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Adding anchor tags back in.
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gunjanbaid committed Jul 27, 2017
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# Core Algorithms
# Core Algorithms {#algorithms}

## Read Preprocessing Algorithms

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In the rest of this section, we discuss the high level implementations of these
algorithms.

### BQSR Implementation
### BQSR Implementation {#bqsr}

Base quality score recalibration seeks to identify and correct correlated
errors in base quality score estimates. At a high level, this is done by
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dataset and reconstruct the quality scores of the read by using the covariate
assigned to the read to look into the covariate table.

### Indel Realignment Implementation
### Indel Realignment Implementation {#realignment}

Although global alignment will frequently succeed at aligning reads to the
proper region of the genome, the local alignment of the read may be incorrect.
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The set returned by this function is used as an index for mapping reads
directly to realignment targets.

#### Candidate Generation and Realignment
#### Candidate Generation and Realignment {#consensus-model}

Once we have generated the target set, we map across all the reads and check to
see if the read overlaps a realignment target. We then group together all reads
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Realigned reads have their mapping quality score increased by 10 in the Phred
scale.

### Duplicate Marking Implementation
### Duplicate Marking Implementation {#duplicate-marking}

Reads may be duplicated during sequencing, either due to clonal duplication
via PCR before sequencing, or due to optical duplication while on the
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