diff --git a/packages/mui-material/src/Tabs/Tabs.js b/packages/mui-material/src/Tabs/Tabs.js
index dfbcd083803bd0..039591c9442d2d 100644
--- a/packages/mui-material/src/Tabs/Tabs.js
+++ b/packages/mui-material/src/Tabs/Tabs.js
@@ -420,9 +420,14 @@ const Tabs = React.forwardRef(function Tabs(inProps, ref) {
       [size]: tabMeta ? tabMeta[size] : 0,
     };
 
-    // IE11 support, replace with Number.isNaN
-    // eslint-disable-next-line no-restricted-globals
-    if (isNaN(indicatorStyle[startIndicator]) || isNaN(indicatorStyle[size])) {
+    if (
+      !(
+        typeof indicatorStyle[startIndicator] === 'number' &&
+        !Number.isNaN(indicatorStyle[startIndicator]) &&
+        typeof indicatorStyle[size] === 'number' &&
+        !Number.isNaN(indicatorStyle[size])
+      )
+    ) {
       setIndicatorStyle(newIndicatorStyle);
     } else {
       const dStart = Math.abs(indicatorStyle[startIndicator] - newIndicatorStyle[startIndicator]);