Remove ArgP-gdhA regulation and adjust Leu KI for postiive Glt import

CovertLab · Aug 18, 2021 · 86cfdc5 · 86cfdc5
1 parent b512dc4
commit 86cfdc5
Show file tree

Hide file tree

Showing 2 changed files with 2 additions and 0 deletions.
diff --git a/reconstruction/ecoli/flat/adjustments/amino_acid_pathways.tsv b/reconstruction/ecoli/flat/adjustments/amino_acid_pathways.tsv
@@ -5,6 +5,7 @@
 "CYS"	"kms"	0.1	"Fit for positive import"
 "GLN"	"km_reverse"	5	"Fit for positive kcat"
 "ILE"	"km_reverse"	5	"Fit for positive kcat"
+"LEU"	"ki"	5	"Fit for positive import"
 "LEU"	"km_reverse"	5
 "LYS"	"km_reverse"	10
 "LYS"	"kms"	0.1

diff --git a/reconstruction/ecoli/flat/fold_changes_removed.tsv b/reconstruction/ecoli/flat/fold_changes_removed.tsv
@@ -9,3 +9,4 @@
 "crp"	"rpsO"	"Remove to increase ribosome counts in with amino acid conditions when simulating with ppGpp"
 "fis"	"rpsO"	"Remove to increase ribosome counts in with amino acid conditions when simulating with ppGpp"
 "fis"	"gltX"	"Remove to get higher charging in with amino acid conditions when simulating with ppGpp"
+"argP"	"gdhA"	"Remove to get stable growth with mechanistic translation supply due to complexity of ArgP signaling and Lys pathway control"