required. In this state, webpack will update palladio.js and palladio.css and their related assets only (not the minified versions). To create new assets suitable for distibution, use yarn build, which creates all the needed assets (minified and unminified).