diff --git a/src/pipx/main.py b/src/pipx/main.py
index 25f9ad08f8..d829d1a227 100644
--- a/src/pipx/main.py
+++ b/src/pipx/main.py
@@ -181,10 +181,12 @@ def run_pipx_command(args: argparse.Namespace) -> ExitCode:  # noqa: C901
         logger.info(f"Virtual Environment location is {venv_dir}")
     if "skip" in args:
         skip_list = [canonicalize_name(x) for x in args.skip]
-    if "python" in args and not Path(args.python).is_file():
-        py_launcher_python = find_py_launcher_python(args.python)
-        if py_launcher_python:
-            args.python = py_launcher_python
+
+    if "python" in args:
+        if args.python is not None and not Path(args.python).is_file():
+            py_launcher_python = find_py_launcher_python(args.python)
+            if py_launcher_python:
+                args.python = py_launcher_python
 
     if args.command == "run":
         commands.run(