diff --git a/packages/compiler-sfc/__tests__/compileStyle.spec.ts b/packages/compiler-sfc/__tests__/compileStyle.spec.ts
index 66fc201f547..624cbaa043f 100644
--- a/packages/compiler-sfc/__tests__/compileStyle.spec.ts
+++ b/packages/compiler-sfc/__tests__/compileStyle.spec.ts
@@ -144,6 +144,23 @@ describe('SFC scoped CSS', () => {
     `)
   })
 
+  test(':is() and :where() with multiple selectors', () => {
+    expect(compileScoped(`:is(.foo) { color: red; }`)).toMatchInlineSnapshot(`
+      ":is(.foo[data-v-test]) { color: red;
+      }"
+    `)
+    expect(compileScoped(`:where(.foo, .bar) { color: red; }`))
+      .toMatchInlineSnapshot(`
+      ":where(.foo[data-v-test], .bar[data-v-test]) { color: red;
+      }"
+    `)
+    expect(compileScoped(`:is(.foo, .bar) div { color: red; }`))
+      .toMatchInlineSnapshot(`
+      ":is(.foo, .bar) div[data-v-test] { color: red;
+      }"
+    `)
+  })
+
   test('media query', () => {
     expect(compileScoped(`@media print { .foo { color: red }}`))
       .toMatchInlineSnapshot(`
diff --git a/packages/compiler-sfc/src/style/pluginScoped.ts b/packages/compiler-sfc/src/style/pluginScoped.ts
index 5394b77743f..f71c304f502 100644
--- a/packages/compiler-sfc/src/style/pluginScoped.ts
+++ b/packages/compiler-sfc/src/style/pluginScoped.ts
@@ -170,15 +170,23 @@ function rewriteSelector(
       }
     }
 
-    if (n.type !== 'pseudo' && n.type !== 'combinator') {
+    if (
+      (n.type !== 'pseudo' && n.type !== 'combinator') ||
+      (n.type === 'pseudo' && (n.value === ':is' || n.value === ':where'))
+    ) {
       node = n
     }
+  })
 
-    if (n.type === 'pseudo' && (n.value === ':is' || n.value === ':where')) {
-      rewriteSelector(id, n.nodes[0], selectorRoot, slotted)
+  if (node) {
+    const { type, value } = node as selectorParser.Node
+    if (type === 'pseudo' && (value === ':is' || value === ':where')) {
+      ;(node as selectorParser.Pseudo).nodes.forEach(value =>
+        rewriteSelector(id, value, selectorRoot, slotted)
+      )
       shouldInject = false
     }
-  })
+  }
 
   if (node) {
     ;(node as selectorParser.Node).spaces.after = ''