diff --git a/big_scape/comparison/lcs.py b/big_scape/comparison/lcs.py
index 492e52b6..adb4a199 100644
--- a/big_scape/comparison/lcs.py
+++ b/big_scape/comparison/lcs.py
@@ -287,9 +287,10 @@ def find_domain_lcs_region(
 
         # Length
 
-        # clear the list if it's not empty and the current match is longer
+        # clear the lists if it's not empty and the current match is longer
         if len(use_longest_list) > 0 and length > use_longest_list[0][1]:
             use_longest_list.clear()
+            use_central_list.clear()
 
         # add the match to the list if it's empty or the current match is equal length
         # or longer than the existing match
@@ -523,9 +524,10 @@ def find_domain_lcs_protocluster(
 
         # Length
 
-        # clear the list if it's not empty and the current match is longer
+        # clear the lists if it's not empty and the current match is longer
         if len(use_longest_list) > 0 and length > use_longest_list[0][1]:
             use_longest_list.clear()
+            use_central_list.clear()
 
         # add the match to the list if it's empty or the current match is equal length
         # or longer than the existing match