Erythrocyte glycolytic and redox metabolism affects muscle oxygenation and exercise performance: a randomized double-blind crossover study in humans

This repository corresponds to our paper, titled "Erythrocyte glycolytic and redox metabolism affects muscle oxygenation and exercise performance: a randomized double-blind crossover study in humans", where we investigated the role of erythrocyte redox metabolism in exercise fatigue using in vivo, ex vivo and computational analyses.

Contact

• Panagiotis N. Chatzinikolaou
• Twitter handle: https://twitter.com/PanosChatz1
• Personal website: panos-chatz.netlify.app
• Email: [email protected]
• ORCID ID: https://orcid.org/0000-0002-8136-1638

Repository structure

• analysis_docs/

  • Contains Quarto Markdown (.qmd) files documenting:
    • 01_Data_Preparation.qmd: Data cleaning, processing and reshaping from wide to long format for analysis.
    • 02_Figures.qmd: Code for visualizing the data in figures and panels.
    • 03_Statistics.qmd: Statistical analyses (repeated measures anova, post-hocs, parametric and non-parametric t-tests, and effect sizes).

• data/

  • Includes raw and processed data files:
    • complete_database.csv: Dataset in wide format in CSV.
    • tidyData.RData: Data in tidy/long format.
  • README.md: Documentation for the data files.

• quantitative_analysis/

  • Scripts and results for quantitative analysis:
    • ODC plots.R: R script for calculating p50 values and plotting Oxygen Dissociation Curves.
    • p50_analysis.R: Statistical analysis of p50 values.

• r_docs/

  • Custom helper functions for statistics:
    • MyCohensEffSizes.R: Functions for calculating Cohen's effect sizes.
    • MyStatsFunctions.R: Summary statistics functions.
  • README.md: Documentation for the R scripts.

License

This project uses a CC-BY 4.0 license. All code is additionally licensed under an MIT license.