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1. AlexandrovLab/SigProfilerExtractor AlexandrovLab/SigProfilerExtractor Public

   SigProfilerExtractor allows de novo extraction of mutational signatures from data generated in a matrix format. The tool identifies the number of operative mutational signatures, their activities i…

   Python 154 53

2. AlexandrovLab/SigProfilerMatrixGenerator AlexandrovLab/SigProfilerMatrixGenerator Public

   SigProfilerMatrixGenerator creates mutational matrices for all types of somatic mutations. It allows downsizing the generated mutations only to parts for the genome (e.g., exome or a custom BED fil…

   Python 101 36

3. AlexandrovLab/SigProfilerAssignment AlexandrovLab/SigProfilerAssignment Public

   Assignment of known mutational signatures to individual samples and individual somatic mutations

   Python 48 11

4. AlexandrovLab/SigProfilerPlotting AlexandrovLab/SigProfilerPlotting Public

   SigProfilerPlotting provides a standard tool for displaying all types of mutational signatures as well as all types of mutational patterns in cancer genomes. The tool seamlessly integrates with oth…

   Python 46 14

5. AlexandrovLab/SigProfilerSimulator AlexandrovLab/SigProfilerSimulator Public

   SigProfilerSimulator allows realistic simulations of mutational patterns and mutational signatures in cancer genomes. The tool can be used to simulate signatures of single point mutations, double p…

   Python 18 4

6. AlexandrovLab/SigProfilerToolkit AlexandrovLab/SigProfilerToolkit Public

   SigProfilerToolkit is a unified command-line interface and containerized environment for mutational signature analysis.

   Python