See the app documentation's here.
Whenever you want to run in production mode you have to have build the app and to after run the app:
Build the renderer server
npm run hyperion:build
Build the React App
npm run web:build
Start the renderer server
npm run hyperion:start
Whenever you want to run in development mode:
Start the renderer server in development mode
npm run hyperion:dev
Start the webpack-web-server to develop the React App
npm run web:dev