big scape classes

BiG-SCAPE classes

By default, BiG-SCAPE will try to separate clusters into eight classes. This is done based on the product annotation from antiSMASH (see here). New labels introduced in antiSMASH 5 and 6 are annotated with a superscript.

The rules followed are currently:

antiSMASH annotation	BiG-SCAPE class
t1pks, T1PKS$^5$	PKS I
transatpks, t2pks, t3pks, otherks, hglks, transAT-PKS$^5$, transAT-PKS-like$^5$, T2PKS$^5$, T3PKS$^5$, PKS-like$^5$, hglE-KS$^5$ and combinations of these with {t1pks, T1PKS$^5$} or themselves	PKS other
nrps, NRPS$^5$, NRPS-like$^5$, thioamide-NRP$^5$, NAPAA$^6$	NRPS
lantipeptide, thiopeptide, bacteriocin, linaridin, cyanobactin, glycocin, LAP, lassopeptide, sactipeptide, bottromycin, head_to_tail, microcin, microviridin, proteusin, guanidinotides, lanthipeptide$^5$, lipolanthine$^5$, RaS-RiPP$^5$, fungal-RiPP$^5$, thioamitides$^5.1$, lanthipeptide-class-i$^6$, lanthipeptide-class-ii$^6$, lanthipeptide-class-iii$^6$, lanthipeptide-class-iv$^6$, lanthipeptide-class-v$^6$, ranthipeptide$^6$, redox-cofactor$^6$, RRE-containing$^6$, epipeptide$^6$, cyclic-lactone-autoinducer$^6$, spliceotide$^6$ and combinations of these	RiPPs
amglyccycl, oligosaccharide, cf_saccharide, saccharide$^5$ and combinations of these	Saccharides
terpene	Terpene
any of {PKS I} + any of {NRPS}	PKS/NRPS Hybrids
acyl_amino_acids, arylpolyene, aminocoumarin, ectoine, butyrolactone, nucleoside, melanin, phosphoglycolipid, phenazine, phosphonate, other, cf_putative, resorcinol, indole, ladderane, PUFA, furan, hserlactone, fused, cf_fatty_acid, siderophore, blactam, fatty_acid$^5$, PpyS-KS$^5$, CDPS$^5$, betalactone$^5$, PBDE$^5$, tropodithietic-acid$^5$, NAGGN$^5$, halogenated$^5$, pyrrolidine$^6$ and any combined annotation	Others
*	< mix >

Hybrids

If the hybrids mode is enabled, some clusters could be analyzed in different classes (if those are valid classes):

If cluster is the PKS-NRP_Hybrids BiG-SCAPE class: the cluster will also be put in the NRPS class and one of the PKS classes (PKS I or PKS other). If the cluster contains the t1pks annotation, it will always be put on the PKS I class.

If the cluster is classified as Others and BiG-SCAPE detects that it's because of a multiple annotation (e.g. terpene-t1pks), BiG-SCAPE will also put the cluster in every different individual class.