erratum 23586

modules/m58879/index.cnxml

@@ -21,7 +21,7 @@
 <para id="fs-id1172100985194">Red blood cells are primarily responsible for carrying oxygen to tissues. Platelets are cellular fragments that participate in blood clot formation and tissue repair. Several different types of WBCs participate in various nonspecific mechanisms of innate and adaptive immunity. In this section, we will focus primarily on the innate mechanisms of various types of WBCs.</para>
 <section id="fs-id1172098550141">
 <title>Hematopoiesis</title>
-<para id="fs-id1172100952314">All of the formed elements of blood are derived from pluripotent <term class="no-emphasis" id="term-00006">hematopoietic stem cells (HSCs)</term> in the bone marrow. As the HSCs make copies of themselves in the bone marrow, individual cells receive different cues from the body that control how they develop and mature. As a result, the HSCs differentiate into different types of blood cells that, once mature, circulate in peripheral blood. This process of differentiation, called <term id="term-00007">hematopoiesis</term>, is shown in more detail in <link target-id="OSC_Microbio_17_05_Hematopo"/>.</para>
+<para id="fs-id1172100952314">All of the formed elements of blood are derived from multipotent <term class="no-emphasis" id="term-00006">hematopoietic stem cells (HSCs)</term> in the bone marrow. As the HSCs make copies of themselves in the bone marrow, individual cells receive different cues from the body that control how they develop and mature. As a result, the HSCs differentiate into different types of blood cells that, once mature, circulate in peripheral blood. This process of differentiation, called <term id="term-00007">hematopoiesis</term>, is shown in more detail in <link target-id="OSC_Microbio_17_05_Hematopo"/>.</para>
 <para id="fs-id1172098626646">In terms of sheer numbers, the vast majority of HSCs become erythrocytes. Much smaller numbers become leukocytes and platelets. Leukocytes can be further subdivided into <term id="term-00008">granulocytes</term>, which are characterized by numerous granules visible in the cytoplasm, and <term class="no-emphasis" id="term-00009">agranulocytes</term>, which lack granules. <link target-id="OSC_Microbio_17_05_FormElem"/> provides an overview of the various types of formed elements, including their relative numbers, primary function, and lifespans.</para>
 <figure id="OSC_Microbio_17_05_Hematopo">
 <media id="fs-id1172098550494" alt="A flowchart showing progression of development for formed elements of blood. At the top is a multipotent hematopoietic stem cell (hemocytoblast). This cell divides and after division some of the new cells remain stem cells. Others go down one of two paths depending on the chemical signals received. One path begins with lymphoid stem cells which can either become natural killer cells (large granular lymphocytes) or small lymphocytes. The natural killer cell is a medium-large purple cell. Small lymphocytes can either become T lymphocytes or B lymphoctyes. The T and B lymphocytes are medium size cells with a large nucleus. B lymphocytes become plasma cells which are medium size cells with a large nucleus. The other option for the stem cell is to become a myeloid stem cell. Myeloid stem cells follow one of four paths. One path leads to megakaryocyte which leads to platelets. Platelets are small flecks. The second path leads to erythrocyte. Erythrocytes are small donut shaped red cells. The third path leads to mast cells. The fourth path leads to basophil, neutrophil, eosinophil, or monocyte. Basophils are medium cells with many dark purple spots. Neutrophils are medium pink cells with a multi-lobbed nucleus. Eosinophils are medium size cells with many pink spots. Monocytes lead to macrophages or dendritic cells. Macrophages are large irregularly shaped cells. Dendritic cells have longer tendons branching off of them.">